Hi guys, just a quick tip as to the taste of L-Leucine, I find that mixing the Glycine with the L-Leucine before adding a portion of cold full fatty milk does wonders for the taste. L-Leucine is not easy to dissolve in water but the fat from the milk grabs hold of it and you can then do a quick stir and drink it, and it should save you from the bitter taste, but remember to mix the Glycine well with the L-Leucine first, or else the L-Leucine will lump and clump in the milk. I used about 1/2 a cup of milk. Best Jesper BSc
Hei Jesper. Great info here. I am making somw new links to understanding some things here. But i was eondering about this: Are both Glycine and Leucine making Elastase production to go down? Do you have links articles on the connection between Gly, Leu and Elastase? Seriously interesting work you are doing here! 😊😊😊
Hi Teo Alcantara, thanks for your question. The point is to plump up the skin and to keep collagen and elastin in good condition, preferably before the situation gets too severe, and you can do that by doing as I mention in this video here. If the situation is already severe, then the goal is to smooth it best possible, but obviously are there limitations as to what can be achieved, I mean common sense should be a guide. As always, doing as I do, say, show, write, or whatsoever, is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever, is meant to cure, heal, or prevent anything regardless. Best Jesper BSc
Hey Jesper. Aren't you concerned about the mTor activation that happens when you take L-Leucine, since m-Tor activation is linked to premature aging, and especially prolonged activation of the mTor pathway is linked to various negative health outcomes (according to the National Institute of Health "While acute activation of mTORC1 signaling in vivo does promote muscle hypertrophy in the short-term (Bodine et al., 2001) chronic mTORC1 activation in the muscle through loss of TSC1 also results in severe muscle atrophy, low body mass, and early death"?
Hi BlackSwanStudios, I don't think the issue with muscle atrophy and early death is relevant in this respect. The chronic activation of mTORC1 was done by having TSC1-deficient mice, meaning no regulation at all of mTORC1, that is an quite extreme situation that apparently leads to issues with autophagy, meaning, too much junk builds up in the muscles and they degenerates. It seems mTORC1 can be stimulated to create more muscle but over-stimulation, so it's constantly active, seems to lead to the opposite effect. Bodybuilders have used L-Leucine for years to build up their bodies, so it's unlikely that reasonable supplementation with L-Leucine in vivo causes muscle breakdown and early death, rather the opposite I think. Exercise in itself also activates mTORC1 and it's important for longevity to stay active through out one's live. In short, it's about a proper balance, and knocking out TSC1 clearly creates a complete lack of balance. My husband has used L-Leucine since I first spoke of it, and he has a muscle wasting condition, DM1, and it has clearly been beneficial for him, but I'll make a video on his progress at some point. As always, doing as I do, say, show, write, or whatsoever, is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever is meant to cure, heal, or prevent anything regardless. Best Jesper BSc
@@JesperOffersenBSc Thank you for the reply. As I understand it, there is a point in life (usually around the age of 55) where proactive mTor activation starts to go from detrimental to actually being worth the tradeoff due to the muscle loss that comes with age and the importance of avoiding frailty. In case of your husband, that trade-off seems obvious perhaps even now. So he is a bit of an exception. For most people under the age of 55-60 though, based on what I've heard, it's better to do moderate weight resistance training rather than artifically activate the mTor pathway. It's also worth looking at another amino acid, l-citrulline, which helps boost muscle mass without activating mTor. That one is also used by bodybuilders, although I will add that in general bodybuilders are not a great "role model" when it comes to longevity; their goals are short sighted. Similar to how many top atheletes have shorter life spans than those who do only moderate exercise, because they keep their body in a constant state of inflamation that is suited for the goal of great performances "at the moment", but not for the goal of healthy aging and longevity.
Hi again, BlackSwanStudios, bodybuilders often know a lot about their bodies and supplements, but not all of it one should replicate... basically are they doing a lot of experiments for us we can learn from, good and bad. Sport on top level is not healthy (it seems a whole pharmacy is trailing behind the cyclists in Tour de France...), again, it's about a balance and about listening to one's body. Yes, L-Citrulline and L-Arginine, we have done L-Arginine for years because it helps the body making Nitric Oxide, that in turn leads to cGMP and relaxed smooth muscle cells, which has been quite helpful, to say the least. I think one should do L-Leucine together with exercise, not instead of (and with L-Glycine). I think that with age one's diet becomes more and more important, so people doing L-Leucine and who have found it detrimental in later life should perhaps take a look at their diet, to see if it provides enough protein of the right kind, available minerals, and vitamins, if you don't get the right food then mTORC1 might work without leading to muscle gain and that might be even more so in old age, where the body in general is not good at building itself up, and there just L-Leucine won't be enough, it should be a wholesome approach. As always, doing as I do, say, show, write, or whatsoever, is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever is meant to cure, heal, or prevent anything regardless. Best Jesper BSc
Hi again fabulous papillon spaniel karina, I see that product and it seems to be in a good ratio, as you don't strictly need as much L-Lysine as the two others, however, you can make that mix yourself from Bulksupplements.com, using 100g bags but it will be much more expensive, however, buying in 1kg bags and it's a lot cheaper per gram, like about half price. For both you need to calculate transport though, but if in the US there is no duty. Bulk.com in the UK does not have L-Proline. I have not tried the product you mention and don't know much about the company or the quality. Best Jesper BSc
I just want to say that I love your videos. You tackle beauty from all angles and I love that just want you to know I appreciate the articulation in which you present your findings and for that I have subscribed I don’t do very often.😁
Hi pierre jean, thanks for your question. I take Ubiquinone instead as explained in this video here th-cam.com/video/AJP2xgSVIW8/w-d-xo.html As always, doing as I do, say, show, write, or whatsoever, is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever, is meant to cure, heal, or prevent anything regardless. Best Jesper BSc
Hi Oskar Karo, thanks for your question. No, I have not, but I might, at present have I added NMN to my serum (I use the one from California Gold, iHerb). Best Jesper BSc
Hi again Logical_LB, no it doesn't, Glycine should help with hair in the sense that the base of the hair should improve, due to better collagen and antioxidant effect (Glutathione), but not much for the hair itself should happen but the conditions for producing hair improves if one lacks Glycine (as in old age). Cysteine can stiffen the hair by making more disulfide bridges to a certain extent. As always, doing as I do, say, show, write, or whatsoever is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever, is meant to cure, heal, or prevent anything regardless. Best Jesper BSc
@@JesperOffersenBSc Jesper I had a follow up. In your collagen video from a year or two ago you said you were taking lysine to boost collagen. Are you still taking lysine or only glycine and leucine to boost collagen?
Hi again Logical_LB, I still take L-Lysine, taking L-Leucine and Glycine is not a substitute for that, but it boosts the production of tissue in a different way, but L-Lysine is still needed, but is enough from a normal diet if one is young. Check my quick guide to Collagen here th-cam.com/video/4c7OLh2DSHY/w-d-xo.html Best Jesper BSc
Hi guys, just a quick tip as to the taste of L-Leucine, I find that mixing the Glycine with the L-Leucine before adding a portion of cold full fatty milk does wonders for the taste. L-Leucine is not easy to dissolve in water but the fat from the milk grabs hold of it and you can then do a quick stir and drink it, and it should save you from the bitter taste, but remember to mix the Glycine well with the L-Leucine first, or else the L-Leucine will lump and clump in the milk. I used about 1/2 a cup of milk.
Best
Jesper BSc
Brother help me
Product grey hair to buying amazon
Catalaze grey hair
try L-Carnosine, it is able to break down AGEs (cause for wrinkles)
This is pure gold. Every second of it.
Hei Jesper. Great info here. I am making somw new links to understanding some things here. But i was eondering about this: Are both Glycine and Leucine making Elastase production to go down? Do you have links articles on the connection between Gly, Leu and Elastase? Seriously interesting work you are doing here! 😊😊😊
Wow, what a doll face 🤩
Must try out this Lecine
Hi Jesper, love your videos! What would you recommend for nasolabial folds? Thanks!
Hi Teo Alcantara, thanks for your question. The point is to plump up the skin and to keep collagen and elastin in good condition, preferably before the situation gets too severe, and you can do that by doing as I mention in this video here. If the situation is already severe, then the goal is to smooth it best possible, but obviously are there limitations as to what can be achieved, I mean common sense should be a guide.
As always, doing as I do, say, show, write, or whatsoever, is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever, is meant to cure, heal, or prevent anything regardless.
Best
Jesper BSc
@@JesperOffersenBSc Thank you for replying, Jesper!
Hey Jesper. Aren't you concerned about the mTor activation that happens when you take L-Leucine, since m-Tor activation is linked to premature aging, and especially prolonged activation of the mTor pathway is linked to various negative health outcomes (according to the National Institute of Health "While acute activation of mTORC1 signaling in vivo does promote muscle hypertrophy in the short-term (Bodine et al., 2001) chronic mTORC1 activation in the muscle through loss of TSC1 also results in severe muscle atrophy, low body mass, and early death"?
Hi BlackSwanStudios, I don't think the issue with muscle atrophy and early death is relevant in this respect. The chronic activation of mTORC1 was done by having TSC1-deficient mice, meaning no regulation at all of mTORC1, that is an quite extreme situation that apparently leads to issues with autophagy, meaning, too much junk builds up in the muscles and they degenerates. It seems mTORC1 can be stimulated to create more muscle but over-stimulation, so it's constantly active, seems to lead to the opposite effect. Bodybuilders have used L-Leucine for years to build up their bodies, so it's unlikely that reasonable supplementation with L-Leucine in vivo causes muscle breakdown and early death, rather the opposite I think. Exercise in itself also activates mTORC1 and it's important for longevity to stay active through out one's live. In short, it's about a proper balance, and knocking out TSC1 clearly creates a complete lack of balance.
My husband has used L-Leucine since I first spoke of it, and he has a muscle wasting condition, DM1, and it has clearly been beneficial for him, but I'll make a video on his progress at some point.
As always, doing as I do, say, show, write, or whatsoever, is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever is meant to cure, heal, or prevent anything regardless.
Best
Jesper BSc
@@JesperOffersenBSc Thank you for the reply. As I understand it, there is a point in life (usually around the age of 55) where proactive mTor activation starts to go from detrimental to actually being worth the tradeoff due to the muscle loss that comes with age and the importance of avoiding frailty.
In case of your husband, that trade-off seems obvious perhaps even now. So he is a bit of an exception. For most people under the age of 55-60 though, based on what I've heard, it's better to do moderate weight resistance training rather than artifically activate the mTor pathway.
It's also worth looking at another amino acid, l-citrulline, which helps boost muscle mass without activating mTor.
That one is also used by bodybuilders, although I will add that in general bodybuilders are not a great "role model" when it comes to longevity; their goals are short sighted. Similar to how many top atheletes have shorter life spans than those who do only moderate exercise, because they keep their body in a constant state of inflamation that is suited for the goal of great performances "at the moment", but not for the goal of healthy aging and longevity.
Hi again, BlackSwanStudios, bodybuilders often know a lot about their bodies and supplements, but not all of it one should replicate... basically are they doing a lot of experiments for us we can learn from, good and bad. Sport on top level is not healthy (it seems a whole pharmacy is trailing behind the cyclists in Tour de France...), again, it's about a balance and about listening to one's body. Yes, L-Citrulline and L-Arginine, we have done L-Arginine for years because it helps the body making Nitric Oxide, that in turn leads to cGMP and relaxed smooth muscle cells, which has been quite helpful, to say the least. I think one should do L-Leucine together with exercise, not instead of (and with L-Glycine). I think that with age one's diet becomes more and more important, so people doing L-Leucine and who have found it detrimental in later life should perhaps take a look at their diet, to see if it provides enough protein of the right kind, available minerals, and vitamins, if you don't get the right food then mTORC1 might work without leading to muscle gain and that might be even more so in old age, where the body in general is not good at building itself up, and there just L-Leucine won't be enough, it should be a wholesome approach.
As always, doing as I do, say, show, write, or whatsoever, is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever is meant to cure, heal, or prevent anything regardless.
Best
Jesper BSc
How interesting...I have found a product containing the 3 of them : Collagen amino acids 4.4.1 by nutrimuscle...
Hi again fabulous papillon spaniel karina, I see that product and it seems to be in a good ratio, as you don't strictly need as much L-Lysine as the two others, however, you can make that mix yourself from Bulksupplements.com, using 100g bags but it will be much more expensive, however, buying in 1kg bags and it's a lot cheaper per gram, like about half price. For both you need to calculate transport though, but if in the US there is no duty. Bulk.com in the UK does not have L-Proline. I have not tried the product you mention and don't know much about the company or the quality.
Best
Jesper BSc
bone broth is great and so is collagen plus vitamin c, otherwise it doesn´t work
I just want to say that I love your videos. You tackle beauty from all angles and I love that just want you to know I appreciate the articulation in which you present your findings and for that I have subscribed I don’t do very often.😁
Thanks, hey have a question ❓ are you still taking ubiquinol ?
Hi pierre jean, thanks for your question. I take Ubiquinone instead as explained in this video here th-cam.com/video/AJP2xgSVIW8/w-d-xo.html
As always, doing as I do, say, show, write, or whatsoever, is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever, is meant to cure, heal, or prevent anything regardless.
Best
Jesper BSc
Hello, have you tried to use L-Leucine on your skin?
Hi Oskar Karo, thanks for your question. No, I have not, but I might, at present have I added NMN to my serum (I use the one from California Gold, iHerb).
Best
Jesper BSc
Wow man 47! Holy shoot definately chugging that glycine now!
Does your hair feel stiff from taking all that glycine?
Hi again Logical_LB, no it doesn't, Glycine should help with hair in the sense that the base of the hair should improve, due to better collagen and antioxidant effect (Glutathione), but not much for the hair itself should happen but the conditions for producing hair improves if one lacks Glycine (as in old age). Cysteine can stiffen the hair by making more disulfide bridges to a certain extent.
As always, doing as I do, say, show, write, or whatsoever is at one's own risk regardless. Nothing I say, show, write, do, or whatsoever, is meant to cure, heal, or prevent anything regardless.
Best
Jesper BSc
@@JesperOffersenBSc
Jesper I had a follow up. In your collagen video from a year or two ago you said you were taking lysine to boost collagen. Are you still taking lysine or only glycine and leucine to boost collagen?
Hi again Logical_LB, I still take L-Lysine, taking L-Leucine and Glycine is not a substitute for that, but it boosts the production of tissue in a different way, but L-Lysine is still needed, but is enough from a normal diet if one is young. Check my quick guide to Collagen here th-cam.com/video/4c7OLh2DSHY/w-d-xo.html
Best
Jesper BSc