I think everyone interested in spectroscopy should see this video once. It is simple, clear and gives an overall understanding of the NMR experiment. It's so unfair that it has not the right visibility.
This was incredible explained. I try to keep an eye on the effectiveness of visuals I come across in my educational experience and I must say this is up there with the greats. You have definitely thought about this video and it paid off. Thank you very much!
Worth pointing out: The pulse is not directed along right angles, it is in fact directed axially along B0, but the radio waves are circularily polarized, so the B1 field in the radio wave is actually spinning in the xy plane. It's the B1 field that is at right angles, but constantly spinning at the Larmor frequency (omega0) of the protons. This B1 spinning field forces the nuclei to gain an additional preccesion motion around itself, at a rate of omega1 (omega1 = gamma * B1) and the overall magnetization is then manipulated as we please.
Very well made! The professors should use this video clip to introduce NMR. It will be much easier for the students to understand. Hopefully, there will be more visual teaching materials like this one in this channel and more professors and students can find these clips here. Thanks for making this video!
Hey! I was really confused about the spinning alignment of the nucleus in the presence and in the absence of B. Ur video gave me a good clarity about that Thank you so much 😃
Thank you so much sir for making this very informative video it helped me a lot. This video is itself equivalent to 20 to 25 pages of many books at a time
Thanks a lot to the channel members. A perfect ever explanation given for NMR. All the deep concepts shown perfectly. Please make more videos on Mass spectrometry, Chromatographies and more spectroscopies. This video is very useful. Thanks.
No doubt this was the best video I've watched thus far on NMR. However, I would've preferred more mathematical depth, perhaps covering the quantum mechanics involved.
I have an exame of structure determination and was looking for some basic principle of HNMR and then I found this amazing video wich made me see the complete picture of NMR, thank you for that!
Oh man... I am currently studying the NMR part for my thesis defense and was studying it through two recent papers... However, it is very hard to understand without a visual representation. Your animations pointed my in the correct direction!
Thanks very much, Hedgehog. The relationship between shielding and frequency depends on the Larmor equation. The higher the magnetic field around the nucleus (less shielding), the higher the frequency. More shielded nuclei will experience a lower magnetic field and will have lower frequency. Stay tuned for NMR II coming out soon.
@Mieux Thanks very much. Yes, the voice over is poor, and I have improved since that time. The thing is that you can't replace the audio only. I would have to delete the video and re-post a new video. Thus, the stats and the links to the original would be gone. Is it worth it?
Amazing....I was thinking about why nucleus precesses...you nicely explained, moreover, you explained about doublet etc. What made us to think nucleus as top not like a (hard)sphere.
I am impressed with this NMR explanation. However I thought the triplet in 5.40 minutes should be doublet of doublet and the quartet should be doublet of triplet, because the geminal coupling much larger then the vicinal coupling.
Hi Hilwan, Yes, you are correct. I was trying to simplify the N+1 rule so that two neighboring protons would give a triplet and three neighboring protons would give a quartet, etc. But geminal coupling would most likely result in doubling of the doublet and doubling of the triplet, as you said. Your timing is great because I am in the final stages of making NMR Spectroscopy Two video which will go deeply into vicinal versus geminal coupling. Also I will touch on magnetic anisotropy and how to use integration to assign structures. Many thanks!
1:54 - does this pulse have to be mached exactly to rotate the nuclei? Is it possible that in a given molecule some atoms that are strongly shielded / deshielded would be too far of the tune to be rotated by that RF pulse? Or simply the pulse contains a spectrum of frequencies and all nuclei will find matching tune to rotate?
I'm not sure individual spins actually behave like shown at 2:01, they can only precess along the Z azis, the incoming radiation simply flips them from +1/2 to -1/2 and induces some coherence between their precessions, the following decays of the precessional coherence (T2) and the decay of the non-equillibrium population of -1/2 oriented spins (T1) together give rise to the collective FID behaviour of the global magnetization vector. As i understood it, it's only the global M vector that has this "classical" decay evolution that we detect as a FID signal, the vertical component of the magnetization being purely a result of the populations of +1/2 and -1/2 orientations, and the x-y component evolution of the M vector being the desyncronization of precession of the entire population of spins.
This is also how I understand it. It would be responsible if the creator made a note in the description that the animation of the spin state transitions as continuous is not representative of the salient quantum-mechanical model required to predict MRI phenomena.
Hi Adriaan, thanks for your input and absolutely correct. My intention with the video was to create a visualization of the decay of -1/2 spins in T1 to give the observed FID behavior. I urge the viewers to delve more deeply into the mathematics and quantum theory behind NMR. I will take your advice and add a comments to the description. Thanks for subscribing!
The best fundamental NMR video I have ever seen.Everyone can very easily understand what is going there🤩🤩🤩 Thank you very much❤️
Thank you so much, Suranga. Very kind of you. Be sure to check out ScienceSketch NMR spectroscopy two.
👍 x
Best ever video of NMR Spectroscopy
Thank you very much, Ankita.
I think everyone interested in spectroscopy should see this video once. It is simple, clear and gives an overall understanding of the NMR experiment.
It's so unfair that it has not the right visibility.
Thank you very much, Giuseppe. I hope that the video will get more views and help more students of spectroscopy.
One of the best videos I've watched on NMR! Thanks a lot for the great explanation.
Thank you very much!
Vfhnmd
I read books, I read online articles, I read wikipedia to fully understand NMR --> but this video IS IT. THANSK A LOT. Amazing video.
Thanks, David. I really appreciate your kind words.
This was incredible explained. I try to keep an eye on the effectiveness of visuals I come across in my educational experience and I must say this is up there with the greats.
You have definitely thought about this video and it paid off. Thank you very much!
I am glad to hear that it was helpful. Thanks for watching!
Worth pointing out:
The pulse is not directed along right angles, it is in fact directed axially along B0, but the radio waves are circularily polarized, so the B1 field in the radio wave is actually spinning in the xy plane. It's the B1 field that is at right angles, but constantly spinning at the Larmor frequency (omega0) of the protons.
This B1 spinning field forces the nuclei to gain an additional preccesion motion around itself, at a rate of omega1 (omega1 = gamma * B1) and the overall magnetization is then manipulated as we please.
Hi Alexandru, Thanks for your refinement and further explanation. Much appreciated!
I have little knowledge of chemistry and I understood enough that I now have some idea of how NMR spectroscopy works. In under 7 minutes. Fantastic.
This is great. I was introduced to NMR 30 years ago and could interpret spectra well enough, but I never understood what was happening until now.
Oh, if you don‘t mind answering, what is/was your job?
@@gabrielle9191 I'm a scientist still, but I hadn't thought about NMR since graduating, until last year when I suddenly needed to know about it again.
There could not be any better vedio than this for NMR. Thank you for making it..
best video I seen so far explaining NMR concept .. Thank you very much
Thank you very much for your kind comments!
The best animated NMR video in YT. Thankyou and keep making such videos.
The clearest explanation of the NMR experiment!
Very well made! The professors should use this video clip to introduce NMR. It will be much easier for the students to understand. Hopefully, there will be more visual teaching materials like this one in this channel and more professors and students can find these clips here.
Thanks for making this video!
This is much better than the other video I watched on youtube explaining NMR!
If there was a video like this for every chemistry subject, I would be a flawless scholar.
Thanks for this!
This helped so much. Visualization was awesome. Very clear and informative description all packed into 6 minutes
Thank you so much! The video that makes me understand the topic the most so far🥰. I can't express how much I feel grateful for this🤩!
This is the best video on NMR spectroscopy. Thank you, i'm really grateful.
Wow, thanks very much for your kindness. Please check out NMR spectroscopy two!
That was amazing. Perfectly explained and visualized!
Thanks a lot, Freyshen!
Seh ich genau so!
I studied the material and he put everything in perspective visually and great way of explaining everything. Great video !!!
Glad you enjoyed it!
Great video. This helps a lot. Should be shown before teaching an NMR unit.
Fantastic demonstration of NMR. Really appreciate your neat work providing such educational content.
Such a thorough and clearly explained video. Thank you so much.
agradecido de poder tener este tipo de videos tan informativos detallados y gráficos, gracias
Estoy agradecido por sus generosos comentarios.
Best explanation on TH-cam
Best explanation I've seen on TH-cam! Nice work, thank you so much!
Hey!
I was really confused about the spinning alignment of the nucleus in the presence and in the absence of B. Ur video gave me a good clarity about that
Thank you so much 😃
That. Was. Amazing. Thank you. They did not teach me half of that in organic chemistry and I have always had questions to how this actually works.
how I admire you, this is so pedagogical! thanks a lot
The best presentation I had ever seen
best video i have ever seen to explain the theory,good job
Thank you very much. I like your channel!
Best video which clear all concepts
Incredibly well explained in a short video. Thank you so much!
Thank you so much sir for making this very informative video it helped me a lot. This video is itself equivalent to 20 to 25 pages of many books at a time
Thank you very much for your kind comments. Please check out NMR spectroscopy two th-cam.com/video/DPK8hzxed1o/w-d-xo.html
This is amazing and finally makes more sense.
thank you so much sir for your amazing video, you explained much better than professor does.
Thanks a lot to the channel members. A perfect ever explanation given for NMR. All the deep concepts shown perfectly. Please make more videos on Mass spectrometry, Chromatographies and more spectroscopies.
This video is very useful. Thanks.
very clear video on NMR spectroscopy i found
Thank you so much
No doubt this was the best video I've watched thus far on NMR. However, I would've preferred more mathematical depth, perhaps covering the quantum mechanics involved.
I have an exame of structure determination and was looking for some basic principle of HNMR and then I found this amazing video wich made me see the complete picture of NMR, thank you for that!
Glad it was helpful!
How to earn structure elucidation
this video is literally so amazing and make my life so much easier
Incredible explanation! The best I 've found so far! Thank you!
preparing for the school olymp and finally found this video, tysm
It was a very good and simple explanation of NMR! I learned and enjoyed. Thanks😊
You are welcome!
Great Video! Looking forward to further video from your end!
Thank you, Mazdak. Please check out NMR Spectroscopy two
th-cam.com/video/DPK8hzxed1o/w-d-xo.html
thank you very much. Best video about that topic so far!
Awesome visualization of complex phenomena!
Oh man... I am currently studying the NMR part for my thesis defense and was studying it through two recent papers... However, it is very hard to understand without a visual representation. Your animations pointed my in the correct direction!
Thank you very much!
Concise and Complete.great explanation.
Thank you very much, Thanos! I appreciate your support and encouragement.
Excellent explanation! Thank you so much!
Amazing! Thank you for dedicating the time to this! The visual adds so much to the intuition
Glad it was helpful!
Extremely good explained,
Amazing! I see bright future for this channel.
🙏 Sir thank you so very much! Explanation is PERFECT
Its really helpfull to understanding how nmr spectra obtained...
Thnk u...
We need more nmr videos....
Glad to hear that
ngl, this video goes hard. excellent explanation, amazing visual to go along with it. wish my professors had shown me this along with their lectures!
amazing explanation, thank you for the video.
would have liked some elaboration on why frequency and shielding relate
Thanks very much, Hedgehog. The relationship between shielding and frequency depends on the Larmor equation. The higher the magnetic field around the nucleus (less shielding), the higher the frequency. More shielded nuclei will experience a lower magnetic field and will have lower frequency. Stay tuned for NMR II coming out soon.
Great visualization! Many thanks!
Thanks a lot. Very clear.
That was extremely helpful and visual. Thank you!
Awesome visuals along with concise explanation of NMR jargons 💯
The animations really helped! Thanks for explaining
You did really excellent describing this!
Thanks for the introduction to NMR and the direction to head after the video.
Wow wow really wonderful explanation ... Thanks thanks.. best ever explained than my professor
Thank you very much for your kind comments.
Tnk u Sir ! Awesomely described and visualised ❤❤
Most welcome 😊
Amazing visualisation, very well done! 👍
Thank you very much, Ekaterina. Be sure to check out NMR Spectroscopy 2.
Wonderfully explained; thank you.
With explanations like this, maybe not every biologist will be scared of vectors and constants! Just comes down to communication!
Brilliant explanation
Best video on NMR 👍
Well done 💯👏👍
Thanks a lot!
Wow this was soo wonderfully explained , thank you sooo much dude.
Great video! Would you consider re-mastering your sound. It's sounds hollow and loud.
Thanks, Good job!
@Mieux Thanks very much. Yes, the voice over is poor, and I have improved since that time. The thing is that you can't replace the audio only. I would have to delete the video and re-post a new video. Thus, the stats and the links to the original would be gone. Is it worth it?
Watching this 2hours before exam and I feel much better about the topic
Glad to hear that!
Awesome visual explanation, well done and thank you!
Amazing animation and explanation, thanks!
Beautifully explained. loved the explanation!!!
Thank you very much, Abhishek.
There is so much info here, thank you!
Love the visual explanation! 😊
this explanation is awesome! thanks
Best vedio for NMR
Amazing....I was thinking about why nucleus precesses...you nicely explained, moreover, you explained about doublet etc.
What made us to think nucleus as top not like a (hard)sphere.
Really good explanation!
Thanks for the video, explained really well
Thank you for that perfect video!
Excellent explanation can i get notes for this????
That's a Fantastic Visuals!
Thanks very much.
admirable
Best video to grab the concept
Thanks for watching, Gowri!
I am impressed with this NMR explanation. However I thought the triplet in 5.40 minutes should be doublet of doublet and the quartet should be doublet of triplet, because the geminal coupling much larger then the vicinal coupling.
Hi Hilwan, Yes, you are correct. I was trying to simplify the N+1 rule so that two neighboring protons would give a triplet and three neighboring protons would give a quartet, etc. But geminal coupling would most likely result in doubling of the doublet and doubling of the triplet, as you said. Your timing is great because I am in the final stages of making NMR Spectroscopy Two video which will go deeply into vicinal versus geminal coupling. Also I will touch on magnetic anisotropy and how to use integration to assign structures. Many thanks!
@@ScienceSketch thanks for the immediate responses. I will be happy to review your next videos before you publish them.
1:54 - does this pulse have to be mached exactly to rotate the nuclei?
Is it possible that in a given molecule some atoms that are strongly shielded / deshielded would be too far of the tune to be rotated by that RF pulse?
Or simply the pulse contains a spectrum of frequencies and all nuclei will find matching tune to rotate?
Thanks for your question. You answered it in the last sentence. The short Rf pulse has a spectrum of frequencies and will excite all the nuclei.
Awesome vid! Been struggling to understand this topic for a whole, this certainly cleared things up a whole lot
Glad it helped!
I'm not sure individual spins actually behave like shown at 2:01, they can only precess along the Z azis, the incoming radiation simply flips them from +1/2 to -1/2 and induces some coherence between their precessions, the following decays of the precessional coherence (T2) and the decay of the non-equillibrium population of -1/2 oriented spins (T1) together give rise to the collective FID behaviour of the global magnetization vector.
As i understood it, it's only the global M vector that has this "classical" decay evolution that we detect as a FID signal, the vertical component of the magnetization being purely a result of the populations of +1/2 and -1/2 orientations, and the x-y component evolution of the M vector being the desyncronization of precession of the entire population of spins.
Thank you for your thoughtful comments.
This is also how I understand it. It would be responsible if the creator made a note in the description that the animation of the spin state transitions as continuous is not representative of the salient quantum-mechanical model required to predict MRI phenomena.
Hi Adriaan, thanks for your input and absolutely correct. My intention with the video was to create a visualization of the decay of -1/2 spins in T1 to give the observed FID behavior. I urge the viewers to delve more deeply into the mathematics and quantum theory behind NMR. I will take your advice and add a comments to the description. Thanks for subscribing!
Fantastic video and thanks a lot.
amazing vedio
This video is fantastic! thank you a lot!!!
You are the NMR-god!
Well said!
amazing explanation. thank you!
Simply spectacular