How mRNA Vaccines Work - Simply Explained
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- เผยแพร่เมื่อ 14 พ.ค. 2024
- mRNA vaccines have to potential to end the COVID19 pandemic. How do they work? Are they safe? And how could they've been developed so quickly?
The main idea of mRNA vaccines is to trick our bodies to produce part of a virus. This kickstarts our immune response, without getting us sick. All that's needed is a part of the virus's DNA or RNA, packaged into mRNA. Cool!
(mRNA is the technology behind the vaccines from Pfizer/BioNTech, Moderna & CureVac)
💡 Follow-up video
• mRNA Vaccines: Questio...
I answer 10 of your mostly asked questions (and address some misconceptions).
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#mrna #vaccine #covid19 #simplyexplained - วิทยาศาสตร์และเทคโนโลยี
I really appreciate how you didn't have any background music or sound effects in this video. I'm so tired of all the noise/racket in the background of videos.
True💯💯
too true.
Nothing worse than a two minute intro of dubstep at level ten.
Oh my gosh yes!
I cannot agree more. I find background 'music' so irritating and intrusive that I am unable to watch the video. This video was brilliant, thank you very much!
Yes, and 2 vaccines and 100 boosters later!!
The problem is that spikes circulate in the blood and the complex of spike and antibody may deposit itself on the cells of blood vessels causing an inflammatory reaction that damages the cells lining the blood vessels.
But why we also hear people still experiencing symptoms and other illness after getting mRNA vaccines..??
so basically you don't need the whole enemy to train your soldiers only show them how the enemy's weapon look like.
Haha yeah! Cool analogy!
If your immune system will not react the spike you now produced more coronavirus. Can you have a presentation using DNA.
Absolultely!
We need to keep things in perspective. About 54 million covid vaccine doses have been given worldwide. We would all hope that no one experiences any side effects from the vaccine. I suggest the incidence of serious side effects is rare! It is very easy to highlight cases and blow things totally out of proportion. Which is greater: Getting a severe side effect or getting covid (which has known long-term side effects) and passing it on to others? What is your solution to getting out of the pandemic?
More like showing a photo of their enemy rather than just their weapons, and rather than letting them figure out by themselves.
wow, not mentioned any risks, only the benefits. Bravo
I swear the thought process that went into these vaccines was clever as hell. Like, who thinks of using our own body to make the key markers of a virus which it will use to identify said virus? That's the most ingenious piece of biomedical engineering idea I've ever heard of.
It is clever as hell. Some have likened it to the invention of the transistor.
But with so many variations one will need booster after booster.
Clever as HEAVEN. Hell isn't that clever.
I believe the originator of the mRNA idea struggled to get funding or anyone interested, until of course until COVID came along…
@@reveal102 Nobel Prize stuff for services to medicine and humanity in my opinion.
Why do we need second dose if our immune systems already know that thing
B cells doesn't last forever, and if it is a reocurring experience your immune system will increase the amount of b cells in total in your body.
Many vaccines have a second dose
*10th dose
This is the best and clearest explanation of mRNA vaccines I have heard so far. Excellent !
seriously !
Very good indeed!
Better than my coworkers over a Skype call this morning. "mRNA will fuse to your genes and kill you." I'm still speechless. These people get paid around $25-40 an hour and they think Bill Gates is trying to microchip us. I only realized this morning how nutty a couple people on my team really are.
@@funkyfreak97 Isn't 25-40$/hour quite a bit even for well developed countries? 25-40$/hour is a lot in my country where minimum net salary is 317 US dollars like imagine getting paid around1,5$/hour like not getting paid in a day of work as much as you get paid in one hour.
I agree 100%!
Great vid! Straight to the point, easy to digest, and quick. Literally everything i needed to know!
I think it is misleading that the video didn't make clear that the vaxxx is meant to kill us all.
@@conniemcmurray5146 go back to school
@@conniemcmurray5146 so where are all the millions of dead people?
Good simple explanation but missing important parts like how does the body stop this loop of continuing to make the spike proteins. And what are the long term affects.
Long term effects? It's still in Experimental stages
Spike proteins themselves can still cause lung damage and blood thickening.
💩
@@talltree3941 like, oh 💩 !!!?
@@awayfarer6813 no, like this guy “David” is trying to push some bullshit story to try to scare people from getting the vaccine. So the emoji is meant to mean “bullshit”. But maybe I coud Try: 🐂💩
@@talltree3941 Haha, well, I just hope people are doing their due diligence and homework about the vaccine before making a decision, and not stopping at this simple video. I respect whatever personal decision people make...and what I mean by personal is thinking for oneself, and not giving in to coercion or societal pressure either way you go.
@@awayfarer6813 I got fully vaccinated in March. No issues. I live in a large city. Millions have gotten fully vaccinated. I haven’t heard of anyone experiencing any serious side effects.
I gave thumbs up for the last part of your Video. Dont just trust me, deep dive into the sources. Nice .
Sources: Forbes, Wiki, Business Insider, Twitter?
At 3:05 it says you don’t get sick but many people have gotten sick with the injection , how come ?
You don't get sick as in you don't get sick with covid
@@goodvibes1525 but people with the vaccine have been getting sick with Covid and the different variants.
The symptoms right after receiving the vaccine are common responses when your body wants to build immunity. Getting the vaccine doesn't make you invulnerable, just like wearing seatbelts doesn't mean you're not getting hurt if you crash
It's symptoms, but not full blown sickness (most times). Your body is producing active virus DNA, so when your cells replicate it, you might experience symptoms of the virus before your body can shut it down. And by the next day, you're usually a-okay again.
Thank you for taking the time to simply explain. First video that I have found that actually makes it clear and precise.
I love your ability to Simply Explain complex topics. Subscribed.
Thank you so much.. saved me from failing in my Final school year Bio Examinations
... Hoping to get at least 90... 7 questions from the subject came and I answered it will thanks to you
You will not get 90 if you take vaccines frequently.
@@MacLuckyPTP what?
@@stellarch9524 you will not live to be 90
@@SHREDTILLDEAD I like how you didn’t even correctly explain it, this guy is talking about grades not the age so your clearly just as stupid as the guy I replied to
Wonderful! Thanks for the straightforward explanation. Brilliant!
So that's the theory. But what about all the spike proteins travelling around the body and causing mayhem in vital organs?
You can tell if someone is really smart they can explain complex things simply with ease.
asking the body to build lots of spike proteins? teaches us how to fight them off? may make sense to some but not to me.
The really smart people never took the jab in the first place
I've been trying to find a clear and simple video to show friends and family, this is perfect - thank you!
My concern is by sending a message to your cells to replicate the "spike" and then to later attack that spike could be setting our bodies up for autoimmune disease.
Which might not materialize for many months or even years later. I am not taking an experimental medication like this until it is proven safe.
The mRNA that tells our cells to produce the spikes are very unstable. They are degraded very quickly and does not remain in your body long term. It is only temporarily there to teach your cells to recognize the enemy. It's like how you would teach maths to kids , but you're not going to stay with them the rest of their lives to show them how to multiply.
@@kenn3758 all you are doing is describing the theoretical mode of action and the intention of the medication. What happens in real world situations is unclear at this stage, though people have already died after taking this experimental medication. Describing the intention is somewhat meaningless in this context.
@@slooob23 I understand your point of view. Though I must highlight that this 'theoretical' mechanism has been well studied for decades, meanwhile the deaths (if any) from this category of vaccines are extremely rare. That is like saying you won't walk outside during the rain because lightning could hit you. Yes there may be a slight possibility of negative effects, but the expected benefit you and your community get from this vaccine heavily outweigh them.
@@kenn3758 to my knowledge this is the first RNA vaccine ever produced, in that regard how can we have high confidence in it until a suitable period of time and the associated monitoring is complete? We also don't know how long it is effective for, corona viruses being notoriously difficult for lasting immune response. If the vaccine is only effective for a few months the risk profile becomes rather more of an issue.
The immune system is amazing. I think you could add to the video the effects someone might experience while the immune system tackles the intruder. But keeping it simple is a good way to teach, generally.
One of the best explanation videos ever!!
Thank you brother!
Thank you for making this so easy to understand. It really does help give me peace of mind.
Listing sources gets a huge thumbs up.
You get a gold star if u get ur 2 injections :)
Well that shattered one or two illusions I had! Thanks for that video.
just like that huh? did you bother to research further? probably not...
@@taraakins8273 Whaaaat? Wow, just....wow 🤦
Perfect amount of information, explained concisely. Thank you!
Thanks for the explanation. Easy to understand and relatively quick/to the point.
Glad you liked it!
Now Govts need to market this with a brief explanation of how the vaccines work and endorsements.
Exactly, they’re currently just advertising that you should get it and that everyone’s getting it, instead of actually explaining it so people can see it’s safe without having to take the governments word for it
Nie,nie
You really make it easy to understand. Thank you so much!
Thanks for sharing! Finally some clarity : )
Awesome, couldn't find any info on the actual breakdown of the produced spikes by the body's immune system after vaccination has taken place. This was clear and concise for laymen like me. :-)
Me too
Then why are people getting so sick after the second dose?
Great explanation and graphics!
Thank you, most articles act like I am a child when I read them.
Glad you liked it!
That might be because most of the people are behaving like children during this whole pandemic
Thank you so much! This really helps me with my Life Sciences 11 Project!
This was great! Thanks for putting together such a logical and simple presentation.
Really good explanation and super understandable, thank you!
Except he didn't mention the following:
1. The purpose of the research Dr. Fauci funded was to engineer the spike protein to be EXTREMELY toxic. So the spike protein our bodies manufacture are just as toxic as the spike protein on the virus, and they are causing major problems.
2. It's the spike protein that is mutating to create the new variants, which is why these vaxes don't provide lasting immunity ---- after the spike protein mutates, our immune system no longer recognizes the spike virus. Which is why dead antigen vaccines are so superior --- because we develop immune recognition to all 32 viral proteins, so when the spike protein mutates we can still recognize the rest of the virus.
Incredible video explaining some incredible technology! I'm amazed by the scientists that managed to come up with this technique and put it into effective use! Incredible stuff!
I wouldnt get to excited. Lets see how it works a year down the line.
@@garryallison5679 it works great
@@garryallison5679 I got the vaccine it’s awesome. I feel great
@@nickizcool20 the placebo effect....
why are people dying from the vaccine?
This is such a great explanation! Thank you so much!
This is great:) now u too can get this amazing injection from god.
Amazing, super clear explanation. Well done!
Really helpful and easy to understand. You've greatly put my mind at rest! Thank you so much for taking the time to put this video together!
You have done the world a public service by creating this video and I will share this to all corners of my little world and hopefully it'll spread. Thank you also for providing references in the description. Well done!
Thanks for your kind words! Really means a lot. I hope other people will also see the value (and the trolls stay away)
@@simplyexplained You are very welcome. Ignore all the trolls and anybody else that doesn't have a constructive question or comment. I know, easier said than done. In particular, there is one person I will target this video to: she is a fitness/motivational influencer on TH-cam and has urged her followers to avoid vaccines at any cost. I will be sending her your video link directly. Her chief complaint is the mRNA component of the vaccine. This is especially why I'm appreciative of the references in the description. Keep up the fantastic work!
Spread...like a virus!? (Sorry, little vaccine joke)
@@martyes9563 we need laughs so no need to be sorry ;-)
Hope this video will calm down the anti-vaccine people.
My concern is that this is the first time mRNA has been used on humans in such a wide scale before. The experts say it is safe, but how can we know for sure that there will not be long term side effects?
Because we know exactly how it works. It's isn't just some random procedure. We have known how mrna works for decades and we simply are using that knowledge to teach out cells to fight off a virus.
@@jonny555333 we don’t know the ramifications and the majority of us can fight off the virus with our immune system so we don’t all need it
@@jonny555333 no, this has never been done before on humans and everyone gettin it are guinea pigs to fight a virus that’s 99.998% survivable!
@@minpat7518 lol if you don't have a good resson to get vaccinated (like a disease or whatever) and you don't want to be vaccinated you're irresponsible and more or less an idiot
@@maxmorris4562 we know how RNA works, my buddy began working on this more than 20 years ago.
The easy going explanation so far.
Very Well, and clearly explained, Great job👍
In theory it sounds great, in practice its unfortunately not.
Dude. Thank you. I’ve recently got the new kurzgesagt book on immunology. It’s great but I either haven’t got to the MRNa but yet or it’s not covered. But I keep hearing about it and I keep hearing about “MRNa entering the cells nucleus” which sounded like bullshit. This totally clears up what the MRNa does so thank you 🙏
Talk about the side effects now.
Still doesn't explain what happens to the cells that manufactured the mrna.
So helpful! Thank you so much for this video.
Yes, I agree with you. cool video! clear and easy to understand!
Can you make a video for inactive vaccines (eg: for Covid 19) comparing to mRNA vaccines by versus? Appreciate. Great job.
So if you can’t get sick, why are some people getting symptoms after taking it?
1) So why more than 1 injection is needed?
2) Why there are any side effects or people feel sick and so on?
3) Why there's a talk about "long term side effects"? How learning the body to fight against virus can cause long term side effects?
you can find these all with a simple google search
@@coleross1562 but im too lazy
Unfortunately studies are showing that the spike is toxic and also very damaging. So Mrna thought our bodies to produce damaging toxins in a large way therefore making our immune systems go into continuous overdrive eventually leading to self destruction causing immune failure.
So by your reasoning this would happen with the natural virus as well as the vaccine?
@@jimmyswaggart1189 What is the Covid-related mortality for non-elderly persons with no comorbidities??
@@JK_JK_JK Well that's a question that is impossible to answer now isn't it so why ask it?
@@jimmyswaggart1189 Try again after looking at the data.
@@JK_JK_JK Again this has been answered before and it's an impossible to answer.
Short and sweet, wonderful and informative video!
The most beautiful explanation in its simplicity. Great video !!
I had the worst reaction from my second phizer vaccine and so did my partner.
You don’t know why that happend. It could be something else that caused your reaction. Don’t make the assumption that because two phenomena occour simultaniously, that one is caused by the other. That is a logical fallacy. It could be the vaccine but to claim it is a mono-causal and often erroneous explanation.
Thanks! Easy and understandable.
You really made this very easy to understand! Thank you!
Great explanation and easy to understand. Everyone should watch this.
Amazing and totally clear, understandable explanation of covid vaccines. No highly technical mumbo jumbo that most researchers like to try and impress you with. A real breath of fresh air for anyone who wants to know what is happening inside them when they get that shot.
That's me right now. Just got the second shot so I am wondering what happens to see if I am going to feel bad or not.
Amazing video
Forgot to mention ade
Very true. Same here
ikr? I watched one and they were like "fancy science words... blah blah" and I didn't understand a thing. This one makes sense! I think it's really important that people explain things in normal terms, so ordinary people can understand it too. Don't try to impress us with technical terms, impress us with a clear, understandable explanation
@@telemarketer1584 for a better explanation on how these “vaccines” work. Just go to John Hopkins COVID tracker. Pick your favorite heavily vaccinated country (Israel, Canada, Australia, Gibraltar) look at the timeline of COVID cases and deaths. Notice how the majority occur AFTER the “vaccine” rollout . I’ll let you figure out what that means.
This is the first time in my life I'm learning how vaccines work. Thank you for making this knowledge so accessible!
This isn't how vaccines work though. This is an experimental technology 😂 learn some basic science please
@@pungency101 The video starts with the basic principles. What are you on about?
@@surfinmuso37 Would be interested in seeing the research you're looking at that puts these numbers in context.
@@pungency101 You're so smart dude
@@Apochocolate I've been studying medicinal chemistry for over 5 years... I'm well enough informed to know this is an experiment
Excellent video. So simple, easy to understand, informative and educational. Thank you! In fact, this video should be sent to the CDC so they can better inform the public instead of confusing them.👍👏
Maybe their intention and point, is to confuse
@@MegaTrivial yeah they want fear, not facts.
@@mommyshark5106
- it sucks.. I wish authorities were starting to behave normal, no need of power over us LoL 😆😆🙂🔌🔌🔌🔌
Awesome explanation. Keep up the good work Champ!!
Nice animation. I rarely looked at this quality video.
The vaccine is mRNA. mRNA is genetic code. The vaccine is genetic code. He forgot to mention that.
a very nice simple explanation - thanks so much!
Explained really well for the mere mortal such as I
You got my subscription. Totally clear explanation.
Towards the end, the video man says "don't take my words".
Thankful for this video and the (majority) of comments being informed and intelligent for once.
Thanks so much for sharing. 😎👌🏼
Brilliant explanation.thank you so much ❤
This video said "Don't take my word for it", i quote in verbatum
I like your explanation. However, it must be cautioned that this technology does not have a track record. What will happen when this synthetic rna is produced in other parts of the body? In the case of covid, what about the lipid enclosed nano particles? They are basically tricking the cells into making a synthetic compound. What is being used to create this synthetic compound? What happens to the synthetic compound that was used to create this protein? Can the nano particles be remotely manipulated? How is it possible for the vaccine to enter the cells?
@@renitapayno Jerusalem Times had an article about these mRNA vaccines. I am not an antivaxer I know vaccines work, but this is an entirely new type of vaccine, never been approved for use in humans before. I don't know why they would not used the tried and true weakened/dead virus for a vaccine
@@renitapayno , do you mind sharing that article? I have too many questions about the platforms that they are using with this vaccine. I personally find the whole process very troubling. No one is talking about the nanotechnology used in this vaccine.
Tried to warn coworkers against using this new technology that, ultimately, injects itself into your cells and manipulates them to produce spike proteins instead of what it normally produces.
Extremely invasive.
Most importantly, I said it's not worth taking a risk given you are young and healthy and are at no risk.
Of course, they called me anti-vaxxer.
Thank you for the clear explanation
Awesome video, straight to the point and very comprehensible.
Nice explanation and appreciated. The part about not getting sick is not quite accurate though. Maybe that is supposed to work that way, but typically doesn’t from all that I talked with, at least a few days. One study even indicating that the spike protein may be getting in the blood in a few cases, anything can take place if that happens. Guess will find out over time.
Exactly
As time passed we found out in a very concerning way
What an excellent and informative video! Thanks!
superb....hats off to those people who thought the idea of making a blue print of that portion in the virus that produces the spikes... excellent
Very good video - simple and clear explanation!
The fact this doesn't have too many views has me worried about humanity as a whole...
Half million isn’t enough?
The anti-vaxxers are too proud of their ignorance to learn how it all works. After all, learning some basic biology might make them realize they were wrong. Can't have that.
@Jonathan Bacon-Sandwich Nope, but I know enough to understand the science behind how mRNA vaccines work. Its really quite fascinating. The folks screaming from the roof tops about gene therapy are, to put it bluntly, clueless. They don't understand what mRNA is or how it works at even a basic level.
@@jarynn8156 The anti-vaxxers are the ones that actually did their own research and came to the conclusion to stay the fuck away.
@@tdottees7146 Eh. They may have done their own Google searches, but lets not call it research. Very rarely are their opinions based on actual scientific evidence. They are based on pulling quotes wildly out of context, extracting numbers from sources that never proclaimed to have the numbers they are after, and, when all of that fails, just straight up making stuff up. I've seen so many people down here in the comments go on about everything from gene therapy to autism to fake quotes from Pfizer that the vaccine will cause miscarriages to claims that the vaccines are somehow the Mark of the Beast. All of which are absolutely devoid of fact. And since proving a negative is super hard, good luck ever reasoning with them.
This was an amazing simplified description of how the vaccine works!
Thank you! Clear and short explanation.
What if a person already has a hyperactive immune response and how long dies this stay in your body and what is the connection to heart and kidney disease?
I wanna to know what kind of body cells will take up those mRNA? Are those cells being specifically selected or randomly absorbed? Once those body cells start marking the viral protein and display on their surface, will the T-cell treat them as foreign and attack those cell also? Just like rejection in transplantation?
Good question and it is about 4 days no answer)
@@azaraliyev2064 Either no one can give the exact answer, or someone know the answer but not wanna disclose it.
I've been wondering about that too. I would assume they're just thrown out of the cell to hang out in the tissues or work their way over to the bloodstream where immune cells can find them. (Cells absorb and release proteins all the time after all.)
How the body knows when to stop building spikes?
cell producing spikes dies... oh wait
When mRNA runs out
that is a good question, 3:20 is it explain, but really is it? cell it self get cleaned??? and if not then what, my cell will be making some bulllhsittt spikes instead of something else?
Better question, howcome mRNA are giving symptoms
Especially on the 2nd shot?
@@inbaedae3733 Relatively simple: immune reaction (interleucines, interferon etc).
Thank you for this! After tons of videos, now I finally get it
Well done! Now you take multiple injections of this to protect the ones you love.
Doesnt the immune system also destroy the cells that produce these spikes though?
Good, now we know how it is **supposed** to work, but what are the possible downsides to teaching the body how to make spike proteins.
Finally! I found an easy version to explain my primary kids. Thanks a lot for the upload. Great Job!
Young ppl don’t need it
With every mRNA vaccine I become closer to immortality.
That was a very precise explaination. Thank you
missing the explanation of how those spikes got out of the human cells though... One source I read said that the spikes end up attached to the cells exterior not floating around randomly like in the video... If one fact is wrong, what else is wrong...
Very good explanation, thank you.
Many people I know who get vaccinated get sick almost immediately with covid type symptoms. Why is that?
Nice explanation, but I still don’t understand how the immune system understands that those produced spikes have to be killed, as they don’t cause any harm.
Thank you so much for the fantastic lucid explanation ❤️
Please explain how it is impossible for the synthetic mRNA to enter the cell nucleus. I've not seen any explanations on why this is impossible anywhere. They just say it's impossible. As a commercial risk analyst my role requires me to list all the possible risks (even unlikely ones) for any large purchases/contract agreements that need approving by the exec. This is so they can make an informed decision. No one is giving any detailed listing of the risks, including 1, 2, 3 - 5, 10 year and longer term horizons. What are the potential risks, however unlikely, if its even remotely possible, they should be listed so we can make an informed decision. If execs expect such for a mere $1 million purchase, what makes this any different?