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Can you take Quercetine and Berberine together ?

Amazing video as always! Thank you for your efforts 🙏

Another great material. The mitochondria are the " gound ZERO" of all health problems. I think you nailed when you said that we should be really mindful what we put into our body so what we eat and what we drink. If you look at our 4.5 M years of being on this planet we should eat only meat and drink water which is carnivore as our body and metabolic pathways and anathomy evolved in this enviroment. Any " variations" to this will stress our system and trigger the response and adaptation but it cant last forever hence we fall ill at some point sooner or later.

The cell can run on 1 fuel at the time so either gluocse or fatty acids what is managed by the Randle Cycle. If we put both fuels via our diet ( which is the case for 95% of people on planet earth) then you trigger the Randle Cycle and the whole host of bad events start to happen inside the cells and in the cardiovascular system. Check Prof Bart Kay and his vids on the Randle Cycle. Take care sir and keep going

Hi Dr Case, its great what youre doing. Your chanell should grow. Tip: think of " cross- pollynation" meaning you host some guests who run similar channels and then they host you. Folks will subscribe you. Keep going ❤

Dr. So far i havnt gotten any answer from any doctor on utube but i know you cant give advice but if you had a brother that had squamous cell carcinoma and he was medically using marijuana for various reasons and not doing any cancer treatments but eating right cutting out as much sugar would you tell him he should not smoke that for various reasons like lowering his immune systen. Anybody else's opinion would be appreciated. Thank You

What type of exercise?

What is the synergy of exercising in fasted state? How about prolonged fasting with exercise under the sun?

THANK YOU DOCTOR. I HAVE RETURNED TO UR SITE SEVERAL TIMES AND BEEN AMAZED AT THE NEW SUPPLEMENTS WHICH AFFECT CANCER. MY FIRST VISIT OVER WHELMED ME WITH TECHNICAL TERMS BUT I HAVE LEARNED TO HEAR THE MAIN POINT OF INFO BEING PROVIDED. I HEAR THESE THINGS NO OTHER SITE SO I KEEP COMING BACK. THANKS FOR WHAT U DO.

I'm glad you covered this. Serious exercise is now the 3rd leg to my cancer fighting program. I heard that just the blood circulating fast when your heart rate is up will shear the fragile cancer cells that might be trying to spread though your body. An example of 2 women beating breast cancer in their 40s with a vegan diet to lower methionine and get nutrients and doing some serious running is (Ruth Heidrich no standard treatments) and Jenette Murray Wakelin, now near 80 yrs old and still cancer free. Chris Wark of Chris beat cancer fame. I don't know if he exercised or not.

Just look at Sami Tugano. Her regimen blows me away . Stage 4 colon cancer with metastasis. Looking at her you would never know it . That would be a great interview!

Would black seed oil have a good effect also

I havent read yet, but the book "A race for life" from Ruth Heidrich came to my mind here.

Two further natural extracts that you might not know that selectively inhibit both glutamine and glucose in cancer cell metabolism. Black Seed and Ashwagandha. * Black Seed (Nigella sativa) Mechanism of Action: Black seed, primarily through its active compound thymoquinone, exhibits anticancer effects by modulating multiple cellular pathways, including NF-?B and PI3K/Akt, which influence cell survival, inflammation, and proliferation. Effects on Glucose and Glutamine Metabolism: Glucose: Thymoquinone in black seed inhibits glucose uptake and glycolysis by downregulating glucose transporter proteins, effectively limiting the primary energy supply for many cancer cells. Glutamine: Thymoquinone has been shown to reduce glutaminase activity, decreasing the conversion of glutamine to glutamate, a critical fuel for cancer cell energy production and raw material for cell reproduction. By targeting both glucose and glutamine pathways, black seed creates a double metabolic blockade. * Ashwagandha (Withania somnifera) Mechanism of Action: Ashwagandha's active compounds, especially withaferin A, target multiple cancer-related pathways, including AMPK and mTOR, making it effective in reducing cancer cell growth and survival. Effects on Glucose and Glutamine Metabolism: Glucose: Withaferin A in ashwagandha inhibits glucose uptake and glycolysis by reducing GLUT transporters and inhibiting glycolytic enzymes, disrupting the Warburg effect in glucose-dependent cancer cells. Glutamine: Ashwagandha also inhibits glutaminase, thereby limiting glutamine's conversion to energy and building blocks, and weakening cancer cells' metabolic flexibility, particularly in glutamine-reliant cancers. [Hopefully this posts ok - used a very basic editor.]

thank you Doc, great video

Why did you take my comment down? Professor Seyfried makes the vey clear about needle biopsies censoring truth does not help us.

Thanks for sharing this important analysis and information

Which type of exercise would be better, Aerobic exercise or Anaerobic exercise? Thank you for your presentation.

That's interesting to know. I'm starting to watch the video so you may have covered this. But it stands to reason that you would need to exercise either fasted or in keto. I know a number folks who died from cancer who ran marathons while fighting it and passed. But if they followed the conventional wisdom and consumed an insane amount of carbs while running those marathons I could see why that would negate the effect of the exercise.

Bioavailability of natural extract is NOT a problem. The criticism that natural extracts lack bioavailability is a common one, but it is ultimately shortsighted, especially when considering their powerful potential within a metabolic therapy approach. While it’s true that some natural compounds have limited bioavailability when taken alone, modern techniques can enhance absorption, and the therapeutic benefits of these extracts go far beyond their concentration levels in the bloodstream. Here’s why the bioavailability critique often misses the bigger picture: 1. Bioavailability Isn’t Everything: Localized and Cumulative Effects Matter Targeted Accumulation: Many natural compounds tend to accumulate in certain tissues where they’re needed most, even if their blood concentrations aren’t high. For example, curcumin and EGCG are known to preferentially localize in the digestive tract, liver, and certain tissues where cancer cells may reside, allowing them to exert therapeutic effects directly where they’re most beneficial. Cumulative Benefits with Continuous Use: Even low levels of bioavailable compounds can have cumulative effects over time. Regular intake of these compounds-through dietary sources or supplementation-creates a steady-state presence that allows for sustained interaction with cellular pathways and cancer cells. Direct Effects in the Gut Microbiome: Many natural extracts act on the gut microbiome, where they can alter the balance of beneficial bacteria and reduce systemic inflammation. By supporting a healthier gut environment, these compounds indirectly benefit metabolic health and immune function, which are critical in fighting cancer. 2. Synergistic Effects Amplify Therapeutic Impact Multiple Compounds Working Together: A core strength of natural extracts in metabolic therapy is their synergy. When combined, these extracts can boost each other’s absorption and efficacy. For instance, piperine from black pepper increases the bioavailability of curcumin by up to 2000% (200x), enhancing its therapeutic effects at lower doses. Such combinations allow for highly effective, lower-dose applications, minimizing side effects and maximizing impact. Pathway-Specific Synergy: Different compounds can target multiple metabolic pathways simultaneously. For example, curcumin, EGCG, and resveratrol each influence glucose uptake and cancer cell glycolysis differently, but together, they create a more robust blockade against glucose metabolism. This multi-pronged inhibition not only weakens cancer cells but makes it harder for them to adapt or find alternative routes for survival. Enhancing Each Other’s Bioactivity: Beyond bioavailability, many natural compounds work synergistically by enhancing each other’s bioactivity within cells. For instance, resveratrol and quercetin together strengthen each other’s anti-inflammatory and pro-apoptotic effects, achieving greater efficacy in killing cancer cells than they would alone. 3. Broad Coverage of Cancer’s Metabolic Pathways Comprehensive Pathway Inhibition: Natural extracts have been shown to inhibit a range of pathways critical for cancer cell survival, including glucose and glutamine metabolism, angiogenesis, oxidative stress response, and cell cycle progression. Targeting multiple pathways is key to preventing cancer cells from finding bypass routes. Natural extracts offer this multi-pathway coverage, often affecting different cellular mechanisms within a single compound, which pharmaceutical drugs rarely achieve without significant toxicity. Reducing Adaptation and Resistance: When only a single pathway is targeted, cancer cells can often adapt, finding alternate ways to meet their metabolic needs. By using a combination of natural compounds that cover all critical pathways, metabolic therapy creates a “metabolic trap” that makes it increasingly difficult for cancer cells to survive, proliferate, or evolve resistance. This comprehensive approach hinders cancer’s ability to use other pathways for energy and growth. 4. Low Toxicity Allows for Continuous Use Sustained Therapy Without Toxicity: Unlike many conventional drugs, natural extracts have low toxicity, allowing them to be used consistently over time without harmful side effects. This continuous, gentle approach places ongoing metabolic pressure on cancer cells, keeping them vulnerable and less able to adapt or develop resistance. Safe, Long-Term Modulation of the Tumor Microenvironment: Natural extracts can maintain a microenvironment that is hostile to cancer cells but supportive of normal cells, in part by reducing inflammation, improving immune response, and selectively disrupting cancer cell metabolism. This approach benefits patients’ overall health and resilience during treatment. 5. Advances in Delivery Systems Overcome Bioavailability Challenges Liposomal and Micelle Delivery: Modern formulations, such as liposomal and micelle delivery systems, enhance the absorption of less bioavailable compounds like curcumin, quercetin, and resveratrol. These delivery methods encapsulate the extracts in microscopic particles that improve their solubility and make it easier for the body to absorb them effectively. Nanoencapsulation: Nanoencapsulation is another cutting-edge technology that packages natural extracts in nanocarriers, allowing them to bypass certain barriers to absorption. This technology allows extracts to reach targeted tissues in higher concentrations, improving their bioavailability and therapeutic impact. Emulsions and Phospholipid Complexes: Emulsifying natural extracts with phospholipids or healthy oils can enhance their bioavailability. When consumed with healthy fats, compounds like curcumin, quercetin, and vitamin D3 are absorbed more effectively, making it possible to achieve therapeutic levels even with modest doses. In Summary The bioavailability argument against natural extracts in metabolic therapy fails to consider their unique benefits and flexibility. Natural extracts’ localized and cumulative effects, combined with powerful synergy and pathway coverage, allow them to effectively target cancer metabolism in ways that isolated pharmaceutical agents often cannot. Advances in formulation and delivery overcome many bioavailability challenges, making these compounds not only viable but powerful tools for multi-pathway, low-toxicity cancer treatment. The strength of natural extracts in metabolic therapy lies in their broad action, adaptability, and low toxicity, allowing for a sustained and comprehensive approach that keeps cancer cells under constant metabolic pressure. This “all-pathways” strategy, combined with the therapeutic potential unlocked through synergy, makes natural extracts a highly effective and underappreciated option for metabolic cancer therapy.

Unfortunately, biological reality is much more complex than all those figures with molecular interactions. One example from many that I see almost every day: fitness expert, everyday about 15 miles on the bicycle + other exercises, vegetarian diet, supplements such as vit D3, melatonin, green tea extract, resveratrol and ... one year after radical prostatectomy biochemical recurrence with the current PSA 0.25 ng/ml ... Is he doing anything wrong or is nutrition a method with some limits that exclude better outcome?

Why KETO + DOM is half-baked, at best. While some advocate for a ketogenic diet (keto) combined with 6-diazo-5-oxo-L-norleucine (DON) as an effective metabolic therapy for cancer, there are serious limitations with this approach. The primary benefit of keto in cancer therapy is actually its ability to lower insulin and IGF-1 levels, hormones that can promote cancer cell growth. However, while keto reduces blood sugar intake, it doesn't eliminate glucose from the bloodstream. The body will maintain blood glucose levels via gluconeogenesis, ensuring a consistent supply that cancer cells can exploit. Therefore, targeting glucose uptake and metabolism inside cancer cells directly is likely to be far more effective than reducing dietary glucose alone. Similarly, DON's inhibition of glutamine metabolism is non-selective, affecting both cancerous and healthy cells alike. This lack of selectivity can lead to toxicity, as many normal cells also rely on glutamine for important functions. For an effective therapeutic strategy, we would need to selectively target glutamine metabolism within cancer cells, sparing normal cells from the inhibitory effects. Achieving this specificity would reduce the need for 'pulsing' (intermittent dosing) to manage toxicity, allowing for a more continuous, less toxic approach. Additionally, a combination of natural extracts can cover multiple critical pathways simultaneously, rather than focusing on a single target like glucose or glutamine metabolism. Many natural compounds, such as curcumin, EGCG, sulphoraphane and resveratrol, can influence glucose and glutamine metabolism selectively within cancer cells, inhibit cancer-promoting pathways, and support immune function, all with far less toxicity than DON. This multi-targeted approach reduces cancer cells' ability to adapt and bypass treatment, potentially leading to better long-term outcomes and fewer side effects. In summary, directly targeting metabolic pathways within cancer cells and employing a range of synergistic, low-toxicity natural extracts offers a broader and more precise strategy for cancer therapy than keto and DON alone. This approach addresses the metabolic needs and vulnerabilities specific to cancer cells while reducing harm to healthy cells, providing a potentially more effective and sustainable metabolic therapy.

I’m recently got to know that I have stage 4 lung cancer, I have started keto diet and cut off sugar and doing YOGA

Cancer is NOT a metabolic disease. BUT ... Cancer is a multi-faceted disease, with genetic, epigenetic, immune, and environmental factors all playing significant roles in its initiation and progression. The view that 'cancer is a metabolic disease' oversimplifies this complexity (the same as 'cancer is a genetic disease'), potentially overlooking the many factors beyond metabolism that drive cancer behavior. However, approaching cancer AS a metabolic disease - focusing on the unique metabolic demands and vulnerabilities of cancer cells - provides one of the most actionable strategies for treatment. 1. Metabolic Approach as an Actionable Strategy Cancer cells exhibit metabolic behaviors distinct from those of normal cells, such as increased glucose and glutamine dependence, altered mitochondrial function, and higher rates of fermentation even in the presence of oxygen (known as the Warburg effect). These metabolic shifts are fundamental to cancer survival and growth, regardless of the specific genetic mutations or environmental conditions involved. By targeting these metabolic dependencies, we can effectively disrupt cancer cells’ ability to sustain rapid growth, proliferate, and spread - without necessarily needing to address each individual genetic mutation or pathway alteration. This makes metabolism an attractive target, as metabolic pathways are relatively accessible and modifiable through dietary, pharmacological, and lifestyle interventions. 2. Metabolism as a Convergent Point for Multiple Cancer Types While each type of cancer may have unique genetic mutations or molecular characteristics, nearly all cancers rely on similar metabolic adaptations to thrive. Focusing on metabolism allows for a unifying approach that can be applied across a wide range of cancers. Cancer cells, for example, generally depend on increased glucose and glutamine uptake, altered redox balance, and heightened resistance to apoptosis (programmed cell death). By viewing cancer as a disease that is heavily reliant on altered metabolism, we gain the opportunity to tackle a central vulnerability that is common to many cancers. This can lead to broader and more versatile therapeutic strategies, potentially simplifying treatment across diverse cancer types. 3. Metabolic Interventions Are Less Invasive and Can Complement Other Therapies Approaching cancer as a metabolic disease opens up options for interventions that are often less invasive and less toxic than traditional treatments. Dietary interventions, like a ketogenic diet or intermittent fasting, as well as natural compounds targeting metabolic pathways, can often be combined with conventional therapies (chemotherapy, radiation, and immunotherapy) to enhance treatment efficacy. This approach allows for a more holistic and integrated treatment plan. By supporting normal cells while stressing cancer cells, metabolic therapies may also reduce the collateral damage and immune suppression typically seen with high-dose chemotherapy or radiation. As such, a metabolic approach can support a patient's overall health and resilience during treatment. 4. Potential for Greater Selectivity with Metabolic Targeting Cancer cells’ metabolic alterations create vulnerabilities that are distinct from normal cells, allowing for the potential to selectively target cancer cells while sparing healthy ones. For example, inhibitors that block glucose or glutamine uptake, disrupt cancer cells’ redox balance, or target cancer-specific enzymes like glutaminase can induce stress in cancer cells that are metabolically flexible, without harming normal cells. This selectivity is particularly important for long-term treatment strategies, as it reduces the risk of cumulative toxicity. When applied consistently, a metabolic approach could limit the cancer’s ability to adapt or evolve resistance, potentially improving outcomes while minimizing adverse effects. 5. The Potential for Prevention and Long-Term Maintenance Metabolic interventions can be proactive, not only treating existing cancer but potentially reducing recurrence or new cancer development. By modulating metabolic risk factors-such as insulin sensitivity, chronic inflammation, and oxidative stress-a metabolic approach may help prevent cancer from finding a hospitable environment in the body in the first place. Additionally, in patients who have completed primary treatment, maintaining a metabolic approach could reduce recurrence risk. For instance, ongoing dietary interventions, lifestyle adjustments, and natural compounds can help maintain a metabolic environment that is inhospitable to cancer cells, supporting long-term health. In Summary While cancer is undeniably complex and multi-dimensional, approaching it as a metabolic disease provides a practical and effective avenue for intervention. Focusing on cancer’s metabolic dependencies allows us to target its unique vulnerabilities in a way that is adaptable, less invasive, and highly selective, with the potential to complement or even reduce the need for conventional therapies. Rather than replacing other approaches, a metabolic strategy integrates well with the broader understanding of cancer and offers tangible ways to disrupt its growth, support the body’s defenses, and foster a healthier internal environment.

Fantastic as usual! I started using an exercise ball to sit on and bounce while I lift weights and wear ankle weights. Infinite gratitude to you and this group!

Who here wants to rob glucose AND glutamine from tumors? Exercise must be a tool used in your toolbox 🧰!

Awesome !

I was diagnosed with metastatic melanoma in my brain, lung and liver. The oncologist put me on Ipilimumab and Nivolumab once every three weeks for a projected four treatments. After three my liver enzymes shot up so he paused and suggested I go get scans to check for progress. The scans found Zero evidence of cancer. Immediatley upon diagnosis I implemented a keto diet and I lift three days/week and do HIIT three days/week. Every morning I go for a two mile brisk walk. All summer I went shirtless within 30 min of sunrise. Every afternoon I got 15-30 minutes of direct sunlight. Are there any studies that address the amount and timing of excercise to maximize the effect of tumor stravation? I really enjoy and appreciate your content.

ALL TOOLS ON DECK nice video

I normally walk for 50 minutes after work is it enough doctor?

Excellent video Doc, amazing info

I started weight training 8 months ago 3 months before my colon cancer diagnosis . I used to do a lot of body building and martial arts in my 20s and 30s but that stopped when I got married and needed regular guaranteed money, instead of working as a bouncer and close protection body guard. I wish I kept it going now, but at 280lbs in good condition, I could not financialy afford the 6000 to 7000 calories a day to maintain that size now. The one good thing is muscle memory and epigenentics kicked in, since starting again I have lost 2 inches of my waist and stayed the same weight, I only measured my arms and chest before I started training again and I have increased the size by 2 inches for my arms and 1 and half inches on my chest, my legs have improved in size as well, which would probably be not possible without the muscle memory in this short span of time. I saw a study that advises keeping your heart rate above 130 beats a minute for 20 minutes, 4 times a week, kills off rogue cancer cells in the blood stream from the turbulence and increased pressure. Another study shows if you use 3 to 5 grams of Leucine with each meal on a low protein diet it prioritizes the protien for muscle synthesis, 5 grams a day of hydroxy methyl butyrate keeps muscles from wasting when fasting or on calorie resticion while exercising. I use these as well as creatine and taurine to boost my muscle growth. The problem I have with areobic exercising is my anemia, so I struggle to get that 130 beats a minute for more than 5 minutes without feeling like I am going to have a heart attack, from the pain in my left upper chest. I am going to ask my doc if I can get some intravenous iron done to hopefully alleviate this problem and improve my stamina. It doesn't affect the weight lifting as I rest 90 seconds between sets apart from when training my quads, I guess they are more oxygen needy.. Some studies I saw about 3 months ago say that keeping your heart rate above 130 beats a minute for 20 minutes 4 times a week destroys rouge tumor cells in the blood stream due to the turbulence and pressure.

So, glycation of RBCs and small vessel walls by blood sugar excess, is further causing hypoxia pressure, affecting HIF1a? So, is this what the fasting is getting at? Perhaps, helping to maintain the mitochondria functioning that cancer is causing decline?

Do you think strenuous exercise during fasting would multiply the effect of robbing tumors of glucose and glutamine?

Folks with 80-100+ ng/ml did you find were the healthiest?

Great news as I would much rather than exercise than fast!

It make sense but I think especiallly in prevention as the excersise should help improve the the energetic " well being" of the cell that is already healthy but what is more important it can change the metabolic trajectory of the cell that is already struggling and is on the brink of getting into the fermentation for good ..... indeed sport can help in keeping the healthy ratio of mitofagy and creation of the new mitochondria.

Dr P. I reached out on another video but one thing I struggle with is the science supporting cancers ability to use fatty acids ketones for fuel. Reading "How to Starve Cancer" which states it can be a fuel source . I heard Ben Bickman state no evidence in human studies. Seyfried says no. Just wonder where to truth lies (at this point anyway).

Stunning

Excellent!!! I will up my exercise. I’m going for a needle biopsy today of my lymph nodes. Prayers appreciated. Thanks Dr; Peavler.

Great again. Thanks for your unrelenting research. It seems to make a lot of sense to include exercise. Going for hiit training like yesterday.

What is the better choice of exercise: strength training or aerobic?

Interesting! I look forward to learning more.

i would think excercise is a powerful preventative for many things. and sunlight. kinda like our ancestors.

…anaerobic core body exercises have additional benefits of releasing growth hormone…internal stress on tissues and joints produces cascading health benefits throughout the body which sequesters glutamine for muscle repair…every longevity paper shows resistant training out performs cardiovascular exercise…references presented by Thomas de Lauer …more esoterically speaking, Mother Nature confers the ‘use it or lose it’ theory with the ‘survival of the fittest’….

Going for a brisk walk in the sun right now!