Tryptophan Metabolism (Degradation) and the Kynurenine Pathway

Lesson on Tryptophan Degradation (Metabolism) and the Kynurenine Pathway. Tryptophan is an essential amino acid required for the production of serotonin and melatonin. Tryptophan can be degraded by the kynurenine pathway, which can be activated by stress and immunocytokines. Activation of the Kynurenine pathway can reduce the production of serotonin. Kynurenine metabolism will eventually lead to the production of the end metabolites quinolinic acid and picolinic acid. Quinolinic acid and the Kynurenine Pathway have been implicated in various psychiatric conditions including major depressive disorder, due to the reduction in serotonin production and function.
I hope you find this video helpful. If you do, please like and subscribe for more videos like this one :)
Subscribe for more free medical lessons / @jjmedicine
-------------------------------------------------------------------------------------------------------------
For books and more information on these topics
www.amazon.com...
Support future lessons (and get other cool stuff) ➜ / jjmedicine
Follow me on Twitter! ➜ / jj_medicine
Come join me on Facebook! ➜ / jj-medicine-1006426481...
Start your own website with BlueHost ➜ www.bluehost.c...
Check out the best tool to help grow your TH-cam channel (it’s helped me!)
www.tubebuddy....
-------------------------------------------------------------------------------------------------------------
Check out some of my other lessons.
Medical Terminology - The Basics - Lesson 1:
• Medical Terminology - ...
Fatty Acid Synthesis Pathway:
• Fatty Acid Synthesis P...
Wnt/B Catenin Signaling Pathway:
• Wnt/β-Catenin Signalin...
Upper vs. Lower Motor Neuron Lesions:
• Upper and Lower Motor ...
Lesson on the Purine Synthesis and Salvage Pathway:
• Purine Synthesis and S...
Gastrulation | Formation of Germ Layers:
• Gastrulation | Formati...
Introductory lesson on Autophagy (Macroautophagy):
• Autophagy | Macroautop...
Infectious Disease Playlist
• Infectious Diseases
Dermatology Playlist
• Dermatology
Pharmacology Playlist
• Pharmacology
Hematology Playlist
• Hematology
Rheumatology Playlist
• Rheumatology
Endocrinology Playlist
• Endocrinology
Nephrology Playlist
• Nephrology
----------------------------------------------------------------------------------------------------
**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
----------------------------------------------------------------------------------------------------
Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :) And please don't hesitate to send me any messages if you need any help - I will try my best to be here to help you guys :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

[@camwhitman5425]

Excellent! I’m a former IT guy of 26 years and I recently took up learning this health and biological information just out of interest, because I find learning these concepts very challenging.

[@lisa-rouletlawfirm9307]

Super cool to know that tryptophan + inflammatory cytokines or + stress (cortisol) = kynurenate acid / quinolinic acid (which is neurotoxic/can cause depression), and lead away from serotonin (feelings of wellbeing) and melatonin (better sleep). Biochem incentive to reduce inflammation and stress :)

[@lynnew8811]

This is the very fist channel that actually explains metabolic pathways in an understadable and complete way. Several methabolic pathways I have had researched yet didnt understand/find here they are. Its lovely (greetings from mx)

[@swen6797]

Still gotta use the information wisely.

[@streamdungeon5166]

Good content... that cut off right before it got really interesting and informative.

[@mostafaalatweh4850]

Thank you so much sir for this amazing video. Could I ask about NAD (niacin) please, what I got from your explanation is that NAD is one of the metabolites of the kynurenine pathway, so if we give NAD (niacin) in enough high doses to psychiatric patients then we can reduce this catabolic pathway and shift it to more serotonin and melatonin synthesis, and the decreased level of neurotoxic metabolites and then treat the patients. Please correct me sir if it is wrong.

[@geekspeak1066]

Eat more meat

[@a.i.1823]

Thank you very much for this very clear and concise summary!

[@bevnae]

What are some of the most effective ways to lower kynurenine other than Vitamin B6? Thanks!

[@ParallaxView111]

Do a search on kynurenine NAC

[@Preeti198019]

Can you please provide a reference for this information?

[@alizbhahussainkhan5696]

Can you please mention book name from where you have taken this information i need for my presentation

[@د.عرفاتالسليمان]

thanks for this video, link between stress and insomnia

[@czarnykotek2000]

Thank you for this video, its a life saver❤

[@Роза-т5ъ]

Excellent! Thank you very much from Russia!❤

[@gracerobertson8772]

Came here after watching Robert Phair's talk about ME/CFS and Metabolic Traps.

[@Niptucked]

Any relation to this and celiac disease?

[@dominic2446]

is picolinic acid associated with psychiatric disorders?

[@bodycareforhealth8656]

brilliant clear and informative thanks so much

[@example101]

Could you do a follow up of tryptophan in context of Chlostridium Sprogenes with/without prebiotic sugars for healing gut? Seeing this makes me think/worry that boosting tryptophan foods intake without knowing if gut has c. sporogenes might be seriously counter productive.

[@suelinboby]

treatment to reduce quinolinic acid?

[@TrainingIsBelieving]

can I get the peer reviewed sources linked to me please ?

[@NickArcade]

So basically don't use l-tryptophan upon waking when cortisol levels are spiked

[@gabyfridman7475]

Excellent. Thank You !!!

[@jawza7x]

Sir please make video on tyrosine metabolism and alkaptonuria

[@edwardpcs]

indoleamine 2 3-dioxygenase (IDO)

[@hema11901]

Good job

[@olgaw1620]

thank you for this!

[@jjmedicine]

You’re very welcome! Glad you liked it :)

[@alexserrell5383]

Thanks.

[@ambrosialovly3676]

If there's depression there's a lack of depression

[@aurielcastro9903]

I'm here to find a solution for my son's eczema flair up.

[@lorenzomiguelalde2500]

U didnt help