Dosing and safety of Methylene Blue
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- เผยแพร่เมื่อ 2 ต.ค. 2024
- There is a lot of confusion about the dosing of methylene blue for brain health and optimal cellular function.  This video discusses dosing of oral methylene blue as well risks and side effects. 
#methyleneblue #supplements #mitochondrialhealth
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I had a genetics testing panel which showed a mutation for Mitochondrial I Complex process. I began taking MB about 1 year ago, 30mg daily. Lifelong dark circles under my eyes cleared up, my skin health improved vastly and I no longer feel fatigued by early afternoon or evenings. I also tapered off of an SNRI and feel MB is a very natural antidepressant (at least for me). I will continue taking it as I also have APOE Alzheimer’s risks.
Thank you for your comment. I’m glad to hear that this works so well for you. A lot of my patients have reported great benefits.
Was the 30 mg your starting dose or did you gradually go up there?
@@JonasKuehneMD I began with 5mg and felt a noticeable improvement in energy but not much in terms of mood. I titrated to 30mg quickly, I do remember it being within my first order, so less than 1 month. I have responded very well, can’t think of any negative side effects.
Hi . Where did you buy it please ? Pharmacy or Amazon ? Liquid or capsules ? Thank you .
@@mgkchwould love to know as well. Ty for sharing your experience.
@@ToWhateverEnd Were you still on your SNRI when you started MD? Did you use MD to taper off your meds. Also, what SNRI were you taking if you dont mind me asking? Thank you, hope its okay asking all these questions.
I've been taking this just before and during my cardio workout. I've noticed I can ride my bike at very high levels: levels 13,14, and 15, breathing very easily through my nose and heart rate max 120 but usually 118 for 40 minutes on hills and I'm 64 years old. My leg muscles never burn. They are stressed but never burn. I find this amazing. I used to be a personal trainer and fitness instructor for 13 year.
That is amazing and sounds like you’re responding extremely well to MB. I find that it increases my heart rate and blood pressure too much so that it caused discomfort during a workout with weights.
@@JonasKuehneMD , I heard that it inhibits nitric oxide, so it was explained that it might not be a good idea to take it right before doing weights. I just started it and I seem to be having quite strong detox reactions from it: headaches, lethargy, fitful sleep. I can definitely tell it is working on my brain. I have also felt more energy and better mood already. Just one drop, two at the max in a glass of water. My pee is not blue or green yet though. Wonder if that means anything. I have not seen people mention detox reactions from it.
If stuck on a deserted island and could only have one health enhancing compound, I would choose Methylene Blue. Micro dosing, 2 days on and 1-2 days off with intermittent longer breaks off, has been most effective. Improved focus, energy, mood, and restful sleep- with no side effects. Overall well being noticeably impacted.
Thank you for sharing this!
I have small pwder vial..how do u measure dosage ? Dropper measures 1ml up to 3
Mine comes today, I'm stoked to try it! Any tips for a noob
I would choose food and water.
@@robertauclair2278 Ha ha ha..now you know she means supplement.
I've been taking about 20-30mg daily for month or bit more (in split doses, restored by ascorbic acid), which is 0.25mg/kg to 0.38mg/kg in my case and after that did a 4 day water fast and I actually noticed that urine was colored green until the very end of 4th day. So seemingly it did accumulate over time and I'll need to tune down the dosage. I've actually seen something similar in literature when they proposed that color may be indicative of patient oxidative status (the darker urine gets, the more oxidative stress there is), but I also think that taking pauses can help figure out individual dose. Thanks for the vid, was one reason I considered reducing the intake
That’s great information. Yes, ideal doses will vary individually. I always take one day off completely per week. I also noticed that while I take it in the morning usually around 9 AM, green or blue urine sometimes continues until the evening or longer. It is difficult to say how well one can predict the half-life based on that, but if methylene blue is still accumulating in urine, and able to change color then there should still be a significant amount left.
Thanks, the sleep disturbances I've had have been crazy nightmares, so now make sure I take last dose way earlier in the day
Did it work?
@@JonasKuehneMD aye, takin 7mg with breakfast and 3mg with lunch, rather than the 3mg, 3mg, 3mg every meal that I started with, sleeps fine now and I do feel I'm a wee bit sharper for it, but this is just the 2nd week of using it
Oh my God.. I had the worst nightmare in a long time the night after taking it, in the Am, now I know it to have been too much.. I feel some relief seeing someone else say it.. I woke with a terrible headache also. Embarrassed to say I couldn't find my syringe for measurement so I sort of trucked on and figured I would be OK.. (I had a busy day ahead and wanted to be focused and on point).. I was horrified by the nightmare. Wow.. dosage is truly important
Very informative. Thank you for the clarification on dosing.
Glad it was helpful!
@JonasKuehneMD it's great to talk about taking too much of it. Research has found that low doses have a better effect than high doses (Bell curve results) as you say, and that for Alzheimer it meliored the damaged parts of the brain but was detrimental for the healthy parts. Scary. See this full (a bit tedious but very thorough) review about demonstrated dangers: th-cam.com/video/XhgGGbdw4zE/w-d-xo.htmlsi=Cg_-5a5qMiGNjvAA
I take 3 drops in water in the morning, a few times a week, then fully stop for a week or two.
@@JonasKuehneMDHi your product is what i am looking for, because the dosage is what i was afraid, your products are already ready to use without be afraid to make an OD so you say that 2 tablets for the one with vitamine C is the right dosage ? Thank you
My MD has put me in the CFS box and I do notice a significant difference when I stop using methylene blue. Essential returning to brain fog and low energy.
What dose of MB are you using?
Very good information. Clear, concise and to the point. Helps a lot. Thanks.
Glad it was helpful!
I started taking methylene Blue about five days ago, mainly for energy and for arthritis pain. I feel as of today it’s been helping and after dinner it seems like the pain was back and my energy had dipped so I’m glad you mentioned the half-life. I’ve been taking eighth drops in the morning. I think I may take another another eight in the afternoon now and see how I feel. Thanks for the video.
Thank you for your feedback. I noticed taking it too close to bedtime Impaired my sleep. I often take it in the morning around 9 AM, and then a second dose around 1 PM.
@@JonasKuehneMD thank you I think I’ll do a similar strategy. We’ll see how that works. Thanks again for the video and your information.!
Also, there is "nothhing boring about B0ron".
Or read the B0rax C0nspiracy, by WaIter L@st.
I just try not to mix it in glass or stomach, so at least some 1/2 hr apart.
If digging deeper, you will find many working remedies, and may smear campains against them.
I just discovered my biggest potential for self-healing is my infinite soul if one got his amygdala decalcified and dedicate to healing.
All the best!
Can you explain milligrams in terms of drops? I have been doing five drops a day sometimes twice a day and
I feel good but
I would like to know if five drops is too much too little.
@@Lovemarvez People vary in tolerability in multiple orders of magnitude. So do not count the milligrams, but do your proper dose finding and do dosing repeatably.
The calc is easy: 5dr * 0.05ml/dr * 1% g/ml = 0,0025 g = 2,5mg.
I assume a drop for you is standard drop 0,05ml (you only know if measuring it, mine on "Amaz EU is 0.075ml;) and you use a 1% solution, 1% is some eclipse of "1% g/ml" - and with the units it implicitly makes sense ;)
If you want to compare your redox state from what you see in your urine, you can first measure "blue absorption" in native urine, which is the "oxidized form" of MB, then add some ml CDS, and this makes all MB blue, so oxidized, so measure again absorption ratio to determine full content of MB.
I use some "Color Meter" by Contechity in iOS to measure colors with white balance on white paper I put next to probe.
Well works to some extend.
For the ones having heard of "Arduino":::
To do this more repeatably, any light interruptor circuit best with some modulation technique to eliminate daylight is welcome.
Most not wanting to modulate the led do it it dark cardboxes and by ramping up a LED till the reception levels match. Very linear.
But you can also do it to cross correlation I found nicely explained for cypress PSOC in AN2042 of cypress, see web.archive.org/web/20180702175100/www.cypress.com/documentation/application-notes/an2042-psoc-1-multifunctional-optical-sensor
You can of course download the zip with example code from archive. But since cypress was acquired by Infineon, do not expect the example code to run in their latest PSOC creator, but download some old one of the time of the code example.
Or transfer the code to a platform of choice, like some Arduino or raspi with some 24 bit A/D and D/A chip doing the job nicely and away from the noise of the micro controller. The neurotic will do optical signal transmission to the analog board that gets some analogue regulated power supply in some properly shielded case by some LED lighting fibre or TosLink fibre. So for the data transmission. But also for the measuring light signals. No EMF can creep to the AD if you shield it properly and use multi-layer PCB. And many capacitors and adjacent PCB layers 50µm ajar to have a ground plane capacitance.
By the same setup, and searching for DIY UV-VIS spectrometer, you can do full UV-VIS spectroscopy with reference points by cheap laser diodes with known wavelenghts, you can also use for fluorescence, so two-channel spectroscopy (one frequency illuminating and evoking fluorescence), and also determine some other useful concentrations, like CIO2 having 1250/cm as epsilon at 359 nm you will only find traps in internet Alibaba etc, so just get some standard money bill checking led 365nm and be done. And a multicolor LED for "unexpected" things like MB you can detect in red while green is the common reference channel, so measurement of both residual CDS and MB is possible, so you can check if they really kill themselves in conditions that are there in body. Please answer in substack or TG if this is interesting to you, and first here.I try o look after the bell some times a week ;)
Good information Dr Jonas. I started taking MB, 35mg daily, yesterday for sarcoma cancer. Thank you for your posts!
Do you also take black cumin oil?
Essiac Tea 🙏🏻
@@m.b.593 do you have personal experience with essiac tea?
How is that going? I have sarcoma also and would like some feedback please
MB binds to 80% something of cancers - but what do you do with it? Which agent kills the bound cells?
I use CISS cure, so first deplete blood of antioxidants by taking F+ protocol to J.H., then after 3 hrs, I take a (sub-) drop of NaCIO2 I slowly rise.
This will hop sour tissue into the face, meaning NaCIO2 gets slit up and frees a CIO2 in sour milieu; and so far I found ALL cancer tissue is sour, because of ... GREED. It lost oxygen breathing and only does lactic acid circle.
But of course, many remedies and meditations, prayers, pure joy and lots of other brain states activating the amygdala more are purifying and doing the job of HEALING you.
So detox brain thus "decalcify" Amygdala from F, Hg, Pb, Al, and glyphosate and spike. Whatsoever toxins hacking down on breath of Life.
Am I making a mistake??? Excellent information doctor. I have been taking MB in the 10mg/daily range daily. I consume it by mixing it in water with about 1 gram of pure Vitamin C powder. I allow it to sit for a few hours which turns it clear and allows me to drink it without the nasty staining in my mouth.
The information about working out and raising BP did give me pause for thought. I have been using it prior to working out , thinking it would oxygenate my blood and facilitate my workout. I also usually take a far infrared sauna after my workout. It sounds like I may be making a mistake ! I understand you are not giving medical advice or making a medical recommendation. Do you have a general opinion? Thanks again for your great content.
Thank you for your great comment. Methylene blue can slightly increase blood pressure and heart rate. Some people are more sensitive to this than others. For that reason, I do not take it before or right after a workout. Mixing it with vitamin C is a good idea as it turns it into leukomethylene blue, which converts back to methylene blue in the body.
I believe everyone is different in terms of how they may react to methyl blue for exercising; it seems that’s what the doctor is implying. I am interested myself, so I plan to start small dosing for workouts as starters.
@@JonasKuehneMD
Ratio m blue and Vit C?
@@mfrmll3786 i want that info too please
I ordered mine today. Let’s see what it does.
Such a handsome man.
❤️🙏…blushing over here 😳😂
Awesome!!! Yup I was confused for this reason.
Hello thank you for your video. I have been taking MB for 2 days. 5mg via the dropper once in the morning and once in the evening. I took mines this morning and after two hours I started to feel like I had a fever and felt like I had too much coffee. is this something that happens? thank you :)
I have sort of felt that way after I took methylene blue before a workout. It can increase blood pressure and heart rate. This may vary from person to person and might need titration or cessation of use.
Common. You can reduce dose by half and see if your still have the positive effects without the undesirable side effect...
Usually as long as you're peeing green you've got enough
Does taking MB REPAIR the diminishing effectiveness of the mitochondria ?
MB can help mitochondria become more efficient again. So I would answer your question with yes.
@@JonasKuehneMDThank you! 😊
I am 50kg and am taking 15 drops of 1% USP grade MB. I am 78 yrs old and taking MB for improved brain function - memory, focus etc as well as back pain and Neuropathy. What wold be a suggested ideal dosage for me?
Great question. It varies, but most companies are doing research with around 15 mg daily. For most liquid preparation that would be 30 drops. This may be too much for some people though. Keep in mind that methylene blue can increase blood pressure and heartrate slightly. I think your current dose of 15 drops or 7.5 mg maybe sufficient. If your physician knows about methylene blue then this would be a good person to ask more specifically about your individual situation.
Can this help my wide who took the covid vaccine and then the booster and since then she has had high platelet counts and lymphocyte count.
How about taking methelen blue with lugos Iodine, Boron and a metheleted B complex?
These supplements should not influence the potency of methylene blue.
@@JonasKuehneMD Thanks! What is your opinion on Boron and Iodine? Have you or ae you doing a video on them?
@@sassyterminator3858 I take Dr. Walter Last's borax protocol, which is very easy, since the body actually absorbs boron more easily from borax than a boron supplement. Very helpful.
I only take 8 drops, max/day. Sometimes only half. 60 kilograms
Glad your video popped up. I bought some a couple weeks ago, have put a couple drops in aloe vera juice. I skip every 3rd or 4th day. A little of anything goes a long way with me- but wondering if I should use more. Not taking any shots/pharmaceutical medications. Thank you
Thanks for sharing this. Yes, for many people small doses are sufficient.
Thank you for this great & informative video Jonas ❤ I have been searching for a tablet form of MB for some time now and very excited to find your recommendations. However one of my concerns are the added ingredients like DiCalcium Phosphate. I’ve read it can cause adverse effects. I’m wondering how much is added to the MB and what purpose?
Thank you kindly for your feedback. Dicalcium phosphate is added to many tablets and medications in small amounts. I could not find out how much of it is contained per tablet. I am not concerned about it causing adverse effects in the small quantities that would be necessary to help with the stability of the pressed tablet.
Excellent info and very comprehensive, thanks and I subscribed 🙂
Thank you! Much appreciated!
Thanks for the info doc much appreciated . How long does it take for it to kick in and you will feel the mental effects ? Do you stack it with other compounds to support mitochondria health and function ?
I noticed the effect within half an hour. I use coenzyme Q10, as well as nicotinamide riboside as well.
@@JonasKuehneMD Hey doc thanks for answering yeah i take nr/nmn , coq10 normal plus in ubiquinol form , Pqq, glycine/nac (and redlighttherapy) and now i am considering taking MB or do hyperbaric oxygen therapy. Again i appreciate you answering me and have a nice day my friend . 💪🙏✌
Tried it for the first time today. Both my urine and #2 were very blue all day so far…😮
Yes, most of it is excreted unchanged.
Thanks for the link. I had no idea where to buy pharmaceutical grade at a reasonable price.
Happy to help
Quantum on Amazon
Amazon has it. Amazon's Choice has one for $31+.
Taking a large dosage during pregnancy will give you a baby smurf. 😮👶💙😅😅
Nooo, it’s dangerous for the baby during pregnancy.
@@JonasKuehneMDthey are having a joke. You are such a worthwhile person. Greetings from Australia.
It seems that you need to update your recommended dosage: a dose of 15 mg/kg in mice improved physical and mental performance, and gut microbiota; but increasing the dose worsened both. This is equivalent to 1.216216216mg/Kg in humans th-cam.com/video/qFvY9c68Tkc/w-d-xo.html
The doses used in animals are usually far exceeding the doses we use in humans. For oral administration I believe we do not need more than 15 to 30 mg daily total. If we use it intravenously in the emergency room for carbon monoxide or cyanide poisoning for example, then higher doses are needed on the order of 2 to 4 mg per kilogram. This is a dose though that is not continuously taken.
If I race or have an intense workout, why is there not indication of methylene blue in my urine for about a day...even though my normal dosing schedule is uninterrupted. It's a great recovery indicator I just don't understand why really hard (above LT2 or 4mmol blood lactate) efforts seem to 'absorb' methylene blue for ~24 hours or so.
That’s an interesting observation. I don’t know the mechanism, but will look into this.
10mg = 1ml
If it’s a 1% solution that is
@@dominickdelongpre4535 Volume has nothing to do with concentrations.
Do you know if anyone has tried to introduce this into their diet to help fight or manage limes disease?
I read that it has been used for Lyme disease, however I have not seen any studies or had personal experience with patients using it in this way. I will look into finding more research about this.
@@JonasKuehneMD, I just started taking MB for chronic lyme. I went 25 yrs undiagnosed. And by the time I was finally diagnosed, it had done serious damage to every system and organ in my body. I was finally diagnosed around winter 2014.
The detoxing was pure Hell. But I had reached the point where I was dying after being exposed to black mold.
So when I started on mb going on 10 days ago, I started with 1 drop of .05, adding one more drop a day. I think I will try staying at the 10 drops and see how that goes. And taking breaks a day or 2 a week.
Thank you so much for your video and actually answering questions on comments!
Dear Dr Kuehne, hopefully you will see this question which wasn't answered in your video. Re dosing does it make a difference for what one is dosing? In my case M.E. which is also known as CFS. You are the first person to point out that the recommended dose of .5- 4 mg per kg is for intravenous!
Thank you for comment. Yes, there can be variations in dosing for different applications. It is interesting that thereis not a very set dosing schedule. In my opinion, oral dosing can be anywhere between 5 mg to 30 mg daily. I would suggest to start low and slowly titrate up. The doses can be broken up to twice daily, however, I do not recommend to take it too late in the day as for some people this might impair sleep.
Do some research, he’s not a good dr trying to help, he’s a poison pusher!
These scammers use people vulnerabilities and illnesses.,
Vitamin C will neutralise any potentkal stain if you can apply early enough, apparently.
Thank you for the tip. I will try it out.
What happened to "Eat your rainbow (of food)." Which is saying colors have important micronutrents. Do we loose anything with the blue?
@ShimmeringWind it's rubbish. You don't need color. You need nutrients.
@@JulioMacarena Ciruloplasma is what makes blood blue ascorbic acid destroys this so yeah color is key
@@JulioMacarenathe color indicates the nutrients in the food it isn't "rubbish" to know that.
We just started my.dad on it yesterday. He is dealing with Parkinson's. Have you seen any success with it for that?
Nicotine patches...DR ARDIS. SEARCH HIM OUT
Does it cause constipation? If so, what can be used to avoid that? Thank you.
It is not known for causing constipation.
Thank you 🙏🏼
All guys should be taking this given the effect it’s having upon you. 😉 Additionally, I am using various MB protocols upon cats and dogs & birds, dosing according to weight. It’s blowing me away.
I take methylene blue 1.5 times per week and it does help!!! (my short serotonine ----- former addict ____ syndrome) where in the web can I get DNA test for short ''serotonine gene''??? thank you ! (proof will make me feel less psychotic! ) and will amaze my psychiatrist!
I have not seen that particular blood test before.
Is it a good idea to use Methylene Blue in suppository form? My concern is that after mouth cancer my mouth is so dry that I cannot get the stains off of my tongue/mouth. If taken orally is it best to dilute with water and drink or place the drops on the tongue? Even when I take it in pill form it stains my teeth and tongue for days.When I had cancer I used suppository forms of THC for better absorption and less stomach issues. I feel that suppository from of this might be best for less worry of staining but not sure if the MB could be placed in freezer. I usually keep my suppositories in freezer.
I am not aware of a suppository preparation of MB. If you take the tablet just as you are about to swallow your food it should not make any contact with your gums or tongue.
Take it with a straw to avoid a blue tongue?
@@denarogreen4924 i mix with a tablespoon of tang and it seems to go down without the blue mouth effect. The tang makes it turn greyish blue
I would appreciate if you could suggest how much water should one mix the drops with.
I usually use a quarter of a regular glass.
Thank you for your prompt answer!
Hello just wanted to run some information if my bottle size 30ml
It says 10g/ml how many drops would you suggest i take for neoptropic purposes
1mL is usually 20 drops. So 0.5mg per drop here. Cannot give official advice on this platform. Most of my patients take between 5 and 15 mg daily. 10mg would be 20drops here.
There are some contraindications, including pregnancy, breast-feeding, and concurrent use of an SSRI.
@@JonasKuehneMDThanks for the quick response, I think I'll start with 10mg a day to see if it helps my brain focus and be locked into my work. Would you recommend getting a small spray bottle which will deliver 0.5mg with each spray
Amazing advice, thank you and subscribed. Question regarding dosing for a younger child with ADHD, and I understand that this is not official medical advice, but is body weight a consideration? Child is 30kg in weight.
Thank you kindly! I would run that question by your pediatrician. It is a great supplement for symptoms of ADHD in my opinion. Bodyweight does certainly play a role. You could discuss with your pediatrician low-dose around 2.5 mg to start with. Also would suggest as with other ADHD medications to take breaks over the weekend.
Methylene blue (MB), now called methylthioninium chloride, has recently been noted to cause central nervous system (CNS) toxicity, variously described as encephalopathy, CNS toxicity, serotonin syndrome (SS) or serotonin toxicity (ST), but seemingly only when given to patients already on (selective) serotonin reuptake ...Feb 8, 2010
Being on an SSRI is a contradict ation to using MB. Toxicity to do central nervous system, but only result after extremely high doses. The doses that researchers are looking at to prevent or treat dementia around 15 to 17 mg daily orally. This is of course, not medical advice. Always discuss with your primary care doctor prior to starting any supplement or medication.
I just started 300 milligrams of bupropion - is low dose of methylene blue a problem to add
This is not medical advice. Bupropion or Wellbutrin is a norepinephrine and dopamine re-uptake inhibitor. It should not interfere much with serotonin. Also, as mentioned in the video, the low-dose that people usually take, myself included, of methylene blue around 5 to 15 mg daily is very unlikely to trigger serotonin syndrome even in someone on a higher dose of an SSRI. Of course ask your physician prior to starting.
How safe would MB for someone who has had a colon rupture with need for more repair in future, but left with severe fog and apathy from the sepsis. By the time I got to ER my ankles were blue and creeping up and I was hallucinating. That was only 30 minutes after and was in OR 30 minutes after that. O2 was mid 80's for several days. It also took a while to type and small tasks. Almost there, and this was in March this year.
I would definitely suggest to run this question by your surgeon. I’m sorry to hear about your scary experience. One of the treatments for sepsis is high dose IV vitamin C (50,000 to 100,000mg) if G6PD is normal.
Wondering when using the dropper how much drops would be recommended to take ( say for ADHD etc symptomps(?
Not official medical advice, but most people do well between 5 mg and 15 mg per day, with two days off per week. Most solutions at one percent will say on the label 0.5 mg per drop. If that is the case, that would mean anywhere between 10 and 30 drops.
Thanks for that - is there any reason Caffeine could be a bad stack?
The company that makes the product on the thumbnail makes a version that uses L theanine and caffeine together with methylene blue for focus and memory. I think it is OK to combine them.
I feel fatigued when I take methylated Blue
I’ve been taking 15 drops for 2 months and waiting for the good results
It is an unusual experience. I’m wondering why you are reacting with fatigue. Are you taking any other supplements at the same time?
@@JonasKuehneMD sometimes it will give you a candida yeast die off in people that’s why their fatigue it goes away in time
Get tested for G6PD! If you have this genetic mutation, red blood cells will be broken down too fast. Most anti-malarials will cause the same along with legumes, especially Fava beans. G6PD is also called Favism for that reason. It's similar to sickle-cell disease but more prevalent in the Jewish population.
So, dial back the dose.
I take 10 drops
Just starting MB. What dose for 135lbs? Looking for clarity and benefits to stay healthy!
I cannot give medical advice on this platform. There are some contraindications to taking methadone blue, including pregnancy, breast-feeding or concurrent use of an SSRI. Personally, I take between 10 and 15 mg MB 4 to 5 days per week in the morning. Some people go up to 30 mg but I think that that is excessive.
I take two drops every 8 hours. Assuming the half life of MB is 6 hours, that gives the same end-of-day concentration of MB in the blood as 20 drops taken at the beginning of the day. Amazing, isn't it?
Does it impair your sleep if you take it later in the day?
@@JonasKuehneMD No, I can't say that it does. I get tired in the evening as usual. My thinking is that MB is not a stimulant like coffee or amphetamine. Also, two drops doesn't "spike" the blood concentration of MB.
I have been taking MB for 16 months at about 10-20 mg per day. I notice clearer thinking, more energy and most of all I NEVER get sick. No colds, no flu nothing. Once there was a slight fever in all these months. So I am dedicated to taking it and I am sharp at age 72.
Amazing! It has antiviral and antibacterial properties and can greatly enhance the immune system by optimizing mitochondrial function. If tolerated, I think it is a great supplement.
I am wondering if MB could be helpful for someone with long term cognitive impairment post sepsis event? Could MB help slow further cognitive decline?
It might. There are good studies showing that it can help prevent or even treat dementia. My official advice is to discuss this with your treating physician as there are contraindications to using MB.
Has anyone noticed any improvements with peripheral nephropathy?
I have not seen any studies, specifically, looking at peripheral neuropathy, and methylene blue. Giving its mechanism of action and ability to be absorbed into nerve cells, It might give some improvement. It’s best to discuss this with your neurologist.
Hello? Not difficult to remove at all. Just mix an acid with water and apply to stain. Will get rid of the blue color. I have used dilute HCl, ascorbic acid, etc.
Thanks for the tip. I will try this out.
Vinegar?
I recently discovered that I have both APOE4 genes, what dosage would you recommend?
I cannot give official medical advice here, but in studies most researchers looked at 15 to 17 mg orally daily. There are contraindications to taken MB so it’s always a good idea to check with your treating physician.
Thank you for great info.
Glad it was helpful!
Could anyone please confirm if MB can reduce muscle protein synthesis due to it reducing nitrous oxide?
I have no literature on this. But keep in mind that methylene blue improves mitochondrial health and function. This is certainly benefits muscle tissue building.
@@JonasKuehneMD yes in theory. I’m sure l read a paper that said a study had shown that MB had no effect and didn’t appear to inhibit muscle synthesis ( l can’t find that literature now) 😩…. However it didn’t explain the mechanism in which this was possible? Due to the presents of nitrous oxide during muscle protein synthesis is such a major contributing factor this a question that plages me! l am determined to find the answer! I’m obsessed with science and l have literally lost sleep trying to figure it out lol 😂💯 x
I love MB!!! It has made such a difference to my life! X 😊
@@juliafisherlmmortalbeauty9119where do you buy MB? I want to try it
@@juliafisherlmmortalbeauty9119 you might want to see if you can find an exercise physiologist who can give you the answer
Thanks, great summary.
Some of the literature discusses drops, others mg.
The leaflet that came with mine stated 1% solution, each drop contains 0.5mg, and instructions to build up to 7 drops (3.5mg). The dosing chart in Mark Sloan's book is helpful.
I wanted to improve mental clarity (im 66) so i now take 14 drops or 7mg, which is enough for me.
Interesting info re: half life and taking a break.
PS, no microbiome issues at all, in fact i would say gut tolerance of grains has improved. I make my own yoghurt with foundation species like L. Reuteri
Thank you for your details comment. I also find that about 7 to 10 mg daily is sufficient. The issue with disruption of the gut micro biome seems to occur at higher doses above 30 mg daily for most people. Mental clarity and focus are also the reasons why I use it.
I found my dripper from my MitoBlue actually has 0.07ml, not the usual 0.05ml. No one does laser abrasive fine tuning on drop size of dropper tips fitting to viscousity of your fluid. But one can check with a scale or ml syringe. :)
Please use eg. 1 % g/ml as concentration, and calc with units.
(% is an abbreviation that leaves out the proper dimensions:
1% in reality is only a number, 0.01 - that‘s it.
What companies and private persons should do is write dimensions to numbers. So we do not buy apples and get pears.)
So we have a weight of an active ingredient like 1g and solve it in 100ml by „adding water till 100ml is reached“, in pharmacy latin „ad 100ml“.
This corresponds to concentration as mass per volume.
c=m/V so here
c = 1g / 100ml = 1% g/ml
Then you can actually calculate and check if all turns out nicely.
You take 8 drops of 0.07ml and want to know the dose in mg:
m=c*V = 1% g/ml * 0.07ml/drop * 8drops = 0.0056g = 5.6mg
(Yes, we use drops as a unit and it nicely cancels out, so all is fine!)
Done.
Measure drop size…:
So it may be informative to count e.g. 20drops and measure them out with a small syringe of proper size (I always buy some 1 / 2 / 5 / 10 ml , sometimes I get hold on a 20ml, to have easy fluid measurement available.
Found one 1ml that extends its piston into the outflow tip, so it has no „dead volume“, cool. B.Braun Inject-F 1ml. Very fine scale 0.01ml also).
@@andshofs5769 thank you for taking the time to reply.
Yes, I did in fact use a tiny 2ml syringe, removed the plunger and counted my drops into the empty chamber. It just helped me to reframe the volume I was using from drops into ml. 😊
@@maryhall3722 After using the dripper a while, I came to a larger dose and now count whole load of a dripper I repeatably fill. One can also use pump systems that have very repeatable volumes per puff. For sprays, one would have to drill the nozzle wider so no hard jet or droplets form.
I like to dig into combining it with detoxing stuff, had too many Hg fillings in teeths and too much ongoing reaction on certain safe-and-effective smurf parties... - as it improves the effectiveness of chelator like substances, VIt-C, NAC, Na-gluconate, EDTA (liposomal) etc., perhaps even to charcoal one swallows and that is a nice deposit also for stuff diffusing from blood into lumen of intestines.
Perhaps it works even to boost the citric oils also helping there.
from what vendor do you purchase your L. Reuteri and others?
Also what is the best time to consume this? I am weight training in the morning? Thank u for your video 😊
He said after a morning workout is a great time.
Sorry, just saw your message. I would recommend to use it two hours before or one hour after a workout at least . taking it too short before a work out can increase blood pressure and heart rate which my case was very uncomfortable and potentially might have some danger as well. I do not take it later than about 2 PM as it is a bit activating and I found taking it at night kept me from sleeping. This varies from person to person though.
Usually have green urine, but not today. Why?
Please clarify the dose. Are you talking mg of the 1% solution or mg adjusted to reflect the total amount of MB ?
I always refer to the total dose in milligram. If you use a one percent solution, and you have to check the label here, it usually means 0.5 mg per drop.
If I’m 92kg how many drops do I take. My bottle says 20 drops is 10 mg.
I cannot give medical advice on this platform. For myself and my patients I usually opt for 10 to 15 mg daily. The maximum dose I would suggest to take orally for anyone is 30 mg daily. Above that there is a risk of interfering with the gut microbiome in my opinion.
I take 200 mg. 5-htp. Since this interacts with SSRIs, would it be a problem in combination with 5HPT since it's a seratonin precursor?
As 5-htp is a precursor to serotonin, it’s purpose is to increase serotonin levels. I am not sure if this would raise serotonin levels sufficiently to interact with MB. I would check with your prescribing physician on this.
@@JonasKuehneMD Thanks so much for your response, and I acknowledge and understand your disclaimer. My MD of 25 years retired right before 'the big event', and I've not returned to the medical community since, so I won't be checking with a prescriber. I will not be using the 5-HTP when I do begin the MB, to be on the safe side. I also only use the 5-HTP 4-5 days per week, in addition to other supplements, the most important being niacinimide for mood regulation.
I'm new to your channel, and thought it valid to ask something that others might want to know about, so I hope this wasn't repetitive information for you or anyone else. Thank you so much for your contributions to all! Happy day!!!
Is it sold in pharmacies?
If it’s not sold, why?
It is available online. Amazon is one example. Keep in mind that there are contraindications to using this such as pregnancy, breast-feeding, and a concurrent use of an SSRI. My official advice is to check with your doctor prior to using any supplement.
@@Ciddiyetle I got also a 15% off discount code for you: Jonas15 for a 15% discount. www.best365labs.com/?ref=Jonas
thats to bad I suffer already from high BP.
I would have a urine tested for heavy metals! I had high heavy metals and after chelations treatments my BP dropped down to normal ranges.
I'll pass. The medical.
Industry doesn't make money unless you're sick. Before I would take something like this or anything else that It seems like a new fad. I would not only read the research myself.I would research the researchers
Thanks for the dosing information. I'd been taking a moderate dose for a year, then upped it to 90mg's per day (split into 2 doses) to see if I'd notice any difference.
Not really. Only think I did notice was the half-life of color in my urine was blue to blue green all day and night. So looks like I'm saturated and need to drop back down.
I agree, I had tried increased doses and did not find improvement in cognitive function or energy levels. The risk of doses above 30 mg daily is disruption of the gut Microbiome, as MB can act as an antibiotic.
CONCERNED RE REDOX AMPLIFICATION?
You too should stop for a minimum of thirty days. And use a very very low dose if you start back. Being aggressive is unwise in most things. These thing's have real biochemical reactions.
Best explanation on how to dose methylene blue I was able to find on TH-cam, as well as other clarifications which were not elaborated in other very informative and lengthy videos -- thank you, Doc!
Subscribed!
Thank you for your amazing feedback! Highly appreciated.
Yes I bought a bottle a long time ago but barely took any (1-2 drops every few days) since I had no idea how much to take and now I have leaky gut so need to check into this topic again
@@avarysse5782 The best info on how to heal a leaky gut I have found in the books and videos of cardiologist dr. Steven Gundry. Every 3 months he does blood tests on markers in his patients, to check if all the strategies he advises indeed have the desired results.
How do we take it? Water? Tea? Coffee etc
You can take the tablets with food or just with water. The liquid drops are best mixed with water, but be careful because even diluted they will stain everything they touch.
@@JonasKuehneMD, I place mine in '00' gel caps. You can order 1,000 ct packs online. No staining if you are careful and wear your reading glasses;).
Can it help an ekderly man with COPD?
I don’t think that methylene blue can specifically address the symptoms of COPD. It helps with energy production in all cells, so there might be mild, symptomatic improvement, however, it will not change the existing pathology.
I am 33 years old. I want drink for prevention. I am from another country. I don't understand well. Please tell me, I weigh 62 kg. What is a SAFE DOSE FOR ME? I bought a 1% solution at the pharmacy. How many drops a day can I drink safely? And how many days in a row can I drink it and how often should I take a break. Or shouldn't you drink it every day? Please answer in more detail
I cannot give medical advice on this platform. A one percent solution should be 0.5 mg per drop. For my patients I usually recommend anywhere from 5 to 15 mg daily. That would mean 10 to 30 drops.
@@JonasKuehneMD what about breaks.
Would anyone happen to know how many drops are safe to take of a 0.1% MB solution and how much other liquid should be added?
I can't seem to figure it out. Seeking Cerebral Healing. Thanking you in Advance.
This is not medical advice, but many people use anywhere from 5 mg to 15 mg MB daily. Most solutions are one percent. One drop then is 0.5 mg. This would mean anywhere from 10 to 30 drops per day. Much easier than that there is a tablet form available, which you see on the thumbnail. If interested, there is a link in the description.
Thank you Dr. Jonas.
Yet, in my haste I created a “0.1%” mixture as opposed to the “1%” with the powder I purchased.
The vendor provided a dropper with measurements in “milliliters”, i.e. #1,2,3+
Oh-Oh-Ok! Wait a minute!
As I am presently composing this comment, after ingesting just one drop of MB, it seems that my tangles are smoothing out and I’m able to receive the info clearer.
Wow!
So-oo… i.e.
1ml ➡️ 1,000 mg = 1 drop
25ml ➡️25,000mg = 25 drops
I’m trusting that no one will comment here with a “ Duh” because I’m sure on the day that the Math teacher taught measurements…
I was absent. 😆
Thank you again Dr. Jonas for your expedient response.
💧 Blue Magic 🪄 💧
Always ❤ Me too and half gone
Can i still take melatonin at night if i take MB in the morning?
There should be no interaction between the two, but of course this is not official medical advice.
I am thinking twice on not using it. Way too complex.
It is a complicated topic. A lot of people do not have to take large amounts of this. I have seen patients that did well with just 5 mg daily. There are contraindications to taking it so my official recommendation is of course to discuss this with your physician first.
I drank it with a straw. No blue tongue.
👍
🌷Thank you so much for the information :-)
You are so welcome!
Thank you for the information. I understand that this is not medical advice…I’m a highly functioning 65kg female with both Lyme and Multiple Sclerosis. I’ve never taken traditional medicine for either and this is the first I’ve heard of MB. A friend of mine who also has Lyme has said it has helped him with energy, focus and pain. I started taking 5 drops of the liquid so 2.5mg for the last 3 days. I started low as I am very sensitive to supplements. The only thing I noticed so far is that my urine is NOT blue or green. I do take vitamin C as well as a B complex that does change my urine to bright yellow. I didn’t take either of those today and still no blue urine. Does this mean my body isn’t digesting the MB? I’ve tried to find more information about this but can’t find anything definitive or helpful. 🙏🏻
With lower doses it is less likely for the urine to change color.
MB is largely excreted unmetabolized.
If you mix MB with vitamin C prior to taking it, it will turn into leukomethylene blue which is colorless. In the body, it will change back to regular methylene blue.
@@JonasKuehneMD Thank you for your time and information. I appreciate you. Last night for the first time in years I didn’t have muscle twitches and less pain. I actually got a good night sleep!! In some ways I wish I knew about MB sooner as I have been living with MS for 18 years. However if I discovered it sooner I don’t think I would have done the inner work I needed to do to heal the core emotional and psychological wounds surrounding my dis-ease nor would have I started meditating. Both have saved my life in ways that are ineffable. This feels like the cherry on the smoothie! Thanks again. 💜🙏🏻
where can you buy it in Germany?
On Amazon.de. Make sure that it is pharmaceutical grade.
Robert Franz.
think i deleted my neurons with some fishtank dye
www.best365labs.com/?ref=Jonas
This is a lot better than fish tank cleaner!
Could you add a few drops to a nasal spray and use for sinus infections?
Interesting thought. I have not seen this done.
I have stage 4 liver disease. Is this a contraindicatior
MB has minimal liver metabolism, and may have liver protective mechanisms. This is of course, not medical advice. It’s always best to check with your primary care doctor before taking any supplement.
www.sciencedirect.com/science/article/abs/pii/S1567576915002088
Hello, can you tell me for how many months or years can I take methylene blue daily?
There are no long-term studies on this unfortunately. As with any supplement, it is probably good to take breaks here and there for a week or longer. Also, in my opinion, the daily dose should not exceed a maximum of 30 mg. I currently take between 10 and 15 mg daily.
Is it better to take methylene blue with an empty stomach or a full stomach? Do you take it with an empty stomach or a full stomach?
I usually take it with some food, but it is OK to take on an empty stomach as well.
Would methylene blue do anything good for long covid? I know that the good bugs need to be replanted afterwards...
Long Covid is one of the indications why people used it over the last few years. I have a couple of patients that responded extremely well to it, and it has greatly decreased or even eliminated their brain fog. This is of course, not medical advice. For my patients I generally use around 15 mg daily.
If I want to use it as respiratory disease prevention, what would be a suitable dose and frequency?
This is not medical advice, but for my patients, I generally recommend between 10 and 15 mg daily.
@@JonasKuehneMD Thanks!
Do people experience blurriness of vision? I have a friend who experienced this and i am wondering if this a general side effect or not
Blurred vision is a possible side effect. It is dose dependent, and should be discussed with your primary care physician.
I’m not disputing what you’re saying, but you’re the only one saying that you shouldn’t be taking 30mgs of MB per day!
When 30 mg is said to be the minimum dose, just to achieve the maximum benefits from methylene blue
It's best to be cautious and take it slow though. Some people might react negatively to a dose that high. It's impossible to say for certain which dose is best for everyone to start with.
Hello Dr, thank you for your video, a question if you have time? I have chronic pain - multiple thoracic fracture and TBI from an accident 10 years ago. The ain and cognitive problems are really stopping me from living a quality life and it’s been a struggle, although I’m trying to be my own advocate and acceptance is a big part of it. So for pain - the dose being
5 mg - BD - starting with the lowest dose ? Maybe 3mg BD starting dose? 70kg, 53 years and blood pressure and pulse fine. ADHD not medicated.
Wondering if you have any advice in effectiveness of MB and pain - thank you if you have time to reply. Thank you
MB can be used for chronic pain, but I am not aware of the best dosing or schedule here. I think it is important to explore this together with your physician. They are, of course, some contraindications to using it as well.
www.ncbi.nlm.nih.gov/pmc/articles/PMC8165385/
www.sciencedirect.com/science/article/abs/pii/S0006291X21000413
drink only on an empty stomach? And when can I start eating food
You can take methylene blue with food.
So how many drops is 15 mg?
You have to look at the concentration that is listed on the bottle. It is usually 0.5 mg per drop. If that is the case then 15 mg would be 30 drops.
I have problems with the gut/brain axis and suffer from migraines and stomach issues. Has anyone tried MB for this?
I would need to understand your specific issue a bit better. In general, methylene blue gets very concentrated in the brain and has been very helpful for healthy neuron function, which may help with migraines. At doses below 30 mg it should not disrupt the gut microbiome.
.5 mg per kilogram comes out to 45 drops for 200lb person. Am I missing something. I hear 6 drops in the morning and 6 drops in the evening. So 12 drops not 45? Am I missing something?
0.5 to 2 mg/kg refers to the intravenous dose used in the hospital setting. For oral dosing a total of 5 to 15 mg daily seems to be sufficient for most indications. Keep in mind that MB has almost 90% oral bio availability.
I put it in a capsule so no taste but green urine. I’m very careful of the microbiome. I’m 100 pounds and I only take 10 drops of 1% 5 times a week.
I also stopped the HTP I was taking.
I am not sure if you are in the us but best365labs has it in pill form:
www.best365labs.com/?ref=Jonas
@@JonasKuehneMD Thank you. 🙏🏼
For person who take SSRI medication, what is the safe dose of MB?
Great question. I am not aware that there is an established dose. It also depends on the dose of SSRI. Out of caution, it is generally contraindicated to mix them.
@@JonasKuehneMD thank you doctor, does it mean it is ok to take MB few hours before or after SSRI ?
Great information Doc. Doc, quick question, for someone who has cancer, is it counterproductive to take MB with NR or NAD+?
Really appreciate a response.
thank you.
A
Thank you for your comment. It should not be counterproductive to take MB with NR or an injection of NAD+. This will be very beneficial for your healthy cells. Cancer cells have malfunctioning mitochondria that are using fermentation rather than the Krebs cycle and electron transport chain.
There is confusion because most people talking about it will not demonstrate what an average dose looks like, and will not demonstrate actually taking it.
I get the powder of 1gm and mix it with 100ml of distilled water to make a 1% solution. I use a plastic pipette to draw about 3 ml, and squirt this to the back of my throat. I am not all together sure if this is the right way as non of the experts demonstrate it, I just get anecdotes from comments.
The tablets are easier to dose in my opinion. I take either 10 or 15 mg daily. The company is called best365labs.
Can i take it by Insufflation ?
No, I don’t think that that is a good idea. The oral absorption is close to 90%. Intravenous use is only for treatment in the hospital setting. Other routes of administration have not been studied.
@@JonasKuehneMD ok now tell us about 3% h2o2 drinking it in water. legit?
I seen people doing like as eye drops? Is it safe to put in your eyes ?
No, you should not put it in your eyes.
Have you heard about Dr John Lierance ? He’s actually puts in his eyes methylene blue gold, silver, and a splash of peppermint. His Instagram account has so many post. I’m about to start taking but what’s the timing I take tons of vitamins in a morning.. does it has to be taken on empty stomach?
Thank you again for your response 🙏
So if I have a 1gm per 100ml solution that’s a 1% solution. I’m 54 kg. How much should I take?
I cannot give medical advice on this platform as I do not know any of your history. There are also a few contradictions to taking methylene blue. Personally, I take 15 mg daily at 80 kg bodyweight. Many people are OK between five and 10 mg daily. With liquid MB that would be between 10 and 20 drops, but this may vary from product to product.
Can we talk about the heart and kidbeys? This drug is contraindicated for those with kidney disease and blood pressure as it can raise bp.
Yes, however, this is very much dose dependent. At low oral doses (
Where to buy from a trusted source ? Which products ??
In tablet form I like “best365labs”. For drops I like “BpH”. Those are on Amazon.
@@JonasKuehneMDhello delivery to France ?
I usually take 1 drop from the dropper and have done fine. I accidentally took 3 drops from the dropper today. I hope I do OK with that amount.
I would check the dosing on the bottle. Usually one drop is 0.5 mg. So an extremely low dose.
For reference, I am taking 10 to 15 mg daily. On the bottle that I have been using that would be between 20 and 30 drops.