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You are SO damn good! Able to encapsulate and convey a complex subject matter, into a very comprehensive easy to understand manner, without losing any of the important scientific medical detail, or dumbing down Can you do a video lecture of a flow chart of vitamins and minerals and their interactions to each other, including the importance of cofactors
Ninja Nerd.... My daughter has inherited Hereditary Spherocytosis. However, my dr told me I am a sporadic case (Gene mutation). As you know, this is very rare and I want to show my daughter more about our disorder to give her some self awareness. Everywhere I check, its explained very minimally and not as explanatory as needed. Can you do more videos on H.S?
Brilliant. Every medical student and doctor who thinks they have all the knowledge, and keep it to themselves instead of explaining to their patients, should go through a mandatory course with this Prof on how to teach Biology
WOW dude!! I am not even a med student, or even remotely related to the med field in any way, but came here for Thalassemia (was diagnosed today). I am completely blown away by the quality of you, and feel so fortunate to have found your channel! Thank you SO much. You are EXCELLENT.
Wow, it’s rare to find someone like you who is passionate, knowledgeable, and clear speaking. If you aren’t already, you would make a great teacher. I’ve watched lots of videos related to this topic and yours is the only one that grabbed my attention the whole video and was very well put together. Keep up the good work man!
Your videos saved me, I'm a visual learner and I understood everything so well instead of trying to read my confusing textbooks with long chapters. Thank you, you deserve a million views!
Doc is a brilliant teacher. Every doctor should be trained by him on how to explain humbly and knowledgeably to their patients and loose the white coat
For those who would like a quick reference (thalassemia always trips me up): 00:55 - IDA 06:08 - B12/Folic Acid 10:38 ‐ Hereditary Spherocytosis 13:32 - G6PD 19:28 - Sickle Cell 25:05 - Hemorrhage 26:27 - Aplastic 30:18 - Thalassemia
Found you by accident and i am so grateful. I have had anemia since i was 6 or 7 (i am 53 now). I have stage 4 cirrhosis(sober 6 yrs now), chronic pancreatitis, Crohns w complications(severe anemia), UC, stage 4 COPD. In the last 3 yrs i have been on Hospice 2 times. I learned more about my anemia in 30 mins then i have my entire life.Although i am terminal, i always want to know because each day i wake up is a blessing to me. Maybe something is learn from you can give me another beautiful on this Earth. 🙂 Thank you for explaining this visually. New Sub now and looking forward to learning more from you.
Just in case anyone is watching this, MCV is typically in the range of 80-100. Depends on what lab reports you're looking at and what region you're in, but typically macrocytic is above 100 and microcytic is below 80. Always check what your school lists as normocytic though. Thank you so much for your videos, you've saved me in medical school multiple times.
This IS THE BEST explanation of basic hematology I have ever had!! Thank you for your talented presentation style as well as your solid understanding of this complicated topic.
This is the most helpful video I have ever seen on the subject! You present the details and complex metabolic pathways while streamlining it all into an easy to understand simple focus. You are a gifted teacher sir! Love it! Please keep these videos coming!!!
I hope from the deep of my heart that you never stop doing this videos, please keep teaching cause it goes with you so much, you're born to be a medicine teacher ❤ that's helped millions
This was the best and most informative video I’ve ever seen. I’ve struggled with Anemia for half my life. You’ve made it so much easier to understand. Thank you.
Apparently, it can't be cured. I was researching the entire illness. It can last for years or be chronic to its carriers. You have to receive blood transfusions, and even then, they say that won't really help. It can't be cured overnight, but if you go see a doctor, you might feel better after you've had the transfusion.
Thank you so much, my daughter relying on you on her first year of med school. Being a first year med student in pandemic era that turned every class into online is a tough experience and you helped her soo much. She even thank God for making you exist in this world😊 Sending lots of love from Indonesia💓
Thank you for explaining this so well! I was diagnosed with severe iron deficiency and have started weekly infusions at the cancer center. This helps me understand what's been happening inside my body all this time when I thought I was just over worked and over stressed. Thank you!
I'm a medical teacher (only have an MBBS degree) , the reason why I'm not practising despite being a registered Doctor is my lack of confidence ... and I might be about 5 years elder to him . Thank you sincerely . Clearing my concepts and learning a new way to learn . Hope I'll be a better teacher and doctor soon ...
Just wanted to say thank you for all your videos. I may only be a nursing student but have been a paramedic for quite sometime and while we don't need to know this as in depth as you cover it your lectures have helped me understand the full disease processes in detail that I need. You are hands down the best and I could not be more thankful to have found your videos! You rock man!
Best tutor ever!! what an incredible, professional, enthusiastic, clear and organized way to deliver complex information. I struggled for a long time watching "cute", bored, messy online tutors that make their videos all about "their cute selves". I am sssooo glad I found you!! please, please please never ever stop making those fantastic videos. Nobody is better than you are!!
Literally blow up my mind . Sir I am in med school and I thought that I'll Be doomed in physiology but You are a life saver and I mean Your enthusiasm while teaching is really addictive. Please keep on making these videos.❤
I love it it when you mentioned “if Lord willing to them” despite your brilliance in medicine, you acknowledge above all theres a higher power..thanks for all your free videos..really enjoying it.. hope youll have more…long live!
Very interesting lectures in this channel. Congratulations. I think there is a couple little remarks to add: 1) Vitamin B12 comes from bacterial fermentation in the gut, and it later accumulates in animal tissues. Unlike folic acid, vitamin B12 compounds are not generally present in plant foods, with the exception of fortified breakfast cereals. Similar compounds can be found in some algae/seaweeds, but these do not have the same nutritional value of that of animal vitamin B12 sources. Because of this reason, vegans are often prescribed vitamin B12, because they also remove other essential dietary sources of cobalamins, such as eggs, and milk and diaries. 2) It might be interesting mentioning about the existance of some dietary factors that can precipitate haemolytic anaemia in those patients who have a deficiency of G6PDH (genetic condition that is more common in the Mediterranean and the Middle East countries). These compounds, called glucosides, are found in some legumes such as some varieties of beans, peas, i.e. broad beans (fava beans), and if consumed by those people who have a genetic deficiency of G6PDH, they can trigger haemolytic anaemia (in this case know as favism). Kind Regards.
Hmmm,,, im italian, and im sure i have thallisemia (sp?). (not sure i want testing,, because i wouldn't take blood transfusions anyway,,,, -- but the more i read the more i learn,,,,, There are alot of bean soups in the italian diet, i can only eat a tiny bit of legumes (if any),,, I tried being a vegetarian in the old days,,, I got REALLY< REALLY SICK!,,, I like to cook and i honestly don't Like bean soups, Chicken soup is my specialty, Im 60, so it took a long time to learn this. And my dr is Terrible with paying real attention to my anemia,,, I'd like to find a dr. that can at least diagnose me and give me diet and supplement recommendations. But my ins. won't pay for a specialist,,, (i have medicare),,,, Wish there was even Adequate health care for low income people. i don't know what else to do but eat healthy, which i do,,, there is collard greens and dandelion greens ready to be cooked. I 'might' do better than others in my situation,,,, I don't drink (just makes me tired),,,, or smoke, I've been athletic and active my whole life,, so im strong. The biggest problem is i can get Exhausted Tired just ALL of a sudden.
Not only Vegans but also status- post Gastric bypass Bariatric people. B12 is synthesized in your duodenum which is no longer coming in contact with food- so Eureka- you're not making your own. Every day ( post- lunchtime) a sublingual B12 which actually has a wild cherry taste 😳 And I take with other vitamins in my regime An vitamin A, Calcium, Magnesium and a Prenatal Vitamin( more balanced than a generic Adult vitamin) & B- complex also. Wish I'd bought stock in a Drug house- I'd be approaching Wealthy by Now! And since my stomach acid levels are lowered I take Ferrocite( Ferrous Fumerate)- Oh I have had a verbal set-too with my semi- loving. WALMART pharmacist who said "Vitamins are a Vanity Drug" not if you're processing with a piece of stomach the size of a TurkeyEgg- THEY are mandatory for ME- I Lost more than mere weight with this surgery ! 😳
@@JustMe-gs9xi me too- I'm living in a 76- year- old body- and they sure are slow making replacement parts for Our Models- maybe We're "Out of Production" anymore. But I tell myself we will last longer than the current plastic and fiberglass models- even if we are jalopies WE STILL RUN! Keep.Strong My Sister- maybe the best is yet to come- What's next?
Thank you Jon Lucas for the additional info. Is there something to take for the G6PD deficiency? Or just things to avoid? Dr. Zach didn’t give a solution in his talk on what to do. He just explained the condition.
My mom was just diagnosed with iron deficient anemia. Low blood count etc. all kinds of scopes and tests and they still don’t know why her count is low. This was excellent to watch and understand about the types of anemia. Thank you
Freakin amazing video! You teach just the way I naturally think, learn and probably retain the most - love how you ask questions like and "why" or "so what does that mean" and answer them! it's exactly how i talk to myself in my head lol
You are a blessings ninja nerd! How many students benefiting from your videos are enormous! Grateful for kind people like you out there who are seeking to help share knowledge and lift themselves and other in sciences. Keep shining!
I love this guy. I learn so much from him and i hope he’ll help me pass my AP exam! However, he makes me second guess how I’ve been pronouncing Iron my entire life.
Thank you Zach! As usual, excellent presentation. I really appreciate your whiteboard work which makes the subject matter much more understandable for non ninja-nerds like myself.
I love how you break things down to the microcellular level, but in a really simple and easy way to conceptualize it. I'm in FNP school and this is supplementing my hematology lecture :)
I wish the hematologist that I'm paying loads of money would have taken the time to explain my anemia as well as you have. I can't thank you enough. I finally feel informed!
I’ve watched so many of your videos. They are all very informative and helpful. These videos about blood and anemia I watched several times because I have myelofibrosis, receiving blood transfusion and my stats are getting worrisome. Knowing about it through your video has been comforting. Thank you.
Awesome video man. Keep up the good work! Here are a few extra key points in each of the Anemias you listed: 1) Iron Deficiency Anemia Extra possible causes: Can also be due to : parasitic infection, increased iron demand, malabsorpion. Extra clinical signs from the ones you mentioned are Oral lesions, Angular Cheilitis, Plummer-Vinson syndrome( Glossits, esophageal webbing,dysphagia), koilonychia, pica(desire to eat non-edible things such as clay-paint.) Upon microscopic examination we can see microcytic, hypochromic anemia with anisocytosis and poikilocytosis with presence of target cells. 2.1)B12Folate Deficiency: Peripheral Blood smear= Presence of Hyoersegmented neutrophils, target cells, polychromasia, Howell-Jolly bodies. Measure methylmalonic acid should be elavated. Presents with neurological symptoms 2.2)Foliate deficiency : Occurs due to increased demand during pregnancy, due to alcoholism, due to anti-folate drugs( Methotrexate), or due to malabsorption Measure homosysteine levels( should be elevated). No neurological symptoms are present. 3)Hereditary spherocytosis= Intracorposcular origin. Patients also appear with jaundice. Perform splenectomy to correct reduce anemia. 4)G6PD deficiency= Intracorposcular origin Clinical Signs : Back pain, Hemoglobinemia, Hemoglobinuria 5)Sickle cell Anemia( Intracorposcular- Extravascular) Extra clinical signs= Pain, micro-infarcts, necrosis in joints, bones , GI, lungs, aplastic crisis, sequestration crisis. Extra Treatment= Bone marrow transplant 6)Aplastic Anemia Normocytic, normochromic pancytopenia. Signs and symptoms= Palor,weakness, Petechiae haemorrhages, ecchymosis, mucosal bleeds, recurrent infections, thrombocytopenia, Granulocytosis. Treatment: Antithymocyte Globulin, corticosteroids, Cyclosporine, Cytokines administration( EPO, G-CSF, GM-CSF) , Bone marrow transplant.
Much appreciated! Also the IV fluids are helpful in Sickel Cell Crisis to keep the vasculature full and plump (for lack of a better word) so the sickel cells have less of a chance to accumulate in the blood vessels and cause infarcts.
This video helped me to understand the material for my upcoming Med Surg exam that covers the topics of blood disorders and the lymphatic system. The video was easy to follow and easy to understand. Great teaching and study tips!
Very nice explanation! I was trying to figured my husband's anemia, he has to get blood transfusion now every 5 weeks, it started every 8 weeks but it's getting worse! And his Dr. Told us he was scratching his head because he couldn't figured out / find out my husband's anemia, he retired now and we are going to another Dr. My husband did so many test, bone marrow, colonoscopy, endoscopy and everything comes back normal
Dude this video is amazing. The only thing you could have done better was include a single view of everything at the end for us to print and study from, but you just made 50 pages of gibberish from my biochem book make complete sense. Thanks so much! I’ll definitely be using your channel for other information in the future
Every time he says “ you know ... remember haemoglobin” I nod my head and then smile like an idiot 😅 Love how interactive your videos are 😍 I literally watch them out of interest! You make them so much fun.
+torkil123 wow, thank you so much for your kind words that really means a lot. It would be awesome if it reached that many views. I really hope it helped.
Best explanation of I've heard or Pernicious Anemia. Which I have. B12 shot once a month. This purple liquid called cyanocobalamin. When I was first diagnosed I had to a shot every day for 2 weeks, then a shot once a week for 2 months and now once a month forever.
Great dude! But remember hereditary spherocytosis is diagnosed by a test called osmotic fragility instead of Coombs, this thing is used to differentiate Autoimmune from non autoimmune hemolytic anemia. Treatment might be different because I would use corticosteroids to block antibodies against RBC in an autoimmunity setting.
Addition to pernicious anemia, could also be caused by a parasitic infection. Dyphillobothrium latum tapeworm competes with the supply of folic acid in our body. Thanks for this informative video. Great for reviewing/ refreshing some subjects!
MLS here for 10+ years and Reviewing after 12 years in college... and man, you explained it better than my professor 🤣! In 35 mins i learned everything i had to learn in 1 week! Thanks a bunch! Im subscribing now!
I’m pretty sure this video is why I passed my test today! Thank you thank you! I’ll be watching a lot more of your videos and at some point I’ll donate to your cause! But I am telling all my nursing school buddies about y’all!
I have currently unexplained anemia, my levels went down to 65, I couldn’t stand for more than a few seconds, and I had to have 4 transfusions. Very, very frustrating. Hoping to get answers soon through endoscopy. Thanks for this excellent presentation.
Dizziness is pretty common and probably the first noticed symptom for the person at home when iron deficiency isn't overly advanced. Dizziness when standing up. When it happens to me I know my iron has fallen again, I get a blood test, and sure enough ferretin has fallen into the red. And another at home symptom noticed before the others not mentioned is falling asleep a lot and quickly when seated. These were the only symptoms my wife had until her Dr did a regular blood test, but thinking nothing was wrong, the rung me up later to take my wife to emergency for a blood transfusion since she actually had acute thalessmia that had developed very slowly over a few years, complicated by simultaneous hyperthyroidism.
I get that falling asleep symptom... im from the Meditterian area,,,,, Thallasemia. How does your wife get treatment now?? I don't want blood transfusion.
This video was really helpful! I had recently gotten diagnosed with Anemia. I have Iron deficiency i believe but I'll have to double check. Again thank you this was insanely helpful :)
OMG, you're great! I realised even more, why I didn't study medicine. I already got lost after the second type of anemia 😅 it is sad that I have to educate myself to tell a doctor, what should be checked in a blood test 😩
What what put you ahead of most people in science is that you actually explain the words and why those two syllables are put together like taquicardio the word tacky means time displacement over distance cardi means blood pumping or pressure if I'm not incorrect
Wow! This was so informative! My husband and others in our immediate family have Thalassemia. My husbands grandfather, had Aplastic anemia. This is all coming from my husbands dads side of the family. When his brother did an Ancestry test, .03% was North African. We haven’t known of any Mediterranean ancestors. My husband has had two blood transfusions and many iron infusions. His WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, Platelets are always very low, never in range. Thank you for this wonderful video!
Omg thank you! Coincidentally enough, I had iron deficiency for the last few months which caused me to be always tired and sleepy and lowkey depressed. In turn, I didn't study my that much at that time and when I somehow got better (went to the doctor and found out what's wrong and what to do), I had a lot of studying to do. The funny thing is that Anemia is one of the big themes and now I'm here watching your videos because it's better than reading the book.
Thank you for converting g6pd. It seems some docs don’t focus on it too much, or may not understand it as much, and specifically as it affects females (AFAB), assuming it only affects males and not female “carriers.” Thanks also for the attention to menorrhagia in iron-deficiency anemia.
Finally! Someone who talks about thalassemia! I actually have beta thalassemia, but I only have a minor version of it. If I had a major version, I probably would have had a bunch of what you talked about done to me, but because it’s minor, I never needed anything for it. Also, the iron supplements thing is based on a common misconception. Thalassemic patients don’t necessarily have an iron deficiency. It’s the globin chain particular to their thalassemic type that makes them lack the hemoglobin to carry as much oxygen to their tissues. I don’t make enough beta globins. I make plenty of iron and alpha globins. The only time thalassemia people have to worry about iron is when they develop a severe hemorrhagic anemia. My mom is the one I got thalassemia from and she had an ulcer once. Her average hemoglobin level was like 12. Critical level is 4. When she went to the hospital for her dramatic increase in fatigue, she was at a 5.8. They were surprised she was even conscious.
Agreed. A lot of people with minor thalassemia don’t know they have it unless they do genetic testing. Until I found out I have alpha thalassemia, I was always prescribed iron because of my low MCV , but now that I’m aware, I always request an iron study if I’m there’s concerns about anemia.
I have beta thalassemia as well that I inherited from my mother! This video helped me so much understand anemias more. My MCV is 64 and I definitely feel it. Thanks again for the info!
I've had B12 anemia for months and the doctors couldn't figure it out. They still never could, I just started taking high dose vitamins as a last resort after going to the doctors incredibly ill 15 times. This video actually explains why it happened though!
I want to get this video but I can't understand it . I am getting premature grey hair, memory loss, chest pains. Been on iron tablets for over 8 months.
@@mysecretsketchbook865 Have you tried slow FE? Also don't eat any dairy for maximum absorption and take with 500 mg vitamin C. You may not have the right enzymes to absorb the iron.
I love the way he explains content and breaks it down so simplistically! I always have these moments when everything just clicks when watching his videos. Thank you very much!
@@Fizzlestick I don’t know how you reply back you agree that you can’t get B12 from plants (in the quantity needed), but say overall it’s good? This is extremely important and has been a problem to Vegans to know so I don’t know why you just brush this off! This should be removed from this video and not rely on people reading this thread.
There's a lot wrong in this video. Not only is the source of B12 incorrect but so is the calculation for MCV; and MCV less than 90fL is not microcytic, it's below 80fL, and above 95fL is macrocytic. (Most hospitals will say it's critical if it's at or above 100fL and the person is considered anemic). G6PD is pretty good but he over explained the mechanism. He only needed to mention the first step of the reaction and what needs to be known overall is iron (Fe2+) is oxidized to Fe3+ and hemoglobin cannot transport oxygen when iron is in the ferric state (Fe3+). It is due to too many free radical oxidations. In hereditary spherocytosis it is normally a normal-cytic anemia Not microcytic. The part on sickle cell is correct, except Plasmodium plazforum is not an organism, he got the Genus name correct. Aplastic anemia is not a misnomer. Anemia is a term for a underlying condition.
You're a LIFESAVER NINJA NERD...I mean literally... You make all this boring courses so easy and fun to understand for medcine students like myself and you are indirectly saving lives because of this knowledge you're impacting on us which is going to be very useful in our different medical specialties...We love you and appreciate you a lot❤️❤️❤️
This was very easy to learn from him. Definitely has a talent from that and I have no medical background. Somklh have a complex 6yo whose blood work is a mess and trying to fully diagnose her (mitochondrial is suspected) Google hasn’t been friendly as far as if her numbers are concerning for being anemic but hemo is 8 and every other number is low and dropped. Ig is higher then already normal for her and not very normal numbers across the board. I am used to them all being either low or high though. 😂
This is helpful for any people, it is easy to understand and i like your quick look through lecture style. I would like to express my gratitude upon all the lectures you had been working hard to prepare for us. Thank you for you and your partners' contribution to the society. Goodbye and break your leg!
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had blood count and my mcv is 95 and my MCH is 34.3 some how i ended up here in ur helpful explanation thnx a lot.. may i know how to treat it plz bro
Would you ever give iron to someone suffering from hemorrhagic anemia? Or would they be better served by a blood transfusion?
You are SO damn good! Able to encapsulate and convey a complex subject matter, into a very comprehensive easy to understand manner, without losing any of the important scientific medical detail, or dumbing down
Can you do a video lecture of a flow chart of vitamins and minerals and their interactions to each other, including the importance of cofactors
Ninja Nerd.... My daughter has inherited Hereditary Spherocytosis. However, my dr told me I am a sporadic case (Gene mutation). As you know, this is very rare and I want to show my daughter more about our disorder to give her some self awareness. Everywhere I check, its explained very minimally and not as explanatory as needed. Can you do more videos on H.S?
Brilliant. Every medical student and doctor who thinks they have all the knowledge, and keep it to themselves instead of explaining to their patients, should go through a mandatory course with this Prof on how to teach Biology
WOW dude!! I am not even a med student, or even remotely related to the med field in any way, but came here for Thalassemia (was diagnosed today). I am completely blown away by the quality of you, and feel so fortunate to have found your channel! Thank you SO much. You are EXCELLENT.
Sorry you were diognose with it. How are you doing?
@@Kevessi I am doing so much better, thanks for asking.
@@Finace_chic_777 happy to hear that🙏🏽
How r u now?
@@akilaweerakoon989 I’m doing fantastic. Thanks for asking.
Wow, it’s rare to find someone like you who is passionate, knowledgeable, and clear speaking. If you aren’t already, you would make a great teacher. I’ve watched lots of videos related to this topic and yours is the only one that grabbed my attention the whole video and was very well put together. Keep up the good work man!
Your videos saved me, I'm a visual learner and I understood everything so well instead of trying to read my confusing textbooks with long chapters. Thank you, you deserve a million views!
Lol no one asked
and 3 years later!!
Doc is a brilliant teacher. Every doctor should be trained by him on how to explain humbly and knowledgeably to their patients and loose the white coat
@@Annabelle-j4j who asked u??
You're actually not a visual learner as that's not a thing.
For those who would like a quick reference (thalassemia always trips me up):
00:55 - IDA
06:08 - B12/Folic Acid
10:38 ‐ Hereditary Spherocytosis
13:32 - G6PD
19:28 - Sickle Cell
25:05 - Hemorrhage
26:27 - Aplastic
30:18 - Thalassemia
Thank you!
What Blood test work would you take to detect each of these ?
@@b.a.5027 wow wow . Write them down ,then search TH-cam and make notes .
B
Thank you
Found you by accident and i am so grateful. I have had anemia since i was 6 or 7 (i am 53 now). I have stage 4 cirrhosis(sober 6 yrs now), chronic pancreatitis, Crohns w complications(severe anemia), UC, stage 4 COPD. In the last 3 yrs i have been on Hospice 2 times.
I learned more about my anemia in 30 mins then i have my entire life.Although i am terminal, i always want to know because each day i wake up is a blessing to me. Maybe something is learn from you can give me another beautiful on this Earth. 🙂
Thank you for explaining this visually.
New Sub now and looking forward to learning more from you.
God bless you
Just in case anyone is watching this, MCV is typically in the range of 80-100. Depends on what lab reports you're looking at and what region you're in, but typically macrocytic is above 100 and microcytic is below 80. Always check what your school lists as normocytic though. Thank you so much for your videos, you've saved me in medical school multiple times.
I was just gonna say that
My lab says normal is 78.1, mine is 78.3. Diagnosed with anisocytosis and hypochromia
Ciao Walker are you still online ? Thanks buddy
This IS THE BEST explanation of basic hematology I have ever had!! Thank you for your talented presentation style as well as your solid understanding of this complicated topic.
WRONGGGGGGGG
@@Annabelle-j4j right
You're a real teacher. This is awesome. I have never studied anything related but i understand what my sickness is. Thank you
Llliilll
This is the most helpful video I have ever seen on the subject! You present the details and complex metabolic pathways while streamlining it all into an easy to understand simple focus. You are a gifted teacher sir! Love it! Please keep these videos coming!!!
+Tricia Lyon wow!!! Thank you for your super kind comment I truly appreciate it!
bRAVO, SUPER TEACHER. gOING TO dR TOMORROW...SPOTON...XXXXN
Nancy Thomas-Ward M.B.A I hope your appointment goes well and wishing you good health
Hi
@@NinjaNerdOfficial help.
You have the best videos, best explanation and best pictures! Dude's saving more lives than superman
Thanks so much! Loving the super hero reference 👍🏼
:D truth!
3 years later and im still watching these videos for my final year MBBS D:
@@Supernova-217Same
I hope from the deep of my heart that you never stop doing this videos, please keep teaching cause it goes with you so much, you're born to be a medicine teacher ❤ that's helped millions
This was the best and most informative video I’ve ever seen. I’ve struggled with Anemia for half my life. You’ve made it so much easier to understand. Thank you.
Apparently, it can't be cured. I was researching the entire illness. It can last for years or be chronic to its carriers. You have to receive blood transfusions, and even then, they say that won't really help. It can't be cured overnight, but if you go see a doctor, you might feel better after you've had the transfusion.
Thank you so much, my daughter relying on you on her first year of med school. Being a first year med student in pandemic era that turned every class into online is a tough experience and you helped her soo much. She even thank God for making you exist in this world😊 Sending lots of love from Indonesia💓
Thank you for explaining this so well! I was diagnosed with severe iron deficiency and have started weekly infusions at the cancer center. This helps me understand what's been happening inside my body all this time when I thought I was just over worked and over stressed. Thank you!
+Stephanie Maxwell i'm so happy that we were able to help I wish you the best of luck in your future endeavors.
You’re doing a great service explaining complicated issues made simple. That’s a gift. Thank you.
2:02 in so far and can already tell this is gonna help a ton with my hematology exam this week. This is how everything should be taught! ty ty
I'm a medical teacher (only have an MBBS degree) , the reason why I'm not practising despite being a registered Doctor is my lack of confidence ... and I might be about 5 years elder to him . Thank you sincerely . Clearing my concepts and learning a new way to learn . Hope I'll be a better teacher and doctor soon ...
I wish everything in life was this clearly explained.
srsly
Just wanted to say thank you for all your videos. I may only be a nursing student but have been a paramedic for quite sometime and while we don't need to know this as in depth as you cover it your lectures have helped me understand the full disease processes in detail that I need. You are hands down the best and I could not be more thankful to have found your videos! You rock man!
I have a hematology exam tomorrow worth 25% of my final grade, thank you for rescuing me
@Yoshi got an A+ in that class and a 4.0 👍🥳
@@b2h316 what, that is amazing 👍🥳
Best tutor ever!! what an incredible, professional, enthusiastic, clear and organized way to deliver complex information. I struggled for a long time watching "cute", bored, messy online tutors that make their videos all about "their cute selves". I am sssooo glad I found you!! please, please please never ever stop making those fantastic videos. Nobody is better than you are!!
Literally blow up my mind .
Sir I am in med school and I thought that I'll Be doomed in physiology but You are a life saver and I mean Your enthusiasm while teaching is really addictive.
Please keep on making these videos.❤
I love it it when you mentioned “if Lord willing to them” despite your brilliance in medicine, you acknowledge above all theres a higher power..thanks for all your free videos..really enjoying it.. hope youll have more…long live!
One of the best video about anaemia and its classification on the internet.
this man is a real talent, how can he remember all of this and teach in a very simple way.. god bless u
Just got diagnosed with anemia, this was so helpful 🥰 thank you
How are u now pls reply
@@Random_Butts I’m good 🙂
@@marleyjohnson5223 your anemia problem is fine now or not
I have just been diagnosed with Pernicious Amemia. This explains it nicely, thanks.
Very interesting lectures in this channel. Congratulations.
I think there is a couple little remarks to add:
1) Vitamin B12 comes from bacterial fermentation in the gut, and it later accumulates in animal tissues.
Unlike folic acid, vitamin B12 compounds are not generally present in plant foods, with the exception of fortified breakfast cereals.
Similar compounds can be found in some algae/seaweeds, but these do not have the same nutritional value of that of animal vitamin B12 sources.
Because of this reason, vegans are often prescribed vitamin B12, because they also remove other essential dietary sources of cobalamins, such as eggs, and milk and diaries.
2) It might be interesting mentioning about the existance of some dietary factors that can precipitate haemolytic anaemia in those patients who have a deficiency of G6PDH (genetic condition that is more common in the Mediterranean and the Middle East countries). These compounds, called glucosides, are found in some legumes such as some varieties of beans, peas, i.e. broad beans (fava beans), and if consumed by those people who have a genetic deficiency of G6PDH, they can trigger haemolytic anaemia (in this case know as favism).
Kind Regards.
Hmmm,,, im italian, and im sure i have thallisemia (sp?). (not sure i want testing,, because i wouldn't take blood transfusions anyway,,,, -- but the more i read the more i learn,,,,, There are alot of bean soups in the italian diet, i can only eat a tiny bit of legumes (if any),,, I tried being a vegetarian in the old days,,, I got REALLY< REALLY SICK!,,, I like to cook and i honestly don't Like bean soups, Chicken soup is my specialty, Im 60, so it took a long time to learn this. And my dr is Terrible with paying real attention to my anemia,,, I'd like to find a dr. that can at least diagnose me and give me diet and supplement recommendations. But my ins. won't pay for a specialist,,, (i have medicare),,,, Wish there was even Adequate health care for low income people. i don't know what else to do but eat healthy, which i do,,, there is collard greens and dandelion greens ready to be cooked. I 'might' do better than others in my situation,,,, I don't drink (just makes me tired),,,, or smoke, I've been athletic and active my whole life,, so im strong. The biggest problem is i can get Exhausted Tired just ALL of a sudden.
@@JustMe-gs9xi I buy iron bisglycinate. Sometimes we can be copper deficient, so I also get copper glycinate.
Swanson has a good variety.
Not only Vegans but also status- post Gastric bypass Bariatric people. B12 is synthesized in your duodenum which is no longer coming in contact with food- so Eureka- you're not making your own. Every day ( post- lunchtime) a sublingual B12 which actually has a wild cherry taste 😳 And I take with other vitamins in my regime An vitamin A, Calcium, Magnesium and a Prenatal Vitamin( more balanced than a generic Adult vitamin) & B- complex also. Wish I'd bought stock in a Drug house- I'd be approaching Wealthy by Now! And since my stomach acid levels are lowered I take Ferrocite( Ferrous Fumerate)- Oh I have had a verbal set-too with my semi- loving. WALMART pharmacist who said "Vitamins are a Vanity Drug" not if you're processing with a piece of stomach the size of a TurkeyEgg- THEY are mandatory for ME- I Lost more than mere weight with this surgery ! 😳
@@JustMe-gs9xi me too- I'm living in a 76- year- old body- and they sure are slow making replacement parts for Our Models- maybe We're "Out of Production" anymore. But I tell myself we will last longer than the current plastic and fiberglass models- even if we are jalopies WE STILL RUN! Keep.Strong My Sister- maybe the best is yet to come- What's next?
Thank you Jon Lucas for the additional info. Is there something to take for the G6PD deficiency? Or just things to avoid? Dr. Zach didn’t give a solution in his talk on what to do. He just explained the condition.
My mom was just diagnosed with iron deficient anemia. Low blood count etc. all kinds of scopes and tests and they still don’t know why her count is low. This was excellent to watch and understand about the types of anemia. Thank you
Freakin amazing video! You teach just the way I naturally think, learn and probably retain the most - love how you ask questions like and "why" or "so what does that mean" and answer them! it's exactly how i talk to myself in my head lol
Zack you are literally a lifesaver. I am a MS1 and have my blood block exam tommorow and was stressing out over anemic.
Thanks
I like these kind of discussions where the teacher doesn't just state the def. and stuffs but actually explains it, going deep
This is the best summary of anaemia I think I could have ever found. Thank you for saving my haem module
Found out I have Anemia a few days ago, and this gives me a really good idea of what I'm dealing with. Thank you ❤️
Do you have low blood count from it?
How are you feeling now ?
They just set me an appointment for a hematologist & oncologist so I looked this up💯😭
I think i got anemia too i feel soo weak and short breath and alot more stuff
@@N.W.E__ same
You are a blessings ninja nerd! How many students benefiting from your videos are enormous! Grateful for kind people like you out there who are seeking to help share knowledge and lift themselves and other in sciences. Keep shining!
I love this guy. I learn so much from him and i hope he’ll help me pass my AP exam! However, he makes me second guess how I’ve been pronouncing Iron my entire life.
Hope you passed your exam
Thank you Zach! As usual, excellent presentation. I really appreciate your whiteboard work which makes the subject matter much more understandable for non ninja-nerds like myself.
I love how you break things down to the microcellular level, but in a really simple and easy way to conceptualize it. I'm in FNP school and this is supplementing my hematology lecture :)
He knows how to explain
I wish the hematologist that I'm paying loads of money would have taken the time to explain my anemia as well as you have. I can't thank you enough. I finally feel informed!
If you want more information, do consult Dr. S. K. Gupta for overall info about anemia. He does video consultations also.
I'm dyslexic and slow with competition and that was so clearly presented...well done and thank you 🙂
I’ve watched so many of your videos. They are all very informative and helpful. These videos about blood and anemia I watched several times because I have myelofibrosis, receiving blood transfusion and my stats are getting worrisome. Knowing about it through your video has been comforting. Thank you.
Awesome video man. Keep up the good work! Here are a few extra key points in each of the Anemias you listed:
1) Iron Deficiency Anemia
Extra possible causes: Can also be due to : parasitic infection, increased iron demand, malabsorpion.
Extra clinical signs from the ones you mentioned are Oral lesions, Angular Cheilitis, Plummer-Vinson syndrome( Glossits, esophageal webbing,dysphagia), koilonychia, pica(desire to eat non-edible things such as clay-paint.)
Upon microscopic examination we can see microcytic, hypochromic anemia with anisocytosis and poikilocytosis with presence of target cells.
2.1)B12Folate Deficiency:
Peripheral Blood smear= Presence of Hyoersegmented neutrophils, target cells, polychromasia, Howell-Jolly bodies.
Measure methylmalonic acid should be elavated.
Presents with neurological symptoms
2.2)Foliate deficiency :
Occurs due to increased demand during pregnancy, due to alcoholism, due to anti-folate drugs( Methotrexate), or due to malabsorption
Measure homosysteine levels( should be elevated). No neurological symptoms are present.
3)Hereditary spherocytosis= Intracorposcular origin.
Patients also appear with jaundice. Perform splenectomy to correct reduce anemia.
4)G6PD deficiency= Intracorposcular origin
Clinical Signs : Back pain, Hemoglobinemia, Hemoglobinuria
5)Sickle cell Anemia( Intracorposcular- Extravascular)
Extra clinical signs= Pain, micro-infarcts, necrosis in joints, bones , GI, lungs, aplastic crisis, sequestration crisis.
Extra Treatment= Bone marrow transplant
6)Aplastic Anemia
Normocytic, normochromic pancytopenia.
Signs and symptoms= Palor,weakness, Petechiae haemorrhages, ecchymosis, mucosal bleeds, recurrent infections, thrombocytopenia, Granulocytosis.
Treatment: Antithymocyte Globulin, corticosteroids, Cyclosporine, Cytokines administration( EPO, G-CSF, GM-CSF) , Bone marrow transplant.
Much appreciated! Also the IV fluids are helpful in Sickel Cell Crisis to keep the vasculature full and plump (for lack of a better word) so the sickel cells have less of a chance to accumulate in the blood vessels and cause infarcts.
Mentzers index to diff. Between thalassemia and Ida
Can I just say... I LOVE that you're teaching pathophysiology while still receiving acupuncture cupping. The best of both worlds!
This video helped me to understand the material for my upcoming Med Surg exam that covers the topics of blood disorders and the lymphatic system. The video was easy to follow and easy to understand. Great teaching and study tips!
Very nice explanation! I was trying to figured my husband's anemia, he has to get blood transfusion now every 5 weeks, it started every 8 weeks but it's getting worse! And his Dr. Told us he was scratching his head because he couldn't figured out / find out my husband's anemia, he retired now and we are going to another Dr. My husband did so many test, bone marrow, colonoscopy, endoscopy and everything comes back normal
Dude this video is amazing. The only thing you could have done better was include a single view of everything at the end for us to print and study from, but you just made 50 pages of gibberish from my biochem book make complete sense. Thanks so much! I’ll definitely be using your channel for other information in the future
I didn’t come here to learn everything about anemia but that happened anyway. Great video. You are a sharp guy and have a gift for this.
This was great. I wish you were my Hematology prof. You made everything so much more clear😀
Keep making videos, you gained a subscriber 😊
Woohoo! We love to hear that, thanks so much and tell your friends about us!
Every time he says “ you know ... remember haemoglobin” I nod my head and then smile like an idiot 😅
Love how interactive your videos are 😍
I literally watch them out of interest! You make them so much fun.
Great videos! You'll have a million views in no time.
+torkil123 wow, thank you so much for your kind words that really means a lot. It would be awesome if it reached that many views. I really hope it helped.
Awesomeness
you need to get people to subscribe and like your video!
Million is in NO time.
torkil123 Thanks for the work you put into this. Very well done!
Best explanation of I've heard or Pernicious Anemia. Which I have. B12 shot once a month. This purple liquid called cyanocobalamin. When I was first diagnosed I had to a shot every day for 2 weeks, then a shot once a week for 2 months and now once a month forever.
Great dude! But remember hereditary spherocytosis is diagnosed by a test called osmotic fragility instead of Coombs, this thing is used to differentiate Autoimmune from non autoimmune hemolytic anemia. Treatment might be different because I would use corticosteroids to block antibodies against RBC in an autoimmunity setting.
Thank you for getting right to the point without any introductions, music, or jokes. Excellent job
Addition to pernicious anemia, could also be caused by a parasitic infection. Dyphillobothrium latum tapeworm competes with the supply of folic acid in our body. Thanks for this informative video. Great for reviewing/ refreshing some subjects!
Nice one. Galing
MLS here for 10+ years and Reviewing after 12 years in college... and man, you explained it better than my professor 🤣! In 35 mins i learned everything i had to learn in 1 week! Thanks a bunch! Im subscribing now!
I wish I had found this tutorial while I was studying anemia in my hematology class this past semester. This was great.
I'm from India. I just love your teaching techniques and these are also very informative. I never seen before. You are a great teacher 🙏🏻
Hands down one of the best explanations I have heard yet! Thank YOU! I Needed this.
I’m pretty sure this video is why I passed my test today! Thank you thank you! I’ll be watching a lot more of your videos and at some point I’ll donate to your cause! But I am telling all my nursing school buddies about y’all!
Informative and student friendly discussion. This makes Anemia really easy to learn. Keep it up guys!
I have currently unexplained anemia, my levels went down to 65, I couldn’t stand for more than a few seconds, and I had to have 4 transfusions. Very, very frustrating. Hoping to get answers soon through endoscopy. Thanks for this excellent presentation.
I love this. You have such in depth understanding of these topics. You break it down effortlessly and effectively!
I left school without understanding anything on this , just washing your video omg I can now explain to one else more better . THANK YOU
Dizziness is pretty common and probably the first noticed symptom for the person at home when iron deficiency isn't overly advanced. Dizziness when standing up. When it happens to me I know my iron has fallen again, I get a blood test, and sure enough ferretin has fallen into the red. And another at home symptom noticed before the others not mentioned is falling asleep a lot and quickly when seated. These were the only symptoms my wife had until her Dr did a regular blood test, but thinking nothing was wrong, the rung me up later to take my wife to emergency for a blood transfusion since she actually had acute thalessmia that had developed very slowly over a few years, complicated by simultaneous hyperthyroidism.
I get that falling asleep symptom... im from the Meditterian area,,,,, Thallasemia. How does your wife get treatment now?? I don't want blood transfusion.
You are Amazing! I have a son, who suffers with sickle cell anemia, it's not easy but he is now 34 years old. Thank for the info!
This video was really helpful! I had recently gotten diagnosed with Anemia. I have Iron deficiency i believe but I'll have to double check. Again thank you this was insanely helpful :)
You are better than all the professors I had in Med School! They shoud give you a Degree already!
OMG your handwriting is AMAZING. Please become a nurse and do nursing specific tutorials (LOL)!
The only teacher who can make physio interesting for me! 🙌
You are one of the best on the internet, SALAM & love upon you my friend!!
+ٌRami KH thank you so much for your kind words we truly appreciate that best of luck in your future endeavors!
One of the best and most intelligent person on here. Thank for what you do. God bless.
I am a PharmD student and my only regret is that haven't found you sooner!!!!
I swear, he explained everything perfectly. Thank you I am now starting to gain interest in our hematology subject
I have Bradycardia:
My potassium is 4.8
I had given Carvedolol 6.25
Micardis 40
Now I will get my CBC
Talk to you latter Dok thanks
Take care
Oh I was injected with Jectofer when I was 20yrs old
Now I'm 71
OMG, you're great! I realised even more, why I didn't study medicine. I already got lost after the second type of anemia 😅 it is sad that I have to educate myself to tell a doctor, what should be checked in a blood test 😩
four years later you're helping me so much on my semiology exam. I'm taking it in a few hours so fingers crossed, thanks for everything.
What what put you ahead of most people in science is that you actually explain the words and why those two syllables are put together like taquicardio the word tacky means time displacement over distance cardi means blood pumping or pressure if I'm not incorrect
Thank you for all you do! You are a blessing to many people. God bless you! You are doing great work.
Great videos! You're literally saving lives here.
LIFE SAVER. so many information wrapped in a single video. I really love your channel, THANKS!
I am loving hematology now bc of you. Thank youuuuuu🙂
Wow! This was so informative! My husband and others in our immediate family have Thalassemia. My husbands grandfather, had Aplastic anemia. This is all coming from my husbands dads side of the family. When his brother did an Ancestry test, .03% was North African. We haven’t known of any Mediterranean ancestors. My husband has had two blood transfusions and many iron infusions. His WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, Platelets are always very low, never in range.
Thank you for this wonderful video!
Watchin' you for the first time! Goin' superb, yet!
Thanks so much! Tell your friends!
Omg thank you! Coincidentally enough, I had iron deficiency for the last few months which caused me to be always tired and sleepy and lowkey depressed. In turn, I didn't study my that much at that time and when I somehow got better (went to the doctor and found out what's wrong and what to do), I had a lot of studying to do. The funny thing is that Anemia is one of the big themes and now I'm here watching your videos because it's better than reading the book.
Thank you for converting g6pd. It seems some docs don’t focus on it too much, or may not understand it as much, and specifically as it affects females (AFAB), assuming it only affects males and not female “carriers.”
Thanks also for the attention to menorrhagia in iron-deficiency anemia.
This video is very very useful for me. Thank you very much.I am from Azerbaijan and I am very happy finding your video
Finally! Someone who talks about thalassemia! I actually have beta thalassemia, but I only have a minor version of it. If I had a major version, I probably would have had a bunch of what you talked about done to me, but because it’s minor, I never needed anything for it. Also, the iron supplements thing is based on a common misconception. Thalassemic patients don’t necessarily have an iron deficiency. It’s the globin chain particular to their thalassemic type that makes them lack the hemoglobin to carry as much oxygen to their tissues. I don’t make enough beta globins. I make plenty of iron and alpha globins. The only time thalassemia people have to worry about iron is when they develop a severe hemorrhagic anemia. My mom is the one I got thalassemia from and she had an ulcer once. Her average hemoglobin level was like 12. Critical level is 4. When she went to the hospital for her dramatic increase in fatigue, she was at a 5.8. They were surprised she was even conscious.
I wonder how many people actually know about thalassemia?
+Weirdogirl 127 We are so happy to hear you are enjoying these videos!
I did not know about this till a month ago when i did a blood test and got told i have the trait! And so does my brother
Agreed. A lot of people with minor thalassemia don’t know they have it unless they do genetic testing. Until I found out I have alpha thalassemia, I was always prescribed iron because of my low MCV , but now that I’m aware, I always request an iron study if I’m there’s concerns about anemia.
I have beta thalassemia as well that I inherited from my mother! This video helped me so much understand anemias more. My MCV is 64 and I definitely feel it. Thanks again for the info!
15:00 this is precisely what I knew only in the background and couldnt remember during my biochem test this week
thx Ninja
I've had B12 anemia for months and the doctors couldn't figure it out. They still never could, I just started taking high dose vitamins as a last resort after going to the doctors incredibly ill 15 times. This video actually explains why it happened though!
I've had that issue my hemotolgist ended up figuring out I have a rare immune disorder called Chronic Neutropenia
I want to get this video but I can't understand it . I am getting premature grey hair, memory loss, chest pains. Been on iron tablets for over 8 months.
@@mysecretsketchbook865 Have you tried slow FE? Also don't eat any dairy for maximum absorption and take with 500 mg vitamin C. You may not have the right enzymes to absorb the iron.
@@mysecretsketchbook865 perhaps you have copper deficiency also. I've read that low copper can mimic or cause iron deficiency
What were your symptoms of b12 defiency
THANK YOU THANK YOU THANK YOU for keeping it nice and simple. My nursing professors like to use huge words and make it so complicated.
Your videos are great! So easy to understand and great tips for remembering concepts.
I love the way he explains content and breaks it down so simplistically! I always have these moments when everything just clicks when watching his videos. Thank you very much!
Did you do some cupping? ;)
Your videos are awesome, I love the level of details here, really well explained. I have never found better honestly!
Sometimes you need the right teacher. Thank you!!!
Thanks for your superb teaching. You did one small mistake by saying that B12 comes from leafy vegetables. Plant foods do not contain vitamin B12.
I agree. But overall, it's good.
@@Fizzlestick I don’t know how you reply back you agree that you can’t get B12 from plants (in the quantity needed), but say overall it’s good? This is extremely important and has been a problem to Vegans to know so I don’t know why you just brush this off! This should be removed from this video and not rely on people reading this thread.
No teacher is perfect
Ò
There's a lot wrong in this video. Not only is the source of B12 incorrect but so is the calculation for MCV; and MCV less than 90fL is not microcytic, it's below 80fL, and above 95fL is macrocytic. (Most hospitals will say it's critical if it's at or above 100fL and the person is considered anemic). G6PD is pretty good but he over explained the mechanism. He only needed to mention the first step of the reaction and what needs to be known overall is iron (Fe2+) is oxidized to Fe3+ and hemoglobin cannot transport oxygen when iron is in the ferric state (Fe3+). It is due to too many free radical oxidations. In hereditary spherocytosis it is normally a normal-cytic anemia Not microcytic. The part on sickle cell is correct, except Plasmodium plazforum is not an organism, he got the Genus name correct. Aplastic anemia is not a misnomer. Anemia is a term for a underlying condition.
You're a LIFESAVER NINJA NERD...I mean literally... You make all this boring courses so easy and fun to understand for medcine students like myself and you are indirectly saving lives because of this knowledge you're impacting on us which is going to be very useful in our different medical specialties...We love you and appreciate you a lot❤️❤️❤️
Best lecture every literally sir you saved me 🙏🙏
You are the perfect med teacher out there. Please keep up the work of enlightening humanity. GBU
This was very easy to learn from him. Definitely has a talent from that and I have no medical background. Somklh have a complex 6yo whose blood work is a mess and trying to fully diagnose her (mitochondrial is suspected)
Google hasn’t been friendly as far as if her numbers are concerning for being anemic but hemo is 8 and every other number is low and dropped. Ig is higher then already normal for her and not very normal numbers across the board. I am used to them all being either low or high though. 😂
This is helpful for any people, it is easy to understand and i like your quick look through lecture style. I would like to express my gratitude upon all the lectures you had been working hard to prepare for us. Thank you for you and your partners' contribution to the society. Goodbye and break your leg!