New treatments for macular degeneration! But are they SAFE?
ฝัง
- เผยแพร่เมื่อ 29 มิ.ย. 2024
- In this video, Dr. Michael Chua reviews the newest treatments for macular degeneration released in 2023. Are syfovre and izervay safe and effective?
Timestamps
0:00 Introduction
1:36 What is macular degeneration?
4:41 The Complement Pathway
6:00 Syfovre and Izervay
6:58 Syfovre Clinical Trial Results
16:32 Izervay Clinical Trial Results
Connect with Dr Michael Chua on social media
/ michaelchuamd
Website:
www.puentehillseyecare.com/
Hashtags
#MichaelChuaMD #AMD #maculardegeneration
MEDICAL ADVICE DISCLAIMER: All content in this video and description were created for informational purposes only. The content is not a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health provider with questions you have regarding health conditions. Accessing, viewing or reading this content does not create a physician-patient relationship between you and the author.
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I'm almost 65 and was diagnosed with geographic atrophy. My retina specialist does not do the Syfovre treatment due to the issues you stated. People went blind. I don't see that anyone has gone blind from Izervay. I plan to get that treatment in a few months once my medicare kicks in. My eye doctor told me to look up everything I could and determine the risks for myself. I'm a psychologist, so research is important to me. That said, I realize my visual acuity will not get better, but slowing this awful stuff down is important to me. Everyone has to weigh the benefits to risks. If I'm going to lose my sight anyways then isn't it worth it to have a little more time to see my children and grandchildren with my own eyes? Anywho, that's how I feel. 💓💜 My vision is changing fast and I feel like I'm running out of time to get the things done that I want to do around my home.
That said, I signed up for your newsletter and look forward to learning more from you.
This is terrifying to listen to and shows how little mastery we have over medicine.
Michael, sorry, Dr. Chu. Thanks for this AMD episode. I'm 79 and was suffering from AMD. Two days ago after listening to you I added raw organic leafy greens spinach and kale twice a day. I could not believe how fast my vision cleared up.
No way
Thanks for the video.I’m an ophthalmologist who does intravitreals and I’ve not yet used Synfovre out of the same concerns you have. I think it has a very small place to play and should only be used in a very few patients. I will refer some of my patient’s questions to your video.
M. Chua, MD, you're one of the best in your field. Thank you, for this podcast. I've lost central vision in my right eye in the last two months. When the time comes, I will consider a dog guide. T.Y.
Wow, that point you made at about 19:00 about changing the Izervay study protocol from acuity to GA size was really astute.
I just want to say that your videos like this about specific conditions are amazing. They're entertaining and as informative as medical school lectures,. Astoundingly good work. Please keep it up!
Thank you for this timely information. I am being offered this latest greatest treatment for AMD and needed this information. My hesitancy is validated.
For AMD patients, surely the ability to stop the illness getting worse is a HUGE benefit. Surely that is what the anti-VEGF drugs do, they do not improve, but stop or slow down the worsening of the illness
Thank you. A nice, clear, honest appraisal of the situation. What about the stem cell research going on in the UK?
Your information on both treatments is extremely helpful. I was just diagnosed with GA and told by the RS that he plans on injecting Izervay in 3 weeks. I asked him if there are any side effects to this medication and he quickly said some eye irritation may occur but it's very rare. He walked out of the room and left his tech with me to say that I'm not to go and google etc about this treatment as there are so many false information out there to scare the patient. Well, that's the wrong thing to say to any patient because we all tend to do the opposite. Fortunately, I'm on a MD fb group that kind of brought me to your video. I was listening to another video and yours was the next in line.....which I'm thankful for. Right now after listening three xs to your video, I'm leaning more to cancelling my next appt so I can research further. The side effects of these drugs worry me more than anything. As I'm extremely sensitive to a lot medications. I always lean more towards natural treatments...as much as possible. The price tag on these drugs is astronomical, to say the least especially since it does very little to help the disease. When I noticed the difference between the patients that received the drug vs the placebo....It's depressing. Very little difference in the percentages. It makes me feel that if I did the injections, it would make me become another guinea pig at a high cost. But this is just my opinion. thanks once again for your video.
I m in the same boat.. so good to hear this Dr…
Great info! The explanation is very easy to understand! Thank you for sharing about New treatments for macular degeneration!
WOOOO NEW SUB...GOING OVER YOUR PRESENTATION AGAIN..MANY MANY THANKS
HNYEAR
I am doing the injections for my geographic atrophy. If it helps slow it down that would be a benefit until other more advanced treatments are available. This made sense to me when my doctor told me this information.
Why were they ok to use in the first place by the fda. As my ophthalmologist stated when I was diagnosed with dry AMD, there is nothing available today or in the future to prevent blindness from occurring. AREDS 2 is the only safe and affordable option to delay the eventual blindness..
I am going to change some diet matters i.e. green veggies in particular kale which is very rich in lutein.
Your a genius! Thanks 🙏
@11:38, really seems like it's damned if you do and damned if you don't. The thought of getting wet AMD scares me; the thought of getting dry AMD _terrifies_ me.
Thank you for explaining things so thoroughly. What a disappointment to those who are struggling with this debilitating disease. Hopefully these meds will lead to an effective treatment to reverse this disease and improve quality of life.
ALL macular degeneration starts out dry. 10-15% of dry AMD turns wet. Dry macular degeneration is a much slower progressing disease while wet AMD is much faster but is more treatable.
I was on a path to get one of these two treatments. Both my current and previous retina docs advised it would be best to exercise caution and wait for some post-trial evaluations. We all concluded, in my case, the risk outweighed any benefit. I do want to commend both companies in their efforts to find treatments for this insidious disease where none have been available as yet. I have grown to appreciate the investments made without any guarantee of success.
Two retina docs says a lot. Post trial evaluations is what I think if a prudent approach. I will wait.
They did not tell us any of this and they killed my husband after one injection. Murders drug. Thank God you opted out
@@starrkelsey2304 Say Starr, wonder if you wouldn't mind elaborating a bit. Did the Doc us Iservay or Sifovre? I had concerns after watching this video and you have confirmed my suspicions. These drugs should not be administered. I'm sorry for your loss. For myself I have decided to go the nutrition route. One can view Dr. Knobbe on TH-cam and as I have done read both of his books. I am convinced I can make a big difference going the nutrition approach. Thanks for posting Starr.
Well this is depressing
I think you may be over thinking one part of results. I am a retired RN and have GA. The onset is so slow that you get used to living with the vision loss.You stop driving, you get used to taking the bus, you use a magnifier on your phone, etc. The benefit of these new meds lie in the need to LESS FREQUENTLY change your retime of the gradual loss of vision. Or maybe you can stop changing your retime altogether. Not noticing a change for the better in vision, because, let's face it as I have, there is no cure to fix the damage that has been done. 24 months may not be long enough to evaluate the benefits. One of the questions of the questionnaire might be to ask how long in-between adjustments of vision loss....ie: how long did it take for you to notice vision problems to the time you stopped driving. Or how long did it take from noticing a problem with reading to the time you had to use a magnifier to read. Hope this helps.
I have stage 3 at age 67. No vision problems, no loss of vision. Now eating salmon, tuna and green leafy veggies.
Thank you. When I go to get a second opinion (from a diagnosis received 2018 from an America's Best optometrist), it will be interesting if the Ophthalmologist recommends either of these medications. My doctor referred me to the optometrist, I didn't bother going to the optometrist recommended by America's Best and instead just started ramping up leafy greens.
I'm almost 80 and have both wet and dry. I found the injections painfull and expensive sobI gave up and try to clean up my diet and avoid inflammation.
Like probably 95% of people in the world I have no health insurance and the costs of conventional treatment unaffordable.
Rod, look up Dr. Knobbe on TH-cam. Your diet can be the key to success. No sure about the wet though.
But if the new meds only slow down the progression of MD, it seems that there wouldn’t be any improvement in vision, just a slowing of the disease…what am I not understanding? And thanks for the great info!
Some of the patients in the study received the medication and others received a "sham" placebo injection. We would hope those patients receiving the medication would have better visual acuity than the placebo group at some future date, but they did not. Perhaps Dr. Chua could say "improved visual outcome" instead of "improved vision."
That dark spot at 2:08 looks almost exactly like the blurriness I have in my left eye. This showed up after my eye doctor zapped about 7 leaking vessels. (after 6 months of injections to get swelling down) and he says it's due to my diabetes. But I think the laser did something because I had diabetes before the treatment and didn't have any spots in my vision. And if it is due to diabetes, why does it only affect the one eye that was zapped?
Wonder if autophagy would clean out the dead cells?
💥 I have Chronic CSR - Central Serous Retinopathy in both eyes. I'm almost blind. I can't see anything with the center of my Left eye. I depend now on my right eye, but it's going the same way. I'm almost desperate. Are these injections also good for CSR ? 😮😮
Hi dr chua, could you explain why there seems to be so much buzz around Syfovre and Izervay if there is not benefit to VA outcomes? I guess I just don’t understand how these drugs are marketed if they are just slowing the development of atrophy vs any functional benefit to patients.
Big pharma$$$
Thank you,, I'm not getting shots. I already have glaucoma, floaters and cataracts. Don't want to damage them with side effects for meds that basically do nothing
Why is this not available in the UK ?
how about CRVO? will CRVO patient benefit from this?
I started having problems about two years after I got a heart stent, has anyone done any studies about if heart stent implants can changed the way the heart beats and therefore changes how the blood flow goes to the body and the eyes, could this be the reason for this? Because my heart stent changed the way my heart flows blood to the body and therefore my eyes and my brain, properly functioning heart stents or improperly implanted heart stents could be the cause of AMD
Will this help Lupus patients?
Could gene therapy or some kinda CRISPR solution address the root cause?
Sadly its only a treatment for AMD and not MMD so i am basically up the creak without a paddle
The injections are $1,000 each...
Avastin
😢😢😢😢😢😢😢😢
Seed o
How can a Dr. claim to understand Macular Degeneration and put out a video using slides that no one with the diseased could possibly read? This video is beyond irritating, it is insulting.
I'm sure that no insult was intended. I think that the verbal discussion of the study results presented important information. I know that I learned a lot.
Oh! Early dry diagnosis- I paused video & he does verbalize key points