AKT Signaling Pathway | Regulation and Downstream Effects

Biomedical lesson on AKT (Protein Kinase B) signaling, regulation and downstream effects. The AKT signalling pathway is a highly conserved pathway that induces several important functions including glucose uptake and utilization, protein synthesis, fatty acid synthesis, glycogenesis and cell survival and proliferation.
Hey everyone. This lesson introduces the AKT (PKB) signalling pathway, how the pathway is regulated and controlled, and what are the major cellular outcomes of AKT signaling. Additionally, we also discuss how diseases such as cancer can be associated with abnormal AKT signaling.
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@Clash_In_Saff]

Just started my research masters, this video is sweeter to my eyes and ears than any of my greatest youthful crushes.

[@dena3107]

I have an exam about this today and I was always confused about certain parts in this pathway. This video clearly and succinctly explains the pathway, thank you so much!

[@alexisteja9920]

You are amazing! I wish I can be able to explain this clearly to my students just like you did. Thank you!

[@xinjunwu7941]

thank you for spending time and sharing your knowledge with us.

[@shashidharnrao]

fantastic video on how AKT Kinase works. I learnt a lot. The author has a very lucid style of explanation. Thank you for posting.

[@fieldtripinmyparty]

simply perfect. i wish you could do a similar video to the pathways involved in HSP90 alpha.

[@fatimareginamenasilva1204]

Very didactic and summarized explanation. Thank you¹

[@ikyhwh]

I'm glad you saved the simple explanation for the end because it helped me digest such a detailed explanation of all of the macronutrients it regulates by blocking them... I think 😅
Black seed oil 👍

[@varshaps3165]

Thank you so much for this lecture. It was really really helpful ☺️☺️

[@shangfanggao6880]

Super clear! Bravo!

[@renzofernandoalvafigueroa4031]

A very clearly and useful lesson, greetings from PERU

[@nachinathan3846]

Amazign work!!!

[@mohammedal-hammadi5085]

Thank you, it's pretty clear

[@dubstepXpower]

Thanks mate, great videos

[@salmanisthebest1]

Very helpful. Thank you

[@ishayadav2466]

Love u so much ...Thank you

[@josefinatanco7312]

Very helpfull!! thank you so much

[@rory1234gilmore]

Great. Thank you so much

[@anmarraheem3824]

Your videos are awesome
Keep up the good work!
Thank you

[@edenx4775]

Great video!

[@daniamawa7230]

Thank you sooooo much!!

[@aang7505]

1. AKT is an inhibitor of TSC1/2
2. TSC1/2 is an inhibitor if Rheb.
3. Rheb is an activator of mTORC1
AKT inhibits the inhibitor of Rheb (TSC1/2). Thereby allowing more Rheb to activate mTORC1 allowing for more activation of TSC1/2 as compared to if AKT was NOT present

[@holeung973]

thx sir today my biochem exam has actually have akt pathway

[@chasadisum]

Cool 😎 best ever video

[@abdullabhuyan9276]

Great Job! Really helpful! But in the part relation to Glycogen synthesis is little bit confusing to me. If possible please clear me! Does by GSK3 phosphorylation, GSK3 become inactive? and GS become phosphorylated or dephosphorylated?

[@navit4578]

ថឪ

[@mohamed_mekawyy]

شكراً جززززيلااااااا

[@Firdos7]

Thanks

[@jolienlansens1176]

nice video! What's the source of the image i can refer to?

[@soul5626]

thanku

[@hafizabdulkhaliq3442]

10/10

[@alexanderdiederichs7332]

Is GSK3 the same as GSK3-ß from Wnt-signaling (Activation of Akt leads to inactivation of beta-Catenin Destruction Complex, leading to a proliferative signal through a accumulation of beta-Catenin in the nucleus)? This would be an additional way how Akt stimulates cell proliferation?

[@oliviamccarthy6339]

Dear JJ Medicine, I wonder whether there is an email address I am able to contact you regarding your authorisation to use illustration elements of this material for scientific publication please? Any help is greatly appreciated. Kind regards, Olivia

[@lipeiqi3432]

Why both Glycogen synthesis and Glycolysis are activated?

[@harrygriffin1098]

i’m 16. why am i here lol

[@ronfisher9915]

Enjoy the content bruh

[@srihadjrah3960]

Sncak vidio aktifkan dong?

[@NaushadAli-md3sy]

Very good explanation.