I wrote this whole video out: so here it is for anyone who's wanting it. The role of insulin in your body: Diabetes affects the Pancreas, an organ of the digestive system. An important function of the Pancreas is to make hormones that regulate blood glucose levels. Insulin is produced by beta cells which cluster in groups called islets. Insulin is a hormone that lowers blood glucose levels. After a meal, glucose reaches the pancreas via the bloodstream and is released from capillaries into the pancreatic tissue. This triggers the release of insulin, which is stored inside the beta cells. The insulin travels to other parts of the body by the bloodstream with three main destinations; muscle, fat and liver. Insulin helps these tissues to store glucose as an energy source. Insulin arrives through the fine capillary network that traverses the muscle fibers. The surfaces of muscle, fat and beta cells are covered in insulin receptors. When these receptors bind insulin, they signal to the cells to release special glucose transport channels onto the cell surface. These channels enable glucose to gain entry into the cells, allowing the cells to store glucose as energy for future use. In this way, insulin acts to regulate blood glucose levels. Part 2: Development of type 1 diabetes In type one diabetes a patient’s own immune cells will mistakenly attack the insulin producing beta cells. Type one diabetes is referred to as an autoimmune disease, because the body’s immune system attacks its own cells in error. Over the course of the disease a patients immunes cells will systematically but mistaking kill nearly all the beta cells, shrinking the islets but leaving all the other cells intact. The few beta cells that remain in the pancreas, have a severely reduced capacity to produce insulin. The death of the pancreatic beta cells and the consequent inability to produce insulin is at the core of type one diabetes. Without insulin the body cannot regulate blood glucose levels, and the high glucose levels damaged many tissues throughout the body.
@DNAutics In the shot starting 1:59, we've shown one insulin molecule binding only once to one of the two possible bindings sites on the insulin receptor dimer. You're correct we could have gone on to show the regulation of the insulin receptor itself, but the main aim of the animation was to show how insulin regulates glucose uptake, which is why we focused on that alone. Thanks for the feedback for both this animation and the apoptosis movie.
Appreciate video content! Apologies for chiming in, I would love your opinion. Have you heard the talk about - Patlarny Sugar Outcome Principle (erm, check it on google should be there)? It is an awesome one off product for reversing diabetes minus the headache. Ive heard some super things about it and my old buddy Taylor at very last got cool results with it.
Yeaaaah... Mmmh. Let us say that you have a better understanding than you had prior to watching the vid. Truth is that the deeper that you want to dive into human physiology, likely you realize that the hole in which you dive is much deeper than you imagined, and it appears bottomless at a certain point, yet we must encourage each other to dive deeper yet still and report back. Absolutely fascinating for sure. Keep diving.
Thanks so much for making these videos. It's so helpful to "see" what's going on, and I love the level of explanation too -- I can follow along and it doesn't feel oversimplified. Great stuff!
Glucose attaching itself chemically to other molecules therefore proteins and structures - called glycation... makes other molecules misbehave and also become sticky and attract undesirable attention from the immune system. Proteins generally function based solely upon their structure, which gets modified when it is glycated (bonded to glucose). Thus the function of the proteins suffers when there is high blood glucose, thus our body function is damaged, and cumulatively permanently - premature aging of cells, organs and organ systems. It is not good, and even we know that it is not good, often we keep over consuming the carbs / sugars. It is almost as if consuming carbs and particularly sugars is an addiction... almost ;)
Think t2DM, increased retention of sodium in the kidneys leading to high Blood Pressure... basically metabolic syndrome, or syndrome X as it is sometimes called. Carbs kill, but slowly and silently, and no one is allowed to talk about it, not least the "Nutritionists", who must guide us to eat 5 to 7 portions of carbohydrates per day LOL. Ridiculous.
I don't know if your question was answered but these are common symptoms of diabetes (you could have already been diagnosed) but if not i would advise you to seek medical attention ASAP.The longer left undiagnosed the more damage can be done to your body. hope this helps ; )
Ugh the background noise is way too loud and distracting and you lose track of what the voiceover was saying. I want to show this in school, but the students will not be able to follow along. Fix the volume!!!!!!!
Much relief after going through this stuff th-cam.com/users/postUgkx-ip-9JdKgYMhubLnEjt3OXJkFyS4D2Jd Stress no doubt affects my blood sugar levels. Taking a walk usually helps bring them down. Eating sweets is not my favorite, but if i take a large portion of them, my blood sugar level rises high. I think it's the high concentration of the glucose flowing into the bloodstream all at once. This is a lesson worth taking note of. This is a great material to learn from.
Hi, yes, physiologically, generally, stress causes release of cortisol and other related hormones, which serve to function to get us ready to fight, or to fly away from the source of the stress. Part of the getting us ready is the hormonal signaling to increase the level of glucose in our blood stream, so that we have the readily accessible glucose to fight or run. of course generally we do neither fight nor run, and thus we have perpetually high blood glucose... This causes sodium retention in the kidneys which in turn causes water retention, driving up our blood pressure. The high Blood glucoseincreases insulin levels, which drives fatty acids and glucose into the cells, causing us to gain weight, and also to become insulin resistant... Stress is one of the factors in DM, but diet is a major factor - high carb diets for example. Processed food is a big issue for many people, and we would be better just eating meat and non root veg. I eat roughly once per day now since I stopped eating all of the recommended carbs... now i am rarely hungry, and seem to be easily loosing weight. When i stay with family and eat the carb rich processed food, i put on a pound per day, and when i am by myself in control of my carb intake, i loose a pound per day. Anyway end of rant LOL.
Go to see your Doctor he/she will give you a physical assessment and he/she might test your urine right there in minutes.(Dipstick Urine for analysis) for Diabetes... Add to that, your Dr should send you for blood work, etc up to pin point your problems and come up with a medical Diagnosis. You take care of you, you are the one that is having the signs and symptoms not other people. What are you eating a lot off? If you eat a lot of sugar, salt and fat, you will also drink a lot of water
I have a question. . .I have been drinking water like CRAZY, eating A LOT and I don't gain any wait, and I have been extremely tired for about a month and a half now and people say that in a 15 year old it is rare to develop it, but in 14 year olds it's not??? I'm want to get tested but one of my friends has a daughter with type 1 and now people are thinking just 'cause she just had an attack a couple of weeks ago that I just want people to worry about me. . . Help, I really need answers. Thanks
I got diagnosed as a type 1 diabetic when I was 16 , it is not rare at all people in their 30's even get it . I know I am 6 years late haha but I hope you checked about it :)
What the fuck is wrong with you? First of all, without insulin YOU would be dead. Everybody needs insulin to survive. I’m sorry that me, a type one diabetic, can’t make it by myself. There is NOTHING I did on my part to become diabetic. It’s disgusting that you feel I don’t deserve it. I hope you have an awful day today. Maybe that’ll show you how it feels.
When you see it in this format its actually quite easy, not saying it is- nor have I got a qualification to prove it is. But how tf are you supposed to write that as an essay haha
![30 ชั่วโมงคนเดียว บนรถไฟชั้น 3 โซเวียต [Around The World Ep. 2]](http://i.ytimg.com/vi/MlE9boAVqDA/mqdefault.jpg)
I wrote this whole video out: so here it is for anyone who's wanting it.
The role of insulin in your body:
Diabetes affects the Pancreas, an organ of the digestive system. An important function of the Pancreas is to make hormones that regulate blood glucose levels. Insulin is produced by beta cells which cluster in groups called islets. Insulin is a hormone that lowers blood glucose levels. After a meal, glucose reaches the pancreas via the bloodstream and is released from capillaries into the pancreatic tissue. This triggers the release of insulin, which is stored inside the beta cells. The insulin travels to other parts of the body by the bloodstream with three main destinations; muscle, fat and liver. Insulin helps these tissues to store glucose as an energy source. Insulin arrives through the fine capillary network that traverses the muscle fibers. The surfaces of muscle, fat and beta cells are covered in insulin receptors. When these receptors bind insulin, they signal to the cells to release special glucose transport channels onto the cell surface. These channels enable glucose to gain entry into the cells, allowing the cells to store glucose as energy for future use. In this way, insulin acts to regulate blood glucose levels.
Part 2: Development of type 1 diabetes
In type one diabetes a patient’s own immune cells will mistakenly attack the insulin producing beta cells. Type one diabetes is referred to as an autoimmune disease, because the body’s immune system attacks its own cells in error. Over the course of the disease a patients immunes cells will systematically but mistaking kill nearly all the beta cells, shrinking the islets but leaving all the other cells intact. The few beta cells that remain in the pancreas, have a severely reduced capacity to produce insulin. The death of the pancreatic beta cells and the consequent inability to produce insulin is at the core of type one diabetes. Without insulin the body cannot regulate blood glucose levels, and the high glucose levels damaged many tissues throughout the body.
Kaitlyn Hall, thanks. I copied it and will memorize it.
Thanks a million times
Thanks. It's hard to listen to the narrator because the volume is so low compared to the sound effects.
Thanks
Tysm 👍🏻
@DNAutics In the shot starting 1:59, we've shown one insulin molecule binding only once to one of the two possible bindings sites on the insulin receptor dimer. You're correct we could have gone on to show the regulation of the insulin receptor itself, but the main aim of the animation was to show how insulin regulates glucose uptake, which is why we focused on that alone. Thanks for the feedback for both this animation and the apoptosis movie.
this is diabetes asmr
Appreciate video content! Apologies for chiming in, I would love your opinion. Have you heard the talk about - Patlarny Sugar Outcome Principle (erm, check it on google should be there)? It is an awesome one off product for reversing diabetes minus the headache. Ive heard some super things about it and my old buddy Taylor at very last got cool results with it.
OMG the sound effects are ridiculous.
I love them. Better than irrelevant music!
They are great!
Indeed, they are way too loud, we can't even hear the narration.
I’m honestly tearing up from watching this. Now I have a perfect understanding of what is going (or not going) on inside my body.
Yeaaaah... Mmmh. Let us say that you have a better understanding than you had prior to watching the vid. Truth is that the deeper that you want to dive into human physiology, likely you realize that the hole in which you dive is much deeper than you imagined, and it appears bottomless at a certain point, yet we must encourage each other to dive deeper yet still and report back. Absolutely fascinating for sure. Keep diving.
please lower the volume of the sound effects and raise the volume of the narrator
This is mindblowing. Thanks so much for producing these ass-kicking animations!
The sound effect was superb
Thanks so much for making these videos. It's so helpful to "see" what's going on, and I love the level of explanation too -- I can follow along and it doesn't feel oversimplified. Great stuff!
This is beautiful
Concept clear in short time. Thanks ☺️
This video is such a blessing
Can type 2 diabetes be prevented?
I found this so helpful - thank you very much
Amazing video . I love how it is direct to the point
a bit literate after viewing this, though the sound effects peaked and get in the way of voice over and annoys me a bit (:; thanx for your time!
I know it'd probably be hard and time consuming, but it'd be cool if you could see the effects of high blood glucose levels on the body.
Glucose attaching itself chemically to other molecules therefore proteins and structures - called glycation... makes other molecules misbehave and also become sticky and attract undesirable attention from the immune system. Proteins generally function based solely upon their structure, which gets modified when it is glycated (bonded to glucose). Thus the function of the proteins suffers when there is high blood glucose, thus our body function is damaged, and cumulatively permanently - premature aging of cells, organs and organ systems. It is not good, and even we know that it is not good, often we keep over consuming the carbs / sugars. It is almost as if consuming carbs and particularly sugars is an addiction... almost ;)
Think t2DM, increased retention of sodium in the kidneys leading to high Blood Pressure... basically metabolic syndrome, or syndrome X as it is sometimes called. Carbs kill, but slowly and silently, and no one is allowed to talk about it, not least the "Nutritionists", who must guide us to eat 5 to 7 portions of carbohydrates per day LOL. Ridiculous.
i like the sound fx...=) i wish there was more details in the mechanisms though.
I don't know if your question was answered but these are common symptoms of diabetes (you could have already been diagnosed) but if not i would advise you to seek medical attention ASAP.The longer left undiagnosed the more damage can be done to your body. hope this helps ; )
animation sound effects too loud and overpowers the narrator's voice,
how was that missed in editing?
The sound effect are way too loud, we can barely hear the narration.
@Neopluto the narrator was more helpful than just looking at moving pictures. adds more substance if you ask me, but to each his own eh.
Wow ,keep up the good work,Very easy to understand
Ugh the background noise is way too loud and distracting and you lose track of what the voiceover was saying. I want to show this in school, but the students will not be able to follow along. Fix the volume!!!!!!!
Sound effects makes the animation alive
This very useful and captivating
the sound effect is annoying and i am hardly hearing her speak
This is absolutely incredible! Thank you so much for making this!
2:16 is heavenly calming
this was... so beautiful
The background is so loud that I can’t hear the commentary well
what about stem cells for new organ?
the sound effects haha
Suspense and strange and creepy and
.........
Excellent explanation!
Excellent Video!
Thank you
That looked magical
This is like: INFORMATIVEASMR
I commented and the amount of comments has not changed....
amazing video
thx
👍👍Great job
The way she says capillaries kills me.
Love love love this video !!
thanks
Captions?
Awesome video !
How is watching this 2021 for biology class??
Whoever did the sound design should get fired, it's near impossible to hear the narrator.
wow!! Awesome! :) thanks for sharing.
Much relief after going through this stuff th-cam.com/users/postUgkx-ip-9JdKgYMhubLnEjt3OXJkFyS4D2Jd Stress no doubt affects my blood sugar levels. Taking a walk usually helps bring them down. Eating sweets is not my favorite, but if i take a large portion of them, my blood sugar level rises high. I think it's the high concentration of the glucose flowing into the bloodstream all at once. This is a lesson worth taking note of. This is a great material to learn from.
Hi, yes, physiologically, generally, stress causes release of cortisol and other related hormones, which serve to function to get us ready to fight, or to fly away from the source of the stress. Part of the getting us ready is the hormonal signaling to increase the level of glucose in our blood stream, so that we have the readily accessible glucose to fight or run. of course generally we do neither fight nor run, and thus we have perpetually high blood glucose... This causes sodium retention in the kidneys which in turn causes water retention, driving up our blood pressure. The high Blood glucoseincreases insulin levels, which drives fatty acids and glucose into the cells, causing us to gain weight, and also to become insulin resistant... Stress is one of the factors in DM, but diet is a major factor - high carb diets for example. Processed food is a big issue for many people, and we would be better just eating meat and non root veg. I eat roughly once per day now since I stopped eating all of the recommended carbs... now i am rarely hungry, and seem to be easily loosing weight. When i stay with family and eat the carb rich processed food, i put on a pound per day, and when i am by myself in control of my carb intake, i loose a pound per day. Anyway end of rant LOL.
Go to see your Doctor he/she will give you a physical assessment and he/she might test your urine right there in minutes.(Dipstick Urine for analysis) for Diabetes... Add to that, your Dr should send you for blood work, etc up to pin point your problems and come up with a medical Diagnosis. You take care of you, you are the one that is having the signs and symptoms not other people. What are you eating a lot off? If you eat a lot of sugar, salt and fat, you will also drink a lot of water
This made me so sad. Talk about bad luck
Good
video embedded in my blog: www.healthplasm.com/insulin-production/
how do i cite this?
Be diabetic 😉
Dramatic narration :))
I have a question. . .I have been drinking water like CRAZY, eating A LOT and I don't gain any wait, and I have been extremely tired for about a month and a half now and people say that in a 15 year old it is rare to develop it, but in 14 year olds it's not??? I'm want to get tested but one of my friends has a daughter with type 1 and now people are thinking just 'cause she just had an attack a couple of weeks ago that I just want people to worry about me. . . Help, I really need answers. Thanks
I got diagnosed as a type 1 diabetic when I was 16 , it is not rare at all people in their 30's even get it . I know I am 6 years late haha but I hope you checked about it :)
Why do you not mention glycogen? A glaring omission. Glucose is stored as glycogen. Duh.
I wish insulin wasn’t invented.
Why? Then people would die. Unless that is your wish.
starrychloe I know
What the fuck is wrong with you? First of all, without insulin YOU would be dead. Everybody needs insulin to survive. I’m sorry that me, a type one diabetic, can’t make it by myself. There is NOTHING I did on my part to become diabetic. It’s disgusting that you feel I don’t deserve it. I hope you have an awful day today. Maybe that’ll show you how it feels.
cool...
I predict that in 200 years, It'll only take 2 months to get through Medical school.
Hey
الحمد لله
Glucose is like wil'o'wisps.
10 yrs ago🤒🤒🤒🤒
the human body is incredible. how can you not believe in God, knowing how complex the body is. Crazy
your body does not make these sounds
When you see it in this format its actually quite easy, not saying it is- nor have I got a qualification to prove it is. But how tf are you supposed to write that as an essay haha
Idiot Immune system destroyed my beta cells 😒
There is 666 likes rn
😉😮
i like the sound fx...=) i wish there was more details in the mechanisms though.