Introduction to Cancer Biology (Part 1): Abnormal Signal Transduction
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- เผยแพร่เมื่อ 27 ก.ย. 2024
- This animation is the first part of the series "An Introduction to Cancer Biology", and explains the mechanism of abnormal signal transduction resulting in uncontrolled cell proliferation. This animation also provides an overview of the potential targets of anticancer therapies.
REFERENCES:
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2. Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys. 2004;59(2 Suppl):21-6.
3. Gerharz CD, Ramp U, Reinecke P, et al. Analysis of growth factor-dependent signalling in human epithelioid sarcoma cell lines. Clues to the role of autocrine, juxtacrine and paracrine interactions in epithelioid sarcoma. Eur J Cancer. 2000 Jun;36(9):1171-9.
4. Potapova O, Fakhrai H, Mercola D. Growth factor PDGF-B/v-sis confers a tumorigenic phenotype to human tumor cells bearing PDGF receptors but not to cells devoid of receptors: evidence for an autocrine, but not a paracrine, mechanism. Int J Cancer. 1996 May 29;66(5):669-77.
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6. Di Fiore PP, Pierce JH, Kraus MH, Segatto O, King CR, Aaronson SA. erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science. 1987 Jul 10;237(4811):178-82.
7. Batra SK, Castelino-Prabhu S, Wikstrand CJ, et al. Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. Cell Growth Differ. 1995 Oct;6(10):1251-9.
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12. Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell. 2000 Oct 13;103(2):253-62.
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Ah yes of course, I understood everything.
*rewinding intensifies*
Very good video. It demonstrates how many moving parts are involved in cancer and why most drugs fail to control it. We just do not know enough of the incredible complexity involved in cancer development
pretty dope series about the cancer mechanism! trully enjoyed it.
I found this video extremely helpful, it has provided a basis about signaling within a cell.
I would recommend this video to someone wanting to brush up on intracellular signaling.
this is just EPIC and extremely awesome , i really can`t tell how i loved that series . excellent work INDEED
Amazing high quality video!!! Thanks so very much for creating it!
When your lecturer is useless... go to youtube >,
Transforming Growth Factor Alpha, Not Tumor Growth Factor Alpha. Tumor Growth Factor Beta, Transforming Growth Factor Alpha.
Excellent video! Now THIS is a good way to learn. Keep up the good work :)
Thank you for this amazing and very pratical vidéo.
Very good explanation
Thanks a lot! Excellent video!
Great video
ultimate and outstanding video.
The animation is excellent and the explanation are clear but very unstructured. It was hard to take notes while watching
Very good! I was able to learn more
Awesome explanation :-)
Fabulous
Yes Yes Yes Sir💖💖💖 GooooooD 💚💚
thank you
umm --the video says that overexpression of Growth factor receptors causes ligand independent firing - id look over that one more time
Its more likely structural mutations to the tyrosine kinase receptor cause ligand-independant activation while overexpression, on the other hand, causes hyper proliferation in basal levels of growth factor
When the receptors are over expressed, the Monomers of receptor tyrosin kinases will interact with each other due to the abundance of the receptors on the plasma membrane.
Thus, the overexpression of the receptor will lead to the activation of these receptors by each other by means of transphosphorylation(biochemically speaking-biologically speaking autophosphorylation), giving the cell an oncogenic power.making the cell mitotically active irresepective of the ligand presence. (ligand independent firing).
very very very well explanation
Thank you for a great video
thank u
super nice video!!
nice one
The animation is way too good.
thank you so much
Thanks 👍👍
Cell antenna
great !!!
Introduction to Cancer Biology (Part 1): Abnormal Signal Transduction
I hope someone finds a cure some day
+Yessi Perez ... or at least a way to tame and regulate cancers. Sometimes a mass of fast-replicating cells can come in handy, but we would still need a way to tell them when and where to stop or slow down, and tell them not to metastasize.
Trinitrophenylnitramine just stop eating anything
awsome
Interesting
Great!
can anyone let me know, what does he say in the 50th minutes? solid .... molecules,
thank you
"...extracellular matrix components, or cell adhesion molecules."
trying to wait until they mention mitochandia....when????
Because they hav seen better ones..which are much more clear..
Want arabic translation please
nice
Solution :
*Dr Otto Heinrich Warburg* German MD physiologist and biochemist, Nobel Prize for Physiology or Medicine in 1931:
*>*
This was just a great video !!! thanks for editing, producing and thanks for people on sharing!
Very good explanation
thank u
Where can I find transduction pathways associated directly with gene expression and regulation?
extremely instructive...thank you
superv explaination :)
Can someone please suggest some good introduction textbooks about general cancer biology?
Thanks! uploader
Nice video, it explains how the body can heal itself if we give them good balanced nutrition.
thank u soo much.......
thank you
great vid
Great.
Seems to me like a promotional video of how well they are doing. Which is fine even if it's not true. But not fine if, "not true", holds up some other research which is.
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