Fasting Masterclass: Flipping The Metabolic Switch
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- เผยแพร่เมื่อ 8 ก.ค. 2024
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Questions that will be answered within this video:
- What is AMPK?
- What is the role of AMPK in flipping the metabolic switch?
- What is the importance of AMPK whilst fasting?
References
www.nature.com/articles/1602785
www.ncbi.nlm.nih.gov/books/NB...
www.ncbi.nlm.nih.gov/pmc/arti...
www.annualreviews.org/doi/ful...
www.nature.com/articles/nrm3311
pubmed.ncbi.nlm.nih.gov/15899...
www.ncbi.nlm.nih.gov/pmc/arti...
www.sciencedirect.com/science...
science.sciencemag.org/conten...
I'm putting much more of my content and communication via email now to make sure you get the information that I provide (TH-cam has some new algorithms on health related content). Join my newsletter here: www.thomasdelauer.com/life-optimization-tactics/
AKA "They" aren't happy about people getting healthy.
I've been a part of your newsletter but I'm not seeing anything more different than what I get from here on your TH-cam channel. Am I missing something?
Great video on virtue signaling Thomas. If even done at all in a clinical setting, the identification of metabolic syndrome risk factors (MSRF) is not being assessed in the context of ancestrally appropriate reference ranges. The abundance pathogen is a mind virus degrading aggregate morality in the skinner box of a death cult. A neo-social gulag to be sure.
Thomas, you probably don't know how many lives you're having an immense positive impact on. Can't thank you enough. You're so generous and enthusiastic with your knowledge it's changed my life all the way over here in Australia.
Would love to see a vid on fasting during 'deep winter' and managing carb cravings during intense cold if you ever have time. Thankyou again for everything you do!
I love the deep biochemistry ones! On a fast right now great timing!
@Dust Storm want a job?! 😂
@@ThomasDeLauerOfficial 😂😂
@Dust Storm very impressed sir. As a 47 yr old, I found myself with health issues all of which stemmed from a "Board Certified Doctor " telling me to eat whole grains, fruits, and vegetables, daily! I wrecked my health, but since watching Dr. Paul Saladino and Dr. Ken Berry a few months ago, I've turned my health around, lost weight, optimal on cholesterol levels and on the brink of reversing diabetes, all in about 6 months...good to hear you are doing well at 65! You're an inspiration, sir! As you know, the Carnivore diet gets a lot of heat but hopefully science can prove otherwise. Are you a trainer? Registered Dietitian? What do you do as far as you mentioning clients in your comment.
@Dust Storm Fellow Texan here brother....I'd like to know what you read or follow, sir. Email?
@Dust Storm understood pal...keep well stay safe.. God bless. 🤘🤘
Thomas I love when you post biochemistry videos explaining how it works, it's such valuable information
I just broke my extended fast. I like that it resets your ghrelin levels.
Yes, keep the gremlins at bay
As long as Mogwai is fasting after midnight, you should be okay.
Gremlins coming for ya
For God sakes don’t get them wet! 🤣
@@dalysea26 ok so when can I feed them again?? After midnight until what time???
Thanks for the content as always! Thanks for always being there.
I love this type of content, thank you! Actually, I really enjoy all of your content - it's my daily/weekly dose of motivation, knowledge, and humility.
I’m not a bio chem nerd but your analogies were spot on.
What a fantastic video!!! Very nerdy and I love it. This was probably one of THEE most important videos I've ever seen due to my DAILY (20-hour) fast. Daily! I needed to see this. Thomas, this is your best video yet because of the sheer nature of how widespread this topic is for literally all types of people. Honestly, it's a serious topic. Do more of this kind of content. For "THIS" KIND of content, you got my money through Patreon. You need to stop being stubborn and just hurry up and launch a Patreon already. Virtually all of us will jump on board, brother. We love ya, bud!
I like how deep your knowledge is...good video pal
Awesome! Thanks TD
More videos like this please !! Love your content :)
Thanks so much for helping us understand the science! You're awesome
It’s bad to restrict calories if you are always hungry
People quit diets because they are hungry
Keto and Carnivore does not have this issue
I think that’s why they became so popular
Thank you so much for sharing your vast knowledge so passionately with us. Also i really appreciate when you summarize and try to simplify your lesson....i sometimes nearly drown in trying to absorb the details until you throw out the lifeline 😁. Thank you!!
Love the scientific breakdowns
The one and only!!! 💪🏾💪🏾💪🏾
This information is amazing! i love the deeper dive into the science even if I had to relisten a couple of times, lol. Thank You
Great info
Good info
This is great!
This information is so amazing and I really appreciate your efforts to make it understandable. The human body (or any organism actually) absolutely fascinates me. Thank you, I finally get ADP/ATP/AMPK. 🙂
Too much jargon makes it difficult to understand. It will be easier if EDT, EPT, DDT, EMPK, EKK kind of abbreviations are not used like a rain
Felt the same
There are lots of other resources out there that don't emphasize the biochemistry. Thomas's strength is helping people to understand WHY and HOW prcesses happen. I appreciate the effort.
What’s an abrogation? 🤔Do you mean acronym, or abbreviation? 🤓
@@garylawton230 Yes, corrected.
You can't learn the biochemistry of what's happening without the biological terms used to describe the chemicals and processes, lol.
As a Muslim and now in keto, I’ve noticed how easier it is to fast on this type of nutrition regimen. During shorter days, I fast between 5:00-4:15. I find it not as exhausting and really invigorating!
Hello. Thomas Family & everyone. Have fun & be safe. 🤘🏾🎅🏾🤙🏾💚's🌏
How convenient for this video, my wife and I are at the 46 hour mark of our minimum 58 hour reset water fast, per Dr Mindy. Only taking water with KetoChow electrolyte drops and Pink Himalayan Salt and iodine in it. It's been a piece of cake (pun intended) so far.
I follow mindy too
That's awesome on the extended fast. I've been struggling to get back on the horse
Dr Mindy is awesome
I've been in healthcare for almost 20 years, 15 in the lab. I love the indepth explanations. Keep them coming!
Don't worry, Thomas! You can make it simple enough for us to understand such important stuff within our bodies. Great job! thanks a lot :D
So , is there any oil - egg or suppository we need to take before or during fasting now ? Or was this a blinding by science drive by ?
I have taken the position that humans are naturally lipovores, we have evolved to eat fats and only eat infrequently. Instead of thinking of purposefully temporarily placing ourselves in fat-burning fasts as some kind of break from a regular pattern of all-day eating, we should be thinking of as briefly placing ourselves in a fed state which breaks from our normal state of being in fat-burning day-long ketosis. It may seem pedantic, but changing your state of mind changes the way you feel about the behavior.
Why do I feel like there's a part 2?
Yes, not explained how to boost AMPK
How long into fasting does this start happening? Is 16/8 good enough or does this only kick in with extended fasts?
Also while everyone else in my nursing school class dreaded the Kreb cycle, I loved it. It made sense to me. Love your sciencey vids.
Great explanation. Is there a video on what to expect our blood glucose levels to be like during our intermittent fast while in ketosis? My levels seem a bit higher but my doctor said this is normal is you don’t consume simple carbs and sugar. I test my blood sugar levels periodically to understand how what I eat affects insulin levels. Thanks...
It actually IS quite fascinating! Not to mention, the more we absorb the mechanics & science of our body's processes, the more we can apply same~ both in planning & practice. Nothing but good in all that =)
@Thomas DeLauer
I have a question about the AMPK activation: I make kimchi, and I usually begin my meal with it - so, if ACV is useful because of it's acetic acid as a byproduct of fermentation, could the same be true, in the same way, for kimchi??? Cheers!
Not letting me sign up for a newsletter I click the link and its just got 3 emails for telling me how to eat when going out ect...
Holy biceps batman! Lol, joking and biceps aside, always love your content.
Thom, what type of energy is used to fuel gluconeogenesis? fatty acids?
Hi. Great content, have watched your videos about mtor, nad/sirtuins and 2 videos about ampk. Really helped to understand those processes at least a bit...but still struggling to put the pieces together how do those 3 work in relationship to each other.
P.s. im into the longevity stuff 🙂
Im supplementing berberine, resveratrol and niacin(1000mg)
Hi!
ATP is responsible for most reactions in the body, but not all. You also have GTP, NADH and FADH....
A little bit complex to understand fully but I get the point .. I know I should be fasting the question is for how long? I usually do intermittent fasting for about 13-15 hours my only issues is that I workout in the AM fasted and when I get home I have a protein shake that breaks my fast. Is it absolutely necessary to have a protein shake Half an hour after A work out or can it wait a couple of hours? By the way I do mostly strength training workouts 🏋🏻♀️
Mowing grass in December? Wish I lived there. :-)
I saw a recommendation in another video to take your alpha lipoic and acetyl-l-carnitine in the morning. Then you say not to take antioxidants when fasting, or right after exercising.. How to conciliate this for those that end their fast in the morning?
Do you have any suggestions for people who want to do keto while taking blood thinners? My dad needs to lose weight and he just got put on blood thinners we want to start a low carb diet with him but with his blood thinner he is even more restricted on what kind of vegetables he can have because they have vitamin K in them. Please help!
Can you please do a video on how to eat for wrestlers and loose weight for weight in. Thank you
You can make glucose from fats.Fat is 3 fatty acids with a backbone of glycerol. You break fat? You don't need that many proteins to make glucose. The body uses the glycerol first.
video request: fasting, but blood sugar goes up due to liver generating glycogen, i know you are not a dr., but is very frustrating for diabetics who are losing weight, what they tell us to do, bur blood sugars are still high, thanks
Okay so what do I do??
Gosh I wish there was someone to actually discuss all this with. I have struggled with my weight my whole life and nothing has ever worked for me unless I become a complete gym junkie - I think God gave my metabolism to someone else 🤷🏼♀️
Unfortunately, I had most of my liver removed 12 months ago, then got really sick, have spent all my time since in bed, put on a heap of weight (stupidly depressed and did not have a healthy diet during this period, all my own fault) and am still stuck mostly in bed. So no current possibility of returning to the gym 😔
I have tried so many different things than I’ve ever tried before to try and turn things around & I’m still not losing weight. I went vegan first, then started keto. I’m currently doing a 20hr fast with a 4hr eating window, starting with lemon & acv to break the fast, then my first meal is a 1 egg omelette with a 1/4 avocado. Then in the fourth hour I have a green smoothie - kale, cucumber, spinach, broccoli, green apple, lemon, mint, ginger - about a litre altogether including pulp. Oh and an almond milk matcha tea in the middle. And that’s it.
I’m happy having the same meal everyday as I’m too sick and tired to be any more creative with my diet atm. I watch a lot of videos about all of this, however, as I start to follow one person another will come along and give the opposite advice - or even worse it’s the same person releasing contradictory videos e.g. one video saying don’t eat nuts, next video is all about the benefits of eating pistachios.
I’m so confused now as to what is right or wrong. I’m also extremely tired of being sick. What on earth am I doing wrong? Can someone please release a simple, up to date, 12 step keto plan from start to finish 🤦🏼♀️😞
Apologies and ty to anyone who’s read my rant, sometimes it feels better to just get it out there and try again to keep moving forward ☺️
Thank you so much Derek, it really helps knowing that someone else understands. Perhaps I’m not crazy after all!
Your response was very grounding amidst all the turmoil of so much information.
Sending an abundance of appreciation and prayers towards your own journey of healing from Tasmania 💕
No wonder you're sick, all that plant nonsense is literally poisoning you.
😂
36 hour adf gang
👋
I’m 54 male 50lbs overweight I need to look like you 😂 I’ve heard of intermittent fasting, and I’m hoping that will help. I tired of being tired all the time get home from work and then I feel like a zombie in my chair.
Is AMPK FOOD TO SUPPLEMENT?
I actually built a mind map while listening to this, like back in the uni.
What should be the minimum fast duration to get the ampk going ???
I think 16hrs
I'm fasting today....super starving after cheating over the holiday!
Pros and cons...Leave out the excess verbiage or you forget the point you are trying to make. Fat burns when you have used up your glycogen. Unfortunately it come at a cost of energy and muscle loss. Putting a little more muscle on, more than you need before you fast, will help during fasting.
Are you technically kicked out of a fast first thing in the morning when your insulin levels naturally rise due to the dawn effect and after you workout? Not sure how this works. If your fasting and your blood glucose levels naturally rise since your body always needs some sort of glucose then wouldn’t your body be working to get the glucose back down to normal? Would this still be considered a fasted state?
GOLLY, here I am going on 30 hours fasting trying to get to 36-42 and you keep showing food in this video. :):) So I have a question. I'm trying to fast 36 hrs twice a week, hoping to turn that AMPK on but what happens on my eating days? Does AMPK go away until I fast again?
Idk why Thomas still going to school full time to become a Doctor . ....... do it THOMAS 💪🏽💯
I feel like Billy Madison in science class. Lol thanks for the info Thomas.
Hi Thomas, Is it ok to fast 16/8 for longer than 3 months? any harm to the body?
some people make it a lifestyle. It's not only not harmfull but healthy.
Would you go as far as to say fasting too can make you metabolically flexible? In other words, ketosis + carb cycling may not be the only way?
Yep, if you think about it eating carbs every other day+fasting might be even better than straight keto for developing met flexibility. You are forcing your body to constantly switch fuels. Keto+fasting is good but the body is already in a fat burning mode, so fasting would only mean you are switching from burning more of the dietary fat and more of the body fat.
Read ted naimans pe diet book, he explains it all in an extremely sober and practical way.
@@rappatenebrense Keto here...i have been wondering this for a long time. Many people drop weight with eating whatever they want + fasting. I'm doing Keto + fasting but would love to incorporate more carbs but don't want to gain weight back. Maybe just good carbs on weekend. 🤷
@@suzannecarrier2700 read ted naimans book, he really explain the low carb vs high carb debate. Ideally if you destroyed your metabolism for years, and got fat and diabetic, you should avoid even the good carbs altogether to force your body into building the metabolic machinery to burn fat. But the end goal seems to be able to burn both fuels for energy (of course im talking about good quality carbs and fats here, not donuts or fries).
@@rappatenebrense okay I will! Thanks. I'll look on Amazon.
I've listened to it 4 times. Am I missing the 'how' to enhance the ampk? Aside from fasting?
Don’t forget that energy can’t be created nor destroyed! 😜🤓
I don't know Thomas, have living this lifestyle for about 5 years now. My wife is a geologist, hard science... My lifestyle and energy at 50 are now quite noticeable, and yesterday she says to me as a zinger qiestion, " what do you know about AMPK". These science people like to real lingo, and we should to, cause really what's happening. TRUTH...
But boy did I have a answer for her that took her back, and that I have to thank you for. In the end we should want the details. Thanks for her bio moments.
Cheers
Hey Thomas, I have a question, what can I consume if I get to hungry before my meal while I'm fasting?
Psyllium husk (1-2 tsp) mixed with a cup of water should be safe to consume during a fasting period according to my knowledge
Pink Himalayan Salt and Keto Chow electrolyte drops in all of the water you drink. I mean like a big 1/8th tsp in every quart of water. It will help you curb your cravings. Of course it helps if your body is already "fat-adapted" because your body is really craving CARBS !
@@irissj378 thanks
@@garyfarm thank you
@@eliassanchez4252 My wife and I just completed a 64 hour water fast with only the Pink Himalayan Salt and KetoChow electrolyte drops. Supposedly at 58 hours your metabolism does a reset. We've been Keto for 11 months and 18/6 with a few 23/1 IF every week for the last 7 or 8 months We weren't really even hungry after the 64 hours we just decided it was long enough. After you are fat-adapted your body uses fat for fuel more efficiently, hence we weren't hungry. FYI - I believe the salt and electrolyte drops help a lot.
I live across the street and just mowed my lawn
Did you 🤣🤣🤣
A street
7:08 chicken biryani
Yeah it looked lovely! Not very Keto though! 😜
No clue what this video was all about! Lol. Not sure whether I‘m losing brain cells during this pandemic or whether I‘m just suffering from reduced mental bandwidth? I don‘t know. But I can‘t seem to follow a lot of your recent videos anymore....
I have eaten 3 slices of pizza and some broccoli in 3 days and it feels like my whole body is burining from the inside is that normal
Love these science focused videos, Thomas. I am a sucker for biochemistry. I used to draw detailed drawings of organelles back in college. I went into brain studies as college went on, but I have to say, the mitochondria stuff was one of my favorite subjects, those electron transport chains are so interesting. I remember seeing “ubiquinone” written in the textbooks in the transport chain and that was the moment I figured out what the hell CoQ10 was for. I was so proud of myself for knowing that ubiquinone was CoQ10. Everyone in the class rolled their eyes at my exciting realization, since I had one every class 😆 Good times.
1st commercial was a dairy queen commercial lol
Incredible how many kitchens this guy possesses 😏🤙
Today was my first day doing 16:8!
I was pretty hungry around 2-3 am..
but it felt good thay i did it!
Any recommendation?!
I love it when you say the words,
Bio-chemistry deep!
Gonna be a juicy one!
is there a recommended amount of time to do your first fast?
Are you new to Keto? Is your body fat adapted?
@@garyfarm i'm new to Keto ... I've heard about it, but never done it
I would not go overboard if I was you, otherwise you are going to be turned off by it and say "I can't do this." My wife and I are just finishing a 58 hour fast that is supposed to be the magic hour number to reset your metabolism and we aren't really hungry at all. But we are fat-adapted and have been doing Keto/Omnivore/IF for 6 months or more. IF is Intermittent fasting. We do 18 hour fasts every day with a 23 hour fast thrown in once or twice a week. A person has to come to the realization that you eat for sustenance NOT enjoyment or fun. I know that sounds boring but your going to live a lot longer and be healthier and probably be on do drugs. I would start with just skipping breakfast and if you eat at noon and let's say 7pm you're already doing a 17 hour fast and keep your carb load low like under 50 and have a goal of under 30.
Also, another thing you can do is binge watch Thomas DeLauer and Dr Berry and Dr Cywes TH-cam videos.
Do we think then that the body (thru liver) will produce enough optimal Glucose to live on?
Conclusion: we don’t need sugar/carbs?
You don’t need sugar! 👍
I'm about to do my first prolonged fast (aiming for 48-72 hours) and I was wondering if it's ok to drink sparkling water during the fast? I have a soda stream at home so it's just water and C02 nothing else added. would that disrupt the fast? I've watched a few videos about prolonged fasts and no one mentioned sparkling water so I am curious
مشان الله هسه
What about smoking weed while fasting?
No calories
Munchies 😳🤦🏼♀️
Should I 16/8 daily and build muscle? I seemed to have dropped a lot of weight fat and muscle mass.
Tom doesn’t recommend daily fasts just alternate days. Also, you shouldn’t be losing muscle on a fast!
@@garylawton230 thank you. I am going to stop fasting daily. I been doing daily 16/8
I love it when you get all nerdy LOL.
Add in cardarine for faster fat loss and nutrition partitioning. I tried it for a couple of months and lost 50lb. You have to be sure your source is good though, I got mine from anabolistics.com
So is it safe..??
Wtf... McDonalds advertisement on Thomas DeLauer videos ... this world is upside down
💖
Chlorophyll, more like borophyll!
What is that old man smokin?
Science, he is smokin’ though😘
Waaay TOO confusing 🤯
Sometimes I don't feel like eating once every 24 hours is good enough.
body composition is made in the gym and in the kitchen❤️
You always have opposite oponion than others
8:21 dead cat image. Not cool for those who actually did encounter (and suffered) their cat dying. ☹️ You don't have to use images for everything you say.
I don't think the cat is dead - your can see it panting 🤔😊
@@madeleinebray5205 - I know Thomas is not going to upload an actual-actual dead cat image. That wasn't intended to be the point. It's the psychology behind the matter, that's all.
My bad
اميت
I’m one of the first comments!
😁✌🖖👌👍😎
Hello fellow Ketites, happy fasting! I'm gonna sleep like a baby tonight after a nice liter of acv water! Woot!
A liter of ACV 🥴 that’s strong medicine
Acv WATER! NO WAY am I drinking it straight. Look it up, not hard to find.
@@Stranger_Than_Fiction299 couldn’t find acv water, but I drink 1-2 tbsp ACV raw & unfiltered
Here's TDs recipe: th-cam.com/video/xi37ZVsavuM/w-d-xo.html
Lose the insecure smirk in your opening video screenshot! Remain confident. Your body is confident but your face isn't! Stay strong Thomas!
Who cuts their grass in December? 😳