5:57 Myeloperoxidase is NOT present in bacterial cells . The antimicrobial effect of dapsone is well known in the treatment of ( Mycobacterium leprae ) . It inhibits the synthesis of " dihydrofolic acid " in the mycobacteria by competing with " para-aminobenzoic acid " for the active site of ( dihydropteroate synthetase ) enzyme ! The same mechanism is employed by sulfonamides in bacteria . While the anti inflammatory effect of dapsone is well known in the treatment of ( dermatitis herpetiformis ) . It reversibly inhibits the neutrophil myeloperoxidase (MPO) ===> impaired oxidative burst of neurophils & release of inflammatory mediators extracellularly !
I’ve gone through all 1000 UWORLD, NBME’s, Anking, and AMBOSS, yet I scored 70 on shelf. To be fair, it was my very first shelf but I really needed how to navigate such long question stems… I wish I had seen these videos before I started clerkship 😮😢
G6pd is x linked recessive. Rather rare for a female to get it unless her other X chromosome is inactivated or she has 2 of the recessive alleles on her X chromosome. I get your reasoning on how to answer the question but this pathology does not match the answer you seem correct well
This G6PD deficiency he is talking about in the context of the question is not the genetic condition. It is as a result of whatever drug she is taking. He did mention dapsone which among others can lead to this.
Great Thanks for This valuable information ... Please, I have autoimmune Disorder affecting my digestive system and liver. Now, 30% liver Cirrhosis (Sclerosing cholangitis) Enlarged spleen with thrombocytopenia ... What is your recommendation ... Please, send your contact information
This is exactly what I think would be helpful that isn't quite prevalent on youtube. The way in which to reason through the questions is invaluable.
its crazy.
tough af question but excellent breakdown
Very interesting video because G6PD deficiency is so rare in women! Thanks for walking us through this, very helpful!!
Very helpful explanation. Helped me understand the thinking process needed to get these questions right! Thanks
very good video!! Please, do another video on how to answer the question in less than 80 seconds. Thanks!
Please make more such video's! I found it helpful
5:57 Myeloperoxidase is NOT present in bacterial cells .
The antimicrobial effect of dapsone is well known in the treatment of ( Mycobacterium leprae ) . It inhibits the synthesis of " dihydrofolic acid " in the mycobacteria by competing with " para-aminobenzoic acid " for the active site of ( dihydropteroate synthetase ) enzyme ! The same mechanism is employed by sulfonamides in bacteria .
While the anti inflammatory effect of dapsone is well known in the treatment of ( dermatitis herpetiformis ) . It reversibly inhibits the neutrophil myeloperoxidase (MPO) ===> impaired oxidative burst of neurophils & release of inflammatory mediators extracellularly !
tricky one , good explanation !thank you
I’ve gone through all 1000 UWORLD, NBME’s, Anking, and AMBOSS, yet I scored 70 on shelf. To be fair, it was my very first shelf but I really needed how to navigate such long question stems… I wish I had seen these videos before I started clerkship 😮😢
too bad we only get 80 seconds/?
exactly !! with 5 min per question would be easy !
Great video! thanks so much for sharing
G6pd is x linked recessive. Rather rare for a female to get it unless her other X chromosome is inactivated or she has 2 of the recessive alleles on her X chromosome. I get your reasoning on how to answer the question but this pathology does not match the answer you seem correct well
This G6PD deficiency he is talking about in the context of the question is not the genetic condition. It is as a result of whatever drug she is taking. He did mention dapsone which among others can lead to this.
this question is meant to be missed. The minute it mentions female, I am not thinking about G6PD def, especially with only 80 secs
I picked D. I thought the secondary diagnosis causing the icterus could be a primary biliary cholangitis which can be associated with celiac disease.
Wow!! Very thoroughly explained!! Too bad I’m not a medic ....!!
Try doing it under pressure and under 1 min and 20 seconds.
Thank you so much :-)
Wow I just kept thinking celiac and got sidelined
Thank you!! :D
Nice video!
Great Thanks for This valuable information ...
Please, I have autoimmune Disorder affecting my digestive system and liver.
Now, 30% liver Cirrhosis
(Sclerosing cholangitis)
Enlarged spleen with thrombocytopenia ...
What is your recommendation ...
Please, send your contact information
Wow hope you get well soon!
great
Very interesting video because G6PD deficiency is so rare in women! Thanks for walking us through this, very helpful!!