Alcohol and Disulfiram (Part 01) | Pharmacological Action of Ethanol | Disulfiram Mechanism & Uses

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Disulfiram was the first drug approved for the treatment of alcohol use disorders. disulfiram doesn’t treat alcoholism by reducing cravings. Its effects are psychological. Disulfiram and Antabuse are used to discourage alcohol consumption. The drugs cause adverse reactions, such as sweating, chest pain and nausea, when consumed with alcohol. People who take disulfiram don’t want to experience those unpleasant reactions, so they are inclined not to drink. The reactions are caused by acetaldehyde, a poisonous chemical that is produced when the body metabolizes alcohol. Disulfiram disrupts the way the body breaks down alcohol, causing acetaldehyde levels to build up.
Disulfiram interrupts the way the body metabolizes alcohol, causing unpleasant reactions. Understanding this process helps discourage patients from drinking and increase their motivation to sustain sobriety. However, the physical effects are delayed, and it’s difficult to predict when they’ll occur.
Alcohol has a variety of short-term and long-term adverse effects. Short-term adverse effects include generalized impairment of neurocognitive function, dizziness, nausea, vomiting, and hangover-like symptoms. Alcohol can be addictive to humans, as in alcoholism, and can result in dependence and withdrawal. It can have a variety of long-term adverse effects on health, for instance, liver damage
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