Sickle Cell Anemia | A Genetic Disorder | Lecture 12

Sickle cell anemia is one of a group of disorders known as sickle cell disease.
Sickle cell anemia is an inherited red blood cell disorder in which there aren't enough healthy red blood cells to carry oxygen throughout your body.
Normally, the flexible, round red blood cells move easily through blood vessels. In sickle cell anemia, the red blood are shaped like sickles or crescent moons. These rigid, sticky cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body.
There's no cure for most people with sickle cell anemia. But treatments can relieve pain and help prevent complications associated with the disease.
Symptoms
Anemia, Episodes of pain, Swelling of hands and feet, Delayed growth or puberty,
Causes
Sickle cell anemia is caused by a mutation in the gene that tells your body to make the iron-rich compound that makes blood red and enables red blood cells to carry oxygen from your lungs throughout your body (hemoglobin).
In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. mutation accurs at position 6 of beta chain of hemoglobin
#SickleCellAnemiaCauses #MutationInSickleCellMutation

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0:25

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3:37

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