As a physician (obgyn) with a degree in nutrition, I am completely amazed at the fundamental transformation that is taking place on our understanding of the physiology and biochemistry of these evolved pathways. Thank you for directing us to fascinating articles that help us to stay curious. Most importantly, your educational skills are world class!!! As a DM2 I find Fasting and keeping noisy food out of my environment helps to quell preprandial appetite. Eating higher fat and lower carbohydrates helps to satiate after eating.
Ketosis also reduces food noise. My example - While in ketosis I don’t smell chocolate and cookies or at least I don’t notice the smell. When I am not in Ketosis I smell them and desire them. Same with bread.
I genuinely appreciate your videos. After watching one I feel like I've learned things that are good to know. Too many TH-camrs put out videos that make me feel like I've not only wasted my time but also caused my brain to atrophy.
For me, a ketogenic diet has essentially silenced my food noise. I often forget to eat, and even then, I get to decide whether I _want_ to eat. High-protein plus [animal] fat seems to be key, and eggs (cooked in butter) are great at both. Plus, there seems to be the mental side-effects of activity (especially walking and weight-exercise)-If your mind senses that you are physically well and active enough to procure food whenever needed, it doesn't have to be preoccupied with it.
Nick, the einstein of metabolism, the master aggregator, the feeder of minds, the anti-fructose pharisee, the moses of macros, the hebrew of hunger, the gut galut, the keto kaikel 😂 ❤
@@nicknorwitzPhD The ketone kabbalist, the metabolic maestro, the carb killing king, the sugar-free chaperone, the glucose guillotine, the heart healthy herod, the christ of cholesterol, the red #5 rouge, the oreo overlord, the hungry historian, the caked crusader, and the macadamia menace. I can do this all day lol, love your content, nick!
@@nicknorwitzPhD on a serious note The Feeder of Minds is indeed the best one. That list there by BBWahoo is hilarious I literally laughed out loud. The Moses of macros and all that haha. But self education is everything so you helping people like me Dr Norwitz is where it's at. Metabolic Armies need to be educated soldiers. The weapons are made from KNOWLEDGE. You are the man Dr Norwitz keep it up.
I’ll be eternally grateful that I stumbled accidentally across managing my weight without thinking about it after being diagnosed as diabetic and reasoning that eating less sugar was likely the way to go (some 12 years ago). I can’t help but think it is frightening that we seem to be moving into an era of pharmacological weight management. We’ll stop wondering why we are getting fat and simply inject ourselves instead - so not treating the underlying problem at all. I wonder to what extent we will discover a parallel between this and management of Type 2 Diabetes with drugs. Many now agree that the reason T2D was thought to be ‘chronic, progressive’ is simply because we have been treating elevated glucose without addressing the most likely issue of elevated insulin. By addressing the insulin issue, T2D goes away.
To avoid living an allopathetic pharmavore's life, live in the ketosphere. Do that by eating real food, prioritizing protein, fueling with fat, and cutting carbs.
You asked the question “how do you reduce food noise?” I have been doing keto + intermittent fasting for about 6 weeks and my food noise has reduced to almost nothing. Some days I just don’t feel like eating so I do a 48 hour fast. I’ve lost about 20 pounds and I feel great.
But in mouse model of pcos, you are completely controlling the diet. Pretty sure if you could do the same with women, glp1 would indeed be effective. More research is needed. Lol.
Hi Nick, love you videos. But it is Gila monster, pronounced with an h sound or almost gh sound as it is of Spanish origin. I spent time around Gila Bend as a kid. 😂❤
because GLP-1receptor is displayed to the plasma compartment, one could build a bivalent drug tethering a GLP-1 antagonist to a ligand for something else displayed on the AP (but not on the cells we want to agonize) It would be tricky to get FDA approval for such an agent that would not treat any disease on its own, but would only blunt a nasty side-effect of the GLP1 agonists. And "gila monster" is pronounced "Heelah monster"
Wow, I just learned so much that I could never have distilled from those papers -- if I could have found them to read. Going to hunt down a couple of those deep dives! Thanks!!
What I know. Even a low dose of GLP significantly lowers cravings and the need to graze. It's so much easier to maintain a low carb high protein diet without the cravings fighting with temptations from family and social settings. It's basically cheating, i see nothing wrong with that if you are focused on better eating and activity habits.
Totally agree. Science and learning are part of how we evolve. Zepbound has changed my life. Low carb clean eating plus intermittent fasting plus relatively low dose of the med and consistent resistance training have truly transformed how I feel. I had the information before and could use it until I couldn’t. This makes my decisions easier to manage long term. Thanks for the great videos. Truly balanced and thoughtful
My experience with monjouro was that mild nausea was super helpful. Happened when I ate too much. Was a quick feedback loop that helped train me not to! I wish the affect persisted but at 24 months it is almost totally gone.
It may have gone because you are at your new set point…? Have you tried taking a short break and restarting, or is this not a concern because you have reached your health objectives and are maintaining them?
@@aimeelinekar3902interesting idea. I do seem to be at a stubborn plateau. Lost 80+ lbs. no longer obese, but still should loose 30ish pounds. Since I’m at 15mg-highest dose-not sure it I should stop and restart without a taper up or down?
@@jonathanzivan1885 I plateaued and regained on liraglutide and dose increases (I’d kept to lower doses) didn’t help. Restarting after a fortnight off did.
I'm a little puzzled by people with a knee jerk disdain for these drugs. They may allow people to lose weight without suffering (is that the problem? lol), but that doesn't mean they will be automatically be encouraged to continue a bad diet. Often, with weight loss success, people are thrilled and become passionate for more success. I've been around people struggling with weight their whole adult lives. I'm excited that a drug might help!
Amen. Using them at lower doses through compounding may take longer for weight loss, but the side effects are gone, and you still get the anti-inflammatory effcts. And you are not feeding big pharma. Peptides themselves are not drugs, but if you add something to them and put them in a pen, you can label a drug. You can become insensitive to them just like the peptide insulin, so cycling can help rather than just higher and higher doses.
Yes, and it seems that basic science comes down to understanding more effects of physics on biology! Who would have thought?! Start down this rabbit hole by learning about daylight (all of it, especially the wavelengths we can't see) IMHO.
I think it is an extremely interesting, and very informative. Thank you. However, I think Americans need to get involved, with eating the proper human diet! Which is and should be a ton less sugar to start with, and stop putting high fructose, corn syrup in our food!!!
I agree re Proper Human Diet. That said, we need to be pragmatists AND, I think, taking this lens provides an invitation for productive discussion. Let's try our best not to alienate people. Baby steps, hopefully all in the same direction. Let's remain curious about the science and about each other!
Have you analyzed the data presented? My experience is that far too many papers the abstract and conclusion bear no relevance to an independant analysis of the data.
Excellent content! I’m interested in the interplay between gherelin and GLP-1 drugs. Perhaps the slowing of gastric emptying stimulates Leptin mechanically.
@@nicknorwitzPhDMaybe the paper cited in this video? th-cam.com/video/CBNOZsG7sLs/w-d-xo.htmlsi=RI974P5kMr-Omu1u Thank you, Nick. We are so lucky you devote so much of your time to explain and to inform us.
i find it incongruous of principles, that any hormone that is formulated into a pharmaceutical analog/product, has to have first their levels of the hormone, or equivalent, measured first, and the treatments based on those ongoing labs, but with these drugs there is none. (There is an exception with glucocorticoids used for inflammatory suppression.) What are your thoughts on this?
Not necessarily. This isn't HRT. It's more about presenting a logical physiological basis for an intervention. If the intervention works is patient X irrespective of their exact baseline levels, then what is the clinical utility of measuring baseline levels? Also, when do you do so? Levels fluctuate and there's no continuous GLP-1 meter.
@@nicknorwitzPhD Almost the same, but not. Anyway, I enjoy your page and your comments. The Gila monster (Heloderma suspectum, /ˈhiːlə/ HEE-lə) is a species of venomous lizard native to the Southwestern United States and the northwestern Mexican state of Sonora. From Wikipedia.
Probably ... is that necessarily bad? I have loved ones with PCOS who are otherwise pretty healthy. If that were an innovation that could help them, I'd want that for them.
@@paulb4985 That's not spell-checking is a technical clarification... if someone said "increase" and it's actually "decrease" is clarifying that a "spellcheck?"
reducing the food noise is by feeding the gut microbiome: beans + potatoes without adding shit for 3 days in a row will bring you a huge amount of fiber. you have to understand where GLP-1 is coming from. it comes ONLY from the indigestible parts that you can't absorb with the stomach or small intestine. the L cells that produce GLP-1 are at the end of the small intestine and beginning of the large intestine. if you eat a shitload of potatoes + beans very often then you address the L-cells producing GLP-1. also this has an effect on sensitivity regarding CCK and PYY. if your gut is full of that fiber feeding the gut microbiome, in the next days it is possible to eat one big steak and the resulting satiation from CCK and PYY is enough. so, GLP-1 is somehow an amplifier of the effect of CCK and PYY as well. so, for people who have problems with keto/low carb/carnivore in the context of weight loss, they have to repair their gut first. after years of trying different things, i found the potato diet. it kind of works, even to an extent that i had very low blood sugar from the GLP-1 in the afternoon two times. i now combine it with red and black beans to increase protein intake as well, because long term potato dieter show low protein symptoms - even when they claim the opposite - as known from many horrible looking vegans. it is crazy how effective that is.
You say: "you have to understand where GLP-1 is coming from. it comes ONLY from the indigestible parts that you can't absorb with the stomach or small intestine." This isn't true. I'm not sure where you got this impression, but it's simply not true. That said, I'm fine with you making this comment and sharing your opinion. You seem to have put thought and effort into it, and I appreciate that. But I do just want to be clear that some of the things you are stating are (I assume unintentionally, misinformation). If you'd like to reply to my reply making your case with sources, feel free. Sincerely - N. P.S. Thank you for sharing and I'm glad you're finding approaches that work for you as an individual.
I have zero "food noise" during the majority of my fasting period (18 hrs). About 1 hour before the end of my fasting period I start to notice some hunger, but it is pretty mild. I think that if someone is metabolically flexible, "food noise" really isn't a thing.
@@nicknorwitzPhDI don't. I dont think anyone does. There aren't many people that are metabolically flexible in 2024, but the ones I know don't obsess over food. You're metabolically flexible, do you obsess about food constantly?
I used to be “starving” before lunchtime when I was eating carbs for breakfast. I would eat big plates of carb laden foods. Now, since going carnivore+dairy I am in ketosis almost every day since I started checking 4 months ago. I typically take readings in the morning when I wake up. If my GKI is
I used to be “starving” before lunchtime when I was eating carbs for breakfast. I would eat big plates of carb laden foods. Now, since going carnivore+dairy I am in ketosis almost every day since I started checking 4 months ago. I typically take readings in the morning when I wake up. If my GKI is
Reducing the ovarian cysts is unlikely to make a wonderful effect in humans as a major issue seems to be the blocking of testosterone to oestrogen conversion in the presence of hyperinsulinaemia
Absolutely fascinating! Thanks always for your amazing explorations! So exciting and full of possibilities! I am so grateful to be able to begin, just begin, to understand with your brilliant expression and teaching! At 71!
Hi Nick! I've come across your content recently and become really curious as I went keto half a year ago. Btw I'm also into cholesterol and tried to explain its impact on an organism. But I'm not sure in conclusions which I drew as they seem kinda contradictory to the common belief. So I just wanna know whether you agree with me on that topic or not (especially endings of the videos). Anyway, thanks for the content! Keep it up 💪💪💪
Thanks for the high level overview, but you're not getting at the root cause of why there is insufficient GLP1 in some people.... Here is the root cause: some people have an abundance of H2S producing bacteria in the colon, by diet choices or bad luck... excess H2S depresses GLP 1 secretion by intestinal cells (also leads to inflammation, colitis, IBD and cancer). The solution is not to give more GLP 1, but to fix the deficit... Dietary changes away from sulphur bearing foods, introduction of several strains of bacteria that suppress bacterial H2S production, and using bismuth subsalicylate and inulin to suppress H2S producing bacteria. I can support each line above with research papers, but it's left as an exercise for the reader.
@@nicknorwitzPhD TRUE, wasn't trying to be a troll... just wanted to make the linkage for your audience (I will delete if you want). BTW I started taking an occasional Pepto pill to keep those H2S bugs in check, based on your Pepto video.
I would like to know about where medicine is at for testing mitochondria in say- me! Getting a snapshot on my mitochondria. How's that happening at the moment in reality? Like if I went to my GP Dr Virgillio in Australia and tried to get tests done(I am joking by the way I was lucky to get a fasting insulin authorised, had to quote Dr Robert Lustig!). Look I'd say I couldn't get much here in Australia but what about testing overseas as a medical tourist? I know mitochondria darken fat cells when your lucky enough to get brown fat. So they are tangible and large essentially in numbers at least. Biopsies? I'm fascinating in this question last few days. If you could consider answering or referring me to content I missed I'd appreciate it sir. Andre
Nic, what a silly question! Why would you package two results in one drug, as the idiots at Monjaro have done,( stockholders are not going to be pleased, although , its selling out anyway, so, ?), Instead, sell them two separate drugs, WHAT???? That ,that doesn't seem ethical, does it? What is really interesting is to try to explain to someone that low carb diet is doing the same thing, cheaper! Or allulose! Meanwhile, we are on this level, and Luigisonsdojo, comments below that his world is being rocked because he is getting ads with his premium account. Focus, people, focus!
Sorry, you seemed to be wondering why they weren't packaging them together in one drug, My tongue in cheek response was that they would want to sell you two separate drugs. Unethical was my attempt at sarcasm,( normally my superpower)! Maybe I will listen more and comment less. Thanks, love you format in any case!
@@nicknorwitzPhD When MS is reversed, people drop hundreds of pounds, autoimmunity dissipates, arthritis vanishes, mental disorders vanish... Yes, everyone is entitled to actual healing along with their choices.
@@nicknorwitzPhD I stopped eating plants in June 2023 and within a very few months, completely self cured my T2D, amongst a number of other issues. Here is an 80+ year old goat, a carnivore for life ! 84 yrs old Carnivore for 7 years top weight 265 now 175 . Checked Blood Pressure today SYS 124 DIA 60 PLU 51 NO PILLS. Harvard take your study an stuff it. Dr. Willer should lose his medical license and go back to school!!! Carnivore is the proper ancestral diet humans have eaten for 500,000 years!!, There are piles of evidence pointing that high levels of cholesterol is no longer associated with cardiovascular issues. I have been on the strict lions carnivore diet since January 2023 and my blood work has never been better. The benefits have a list as long as my arm the proof is in the pudding and I feel fantastic. I will never return to a plant-based diet. Can't change me !! I'm 77 been carnivore for 5 years. Lost 50 lbs. Went down 3 sizes in my clothes walk 2 miles a day and feel better than I did growing up. Never thought I would be doing this good in my 70,s. Feel 30 !!! Also have great blood work. Drs. want to pump you full of expensive medicines. Just go carnivore and you won't need meds. I take none. This way if eating us like getting a new lease on life !!!!! It's amazing Arthritis and gout issues are gone due to the carnivore diet. i thought it was a bad joke when i stumbled upon carnivore 1.5 years ago . it has been the best and easiest thing i have ever done .losing 50 kg is great but the fact i feel so much better now, is incredible. 💪 My husband and I have been carnivore for 18 months. I lost 85 pounds in 7 months, heals IBS and my mental health is substantially improved, my husband lost 45 pounds, WAS an insulin dependent diabetic with a pump and HAD 5 tumors on his pancreas. 6 months in his doctor said he is no longer diabetic, his pancreas is working at 100% and his tumors are almost gone. His arthritis has improved, his gout is gone and his testosterone which was non existent is that of a teenager. The only thing that has improved my life more than carnivore is Jesus Christ, my Lord and savior!
Did you listen to the disclaimer at the beginning of the video. My opinion on their breadth of use may not be what you assume. By my opinions are irrelevant to the physiology. So, I challenge myself to set them aside.
![CAMPปลิ้น | EP.82[1/2] แก๊ง 3 สาวเพื่อนซี้บุก CAMPปลิ้นครั้งนี้ห้ามเสียอาการ](http://i.ytimg.com/vi/_6WUjXHe1TM/mqdefault.jpg)
As a physician (obgyn) with a degree in nutrition, I am completely amazed at the fundamental transformation that is taking place on our understanding of the physiology and biochemistry of these evolved pathways. Thank you for directing us to fascinating articles that help us to stay curious. Most importantly, your educational skills are world class!!! As a DM2 I find Fasting and keeping noisy food out of my environment helps to quell preprandial appetite. Eating higher fat and lower carbohydrates helps to satiate after eating.
@@GregF-k7w,
"We ..."? Speak for yourself.
Ketosis also reduces food noise. My example - While in ketosis I don’t smell chocolate and cookies or at least I don’t notice the smell. When I am not in Ketosis I smell them and desire them. Same with bread.
I genuinely appreciate your videos. After watching one I feel like I've learned things that are good to know. Too many TH-camrs put out videos that make me feel like I've not only wasted my time but also caused my brain to atrophy.
Thanks 🙏🏻… that’s very kind of you. I appreciate it
For me, a ketogenic diet has essentially silenced my food noise. I often forget to eat, and even then, I get to decide whether I _want_ to eat. High-protein plus [animal] fat seems to be key, and eggs (cooked in butter) are great at both. Plus, there seems to be the mental side-effects of activity (especially walking and weight-exercise)-If your mind senses that you are physically well and active enough to procure food whenever needed, it doesn't have to be preoccupied with it.
Glad you found something that’s working for you 💪💪💪
Nick, the einstein of metabolism, the master aggregator, the feeder of minds, the anti-fructose pharisee, the moses of macros, the hebrew of hunger, the gut galut, the keto kaikel 😂
❤
Okay... you know how to inflate a head. "Feeder of Minds" is my favorite. thanks BBWahoo
@@nicknorwitzPhD
The ketone kabbalist, the metabolic maestro, the carb killing king, the sugar-free chaperone, the glucose guillotine, the heart healthy herod, the christ of cholesterol, the red #5 rouge, the oreo overlord, the hungry historian, the caked crusader, and the macadamia menace.
I can do this all day lol, love your content, nick!
Haha that's brilliant! Oh my goodness! BBWahoo bravo haha. Andre
I got to ask chatgpt the meaning of a few of these!
@@nicknorwitzPhD on a serious note The Feeder of Minds is indeed the best one. That list there by BBWahoo is hilarious I literally laughed out loud. The Moses of macros and all that haha. But self education is everything so you helping people like me Dr Norwitz is where it's at. Metabolic Armies need to be educated soldiers. The weapons are made from KNOWLEDGE. You are the man Dr Norwitz keep it up.
I’ll be eternally grateful that I stumbled accidentally across managing my weight without thinking about it after being diagnosed as diabetic and reasoning that eating less sugar was likely the way to go (some 12 years ago). I can’t help but think it is frightening that we seem to be moving into an era of pharmacological weight management. We’ll stop wondering why we are getting fat and simply inject ourselves instead - so not treating the underlying problem at all.
I wonder to what extent we will discover a parallel between this and management of Type 2 Diabetes with drugs. Many now agree that the reason T2D was thought to be ‘chronic, progressive’ is simply because we have been treating elevated glucose without addressing the most likely issue of elevated insulin. By addressing the insulin issue, T2D goes away.
To avoid living an allopathetic pharmavore's life, live in the ketosphere.
Do that by eating real food, prioritizing protein, fueling with fat, and cutting carbs.
That has been my personal choice. It doesn't need to be everybody's personal choice. I'm for "metabolic" liberty...
You asked the question “how do you reduce food noise?” I have been doing keto + intermittent fasting for about 6 weeks and my food noise has reduced to almost nothing. Some days I just don’t feel like eating so I do a 48 hour fast. I’ve lost about 20 pounds and I feel great.
Happy for you!
But in mouse model of pcos, you are completely controlling the diet. Pretty sure if you could do the same with women, glp1 would indeed be effective. More research is needed. Lol.
More research is always needed… but the pcos study is cool no!?
Thank you Nick. Insightful as always.
My pleasure and thank you!
Nice summary ... you'd make a great teacher.
Glad you think so!
What about using allulose to stimulate glp-1
My curious mind also wants to know about Rx Sugar/allulose!
I agree, it's fun and exciting ride as long as you keep doing such amazing videos!
Thanks so much! They will keep coming!
Hi Nick, love you videos. But it is Gila monster, pronounced with an h sound or almost gh sound as it is of Spanish origin. I spent time around Gila Bend as a kid. 😂❤
Well, I didn’t expect this comment. Thanks 🙏🏻 … Ghrateful
because GLP-1receptor is displayed to the plasma compartment, one could build a bivalent drug tethering a
GLP-1 antagonist
to
a ligand for something else displayed on the AP (but not on the cells we want to agonize)
It would be tricky to get FDA approval for such an agent that would not treat any disease on its own, but would only blunt a nasty side-effect of the GLP1 agonists.
And "gila monster" is pronounced "Heelah monster"
Wow, I just learned so much that I could never have distilled from those papers -- if I could have found them to read. Going to hunt down a couple of those deep dives! Thanks!!
Wonderful!
For me, (18-6) IF is a big food noise reducer and hunger supressor.
What I know. Even a low dose of GLP significantly lowers cravings and the need to graze.
It's so much easier to maintain a low carb high protein diet without the cravings fighting with temptations from family and social settings.
It's basically cheating, i see nothing wrong with that if you are focused on better eating and activity habits.
i tried a tiny dose of trizepitide and no side effects and great hunger control.
There is no "cheating" when you're making the honest best decision for yourself. F*** peer pressure.
Totally agree. Science and learning are part of how we evolve. Zepbound has changed my life. Low carb clean eating plus intermittent fasting plus relatively low dose of the med and consistent resistance training have truly transformed how I feel. I had the information before and could use it until I couldn’t. This makes my decisions easier to manage long term. Thanks for the great videos. Truly balanced and thoughtful
My experience with monjouro was that mild nausea was super helpful.
Happened when I ate too much. Was a quick feedback loop that helped train me not to!
I wish the affect persisted but at 24 months it is almost totally gone.
Thanks for sharing your personal experience.
N=1
😊
It may have gone because you are at your new set point…? Have you tried taking a short break and restarting, or is this not a concern because you have reached your health objectives and are maintaining them?
@@aimeelinekar3902interesting idea. I do seem to be at a stubborn plateau. Lost 80+ lbs. no longer obese, but still should loose 30ish pounds.
Since I’m at 15mg-highest dose-not sure it I should stop and restart without a taper up or down?
@@jonathanzivan1885 I plateaued and regained on liraglutide and dose increases (I’d kept to lower doses) didn’t help. Restarting after a fortnight off did.
I agree we are at a much better place - thanks Nick
You are very welcome!
I'm a little puzzled by people with a knee jerk disdain for these drugs. They may allow people to lose weight without suffering (is that the problem? lol), but that doesn't mean they will be automatically be encouraged to continue a bad diet. Often, with weight loss success, people are thrilled and become passionate for more success. I've been around people struggling with weight their whole adult lives. I'm excited that a drug might help!
Very reasonable response. Thank you for a level head.
Amen. Using them at lower doses through compounding may take longer for weight loss, but the side effects are gone, and you still get the anti-inflammatory effcts. And you are not feeding big pharma. Peptides themselves are not drugs, but if you add something to them and put them in a pen, you can label a drug. You can become insensitive to them just like the peptide insulin, so cycling can help rather than just higher and higher doses.
To turn away from basic science is to wear blinders to the larger reality.
Beautiful 😍
Yes, and it seems that basic science comes down to understanding more effects of physics on biology! Who would have thought?! Start down this rabbit hole by learning about daylight (all of it, especially the wavelengths we can't see) IMHO.
And, learn about LED light, somewhere in there.
I think it is an extremely interesting, and very informative. Thank you. However, I think Americans need to get involved, with eating the proper human diet! Which is and should be a ton less sugar to start with, and stop putting high fructose, corn syrup in our food!!!
I agree re Proper Human Diet. That said, we need to be pragmatists AND, I think, taking this lens provides an invitation for productive discussion. Let's try our best not to alienate people. Baby steps, hopefully all in the same direction. Let's remain curious about the science and about each other!
Have you analyzed the data presented? My experience is that far too many papers the abstract and conclusion bear no relevance to an independant analysis of the data.
Yes. As I mentioned in the video this is a synthesis video. Want the detailed breakdowns, see each independent video linked in the notes
It is pronounced "hila" monster. 🦎 Southwest US snobbery. 😂
Always interesting video. Remaining curious!
Thanks for watching! #StayCurious
The empty fridge to reduce food noise was hilarious!
Editor’s choice 😂
Who needs Monjarou and Ozempic when you can have steak🥩🍖
Way to steak 🥩 a claim ⛳️
Excellent content! I’m interested in the interplay between gherelin and GLP-1 drugs. Perhaps the slowing of gastric emptying stimulates Leptin mechanically.
Hmmm... not how leptin generally works.
Jones Matthew Hall George Gonzalez Eric
So... I should drink pepto every day?
What is the story of a July 2024 study from Mass eye and ear about drugs like ozempic causing blindness.
What? That's new to me... link please?
@@nicknorwitzPhDMaybe the paper cited in this video? th-cam.com/video/CBNOZsG7sLs/w-d-xo.htmlsi=RI974P5kMr-Omu1u
Thank you, Nick. We are so lucky you devote so much of your time to explain and to inform us.
Dr. Tyna Moore addresses this study in a recent video.
@@nicknorwitzPhD fortune.com/well/2024/07/03/ozempic-linked-to-rare-cases-of-vision-loss/
Miller Matthew Miller Sandra Walker Eric
i find it incongruous of principles, that any hormone that is formulated into a pharmaceutical analog/product, has to have first their levels of the hormone, or equivalent, measured first, and the treatments based on those ongoing labs, but with these drugs there is none.
(There is an exception with glucocorticoids used for inflammatory suppression.)
What are your thoughts on this?
Not necessarily. This isn't HRT. It's more about presenting a logical physiological basis for an intervention. If the intervention works is patient X irrespective of their exact baseline levels, then what is the clinical utility of measuring baseline levels? Also, when do you do so? Levels fluctuate and there's no continuous GLP-1 meter.
Has GIP been studied alone? I'll check the other info.
Paper you want me to review? I assume you saw the "Ozempic obliterated" independent video given this comment.
Gila is pronounced Hee-luh
Toe-May-Toe
@@nicknorwitzPhD Almost the same, but not. Anyway, I enjoy your page and your comments.
The Gila monster (Heloderma suspectum, /ˈhiːlə/ HEE-lə) is a species of venomous lizard native to the Southwestern United States and the northwestern Mexican state of Sonora. From Wikipedia.
This is probably why we feel so much better on a high protein diet, same same but different
What do you mean?
@@nicknorwitzPhD the point about healing happening with regards to polycystic ovaries, presumably high protein would have the same effect
Reynolds Turnpike
In re pcos; pharma will find a way to use this to develop meds targeting pcos and make more money.
Probably ... is that necessarily bad? I have loved ones with PCOS who are otherwise pretty healthy. If that were an innovation that could help them, I'd want that for them.
@@nicknorwitzPhDyour loved ones would have the same relief wo drugs. Fung’s fasting and low carb has the results for PCOS
Okay, looking at your previous video, I would be more interested in the GIP agonists more than the combination.
You mean chronic agonism?
@@nicknorwitzPhD spellchecker lol you know what I mean!
@@paulb4985 That's not spell-checking is a technical clarification... if someone said "increase" and it's actually "decrease" is clarifying that a "spellcheck?"
Seriously man previous video was lit and more visually engazing .
You mean the cancer one?
reducing the food noise is by feeding the gut microbiome: beans + potatoes without adding shit for 3 days in a row will bring you a huge amount of fiber.
you have to understand where GLP-1 is coming from. it comes ONLY from the indigestible parts that you can't absorb with the stomach or small intestine. the L cells that produce GLP-1 are at the end of the small intestine and beginning of the large intestine.
if you eat a shitload of potatoes + beans very often then you address the L-cells producing GLP-1.
also this has an effect on sensitivity regarding CCK and PYY. if your gut is full of that fiber feeding the gut microbiome, in the next days it is possible to eat one big steak and the resulting satiation from CCK and PYY is enough.
so, GLP-1 is somehow an amplifier of the effect of CCK and PYY as well.
so, for people who have problems with keto/low carb/carnivore in the context of weight loss, they have to repair their gut first. after years of trying different things, i found the potato diet. it kind of works, even to an extent that i had very low blood sugar from the GLP-1 in the afternoon two times. i now combine it with red and black beans to increase protein intake as well, because long term potato dieter show low protein symptoms - even when they claim the opposite - as known from many horrible looking vegans.
it is crazy how effective that is.
You say: "you have to understand where GLP-1 is coming from. it comes ONLY from the indigestible parts that you can't absorb with the stomach or small intestine." This isn't true. I'm not sure where you got this impression, but it's simply not true. That said, I'm fine with you making this comment and sharing your opinion. You seem to have put thought and effort into it, and I appreciate that. But I do just want to be clear that some of the things you are stating are (I assume unintentionally, misinformation). If you'd like to reply to my reply making your case with sources, feel free. Sincerely - N. P.S. Thank you for sharing and I'm glad you're finding approaches that work for you as an individual.
Your episodes of low blood sugar might have been reactive hypoglycemia since you were eating potatoes. I’ve experienced that, too. FWIW.
I have zero "food noise" during the majority of my fasting period (18 hrs). About 1 hour before the end of my fasting period I start to notice some hunger, but it is pretty mild.
I think that if someone is metabolically flexible, "food noise" really isn't a thing.
How do you really know if you haven’t lived in another persons shoes? 👞 👟 👠
@@nicknorwitzPhDI don't. I dont think anyone does. There aren't many people that are metabolically flexible in 2024, but the ones I know don't obsess over food. You're metabolically flexible, do you obsess about food constantly?
I used to be “starving” before lunchtime when I was eating carbs for breakfast. I would eat big plates of carb laden foods.
Now, since going carnivore+dairy I am in ketosis almost every day since I started checking 4 months ago. I typically take readings in the morning when I wake up. If my GKI is
I used to be “starving” before lunchtime when I was eating carbs for breakfast. I would eat big plates of carb laden foods.
Now, since going carnivore+dairy I am in ketosis almost every day since I started checking 4 months ago. I typically take readings in the morning when I wake up. If my GKI is
I'm riding the wave of GLP-1's since the Gila Monster's diet was found. they only ate 4 times a year.
Reducing the ovarian cysts is unlikely to make a wonderful effect in humans as a major issue seems to be the blocking of testosterone to oestrogen conversion in the presence of hyperinsulinaemia
683 Mills Meadows
???
Absolutely fascinating! Thanks always for your amazing explorations! So exciting and full of possibilities! I am so grateful to be able to begin, just begin, to understand with your brilliant expression and teaching! At 71!
Welcome! Love the enthusiasm ❤️
Hi Nick! I've come across your content recently and become really curious as I went keto half a year ago. Btw I'm also into cholesterol and tried to explain its impact on an organism. But I'm not sure in conclusions which I drew as they seem kinda contradictory to the common belief. So I just wanna know whether you agree with me on that topic or not (especially endings of the videos).
Anyway, thanks for the content! Keep it up 💪💪💪
I have a whole playlist on cholesterol with >30 videos you can find from my channel homepage. And Thanks 🙏🏻
Have you looked into new gastric fundus ablation procedure that reduces gherelin production by 50%?
GFMA? A bit. Results aren’t surprising. Bariatric surgery acts more through hormones than simple “volume limitation”
The empty refrigerator at 7’10” is depressing. At least it’s very clean.
7'10" ? ... thought this was a height for a moment.
Thanks for the high level overview, but you're not getting at the root cause of why there is insufficient GLP1 in some people.... Here is the root cause: some people have an abundance of H2S producing bacteria in the colon, by diet choices or bad luck... excess H2S depresses GLP 1 secretion by intestinal cells (also leads to inflammation, colitis, IBD and cancer). The solution is not to give more GLP 1, but to fix the deficit... Dietary changes away from sulphur bearing foods, introduction of several strains of bacteria that suppress bacterial H2S production, and using bismuth subsalicylate and inulin to suppress H2S producing bacteria. I can support each line above with research papers, but it's left as an exercise for the reader.
You’re citing me at me:
th-cam.com/video/hiCxpHDAlbs/w-d-xo.html
@@nicknorwitzPhD TRUE, wasn't trying to be a troll... just wanted to make the linkage for your audience (I will delete if you want). BTW I started taking an occasional Pepto pill to keep those H2S bugs in check, based on your Pepto video.
Cheers for that mate. Andre
Cheers Andre
I would like to know about where medicine is at for testing mitochondria in say- me! Getting a snapshot on my mitochondria. How's that happening at the moment in reality? Like if I went to my GP Dr Virgillio in Australia and tried to get tests done(I am joking by the way I was lucky to get a fasting insulin authorised, had to quote Dr Robert Lustig!). Look I'd say I couldn't get much here in Australia but what about testing overseas as a medical tourist? I know mitochondria darken fat cells when your lucky enough to get brown fat. So they are tangible and large essentially in numbers at least. Biopsies? I'm fascinating in this question last few days. If you could consider answering or referring me to content I missed I'd appreciate it sir. Andre
All ul ose?
Thank you!
Welcome!
I pay for TH-cam premium, but had ads on this video.
I don't pay for TH-cam premium and I haven't seen TH-cam ads in years
Not sure... I don't know if I can fix that for you. Sorry.
I use the browser to watch😁. No ads with ad blocker
I’ve had that happen when not signed in to google, so you can check that. 😊
Are you logged into your account?
Nic, what a silly question! Why would you package two results in one drug, as the idiots at Monjaro have done,( stockholders are not going to be pleased, although , its selling out anyway, so, ?), Instead, sell them two separate drugs, WHAT???? That ,that doesn't seem ethical, does it? What is really interesting is to try to explain to someone that low carb diet is doing the same thing, cheaper! Or allulose! Meanwhile, we are on this level, and Luigisonsdojo, comments below that his world is being rocked because he is getting ads with his premium account. Focus, people, focus!
Lots of medications have multiple mechanisms of action... not sure why you'd suggest it's unethical. Guess I'm not following
Sorry, you seemed to be wondering why they weren't packaging them together in one drug, My tongue in cheek response was that they would want to sell you two separate drugs. Unethical was my attempt at sarcasm,( normally my superpower)! Maybe I will listen more and comment less. Thanks, love you format in any case!
Carnivore > GLP1
Everyone is entitled to their opinions and choices
@@nicknorwitzPhD When MS is reversed, people drop hundreds of pounds, autoimmunity dissipates, arthritis vanishes, mental disorders vanish... Yes, everyone is entitled to actual healing along with their choices.
@@nicknorwitzPhD
I stopped eating plants in June 2023 and within a very few months, completely self cured my T2D, amongst a number of other issues. Here is an 80+ year old goat, a carnivore for life !
84 yrs old Carnivore for 7 years top weight 265 now 175 . Checked Blood Pressure today SYS 124 DIA 60 PLU 51 NO PILLS. Harvard take your study an stuff it.
Dr. Willer should lose his medical license and go back to school!!! Carnivore is the proper ancestral diet humans have eaten for 500,000 years!!,
There are piles of evidence pointing that high levels of cholesterol is no longer associated with cardiovascular issues. I have been on the strict lions carnivore diet since January 2023 and my blood work has never been better. The benefits have a list as long as my arm the proof is in the pudding and I feel fantastic. I will never return to a plant-based diet.
Can't change me !! I'm 77 been carnivore for 5 years. Lost 50 lbs. Went down 3 sizes in my clothes walk 2 miles a day and feel better than I did growing up. Never thought I would be doing this good in my 70,s. Feel 30 !!! Also have great blood work. Drs. want to pump you full of expensive medicines. Just go carnivore and you won't need meds. I take none. This way if eating us like getting a new lease on life !!!!! It's amazing
Arthritis and gout issues are gone due to the carnivore diet.
i thought it was a bad joke when i stumbled upon carnivore 1.5 years ago . it has been the best and easiest thing i have ever done .losing 50 kg is great but the fact i feel so much better now, is incredible. 💪
My husband and I have been carnivore for 18 months. I lost 85 pounds in 7 months, heals IBS and my mental health is substantially improved, my husband lost 45 pounds, WAS an insulin dependent diabetic with a pump and HAD 5 tumors on his pancreas. 6 months in his doctor said he is no longer diabetic, his pancreas is working at 100% and his tumors are almost gone. His arthritis has improved, his gout is gone and his testosterone which was non existent is that of a teenager. The only thing that has improved my life more than carnivore is Jesus Christ, my Lord and savior!
Nick - you sound very supportive about using GLP-1 hormones to treat lifestyle diseases. What could possibly go wrong, long term🤷🏼♂️😂
Did you listen to the disclaimer at the beginning of the video. My opinion on their breadth of use may not be what you assume. By my opinions are irrelevant to the physiology. So, I challenge myself to set them aside.
First 🔥
Algo support appreciated ;)
I wonder why people keep referring to ozempic when tirzepitude is a more effective dual agonist.
I have a video specifically on the contrast. Have you wanted it? It’s references in this video and linked in the video notes. Interesting physiology
Because Ozempic advertised constantly on TV with a catchy jingle!