I have tremendous respect for Professor Russell J Reiter; met him personally at a symposium, and have followed his research for the past 15+ years ever since. I, too, was disappointed that Professor Reiter was not present for this presentation, however, I am entirely in agreement that focusing and honoring Prof Reiter in a presentation about him, his research, and accomplishments is well deserved and well worth the time. I have a quite a few things more to add to the discussion, but let me sum it up that he has tremendous support and respect among the scientific community, is passionate sharing knowledge, produced world-renowned scientists who studied in his lab as students, and is the most kindest man you will ever be fortunate to meet. -- Audrey Fischer, Chicago
Thank you for your observations. Dr. Meschino has studied the works of many profound experts in various fields and our purpose is to spread the best information we can find from said experts. I know Professor Reiter has many videos on TH-cam that he has made and of course we encourage all to search for and experience his words directly as well! In the meantime, we will do our best to find the leading experts and share their expertise as well as Dr. Meschino's himself! If you would like further information on Dr. Meschino or his professional supplement line, feel free to contact me directly at tonda@adeeva.com
Dr. Reiter. What of the claims of increased prolactin and the effects of that? That sounds like a serious side effect on amounts over 5 mg and/or outside of night time usage.
I see many similar attributes to the body with Vit D3 & melatonin. Could it be in the coming years that the dose with melatonin will be recommended increase like how vit D3 did!
We are regularly told it's not necessary to take high doses (over 3 mg) of melatonin for sleep regulation. But what are optimal doses for all of these other benefites of melatonin?
Hi, Brian, I haven't seen much that shows benefits above 3mg except as immune support, then up to about 10mg. I know there was a comment previously about articles on PubMed that indicate some benefit at higher dosages, I haven't had a chance to go over those yet. But if you can access them at PubMed, it's probably worth having a look. Sorry I can't be more help at the moment. I'll try and update once I've found and read those studies :)
@@DrJamesMeschino For those higher doses regarding immune support, is there a preference for time of day. In other words, is there benefit to taking melatonin in the morning or afternoon, in addition to a smaller dose later for sleep regulation? Thanks for your response.
@@briandriscoll1480 Honestly I'm not entirely clear on that either. I'm hoping I'll find some support regarding that as I find and study the PubMed research. If I do find something, I'll share - you likewise please if you find it first :)
check out Dr. Dietrich Klinghardt and Dr. John Lieurance. They're using much larger doses to heal people of all kinds of conditions, taking it topically through the skin or via suppositories. I'm talking 200+ mg.
Dr Reiter takes 180mg daily, Dr Doris Loh takes 1-3 grams daily, it seems we also make lots of melatonin within our mitochondria from sunlight NIR which penetrates several inches into our body. To match this amount, considering 15% absorption and short half life of 20-40 minutes, we need to take 10-15 mg every hour from 9am to 7 pm, or 30-60mg every two hours (If we avoid the sun). We also make about 100-120mg daily in our gut but not sure any gets into our bloodstream. I don’t think so.
Pretty much any brand is fine, it's all the same quality. When it comes to how much, it depends. I would start with 3mg one hour before you want to go to sleep. If that doesn't seem to work, increase it to 5mg. Be careful going higher than that as if you take more than you need, you'll have strange, disturbing dreams, which sort of defeat the purpose. If that happens, reduce the dosage the next night. It takes a bit of trial and error, but for most people, 3 - 5mg is plenty. Hope this helps!
Here is a link to our product Sleep E Naturals. It contains a smaller amount of melatonin, and 5-HTP, a form of the amino acid tryptophane that will convert to melatonin if you need slightly more. So it's adaptable to your requirements. The link is below, and if you have further questions, feel free to contact me at tonda@adeeva.com adeevainfo.com/wp-content/uploads/2020/10/Adeeva-Practitioner-Features-and-Benefits-Guide-Sleep-Naturals.pdf
Hi, there, yes that dose does seem high. I've mainly recommended 20mg daily even for immune support for cancer patients. I personally haven't seen any studies to indicate dosages that high are any more effective. If you have any links to studies of that nature, I'd be happy to review them!
@@ws7001 Nope, that's for Melatonin, find Dr. Schallenberger's videos in here, Vitamin C would be 20g, 50g, 75g and 100g at least depending on the toxicity of the person.
@@davinacuellar3121From what I understand is that when you take it orally only a small amount is absorbed. Possibly because of the high acid environment of the stomach. I’m taking low dose sublingual tablets that dissolve under your tongue and get into the tissues that way. Another option is liposomal where the melatonin is encased in several layers of fats for a oral timed release I presume after it reaches the small intestine.
Interesting,,,.... Other research,- AND PAPERS researchers, MD/ Dr's, , say that Oral intake is only about max 2.5 %... due to liver filtering out most ability to get absorbed . Best way is suppository
Thank you for your observation, but truthfully, if oral administration didn't work at all, nobody would be using it. Since the liver really has nothing to do with absorption rates, and mainly deals with filtering byproducts after a substance has been absorbed, I don't really see how that would make a difference. Sublingually, which bypasses the digestive process seems so far to be the best delivery system. However, if you could share links to those studies, I'd be interested in reviewing them.
It certainly does cause weird dreams often quite disturbing ones. Maybe it's detoxing the brain. I've been taking 40mg every night for months. Sometimes I take another 5mg when I'm up to pee in the middle of the night. I'm, 65.
If you are getting disturbing dreams, that's an indication that you are taking more than you actually need. Try backing it down a bit - 40mg is quite high. I'd start around 10mg and see how that goes. You can always adjust up or down as needed.
@DrJamesMeschino Thanks for the reply. I had disturbing dreams on 5mg too. I've followed Dr. Russell Reiter who has devoted his entire career to melatonin. He's been hi-dosing for decades and said 40mg was a good place to start. I'll try going low-dose for a while and see if there is a change. Thanks again.
@@Frederer59 what I usually recommend as a starting point, and is most commonly used to begin with is 3 mg. Maybe start there. Let me know how it goes!
Oh it definitely can if you take more than your body requires - the dreams can be not only vivid, but very disturbing. That's generally my guide for dosages, and often the reason people won't take melatonin because they took too much the first time and had that happen.
Do you see ANY issue with giving melatonin to kids to ease sleep issues? I’m a medical coder who sees providers prescribing clonidine for children to sleep but they will say absolutely no melatonin. Makes no sense to me.
I have seen doctors prescribe melatonin for children who are on the ADHD spectrum to help them get to sleep. I believe the thought is that children make plenty of melatonin. However, many factors can impact melatonin production like video games before bedtime, or screens of any kind as the blue light blocks natural production of melatonin. I suggest to try limiting these things to stop at least 2 hours before bedtime. But no, I agree with you, if it's one or the other, I'd be more inclined to melatonin.
@@tondamcgillis There is a suggestion that melatonin supplementation for children/adolescents can delay onset of puberty. Please research this. You may want to find Doris Loh's research. She works with Dr. Reiter.
I have tremendous respect for Professor Russell J Reiter; met him personally at a symposium, and have followed his research for the past 15+ years ever since.
I, too, was disappointed that Professor Reiter was not present for this presentation, however, I am entirely in agreement that focusing and honoring Prof Reiter in a presentation about him, his research, and accomplishments is well deserved and well worth the time. I have a quite a few things more to add to the discussion, but let me sum it up that he has tremendous support and respect among the scientific community, is passionate sharing knowledge, produced world-renowned scientists who studied in his lab as students, and is the most kindest man you will ever be fortunate to meet.
-- Audrey Fischer, Chicago
Thank you for your observations. Dr. Meschino has studied the works of many profound experts in various fields and our purpose is to spread the best information we can find from said experts. I know Professor Reiter has many videos on TH-cam that he has made and of course we encourage all to search for and experience his words directly as well! In the meantime, we will do our best to find the leading experts and share their expertise as well as Dr. Meschino's himself! If you would like further information on Dr. Meschino or his professional supplement line, feel free to contact me directly at tonda@adeeva.com
Dr. Reiter. What of the claims of increased prolactin and the effects of that? That sounds like a serious side effect on amounts over 5 mg and/or outside of night time usage.
I'd be interested too. Rare claims of gynecomastia
Tons of good info on melatonin. I enjoyed this a lot, took lots of notes, and added mel to my Pc toolbox.
Muchas Gracias
I see many similar attributes to the body with Vit D3 & melatonin. Could it be in the coming years that the dose with melatonin will be recommended increase like how vit D3 did!
It's a possibility. I'm still looking for studies on higher doses of melatonin and any benefits that may provide. If I find some, I'll share them :)
THANK YOU!!!
Awesome review for me . Truly enjoyed your lecture. Cheers Dr. Ginge
We are regularly told it's not necessary to take high doses (over 3 mg) of melatonin for sleep regulation. But what are optimal doses for all of these other benefites of melatonin?
Hi, Brian, I haven't seen much that shows benefits above 3mg except as immune support, then up to about 10mg. I know there was a comment previously about articles on PubMed that indicate some benefit at higher dosages, I haven't had a chance to go over those yet. But if you can access them at PubMed, it's probably worth having a look. Sorry I can't be more help at the moment. I'll try and update once I've found and read those studies :)
@@DrJamesMeschino For those higher doses regarding immune support, is there a preference for time of day. In other words, is there benefit to taking melatonin in the morning or afternoon, in addition to a smaller dose later for sleep regulation? Thanks for your response.
@@briandriscoll1480 Honestly I'm not entirely clear on that either. I'm hoping I'll find some support regarding that as I find and study the PubMed research. If I do find something, I'll share - you likewise please if you find it first :)
check out Dr. Dietrich Klinghardt and Dr. John Lieurance. They're using much larger doses to heal people of all kinds of conditions, taking it topically through the skin or via suppositories. I'm talking 200+ mg.
Dr Reiter takes 180mg daily, Dr Doris Loh takes 1-3 grams daily, it seems we also make lots of melatonin within our mitochondria from sunlight NIR which penetrates several inches into our body. To match this amount, considering 15% absorption and short half life of 20-40 minutes, we need to take 10-15 mg every hour from 9am to 7 pm, or 30-60mg every two hours (If we avoid the sun).
We also make about 100-120mg daily in our gut but not sure any gets into our bloodstream. I don’t think so.
Great presentation Dr. James
Thank you for your feedback! If you have any specific questions about Adeeva products, feel free to contact me at tonda@adeeva.com
You say 1 pg = 1,000,000 mcg no. 1 mcg = 1,000,000 pg
English Please??
And he said 1 pg equals 1/1,000,000 mg which is wrong.
1pg is 1/1,000,000,000 mg
What is a good brand of Melatonin?? How many mg's?
Pretty much any brand is fine, it's all the same quality. When it comes to how much, it depends. I would start with 3mg one hour before you want to go to sleep. If that doesn't seem to work, increase it to 5mg. Be careful going higher than that as if you take more than you need, you'll have strange, disturbing dreams, which sort of defeat the purpose. If that happens, reduce the dosage the next night. It takes a bit of trial and error, but for most people, 3 - 5mg is plenty. Hope this helps!
Here is a link to our product Sleep E Naturals. It contains a smaller amount of melatonin, and 5-HTP, a form of the amino acid tryptophane that will convert to melatonin if you need slightly more. So it's adaptable to your requirements. The link is below, and if you have further questions, feel free to contact me at tonda@adeeva.com
adeevainfo.com/wp-content/uploads/2020/10/Adeeva-Practitioner-Features-and-Benefits-Guide-Sleep-Naturals.pdf
Check out the book MELATONIN by Russell Reiter, PhD, and Jo Robinson...
look into melatonin and ostoporsis
Hi, Ralph. What would I be looking for, and do you have a link to that information? I'd love to take a look
On big C proto, 60 mg morning, 60mg afternoon and 120mg bedtime. Too much? No dreams that I remember.
Hi, there, yes that dose does seem high. I've mainly recommended 20mg daily even for immune support for cancer patients. I personally haven't seen any studies to indicate dosages that high are any more effective. If you have any links to studies of that nature, I'd be happy to review them!
@ Thanks Dr. I’ll have to find the videos/references for you.
@@DrJamesMeschino m.th-cam.com/video/Roh4lQXneQg/w-d-xo.html go to 46:21
Sorry I’m just a lay person not scientific.
Pretty sure Riordan Clinic IV's 4750mg as adjunct cancer therapy.
@@ws7001 Nope, that's for Melatonin, find Dr. Schallenberger's videos in here, Vitamin C would be 20g, 50g, 75g and 100g at least depending on the toxicity of the person.
Some take large dose melatonin glutathione in rectal suppositories slow releas in cacau butter
How does this differ from Orally?
@@davinacuellar3121From what I understand is that when you take it orally only a small amount is absorbed. Possibly because of the high acid environment of the stomach.
I’m taking low dose sublingual tablets that dissolve under your tongue and get into the tissues that way.
Another option is liposomal where the melatonin is encased in several layers of fats for a oral timed release I presume after it reaches the small intestine.
Interesting,,,.... Other research,- AND PAPERS researchers, MD/ Dr's, , say that Oral intake is only about max 2.5 %... due to liver filtering out most ability to get absorbed . Best way is suppository
Thank you for your observation, but truthfully, if oral administration didn't work at all, nobody would be using it. Since the liver really has nothing to do with absorption rates, and mainly deals with filtering byproducts after a substance has been absorbed, I don't really see how that would make a difference. Sublingually, which bypasses the digestive process seems so far to be the best delivery system. However, if you could share links to those studies, I'd be interested in reviewing them.
It certainly does cause weird dreams often quite disturbing ones. Maybe it's detoxing the brain. I've been taking 40mg every night for months. Sometimes I take another 5mg when I'm up to pee in the middle of the night. I'm, 65.
If you are getting disturbing dreams, that's an indication that you are taking more than you actually need. Try backing it down a bit - 40mg is quite high. I'd start around 10mg and see how that goes. You can always adjust up or down as needed.
@DrJamesMeschino Thanks for the reply. I had disturbing dreams on 5mg too. I've followed Dr. Russell Reiter who has devoted his entire career to melatonin. He's been hi-dosing for decades and said 40mg was a good place to start. I'll try going low-dose for a while and see if there is a change. Thanks again.
@@Frederer59 what I usually recommend as a starting point, and is most commonly used to begin with is 3 mg. Maybe start there. Let me know how it goes!
@@DrJamesMeschino3mg has been excellent for my anxiety, however it lowers my libido, any reason for this? Especially at such a low dose?
Vivid dreams are good, dreams are real and can help you predict what will happen and how to live a fruitful life
There is time released melatonin as well.
And now there is Liposomal Melatonin as well.
I don't believe melatonin CAUSES vivid dreams. I think I just REMEMBER the dreams better.
Oh it definitely can if you take more than your body requires - the dreams can be not only vivid, but very disturbing. That's generally my guide for dosages, and often the reason people won't take melatonin because they took too much the first time and had that happen.
You're so right @HarryJensen-kr4qz and definitely don't follow doctors advice, they're basically all drug dealers anyway
😮😮😮
Where is Reuter?
this is a webinar by Dr. Meschino based on Dr. Reuter's work.
Dr. Russell J. REITER
Do you see ANY issue with giving melatonin to kids to ease sleep issues? I’m a medical coder who sees providers prescribing clonidine for children to sleep but they will say absolutely no melatonin. Makes no sense to me.
I have seen doctors prescribe melatonin for children who are on the ADHD spectrum to help them get to sleep. I believe the thought is that children make plenty of melatonin. However, many factors can impact melatonin production like video games before bedtime, or screens of any kind as the blue light blocks natural production of melatonin. I suggest to try limiting these things to stop at least 2 hours before bedtime. But no, I agree with you, if it's one or the other, I'd be more inclined to melatonin.
@@tondamcgillis There is a suggestion that melatonin supplementation for children/adolescents can delay onset of puberty. Please research this. You may want to find Doris Loh's research. She works with Dr. Reiter.