Just wait until you see an animation of ATP synthase, it isn't like things here that merely manipulate molecules, it's a physical machine that forces atoms together until they bond.
@@xaiano794 ATP synthase is also magnificent. However the DNA handling and associated structures were so enlightning in this video and I do more DNA stuff these days. And I've always wondered how this works
How many base pairs are required for a sequence match? That section with the base pair comparison is maddening! To think this is happening every second of every day!
Gosh, it's a great day when the GOAT posts. Grinding my molecular animation skillset at maximum effort right now -- just to achieve even 10% of this clarity and accuracy. I'm not even mad that I'm not at this level yet. It's just so great to see that this mix of clarity and accuracy is possible. Sound design is absolutely off the charts. That Holliday junction is BUTTERY smooth. Will y'all ever consider making the jump from Maya to Blender or Houdini?
0:36 I could just imagine the neighboring histone proteins desperately holding on to each other trying to prevent the ends of the DNA from floating away, probably screaming "NOOO! DON'T LET GO!!!" 😂
I would think given the length of the tails, they would grab ahold of each other before the dna is snipped. And, that the act of grabbing each other might create some sort of binding domain to attract the little snippet tool, alignment it and maybe activation it. Having the ends floating free seems like it would lead to broken repair jobs.00
😱 [When you realize cells are better at unwind and fix broken strands of DNA than you can untangle your headsets.] What I'm curious to see is how fast does this really happens. It's probably a few dozen times faster than this intricate animation shows, or it'd take forever for our cells to do anything.
Small suggestions: * it is good idea to describe proteins involved in the process also during the video (each time when new protein appears) * you mentioned enzymes at the end of animation; however histones are not enzymes; I would change it to proteins
Does anyone else get light-headed looking at this? The speed, the complexity, it's amazing. And that's just the animation, haha. (the actual process occurring inside cells is beyond comprehension.)
FYI : Homologous recombination can be defined as interaction between two DNA sequences sharing extensive nucleotide sequence identity, present on a single or two different DNA molecules, which results in a generation of mixed sequences derived from two parental ones.
Amazing to the nth degree.... I like how the Enzymes are listed when the Credits Roll. Would be interesting to see how each of these little machines are powered by ATP, powered protein bending, and more of the hydrogen bonding and binding domains of these little machines. The DNA alignment search sequence was fantastic. Can't wait for the narrated version, consider adding the rotating named enzyme off to the side showing important structures/binding domains, as each new character in the cast comes on stage. Fantastic video.
I LOVE these animations. I don't even know what the award is for outstanding sound effects, but Franc Tétaz deserves one! (However, I'd also like to mention I think the volume was too loud in this video -- I had to turn my headphones down a couple notches.)
To think, back to highschool those complex cellular machines were only letter-diagram illustrations. As others have commented, I'd love to see a "real time" comparison as well.
And we think that all of this complexity arose randomly via natural evolution, even with millions of years at its disposal...sorry but that's quite a stretch.
Intelligent design right there, imagine thinking this super complex system exist, cause some mumbo jumbo mutations and evolution lol. This stuff/system has to be precisely programmed BEFORE put to action/use or it wouldnt work at all. Nice vid, also the process is slowed down its much faster in reality.
Well this was the coolest thing I may have ever seen.
I got, lost about halfway through, was wondering if anyone could give a step-by-step breakdown.
Just wait until you see an animation of ATP synthase, it isn't like things here that merely manipulate molecules, it's a physical machine that forces atoms together until they bond.
th-cam.com/video/OT5AXGS1aL8/w-d-xo.htmlsi=5yTTpoPBYKtRvIcS
@@xaiano794 ATP synthase is also magnificent. However the DNA handling and associated structures were so enlightning in this video and I do more DNA stuff these days. And I've always wondered how this works
@@WEHImovies On what are the specifics of your animations based? Electron microscopy? Simulations?
What’s better than a holiday junction? A double holiday junction!
Really happy to see a new post of this animation style. You make the best ones.
1st junction is Saturday and the 2nd junction is Sunday. Work is getting done around them. 😅
How many base pairs are required for a sequence match? That section with the base pair comparison is maddening! To think this is happening every second of every day!
Gosh, it's a great day when the GOAT posts. Grinding my molecular animation skillset at maximum effort right now -- just to achieve even 10% of this clarity and accuracy. I'm not even mad that I'm not at this level yet. It's just so great to see that this mix of clarity and accuracy is possible. Sound design is absolutely off the charts.
That Holliday junction is BUTTERY smooth.
Will y'all ever consider making the jump from Maya to Blender or Houdini?
Let me put my 3-D headset on and fly around the action like an observer in a video game...
0:36 I could just imagine the neighboring histone proteins desperately holding on to each other trying to prevent the ends of the DNA from floating away, probably screaming "NOOO! DON'T LET GO!!!" 😂
I would think given the length of the tails, they would grab ahold of each other before the dna is snipped. And, that the act of grabbing each other might create some sort of binding domain to attract the little snippet tool, alignment it and maybe activation it. Having the ends floating free seems like it would lead to broken repair jobs.00
😱 [When you realize cells are better at unwind and fix broken strands of DNA than you can untangle your headsets.]
What I'm curious to see is how fast does this really happens. It's probably a few dozen times faster than this intricate animation shows, or it'd take forever for our cells to do anything.
I adore the quality and added audio to go with every little action
Small suggestions:
* it is good idea to describe proteins involved in the process also during the video (each time when new protein appears)
* you mentioned enzymes at the end of animation; however histones are not enzymes; I would change it to proteins
Props to the wehi boffins, their unravelling of molecular machines is wondrous to behold.
amazing work done at wehi... incredible what our cells are capable of doing...
Does anyone else get light-headed looking at this? The speed, the complexity, it's amazing.
And that's just the animation, haha.
(the actual process occurring inside cells is beyond comprehension.)
FYI : Homologous recombination can be defined as interaction between two DNA sequences sharing extensive nucleotide sequence identity, present on a single or two different DNA molecules, which results in a generation of mixed sequences derived from two parental ones.
biggest drop of 2024 these videos are so cool
Making these videos must be one of the coolest jobs on Earth. Also, love the sound effects, beat cheesy music every time.
Excellent work!!
Suggestion:I would add a short preview of the process in real time (if you know the speed of it) to impress even more the audience 😉
It blows my mind that we can know so much. Incredible.
Brilliant work as always! Every time I watch one of Drew Berry's animations I am amazed life is even possible given its complexity.
After billions of years of evolution.
I love being a machine made of machines
Very interesting, thank you. Is there any in-depth explanation available of what is happening, aside from the onscreen text?
Narrated version will be published in coming weeks. Stay tuned!
Looking forward to it! I used to watch these when I was a wee little pre-med taking biology courses in undergrad.@@WEHImovies
@@WEHImovies This is the best news of the year!
Absolutely mesmerizing!
Amazing work, sharing it with colleagues
Stupendous animation work! I hope more people see and appreciate this.
Unbelievable. great video thanks
Amazing to the nth degree.... I like how the Enzymes are listed when the Credits Roll. Would be interesting to see how each of these little machines are powered by ATP, powered protein bending, and more of the hydrogen bonding and binding domains of these little machines. The DNA alignment search sequence was fantastic. Can't wait for the narrated version, consider adding the rotating named enzyme off to the side showing important structures/binding domains, as each new character in the cast comes on stage.
Fantastic video.
This is absolutely nuts!
You guys are a Plus to loving Cellular Biology....love your work
Belfast Ireland 🇮🇪
I LOVE these animations. I don't even know what the award is for outstanding sound effects, but Franc Tétaz deserves one! (However, I'd also like to mention I think the volume was too loud in this video -- I had to turn my headphones down a couple notches.)
Every time I see these actions happening smoothly I’m imagining the hundreds/thousands of other helper proteins that aren’t shown
Homologous recombination is also important for genetic recombination during meiosis.
Always mind blowing. 😍
Another superb animation. Are you going to do the Calvin Cycle Mr Berry?
Amazing video about an amazing process
Love the sound effects!
Great work Drew and team!
Magic! Incredible!
and to imagine that this happens billions of times all the time in a body.
To think, back to highschool those complex cellular machines were only letter-diagram illustrations.
As others have commented, I'd love to see a "real time" comparison as well.
Really nice animation
That's insane.
3:34
Animation: 🗿
Programming: 🗿🗿🗿🗿
Sound: 🤪
This is incredible
Just:
WOW!
Unbelievable!
How long is this process in real life?
This is terrifying
Why?
BY USING ION INTERACTIONS AT THE ATOMIC SCALE didn't forget the actual key information. 😮
Why do the molecules do this without any profit incentive?
Why does an apple fall to Earth? Who stimulates him? it'is same reason, just converted, transformed and recombined
Is this animation or simulation?
❤❤
Nice
👍👌
Me when my dna breaks and is repaired by homologous recombination
this is so sick
like watching life on an alien planet....
And we think that all of this complexity arose randomly via natural evolution, even with millions of years at its disposal...sorry but that's quite a stretch.
Chat is this real
brain hurty
Intelligent design right there, imagine thinking this super complex system exist, cause some mumbo jumbo mutations and evolution lol. This stuff/system has to be precisely programmed BEFORE put to action/use or it wouldnt work at all. Nice vid, also the process is slowed down its much faster in reality.
That's not even remotely true. This is the end product of billions of years of natural trial and error. It does not need to be precise to work at all.