Pretty good list, i'd add: 1. Sauna, has been proven it's very benefic for basically everything including detoxing heavy metals and plastics. 2. Minerals, especially zinc/copper in a good ratio for SOD production and overall repair. But all minerals are important 3. Vit D and A in a good ratio, again, for immune system ( k2 mk4 45mg and magnesium ) 4. Melatonin and good quality sleep. 5. Giving blood. Again, very good data on this, it decreases iron load ( and that's a huge problem ) and overall refreshes the blood 6. Reducing EMF exposure as much as you can. Also, and this is critical. IF you're taking NAC you need to know it chelates zinc and especially copper. A lot of people get anhedonia from NAC because they drive their copper into the ground.
Haha, thank you. I think my editor has to take credit for that one. I am planning to do more videos about specific supplements that I find helpful to slow the aging process, and will look at Brian Johnson’s regiment as well. Thank you for your input.
Doing the test is worthwhile. It lets you know you REALLY need to focus on this, AND you need to avoid folic acid which then becomes poison to your body
Appropriate amounts of glutathione can help to detox the liver. However, injecting excessive amounts, especially in intravenous applications, may cause liver damage. www.ncbi.nlm.nih.gov/pmc/articles/PMC5549431/
Question! 🙋♀️ If someone is getting the injections do they need to get them at specific/close intervals to be best effective? My functional doc recommended a transdermal glutathione spray which I’ve been using for a couple of months. It’s not cheap but I don’t always use 2x day. I feel like I get a small boost from it but I think I need to do even more, especially bc I had a mouth full of mercury from age 8, just had last filling removed a year ago, and then tested pretty high for mold toxicity 9 months ago from our old house that we lived in for 7 years🤦🏼♀️ So I def think I need to up my glutathione dose. Maybe I’ll try NAC and injections if I can. We have cauliflower pretty regularly also. Thanks for your great videos! 👍
Thank you kindly! In our clinic, we use glutathione intramuscular injections (400mg) once weekly for people that need increased antioxidant activity. I also do IV glutathione at 800-1200mg for some patients. The transdermal absorption is interesting, but I have not seen good studies to show the bioavailability here. You could try to get an intramuscular injection from your provider to see if you feel a significant difference.
Reduced glutathione is the active form of glutathione. Oral absorption of glutathione is not great, but the reduced or liposomal form maybe better: “ There are two different forms of glutathione: reduced glutathione (GSH, or L-glutathione), which is the active form, and oxidized glutathione (GSSG), the inactive state. As GSH patrols the cellular environment and puts out oxidative “free radical” fires, it becomes oxidized and inactive, thus turning into GSSG. Fortunately, inactive GSSG can be recycled back into the active GSH form, thanks to the glutathione reductase enzyme. When this enzyme is overwhelmed, and too much-oxidized GSSG accumulates (compared to the active GSH), your cells become susceptible to damage.”
Dear Dr. Kuehne, ivwas wondering what you think about glutathione via nebulizer. I start treatment tomorrow. This treatment was suggested to me by my health care practitioner because I have been experiencing colds and sore throat each time i breath in the outside cold air. I get really sick. Its not good. I can only breath warm air.
Do any of the glutathione oral supplements offered do anything enough to make them practical or useful to take? I saw some liquid and even a patches applied to the belly too listed as a direct supplement. I know you did you give shots and listed NAC or MTHF among others to take, but anything that can be taken right from home on a regular basis as a "glutathione" pill? I'm assuming not since you didn't mention any??!!!
From Staffordpharmacy.com: “The reality is that glutathione is not absorbed very well when taken in the oral form. It is largely broken down by enzymes within the intestine. Studies have found that it is not possible to increase the amount of glutathione in your blood by taking it orally. Instead, glutathione must be administered intravenously.” NAC is a good precursor supplement
A glutathione supplement should not significantly increase glutamine levels. Also keep in mind that glutamine is a non-essential amino acid. Therefore, your own body will make it as needed.
I'm on B12 injections due to deficiency and ME/CFS, but as soon as I add folate in any form, I get not only worse neuropathies but also new ones. I guess there's something really weird going on in my methylation pathway. No doctors are willing to let me do a metabolic screening so I'm kind of on my own in this. It's too complicated for them it seems. Would glutathion be a good way to start and see if I will tolerate folate? Where can I source supplies for self injections in EU? Any idea?
Doc, could you please explain why keto might not be for long term for some people 08:05 and what are those drawbacks? I suffer from neuroinflammation (I guess) and I am finding some relief in following a ketogenic diet recently, but I don't know if I should follow it long term or if these benefits are going to last.
There are people who are tolerating ketosis long-term just fine. For some people it can cause some deficiencies. It might also decrease hormones like testosterone. As long as you feel good on this diet and you have improvement in your symptoms, the only recommendation I have is to do regular follow up with Labs to check for any possible deficiency.
NAC is often used to as an adjunct to other cancer therapies. So it can help fight cancer. In animal models it showed acceleration of existing lung cancer. It has not shown to be a carcinogen on its own.
@@bennettjoseph1481 TH-cam doesn't accept links so you'll have to look it up for yourself. But from Cell & Bioscience there's a study named Antioxidant supplements promote tumor formation and growth and confer drug resistance in hepatocellular carcinoma by reducing intracellular ROS and induction of TMBIM1. Just one citation; there are others.
It’s a TH-cam requirement. For the most part, you are correct, but there are more and more physicians who are becoming knowledgeable on nonpharmacologic treatments.
My understanding is NAC is better absorbed on an empty stomach so it’s often taken first thing in the morning. My doctor told me just to try and take it at a time when it’s been at least 3 hours after and 30 minutes before eating.
Pretty good list, i'd add:
1. Sauna, has been proven it's very benefic for basically everything including detoxing heavy metals and plastics.
2. Minerals, especially zinc/copper in a good ratio for SOD production and overall repair. But all minerals are important
3. Vit D and A in a good ratio, again, for immune system ( k2 mk4 45mg and magnesium )
4. Melatonin and good quality sleep.
5. Giving blood. Again, very good data on this, it decreases iron load ( and that's a huge problem ) and overall refreshes the blood
6. Reducing EMF exposure as much as you can.
Also, and this is critical. IF you're taking NAC you need to know it chelates zinc and especially copper. A lot of people get anhedonia from NAC because they drive their copper into the ground.
Great input. Thank you.
I am Canadian. We give blood every week. We play hockey. hehe just a joke.
So its better not to consume copper,zinc rich food/supplement , simultaneosly when u eat glutathione supplement right??
You are ten years older than Bryan Johnson but look younger. I'd love to see a video focusing on your blueprint.
Haha, thank you. I think my editor has to take credit for that one. I am planning to do more videos about specific supplements that I find helpful to slow the aging process, and will look at Brian Johnson’s regiment as well. Thank you for your input.
Bryan looks like Commander Data's older brother. 😊
Doing the test is worthwhile. It lets you know you REALLY need to focus on this, AND you need to avoid folic acid which then becomes poison to your body
Which test
What is the effect of glutathione injections on the liver. Some sources suggest that it can cause liver problems?
Appropriate amounts of glutathione can help to detox the liver. However, injecting excessive amounts, especially in intravenous applications, may cause liver damage.
www.ncbi.nlm.nih.gov/pmc/articles/PMC5549431/
Tank you for this video. I am very interested in your opinion
Thanks for watching!
Question! 🙋♀️ If someone is getting the injections do they need to get them at specific/close intervals to be best effective? My functional doc recommended a transdermal glutathione spray which I’ve been using for a couple of months. It’s not cheap but I don’t always use 2x day. I feel like I get a small boost from it but I think I need to do even more, especially bc I had a mouth full of mercury from age 8, just had last filling removed a year ago, and then tested pretty high for mold toxicity 9 months ago from our old house that we lived in for 7
years🤦🏼♀️ So I def think I need to up my glutathione dose. Maybe I’ll try NAC and injections if I can. We have cauliflower pretty regularly also. Thanks for your great videos! 👍
Thank you kindly! In our clinic, we use glutathione intramuscular injections (400mg) once weekly for people that need increased antioxidant activity. I also do IV glutathione at 800-1200mg for some patients.
The transdermal absorption is interesting, but I have not seen good studies to show the bioavailability here. You could try to get an intramuscular injection from your provider to see if you feel a significant difference.
@@JonasKuehneMD ok thank you! I will definitely give it a try.
What do you think about glutathione reduced form specifically for skin is it effective or better than regular love you vids! ❤
Reduced glutathione is the active form of glutathione. Oral absorption of glutathione is not great, but the reduced or liposomal form maybe better:
“
There are two different forms of glutathione: reduced glutathione (GSH, or L-glutathione), which is the active form, and oxidized glutathione (GSSG), the inactive state. As GSH patrols the cellular environment and puts out oxidative “free radical” fires, it becomes oxidized and inactive, thus turning into GSSG.
Fortunately, inactive GSSG can be recycled back into the active GSH form, thanks to the glutathione reductase enzyme. When this enzyme is overwhelmed, and too much-oxidized GSSG accumulates (compared to the active GSH), your cells become susceptible to damage.”
Dear Dr. Kuehne, ivwas wondering what you think about glutathione via nebulizer. I start treatment tomorrow. This treatment was suggested to me by my health care practitioner because I have been experiencing colds and sore throat each time i breath in the outside cold air. I get really sick. Its not good. I can only breath warm air.
Yes, that is a great way of administration especially for upper respiratory problems.
www.ncbi.nlm.nih.gov/pmc/articles/PMC8349474/
Dear Dr. Kuehne, thank you so very much for taking the time to respond to me. Much appreciated.
Do any of the glutathione oral supplements offered do anything enough to make them practical or useful to take? I saw some liquid and even a patches applied to the belly too listed as a direct supplement. I know you did you give shots and listed NAC or MTHF among others to take, but anything that can be taken right from home on a regular basis as a "glutathione" pill? I'm assuming not since you didn't mention any??!!!
From Staffordpharmacy.com:
“The reality is that glutathione is not absorbed very well when taken in the oral form. It is largely broken down by enzymes within the intestine. Studies have found that it is not possible to increase the amount of glutathione in your blood by taking it orally. Instead, glutathione must be administered intravenously.”
NAC is a good precursor supplement
Dr. Kuehne, does glutathione tablets change to glutamine which feeds cancer cells? Are glutathione supplements unsafe to take?
A glutathione supplement should not significantly increase glutamine levels. Also keep in mind that glutamine is a non-essential amino acid. Therefore, your own body will make it as needed.
Do I need to take magnesium with glutathione? I heard it won’t work without magnesium…
Glutathione should be given as an intramuscular or intravenous injection.
You do not need to take magnesium at the same time.
I'm on B12 injections due to deficiency and ME/CFS, but as soon as I add folate in any form, I get not only worse neuropathies but also new ones. I guess there's something really weird going on in my methylation pathway. No doctors are willing to let me do a metabolic screening so I'm kind of on my own in this. It's too complicated for them it seems. Would glutathion be a good way to start and see if I will tolerate folate? Where can I source supplies for self injections in EU? Any idea?
Are you using methylfolate and methylcobalamin? An MTHFR genetic test, as well as a homocysteine blood test would be helpful.
Doc, could you please explain why keto might not be for long term for some people 08:05 and what are those drawbacks? I suffer from neuroinflammation (I guess) and I am finding some relief in following a ketogenic diet recently, but I don't know if I should follow it long term or if these benefits are going to last.
There are people who are tolerating ketosis long-term just fine. For some people it can cause some deficiencies. It might also decrease hormones like testosterone. As long as you feel good on this diet and you have improvement in your symptoms, the only recommendation I have is to do regular follow up with Labs to check for any possible deficiency.
@@JonasKuehneMD Thank you doc
For how long so far ur taking the NAC ?
About 1 year now, with 1 week breaks every 2 months
Wish all doctors looked like this stud, like someone you can clearly see is a healthy person. Good job, doc!
Haha, thank you for the compliment!
A probllem for low glutathione comes from toxins and a non nutritional thing to consider would be lymphatic drainage
👍
And NAC is also significantly associated with lung and skin cancer. Why does nobody mention this??
NAC is often used to as an adjunct to other cancer therapies. So it can help fight cancer. In animal models it showed acceleration of existing lung cancer. It has not shown to be a carcinogen on its own.
@@JonasKuehneMD Yes, and if you have undiagnosed tumors it could be quite dangerous
@@jontpt - Reference please. Thanks.
@@bennettjoseph1481 TH-cam doesn't accept links so you'll have to look it up for yourself. But from
Cell & Bioscience there's a study named Antioxidant supplements promote tumor formation and growth and confer drug resistance in hepatocellular carcinoma by reducing intracellular ROS and induction of TMBIM1. Just one citation; there are others.
@@jontptsounds like you’re making stuff up
Why should I ask ny doctor everytime I want to try a supplement? Doctors are clueless on supplements.
It’s a TH-cam requirement. For the most part, you are correct, but there are more and more physicians who are becoming knowledgeable on nonpharmacologic treatments.
4:07
What about combining glycine with NAC? Is the time of day when NAC is taken critical?
My understanding is NAC is better absorbed on an empty stomach so it’s often taken first thing in the morning. My doctor told me just to try and take it at a time when it’s been at least 3 hours after and 30 minutes before eating.