Ras Raf MAPK Pathway and Cancer | Mutations, Cancer Pathogenesis, and Chemotherapy
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- เผยแพร่เมื่อ 29 พ.ย. 2017
- Lesson on Ras Raf MEK ERK (MAPK) pathway and its involvement in cancer pathogenesis. Various mutations in EGFR, Ras and Raf proteins can lead to particular types of cancer, which can be treated with chemotherapeutic treatments that target either EGFR or Raf proteins.
Hey everyone! In this lesson, you will learn about how mutations in the Ras Raf MEK ERK (MAPK) pathway can result in different types of cancer such as pancreatic cancer and melanoma. You will also learn various chemotherapies that can target proteins in the Ras Raf MAPK pathway to treat cancer.
If you find this video helpful, please consider liking the video and subscribing to my channel :)
JJ
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
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JJ
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14-91% that range is absolutely massive
YOU'RE A LEGEND I FINALLY FOUND WHAT I NEEDED. THANK YOU. I WAS TRYING TO FIND A MECHANISM OF ACTION AS TO HOW BRAF GENE MUTATION CAN AFFECT MELANIN PRODUCTION AND I FINALLY FIGURED IT OUT.
How
very informative and well made video. Thank you!
Just one thing that might not be completely right: -mab is the suffix/ending for any kind of therapeutic antibody (Monoclonal Anti-Body) and not exclusively for those that target the EGFR.
Great video. Very simplified, easy to understand
Thank you for the helpful prep for my finals! :)
th-cam.com/video/kWHgDLYaj_4/w-d-xo.html
very clear and concise! made understanding a difficult topic much more achievable!
Thank you for sharing this excellent lecture
this and the video before helped so much. thank you!! great work!
Thank you so much for uploading this video!
What about the other EGFR-related proteins like HER2? Great video regardless!
very well explanation ! thanks
Very clear and informative. Thanx
That was such a incredeble video thakns!❤
thanks for the great class
Excellent explanation💞💯
Guy you're cool. Thank you so mutch, it's very needful job that you do
This is a fantastic video
Thanks it is very clear ! What are your sources to give these percentage of cancers ?
Hello sir . Can you please recommend a book from which you prepare all the pathways .
Could you share the literature of H-Ras mutated in bladder cancer. Thank you.
interesting, but which source did you use?
could there also be mutations in RAS proteins to stop the activation?
what about breast cancer from EGFR over expression? am I missing something or you didn't mention it?
th-cam.com/video/kWHgDLYaj_4/w-d-xo.html
Especially HER2
Hairy Cell Leukemia has the most BRAF mutation
Great!
May I underline a small mistake?
Hematopoietic, not Hematopoetic.
there are 4 not 3 ras proteins. KRAS is devided into KRAS4A and KRAS4B because of different spleißing
could you tell me the bibliography?
how can RAS be used to treat cancer cells
If you block or inhibit RAS then it will stop the pathway and the transduction signal in nucleus will not be made. Thus decreasing cell proliferation and metastasis aka DEAD CANCER CELL
th-cam.com/video/kWHgDLYaj_4/w-d-xo.html
Where are you pulling all this info from? What studies lol
are u canadian?? ur accent sounds super canadian lol