The Wnt pathway in a normal and in a tumour cell

In normal cells without a Wnt signal a cytosolic destruction complex phosphorylates the signaling protein -catenin leading to its degradation. In the presence of the extracellular Wnt factor, activation of the membrane bound receptor FZD leads to the dissociation of the destruction complex. As a result, the level of -catenin in the cytosol and also in the nucleus is increased. Nuclear -catenin activates transcription factors that lead to the expression of proto-oncogenes such as MYC and CCND1. In cells that carry mutations in a gene coding for a protein of the destruction complex such as APC or AXIN the level of -catenin is also increased, which leads to the activation of proliferation and inhibition of apoptosis.

[@indiabiologyexplains5013]

This is a very great explanation of how the WNT pathway in tumor cells promotes excessive growth in tumor cells. As a middle school going to eighth grade, I love to understand how tumor cells act in relation to normal ones.

[@mdabusiddiq8237]

This is the best video regarding Wnt signaling pathway, thank you.

[@ned9819]

Dear god thank you for the video.These popped out in a Question bank for USMLE.

[@ewechualphonse2173]

Great work, genius in did

[@EDUARDO12348]

The destruction complex is perfect example of our human susceptibility to disease and why those that are healthy should be grateful everyday. The wrong mutations in the wrong places dissociates the whole thing and bam... expensive cancer treatment bills if your lucky.

[@Yuohani]

Very well illustrated! Great job!

[@indiabiologyexplains5013]

2:28 When you showed the destruction complex being destroyed, I see that APC is being broken. Does this mean that APC carries the mutation in a tumor cell?

[@toocud39]

This video is so easy to understand. Thanks.
I'd like to use it in my oncology class if you're ok. Please let me know ^^

[@musaedy]

Thank you very much.

[@0123juls3210]

I am considering using this in my cell biology class-what is the proper citation information to ensure credit to the author/illustrator?

[@amrkhalil870]

in normal wnt path way why the betatrcp cant help in beta catinin degredation

[@cathymcelwain7814]

I have the same question as 0123juls3210, what is the proper citation information