How to dial in a Mesa MkV Amp.

The Mesa Mark Series are one of the most well-loved and played amplifiers in history. The Who'-Who of guitar players, from Keith Richards, all the way up to James Hetfield have recorded some amazing tones with these amps.
However, these amps are also notorious for being amongst the most difficult amps to dial in and set up. I've had my MkV for over a year, so here's what I have learned.
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NOTE: To view the test tones and their settings, refer to the video here:
• Mesa MkV Test Tones
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TIME STAMPS:
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00:00 - Intro
02:21 - The Clean Channel
04:12 - Misconception #1) The Mark Series are very versatile
07:57 - Front Panel Controls
10:28 - The Second Channel
12:30 - Misconception #2) The Mark Series are mid-scooped
14:15 - The Third Channel
14:48 - Rampant Fanboy Worship
18:17 - GEQ Walkthrough
24:13 - The Dreaded Rabbit Hole
25:20 - How to avoid chasing your tail
27:43 - Conclusions