Aphthous Ulcers / Canker Sores - Pathophysiology, Triggers, Types & Treatment
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- เผยแพร่เมื่อ 7 ก.พ. 2025
- Aphthous ulcers also called recurrent aphthous stomatitis (RAS) or simply known as canker sore is a common ulcerative inflammatory condition of the oral cavity. The reported prevalence in the general population varies between 5% to 66%. It typically starts in childhood or adolescence as small recurrent, painful, round, or ovoid ulcers with well-defined erythematous margins, and a central yellow or gray floor.
The lesions have a recurrent nature meaning that they are episodic once they appear for the first time in an individual’s mouth.
The exact cause or etiopathogenesis for aphthous ulcers (canker sores) is unknown, however, it’s thought that ulceration might result from a sudden activation of the cell-mediated immune system at the site of ulceration leading to the liberation of cell signaling molecules or cytokines like TNF-alpha and some other interleukins. These cytokines cause antigen expression on oral epithelial cells. The oral epithelial cells are then recognized by T lymphocytes which then trigger a cytotoxic response and the epithelial cells are phagocytized by immune cells resulting in ulceration.
Some known triggers can cause the stimulation of such an immune response
Video (diagrams+editing) & Voiceover:
Dr.Maryam Kazman
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Best video about the canker sore! The only channel I saw that covered what happen in the celular scale.
Thanks for the feedback :)
Ma'am,
Thank you for uploading this video.
This was really so helpful.
Very clear and concise.
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This is really helpful. Thanks a lot
Can it be painless i saw one after mixing toothpastes and had taken peanuts ,food that had black pepper and it was hot and its painless
Very helpful, thank you
You're welcome!
What's the causative agent for Aphthous stomatitis?
Thank you
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Why does sirulimus cause these ulcers?
Sirolimus can cause aphthous ulcers due to its immunosuppressive effects. By inhibiting the mTOR pathway, it suppresses immune function, which can impair the healing of minor oral injuries and lead to these ulcers.
My exam period is running and I'm also suffering from Apthous Ulcer 😫😫
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Mam can it occur at same place again and again
Nice
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Vitamin b12 b9 b2 b3 will help zinc folate dental hygienist care and a good probiotic and prebiotic good mouth wash might help you as you must strengthen your immune system 😢
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