I like the graph. So for the days when we can’t get sun exposure, assuming melatonin half life of 20-30 minutes and a 15% absorption rate, we probably need 15mg every 30 minutes for 10 hours, with first dose 60mg to approximate the curve. 60mg 5-8 times a day might be reasonable too? Vitamin D might be more important but the active hormone form is highly regulated so increasing vitamin D3 has limited benefits. Maybe not true for melatonin…. This is very interesting. Thank you!
Sunlight is not enough for daylight melatonin production ! Bcs to be melatonin to be produced in day light ,your body temperature and the surrounding temperature need to be close to around 37 degree centrigrade, ur surrounding temperature must be hot ,not warm ,not cool ,not cold ,all other climate humidity and miosture absorb infrared heat before reaching ur body
Another great video presentation, I’ve been working and playing outdoors most of my life. I stopped using sunscreen back in the late 90’s and rarely use sun or reading glasses, I’m 73
My entire adult life consisted of exercise and sun exposure. Being in the commercial asphalt maintenance business, residential homebuilding and more, the work was 6 a.m. - 6-8 p.m. outdoors and for decades. Some of us were lucky to have careers that kept us healthy. My last project was a hotel build at 10,000 feet in the Andes of Peru where the sun was powerful but I have been inside since then (2020) mostly doing research and trying to figure out what I want to do with the next chapter of my life. I've become fascinated with HBOT and red light therapy which brought me to your channel. New subscriber here binge watching your videos after watching all I could of Kruse, Gulhane, Zimmerman and Alexis Cowlen.... Thanks for what you do!
I love all those guys. Dr Kruse is at least partly responsible for me being on this journey, as I have been a member of his site for years. I know Max and he is a very nice young doctor who is doing amazing things with his channel.
Trying to with redlight-infrared coupled with the sauna space infrared bulb and a halogen flood lamp for some synergistic UVB exposure. Also trying to get outside as much as possible for the full spectrum light. This is all to compensate for living my adult life in Seattle after youth and adolescence in Miami/Cocoa Beach, Florida. (My attempt to deal with SAD) Do supplement with 10,000 in Vitamin D3 and 300 K2 daily.
Theres a doc on youtube that high doses melatonin around 200 mg a day. Personally i make my own liposomal melatonin about 70mg at night it works amazingly. You csn get powdered melatonin from bulk supplements. I also get sunlight every morning to properly set my rhythm.
I've seen higher doses recommended than that! I really do think you are better off making your own nearly unlimited quantities with infrared/sunlight. Unless you had cancer already, that would be another situation and recommendation.
Depends on your age, disease burden, and a lot of other factors. I would get the most natural light I could tolerate. Does not have to be direct skin, can be in shade. Then work on maximum darkness, minimization of blue/green light at night. Then worry about supplements.
I was trying to compute the total-body melatonin from exercise from the graph at 6:40 and I get only approximately 1 mcg based on 4 liters blood volume! That's much much less than a typical dose of OTC melatonin which are typically in mg doses. Did I calculate that wrong or is there vastly more melatonin locked up in tissues than in circulation?
Bob I am going to give you a hard time jokingly. You math people lol! Are you deriving the area under the curve lol? I am kidding of course, and am a bit jealous of your math skills. A couple of things. Number one absorption. Oral melatonin is not highly absorbed. Second, distribution. Is it going to get to the target tissue? Light solves that issue because its made in nearly unlimited quantities in the hyperlocal environment and acts on the same cell its produced, or adjacent cells. If you are not a cancer patient, I would maximize my light and dark environment before messing with supplements.
@@DrCaseyPeavler OK, my calculation might not even be relevant. If it is mostly produced in the same location in which it is consumed then the "free" circulating melatonin might just be a minor player. BTW, the "math" was just concentration x blood-volume. Of course, people like me are going to give you a hard time right back - if you're going to get into the weeds.... Hopefully, even if these Qs are not quite on target, it stimulates your thinking to put more of the pieces together. Thanks Dr Casey!
I am not saying they are irrelevant. Not at all. Your questions are extremely relevant and do stimulate more questions for me. I would say that we know quite a bit more today than 10 years ago about melatonin. But we still have a lot to learn. I look forward to reading about future discoveries and being able to share it here on this channel and with this community!
More research needs to be done into Blood Type and Pancreatic Cancer, also Glioblastoma ! I am in many of the FB Groups for Cancer, most are Type A- or A+ (That doesnt mean everyone with A gets it, or other blood types can't, but higher amounts) Type B seem to have more Throat and Neck cancers. B Negative's very very rarely get cancer this is from looking at 5,000 plus people who shared their cancer and their blood type.
@@DrCaseyPeavler That's a great blood type!! My father is B- and he eats/lives the same lifestyle as 6 of his brothers, they all have health conditions such as diabetes, heart attacks and 2 died of cancer. He doesn't! He drinks alcohol heavily and has been in 2 car accidents, but is in perfect health - its crazy!! Only outlier is he is B Negative
Seems very odd the interaction of humans and sunlight hasn't been studied in depth decades ago. I think that because when in college in the early 1970s a roommate's dad worked at a tree fruit experiment station where he tested wavelenghts, colors, effects on plants over 50 years ago.
I could completely understand that! I think this discovery has turned much of what we thought we knew about melatonin on its head. From my understanding, the vast majority of melatonin is made and consumed locally within the same cell or adjacent cells. Whereas pineal melatonin is released into the bloodstream. There are intracellular nuclear MT receptors and there are extracellular MT receptors. It may be a specific bell curve of release that the body recognizes as circadian signal, is could be solely timing. I am in the process of studying the circadian clock genes and it has been difficult for me to grasp. If I can get an obvious clear answer I will share it.
Subcellular melatonin aslo makes sleep in the daylight Do you know the laziest people who sleep day and night ? the ARABS,the berbers,THE SOMALI peaple in middle 🌏east and north and east africa. They drink caffeinated drink ,tea,coffe,ckat ,coca,nicotine ,sisha throughout the day to counteract their sleep ,not sleep in afraid heat stroke and lazyness .those reagon are the lowest cancer rate,autoimmune disease in the 🌎🌍world bcs of the melatonin produced by infrared throughout the year
Very interesting observations. I don’t know much about those cultures to be very honest. BUT if you look at epidemiological studies and data, the more solar exposure one gets and generally the closer you are to the equator, the lower the modern disease risk goes: cancer, HTN, heart disease, autoimmunity, inflammatory bowel diseases, psychiatric conditions also.
Hello Doctor, are tou recommebdibg that we get batural sublight, especially in the early morning? I have a far infrared blanket. Should I also use that? Thanks for your information -- I try to follow!!
I am recommending as much natural sunlight as tolerated. Do not burn yourself and be patient as your melanin increases to be able to handle stronger UV with time. But for the infrared portion. Any time the sun up is beneficial, as infrared makes up 50% of solar spectrum. The exact spectrum of infrared that increases melatonin is not definitively known yet. Could be one wavelength like 850nm, could be an entire band of IR like infrared A/Near infrared. Mid infrared or far infrared may have some effect also. There may be a synergistic effect of all the red and infrared spectrums. This is why sun is first and foremost recommended. Can you get benefit from photobiomodulation panels, Near infrared heat bulbs, mid/far infrared sauna. Absolutely through a variety of mechanisms. Will all of the above have the same or similar effects on melatonin production, unknown at the moment. The only thing I would say about the blankets or the domes. Yes they provided infrared heat. But I don’t like how close they are to the body. The electric and magnetic fields will likely be high, and your body voltage will increases substantially. I am not a huge fan of that to be honest.
From what I have learned and I can be wrong... Serotonin is a precursor to melatonin and the exercise boosts serotonin production. That might be why exercise might can melatonin?
It’s a great point! The study just simply must be done with exercise not in the sun, in the sun without exercise, etc to tease out the details. Then test specific wavelengths and see if it is just a few key frequencies or sunlight as a whole or infrared as a whole.
I don't know about these sona bulbs you mentioned but I was using 4 regular 250 watt heat lamp bulbs ten years ago. It was quite warm. Uncomfortable. I kinda 8ted it. But it's supposed to be good for you. Like a sauna? Anyway, it mostly made me mad.
You have to find the perfect distance between you and the bulb. If you’re too close it hurts, but if you can find the right distance, it feels really healing.
What do you think of the advantages and disadvantages of high-dose melatonin (200+mg/day) based on research by Russel Reiter, Doris Loh, and Ryker Black? A quick Google Scholar or TH-cam search on melatonin and one of these researchers will reveal the great interest in better understanding the actions of high-dose melatonin on health.
I think for general health I am pretty against it personally. I think a much better idea would to get as much Sun exposure as possible and or augment with photobiomodulation, red/IR heat lamp bulbs, or infrared sauna to produce essentially unlimited melatonin in every cell exposed. If I had cancer, I would do that plus probably supplement very high doses multiple times per day.
@@DrCaseyPeavler Thank you for your reply. I have recurrent prostate cancer and have started taking a few 100mg several times a day. I haven't experienced any side effects, and so far, the cancer hasn't returned since my last radiation treatment 10 months ago.
God that is amazing news! If you are doing well on it and having no side effects, keep going! I would continue to push you to get outside for all the OTHER benefits including huge amounts of endogenous melatonin production.
![[안방1열 직캠4K] 베이비몬스터 치키타 'DRIP' (BABYMONSTER CHIQUITA FanCam) @SBS Inkigayo 241110](http://i.ytimg.com/vi/tnlxo79cAqY/mqdefault.jpg)
Who here picks sunlight and Near light infrared light over supplements?
I like the graph. So for the days when we can’t get sun exposure, assuming melatonin half life of 20-30 minutes and a 15% absorption rate, we probably need 15mg every 30 minutes for 10 hours, with first dose 60mg to approximate the curve. 60mg 5-8 times a day might be reasonable too?
Vitamin D might be more important but the active hormone form is highly regulated so increasing vitamin D3 has limited benefits. Maybe not true for melatonin….
This is very interesting. Thank you!
Sunlight is not enough for daylight melatonin production !
Bcs to be melatonin to be produced in day light ,your body temperature and the surrounding temperature need to be close to around 37 degree centrigrade, ur surrounding temperature must be hot ,not warm ,not cool ,not cold ,all other climate humidity and miosture absorb infrared heat before reaching ur body
Source? @@mohammedabdulkadir2004
Really
Getting NIR every day now. Trying to get the mitos Going!
Another great video presentation, I’ve been working and playing outdoors most of my life. I stopped using sunscreen back in the late 90’s and rarely use sun or reading glasses, I’m 73
Thank you for your kindness! I would have to imagine you vitamin D levels are good as well as your melatonin production!
Amazing to know that sunlight boost melatonin production.
To a HUGE almost unlimited amount with enough time outside! I was shocked when I learned it.
@@DrCaseyPeavler you are doing awesome, watched many of your videos. Keep the good work going!
Thank you! Its very encouraging for me to hear such kindness!
I must second that. Fantastic information, Doc. 👍@@Ranjanagupta0807
Very kind of you also. Your support helps motivate me to keep going and getting this important information out!
Yes, 'a beautiful symphony going on'! We appear to far too often get so distracted that we don't listen very well to this music.
Thanks for showing us more of this complexity of the music.
True Ray
Thank you for your enlightening videos. How kind of you to answer the viewers' comments. Most do not at all.
I really try! Now it’s becoming very hard to comment on everyone’s follow up comments but the initial ones I almost always do
My entire adult life consisted of exercise and sun exposure. Being in the commercial asphalt maintenance business, residential homebuilding and more, the work was 6 a.m. - 6-8 p.m. outdoors and for decades. Some of us were lucky to have careers that kept us healthy. My last project was a hotel build at 10,000 feet in the Andes of Peru where the sun was powerful but I have been inside since then (2020) mostly doing research and trying to figure out what I want to do with the next chapter of my life. I've become fascinated with HBOT and red light therapy which brought me to your channel. New subscriber here binge watching your videos after watching all I could of Kruse, Gulhane, Zimmerman and Alexis Cowlen.... Thanks for what you do!
I love all those guys. Dr Kruse is at least partly responsible for me being on this journey, as I have been a member of his site for years. I know Max and he is a very nice young doctor who is doing amazing things with his channel.
Trying to with redlight-infrared coupled with the sauna space infrared bulb and a halogen flood lamp for some synergistic UVB exposure. Also trying to get outside as much as possible for the full spectrum light. This is all to compensate for living my adult life in Seattle after youth and adolescence in Miami/Cocoa Beach, Florida. (My attempt to deal with SAD) Do supplement with 10,000 in Vitamin D3 and 300 K2 daily.
How are you doing since implementing the sauna space/halogen light?
how about omega 3, B1, B12, glycine for good sleep and regeneration?
Theres a doc on youtube that high doses melatonin around 200 mg a day. Personally i make my own liposomal melatonin about 70mg at night it works amazingly. You csn get powdered melatonin from bulk supplements. I also get sunlight every morning to properly set my rhythm.
I've seen higher doses recommended than that! I really do think you are better off making your own nearly unlimited quantities with infrared/sunlight. Unless you had cancer already, that would be another situation and recommendation.
How much infrared a day would you recommend
How do you make the liposomal melatonin
Depends on your age, disease burden, and a lot of other factors. I would get the most natural light I could tolerate. Does not have to be direct skin, can be in shade. Then work on maximum darkness, minimization of blue/green light at night. Then worry about supplements.
Thanks!
You’re welcome!
You are amazing bro
Thank you for your kindness. I am glad you are enjoying the channel!
Amazing information
I am glad you enjoyed it!
I was trying to compute the total-body melatonin from exercise from the graph at 6:40 and I get only approximately 1 mcg based on 4 liters blood volume! That's much much less than a typical dose of OTC melatonin which are typically in mg doses. Did I calculate that wrong or is there vastly more melatonin locked up in tissues than in circulation?
Bob I am going to give you a hard time jokingly. You math people lol! Are you deriving the area under the curve lol? I am kidding of course, and am a bit jealous of your math skills.
A couple of things. Number one absorption. Oral melatonin is not highly absorbed. Second, distribution. Is it going to get to the target tissue? Light solves that issue because its made in nearly unlimited quantities in the hyperlocal environment and acts on the same cell its produced, or adjacent cells. If you are not a cancer patient, I would maximize my light and dark environment before messing with supplements.
@@DrCaseyPeavler OK, my calculation might not even be relevant. If it is mostly produced in the same location in which it is consumed then the "free" circulating melatonin might just be a minor player. BTW, the "math" was just concentration x blood-volume. Of course, people like me are going to give you a hard time right back - if you're going to get into the weeds.... Hopefully, even if these Qs are not quite on target, it stimulates your thinking to put more of the pieces together. Thanks Dr Casey!
I am not saying they are irrelevant. Not at all. Your questions are extremely relevant and do stimulate more questions for me.
I would say that we know quite a bit more today than 10 years ago about melatonin. But we still have a lot to learn. I look forward to reading about future discoveries and being able to share it here on this channel and with this community!
More research needs to be done into Blood Type and Pancreatic Cancer, also Glioblastoma !
I am in many of the FB Groups for Cancer, most are Type A- or A+
(That doesnt mean everyone with A gets it, or other blood types can't, but higher amounts)
Type B seem to have more Throat and Neck cancers.
B Negative's very very rarely get cancer
this is from looking at 5,000 plus people who shared their cancer and their blood type.
Interesting, a topic I will be honest I know nothing about. Sounds like it needs to be investigated thoroughly!
it does seem AB- and B- are a lot luckier and don't get cancer
I am B- so thank God for that, but I was not aware of these associations…
@@DrCaseyPeavler That's a great blood type!! My father is B- and he eats/lives the same lifestyle as 6 of his brothers, they all have health conditions such as diabetes, heart attacks and 2 died of cancer.
He doesn't!
He drinks alcohol heavily and has been in 2 car accidents, but is in perfect health - its crazy!! Only outlier is he is B Negative
Wow 😮
Seems very odd the interaction of humans and sunlight hasn't been studied in depth decades ago. I think that because when in college in the early 1970s a roommate's dad worked at a tree fruit experiment station where he tested wavelenghts, colors, effects on plants over 50 years ago.
You cannot patent or make money off of sunlight. Most research is funded by industry to figure out patentable drugs to make a profit sadly.
I have always heard about melatonin's role at night in order to promote good sleep but now i'm confused.. if we produce melatonin during the day...
I could completely understand that! I think this discovery has turned much of what we thought we knew about melatonin on its head. From my understanding, the vast majority of melatonin is made and consumed locally within the same cell or adjacent cells. Whereas pineal melatonin is released into the bloodstream. There are intracellular nuclear MT receptors and there are extracellular MT receptors. It may be a specific bell curve of release that the body recognizes as circadian signal, is could be solely timing. I am in the process of studying the circadian clock genes and it has been difficult for me to grasp. If I can get an obvious clear answer I will share it.
@@DrCaseyPeavler thanks! That logic makes some sense.
It seems to but it’s pure speculation. Dr. Kruse I would imagine has a better explanation than I would at this point
Subcellular melatonin aslo makes sleep in the daylight
Do you know the laziest people who sleep day and night ?
the ARABS,the berbers,THE SOMALI peaple in middle 🌏east and north and east africa. They drink caffeinated drink ,tea,coffe,ckat ,coca,nicotine ,sisha throughout the day to counteract their sleep ,not sleep in afraid heat stroke and lazyness .those reagon are the lowest cancer rate,autoimmune disease in the 🌎🌍world bcs of the melatonin produced by infrared throughout the year
Very interesting observations. I don’t know much about those cultures to be very honest. BUT if you look at epidemiological studies and data, the more solar exposure one gets and generally the closer you are to the equator, the lower the modern disease risk goes: cancer, HTN, heart disease, autoimmunity, inflammatory bowel diseases, psychiatric conditions also.
is this intracellular melatonin important for healing of damaged mitochondria (cancer included)?
Yes and Yes! Just hold on…I can hardly wait to share how powerful melatonin is!
@@DrCaseyPeavler th-cam.com/video/SXfOtQkHlig/w-d-xo.html
Thank you!
Hello Doctor, are tou recommebdibg that we get batural sublight, especially in the early morning?
I have a far infrared blanket. Should I also use that?
Thanks for your information -- I try to follow!!
I am recommending as much natural sunlight as tolerated. Do not burn yourself and be patient as your melanin increases to be able to handle stronger UV with time. But for the infrared portion. Any time the sun up is beneficial, as infrared makes up 50% of solar spectrum.
The exact spectrum of infrared that increases melatonin is not definitively known yet. Could be one wavelength like 850nm, could be an entire band of IR like infrared A/Near infrared. Mid infrared or far infrared may have some effect also. There may be a synergistic effect of all the red and infrared spectrums. This is why sun is first and foremost recommended.
Can you get benefit from photobiomodulation panels, Near infrared heat bulbs, mid/far infrared sauna. Absolutely through a variety of mechanisms. Will all of the above have the same or similar effects on melatonin production, unknown at the moment.
The only thing I would say about the blankets or the domes. Yes they provided infrared heat. But I don’t like how close they are to the body. The electric and magnetic fields will likely be high, and your body voltage will increases substantially. I am not a huge fan of that to be honest.
@@DrCaseyPeavler thank you very much.
You are very welcome!
From what I have learned and I can be wrong... Serotonin is a precursor to melatonin and the exercise boosts serotonin production. That might be why exercise might can melatonin?
It’s a great point! The study just simply must be done with exercise not in the sun, in the sun without exercise, etc to tease out the details. Then test specific wavelengths and see if it is just a few key frequencies or sunlight as a whole or infrared as a whole.
Thanks
My pleasure!
Ah... You referred to this video a few days ago.. Will watch it!
Hope you like it! There is much more to come!
I don't know about these sona bulbs you mentioned but I was using 4 regular 250 watt heat lamp bulbs ten years ago. It was quite warm. Uncomfortable. I kinda 8ted it. But it's supposed to be good for you. Like a sauna? Anyway, it mostly made me mad.
You have to find the perfect distance between you and the bulb. If you’re too close it hurts, but if you can find the right distance, it feels really healing.
How to kill this uterine cancer??
What do you think of the advantages and disadvantages of high-dose melatonin (200+mg/day) based on research by Russel Reiter, Doris Loh, and Ryker Black? A quick Google Scholar or TH-cam search on melatonin and one of these researchers will reveal the great interest in better understanding the actions of high-dose melatonin on health.
I think for general health I am pretty against it personally. I think a much better idea would to get as much Sun exposure as possible and or augment with photobiomodulation, red/IR heat lamp bulbs, or infrared sauna to produce essentially unlimited melatonin in every cell exposed. If I had cancer, I would do that plus probably supplement very high doses multiple times per day.
@@DrCaseyPeavler Thank you for your reply. I have recurrent prostate cancer and have started taking a few 100mg several times a day. I haven't experienced any side effects, and so far, the cancer hasn't returned since my last radiation treatment 10 months ago.
God that is amazing news! If you are doing well on it and having no side effects, keep going! I would continue to push you to get outside for all the OTHER benefits including huge amounts of endogenous melatonin production.
4 hours of intense exercise, good God. Did they get navy seals for that study? Too funny.
I can say it wasn’t me! lol
And, the study was done with labs bathed in LED and fluorescent lights? And, the exercise was too?
Nope, done outside completely. Thats why it is impossible to say it’s only NIR that is causing the effect.
@@DrCaseyPeavler Good.
Yup that’s what makes the paper/study so good but also raises more questions!
Melatonin supplements make my restless legs so bad! Even 1-2 mg at bed
Oh wow 😮 I’m sorry to hear that. Add that to the list of reasons I recommend sunlight as a way to massively increase melatonin