vol.4/4) LH-RH Agonists? NOT Antagonists?: Mechanism of Action Simplified.

(side note)
LH-RH agonists:
‣Goserelin (ZOLADEX®)
‣Leuprolide (Eligard®, Lupron Depot®)
The video explains breast cancer hormone therapy, covering receptor blockade, estrogen synthesis inhibition, and estrogen secretion suppression using SERMs, aromatase inhibitors, and LH-RH agonists. It's a concise guide for understanding breast cancer treatment methods.
#cancertreatment #breastcancer #hormonetherapy
【Study Break Oasis】
5-Min Forest Oasis: Healing Sounds for Study Stress
• 5-Min Forest Oasis: He...
5-Min Seaside Serenity: Waves of Calmness for Study Stress
• 5-Min Seaside Serenity...
【Learn about Hormone Therapy for Breast Cancer】
vol 1/4) Why is Hormone Therapy used for Breast cancer?
• vol.1/4) What is Hormo...
vol 2/4) SERMs: Tamoxifen (Nolvadex®, Soltamox®), Raloxifene (Evista®)
• vol.2/4) What is SERMs?
vol 3/4) Aromatase inhibitors: Anastrozole (Arimidex®), Letrozole (Femara®), Exemestane (Aromasin®),
• vol.3/4) Do you know t...
vol 4/4) LH-RH agonist: Goserelin (ZOLADEX®), Leuprolide (Eligard®, Lupron Depot®)
• vol.4/4) LH-RH Agonist...
【Learn about Hormone Therapy For Prostate Cancer】
vol 1/3) Why is Hormone Therapy used for Prostate Cancer?
• vol.1/3) Hormone Thera...
vol 2/3) Androgen Receptor and Androgen Synthesis
Abiraterone (ZYTIGA®, Yonsa®), Ketoconazol (Nizoral®), Flutamide (Eulexin®), Bicalutamide (Casodex®)., Mechanism
• vol.2/3) CYP 17 inhibi...
vol 3/3) LH-RH agonist or antagnist?
Goserelin (ZOLADEX®), Leuprolide (Eligard®, Lupron Depot®), Degarelix (Firmagon®), Mechanism
• vol.3/3) LH-RH Agonist...
【Notes】
▹This video was created based on data as of April 2024, with the purpose of supporting medical students in their exam preparations.
▹Please note that thanks to the tireless efforts of researchers worldwide, this data is updated daily. ▹Unauthorized reproduction is prohibited.
【Reference and figure】 I express my gratitude and respect for your wonderful achievements.
1. Weatherman, R. Untangling the estrogen receptor web. Nat Chem Biol 2, 175-176 (2006). doi.org/10.103...
2. Cui J, Shen Y, Li R. Estrogen synthesis and signaling pathways during aging: from periphery to brain. Trends Mol Med. 2013 Mar;19(3):197-209. doi: 10.1016/j.molmed.2012.12.007. Epub 2013 Jan 22. PMID: 23348042; PMCID: PMC3595330.
3. NIH national cancer institute, NCI dictionary of Cancer terms, selective estrogen receptor modulator.
www.cancer.gov...
4. Riggs BL, Hartmann LC. Selective estrogen-receptor modulators -- mechanisms of action and application to clinical practice. N Engl J Med. 2003 Feb 13;348(7):618-29. doi: 10.1056/NEJMra022219. Erratum in: N Engl J Med. 2003 Mar 20;348(12):1192. PMID: 12584371.
5. Farrar MC, Jacobs TF. Tamoxifen. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: www.ncbi.nlm.n...
6. Quintanilla Rodriguez BS, Correa R. Raloxifene. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: www.ncbi.nlm.n...
7. Nedresky D, Singh G. Physiology, Luteinizing Hormone. [Updated 2022 Sep 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: www.ncbi.nlm.n...
8. Chan HJ, Petrossian K, Chen S. Structural and functional characterization of aromatase, estrogen receptor, and their genes in endocrine-responsive and -resistant breast cancer cells. J Steroid Biochem Mol Biol. 2016 Jul;161:73-83. doi: 10.1016/j.jsbmb.2015.07.018. Epub 2015 Aug 13. PMID: 26277097; PMCID: PMC4752924.
9. NIH national cancer institute, NCI Dictionary of Cancer Terms, “ LH-RH”.
www.cancer.gov...
10. Schally AV, Comaru-Schally AM. Mode of Action of LHRH Analogs. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Available from: www.ncbi.nlm.n...

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I fell asleep watching my video, so I made it shorter.