Emphasizing reading from 3 to 5 and writing from 5 to 3 is not effective the explanation is too stretched it could be effectively explained in half of the time
This is the honestly the only video on DNA Replication that made sense.. you've pretty much included all the important parts without being too fancy.. simple is better!
I believe what makes a good teacher is ability to tell your students what they don't know and all they need to know about that, not telling them what YOU know!
I just found out that Dave Carlson is battling a brain tumour. I am currently studying for the MCAT and the videos from PremedHQ have been very helpful. Dave is a wonderful instructor. I will be donating to his gofundme as a sign of my utmost appreciation.
Omg he explained it very well!!!! I Have been looking for a good explanation and I swear i was postponing the exam of molecular genetics a lot .Because the Professor asks the mechanism of Dna replication! I'm so glad i found this explanation. I know nobody is stupid but we sometimes need someone to clarify our ideas and help us understand more. THANK YOU A LOT.
Thank you Sir. I am not a natural English speaker, that's why I really enjoy your eloquence, the varity of your choice of words. Now all my questions concerning the issue has been answered.
I can't even explain how much this video helped me, I have to give a presentation in two days and no other videos/sources led me to understand the whole Primer in 3' and 5' direction thing. Thank you!
Ohhh Allah 🥺 I don't how to say thanks to u may Allah bless you for clearing my this concept I literally waste my whole day in clearing this topic I watched lots of videos but I didn't get anything from a single video thank you so much for clearing all steps I'm having exam the day after tomorrow and your video really helped me a lot 🥺 I'm doing graduation now that I got clear this topic I didn't even get this topic in 12
just wanted to stop by and say that your videos here have helped me massively in my understanding of a variety of mcat subjects. your calm, patient manner of explanation is irreplaceable my friend!
after personal trainer, I took up sport science university and this is the ONLY VIDEO (or almost only) that explains the reason why Okazaki fragments occour!! not only DESCRIBE but also EXPLAIN (the story of the new primers) very well done
your videos are so clear and you're so good at explaining! - even though I don't need all the information for the exams I'm doing, I keep coming back to your videos when I don't understand something because they are so good! thanks so much
I was really confused after my professor went over this in class, but after watching this video it really gave me a better understanding of how DNA replication works!!!! THANK YOU SO MUCH!
@@bakarolachika187 I do know that... what im saying is do they do this once? and then they dont have to read it again becouse dna gets saved up onto the system or they have to do it before every replication time? That was my question
In fact, I've watched thousands of videos on TH-cam, and this is the coolest and simplest video I've ever found. I really thank you very much it will help me in the final !!!!!
Sir, I just want to thank you so much for explaining this in such a clear and simple way. I thought I was never going to understand replication. Thank you so much!!
My online teachers never ever explain things like they never told me that replication always starts at 3' and moves towards 5' which is one of the things that confused me so much. They never really explained what a primer was they just told us that it starts the process of replication. Like what?!!!! Teachers like you have made my life so much less complicated
This is theeeee first video out of about 10 that I completely understand !! You explained this sssssoooo welll!!! omgeee im so glad I found this channel!!
Enjoyed the video with good understanding of the process as the professor is soft, clean and clear speaker and covered events of DNA replication in a simplest possible way.
Heartily thank you sir. I had come here because i did not able to take clear concept of my lecture and mam was asked questions but i was not able to answering to mam. However mam challenged me next lecture. Through this video i will explain more than mam could expect from me.
OMG!!!! His explanation is superb. I don't think I could have understood it better from anyone else. I feel confident enough to teach this to students someday (I'm a teacher In training☺). Thanks a lot
Thank you sooo much!!! I have exam in 2 days and I've been struggling with this lesson.... now it's completely clear..... and now I'm pretty sure imma Rock it😅
I'm a complete layperson, I have no medical education or training whatsoever. I understood this video, at least at the logical level of what each enzyme does, etc. Thank you for a great video!! I started watching videos about SARS-Cov-2 in an attempt to understand more about it, and now I've fallen down a rabbit hole and I think I want to learn a lot more about molecular biology now. I want to learn way, way more about the processes involving DNA, RNA, cells in general - but more than that I'd love to understand how, physically these things work. Ultimately all of this boils down to chemical reactions, right? That's what I'd love to understand. Molecule X bonds with molecule Y due to its shape, structure etc, and BOOM - now you have what's essentially code being executed and - life. Maybe it's my computing science background which is causing me to be so fascinated by this world which until a week or two ago, I knew zilch about (and still do compared to someone who's actually studied it, of course). My mind is kind of blown and I can see me continuing to fall down this rabbit hole. Maybe I'll start looking for actual constructed courses, but for now, videos like this are a great place to start. Thanks again for such a clear, well structured and explained video!
Minor correction: First: A-proteins separates the strands initially at AT-rich areas throughout the strand (so replication starts at multiple places simultaneously). (Not a critique, but you forgot them). Second step: SSBs keep the strands from annealing, like you said, while simultaneously helicase unwinds the DNA to further separate the strands. After that Topoisomerase is also important, since it reduce the tension, caused by helicase and thereby prevents supercoiling.
Hello! I was trying to find some info on A-proteins but could't find any, can you please share a link where it's written about them? i would appreciate it, thank you!
The origin of replication depends on whether the cell is eukaryotic or prokaryotic. In Prokaryotes, the DNA is circular and there is only one origin of replication. What you refer to as A-proteins are the initiator proteins that bind to the origin of replication. In E.coli, the initiator proteins are called DnaA & DnaB. In eukaryotic cells,there are multiple origins of replication on the linear DNA molecule. The initiator protein in eukaryotes is called the origin recognition complex. Source: www.ncbi.nlm.nih.gov/pmc/articles/PMC3783049/
Clear, concise, and makes perfect sense. I love that you explained popular words that we commonly hear when discussing DNA replication, but may not have fully understood well. We have all heard the term leading strand, lagging strand, semi conservative, etc. but explaining exactly what they mean in conjunction with the full video explanation really increased my understanding.This attention to detail and your clear understanding of the topic really this video apart from all others.
I thought I understood DNA replication but after watching this video, there's so much well-explained info... I have to figure out how to organize it. By far the best channel and video ~
I've always escaped from this topic but finally had to come down cz of my exams ,my biology teacher doesn't develops good communication,also like she just wanna escape off delivering lecture,found that video useful , definitely gonna share, it's really calming to watch such a cute person explaining so nicely,he just soo looks like Clark kent❤️❤️
I’m not sure but it appears they have a leading and lagging computer complexity. I see why the computer fans are getting excited over. Not that it’s resolved. Yet it’s clearly the complexity.
Thank you so much. This is the best video of DNA replication I have watched so far and the only one which made complete sense. This is a life saver video for me... Thanks!
Thank you for sharing this video. You are doing a wonderful job. Simple language and clear in points as a teacher i keep on searching some videos like this to bring some new aspects in my teaching. Just came across this video thank you once again.
very clear explanation of the okazaki fragments and how they occur because of the discontinuous replication on the lagging strand. This part is usually missed by students.
I am Soo grateful for this! Been thinking a lot about this topic and always encountered problems when studing the lagging strand. Thank You for explaining it soo simply and understandably! The enzyme reads the strand from 3' to 5' but the new one is made from 5' to 3' carbon + since the helicase continues to open up the DNA and the ''lagging'' strand is making DNA in the other direction, it simply needs new primers from time to time to catch up with the replicaton fork!
I have watched so many videos on DNA Replication is this was so helpful!!! its crazy how I can watch 5 videos and not understand and watch yours and totally get it thank you very much!
This is probably the best way to teach anything. Dave you have made such a complicated process look like a child's play. I wish I could teach like you. Your appearance, choice of words, voice undulation, vocal clarity and above all the eye contact; all are immensely powerful and magnetic. Keep inspiring and enlightening us. I wish you all the best.
I didn't understand the thing with the leading- and lagging strand. But now I do(At least much better) than i did before, because of this video. Thank you!!
Thank you sir ....this was a difficult topic for me before I watched your video....it made easy for me to learn....🙂....it is the best video on DNA replication 👍
This is by far the best DNA Replication video I've watched, thank you very much.
Emphasizing reading from 3 to 5 and writing from 5 to 3 is not effective the explanation is too stretched it could be effectively explained in half of the time
I agree it is the best becaue it explains WHY and not only WHAT and all of that in ten minutes
This video literally explained 2 weeks worth of confusion in 17 mins, thank you
hahahahhahha, same here
Haha 😂
This is the honestly the only video on DNA Replication that made sense.. you've pretty much included all the important parts without being too fancy.. simple is better!
Good
Iam from South Waziristan
AGREED!!!
It's 2021 and you are still saving liveesss. This is by far the best video i have seen.
I believe what makes a good teacher is ability to tell your students what they don't know and all they need to know about that, not telling them what YOU know!
you're a lifesaver, I was literally struggling until I found this video , you get straight to the point. Thank you!
I just found out that Dave Carlson is battling a brain tumour. I am currently studying for the MCAT and the videos from PremedHQ have been very helpful. Dave is a wonderful instructor. I will be donating to his gofundme as a sign of my utmost appreciation.
Who's Dave Carlson?
@@ownitervi241 The person on this video.
@@rubyrose49 oh, that's sad. Is he doing better?
Oh my goodness. How is he?
Thanks, so much doctor I’ve studied for almost 2 weeks and didn't understand anything till I saw your Channel really appreciate
Great to hear!
This is the simplest, most detailed, yet easiest to understand video I’ve watched about DNA Replication. Thank you so much!
I've watched many DNA replication videos, this is by far the most clear, specific and professional one. Thank you!
This man taught me what 7 HOURS of lectures from an ego inflatted professor couldn't fluidly communicate!😂😅😢🎉
It's my exam in the morning and I find that this video proves to be the most effective way to clear the confusion about DNA replication
This man right here, needs an award for this. Never seen any replication video this clear. Outstanding!!!
Omg he explained it very well!!!!
I Have been looking for a good explanation and I swear i was postponing the exam of molecular genetics a lot
.Because the Professor asks the mechanism of Dna replication!
I'm so glad i found this explanation.
I know nobody is stupid but we sometimes need someone to clarify our ideas and help us understand more.
THANK YOU A LOT.
Thank you Sir. I am not a natural English speaker, that's why I really enjoy your eloquence, the varity of your choice of words. Now all my questions concerning the issue has been answered.
I can't even explain how much this video helped me, I have to give a presentation in two days and no other videos/sources led me to understand the whole Primer in 3' and 5' direction thing. Thank you!
Ohhh Allah 🥺 I don't how to say thanks to u may Allah bless you for clearing my this concept I literally waste my whole day in clearing this topic I watched lots of videos but I didn't get anything from a single video thank you so much for clearing all steps I'm having exam the day after tomorrow and your video really helped me a lot 🥺 I'm doing graduation now that I got clear this topic I didn't even get this topic in 12
just wanted to stop by and say that your videos here have helped me massively in my understanding of a variety of mcat subjects. your calm, patient manner of explanation is irreplaceable my friend!
This is the best video on DNA replication, problem solved within few minutes. Thanks
I love the way you teach, I understand everything you explained.
This is the first time I watch a DNA replication video and not get lost!! THANK YOUUU
Absolutely the best Replication video I have watched!!!...THANK YOU SIR!!!
Watching this before tommorow's exam.
Better to watch one piece
after personal trainer, I took up sport science university and this is the ONLY VIDEO (or almost only) that explains the reason why Okazaki fragments occour!! not only DESCRIBE but also EXPLAIN (the story of the new primers) very well done
I love it too. The tutorial is much easier to understand. English is simple with no deep accent. God bless you sir.
your videos are so clear and you're so good at explaining! - even though I don't need all the information for the exams I'm doing, I keep coming back to your videos when I don't understand something because they are so good! thanks so much
it took 7 classes to finish this topic in my university, but you closed 7 classes in class. and i am not going to forget this class. thanks teacher.
So well explained
I was really confused after my professor went over this in class, but after watching this video it really gave me a better understanding of how DNA replication works!!!! THANK YOU SO MUCH!
That's great to hear! If you think your classmates may find it useful, please do share this video with them! :)
@@PremedHQ professor how do dna polymerase know what exact new dna to produce do they get their information from the coding?
@@mmd123king6DNA polymerase “reads” the existing DNA strands to create two new strands that match the existing ones.
@@bakarolachika187 I do know that... what im saying is do they do this once? and then they dont have to read it again becouse dna gets saved up onto the system or they have to do it before every replication time? That was my question
In fact, I've watched thousands of videos on TH-cam, and this is the coolest and simplest video I've ever found. I really thank you very much it will help me in the final !!!!!
This helped me understand DNA Replication better than my teacher has been trying to get us to understand for weeks. THANK YOU!
I just watched a MIT lecture on DNA replication and yours is 10x better!
I've been hearing about Okazaki Fragments since middle school and I never truly understood it till now! Thank you!
I wasn’t able to understand replication of DNA until I watched this video. Thank u soooooo muchhhh
Hats off
You are genius
The best replication video
Wow, I used to have difficulties with DNA replication. Not until I came across this video, THANK YOU SO MUCH
give this guy an award!! 👏🏻 most helpful video I've ever watched
Out of many videos I have watched, he explains things solid and crystal clear!!!!
Sir, I just want to thank you so much for explaining this in such a clear and simple way. I thought I was never going to understand replication. Thank you so much!!
My online teachers never ever explain things like they never told me that replication always starts at 3' and moves towards 5' which is one of the things that confused me so much.
They never really explained what a primer was they just told us that it starts the process of replication. Like what?!!!!
Teachers like you have made my life so much less complicated
I love how detailed and clear this explanation is. Thank you!
It's 2025 and you're still saving lives...
Thank you ❤
This is theeeee first video out of about 10 that I completely understand !! You explained this sssssoooo welll!!! omgeee im so glad I found this channel!!
This was the clearest vid about DNA replication ive seen so far, thank youuu!!!
omg you are literally a GOD of biology classes, thank you so much!
Enjoyed the video with good understanding of the process as the professor is soft, clean and clear speaker and covered events of DNA replication in a simplest possible way.
Not a premed, I’ve got a bio exam tomorrow and this video honestly helped so much!
I've never understood this concept but after this video.....
Sir Best video ever
Great work sir
Waiting for more new videos 👍👍
Keep going
Heartily thank you sir. I had come here because i did not able to take clear concept of my lecture and mam was asked questions but i was not able to answering to mam. However mam challenged me next lecture. Through this video i will explain more than mam could expect from me.
thank you! have been confused for WEEKS and this video explained everything
OMG!!!!
His explanation is superb.
I don't think I could have understood it better from anyone else. I feel confident enough to teach this to students someday (I'm a teacher In training☺).
Thanks a lot
Great job!
Thank you sooo much!!! I have exam in 2 days and I've been struggling with this lesson.... now it's completely clear..... and now I'm pretty sure imma Rock it😅
I'm a complete layperson, I have no medical education or training whatsoever. I understood this video, at least at the logical level of what each enzyme does, etc. Thank you for a great video!! I started watching videos about SARS-Cov-2 in an attempt to understand more about it, and now I've fallen down a rabbit hole and I think I want to learn a lot more about molecular biology now. I want to learn way, way more about the processes involving DNA, RNA, cells in general - but more than that I'd love to understand how, physically these things work. Ultimately all of this boils down to chemical reactions, right? That's what I'd love to understand. Molecule X bonds with molecule Y due to its shape, structure etc, and BOOM - now you have what's essentially code being executed and - life. Maybe it's my computing science background which is causing me to be so fascinated by this world which until a week or two ago, I knew zilch about (and still do compared to someone who's actually studied it, of course). My mind is kind of blown and I can see me continuing to fall down this rabbit hole. Maybe I'll start looking for actual constructed courses, but for now, videos like this are a great place to start. Thanks again for such a clear, well structured and explained video!
Minor correction: First: A-proteins separates the strands initially at AT-rich areas throughout the strand (so replication starts at multiple places simultaneously). (Not a critique, but you forgot them).
Second step: SSBs keep the strands from annealing, like you said, while simultaneously helicase unwinds the DNA to further separate the strands.
After that Topoisomerase is also important, since it reduce the tension, caused by helicase and thereby prevents supercoiling.
Hello! I was trying to find some info on A-proteins but could't find any, can you please share a link where it's written about them? i would appreciate it, thank you!
whats AT pls?
The origin of replication depends on whether the cell is eukaryotic or prokaryotic. In Prokaryotes, the DNA is circular and there is only one origin of replication. What you refer to as A-proteins are the initiator proteins that bind to the origin of replication. In E.coli, the initiator proteins are called DnaA & DnaB. In eukaryotic cells,there are multiple origins of replication on the linear DNA molecule. The initiator protein in eukaryotes is called the origin recognition complex.
Source: www.ncbi.nlm.nih.gov/pmc/articles/PMC3783049/
adinosine and thymine@@melissaatanga4337
Ur correct
Clear, concise, and makes perfect sense. I love that you explained popular words that we commonly hear when discussing DNA replication, but may not have fully understood well. We have all heard the term leading strand, lagging strand, semi conservative, etc. but explaining exactly what they mean in conjunction with the full video explanation really increased my understanding.This attention to detail and your clear understanding of the topic really this video apart from all others.
Wow! Perfect explanation! This guy deserves it's credit.
I don't usually comment on videos, but this wonderful. Thank you so much!
I thought I understood DNA replication but after watching this video, there's so much well-explained info... I have to figure out how to organize it. By far the best channel and video ~
I've always escaped from this topic but finally had to come down cz of my exams ,my biology teacher doesn't develops good communication,also like she just wanna escape off delivering lecture,found that video useful , definitely gonna share, it's really calming to watch such a cute person explaining so nicely,he just soo looks like Clark kent❤️❤️
I think I'm going to cry ,thank you so much for this..
Thank you!!! I understood the lagging strand problem for the first time! Nice video:)
with your video, i was among the best in my exams. thank you so much DOC.
I’m not sure but it appears they have a leading and lagging computer complexity. I see why the computer fans are getting excited over. Not that it’s resolved. Yet it’s clearly the complexity.
my gosh this was legit the best video on replication
This video is the best thing to ever be created.
This video is the best explanation of a DNA replication procedure.
Thank you so much! I have watched so many videos about DNA replication and this is the most helpful and clear one!
Thank you so much. This is the best video of DNA replication I have watched so far and the only one which made complete sense. This is a life saver video for me... Thanks!
شرح رائع جدا انه افضل شرح شاهدته لهذا الموضوع --احسنت يا دكتور
This video helped me on my MCAT and in my Genetics class. Much Thanks!
Thank you so much,Teacher. I can only memorize because of your teaching style.
The best DNA replication video so far💯
Thank you for sharing this video. You are doing a wonderful job. Simple language and clear in points as a teacher i keep on searching some videos like this to bring some new aspects in my teaching. Just came across this video thank you once again.
very clear explanation of the okazaki fragments and how they occur because of the discontinuous replication on the lagging strand. This part is usually missed by students.
I finally have a clear understanding of the replication process. Thank you!
The best video on DNA replication I have seen. Thank you for the instruction. This was a major help reviewing for my Genetics MIDTERM.
best video that I've seen about DNA replication
I must say this.. Thank You Sir.. Didn't know The DNA Replication was simple like this.. Truly, it's not but you made it so.. Thank you
I am Soo grateful for this! Been thinking a lot about this topic and always encountered problems when studing the lagging strand. Thank You for explaining it soo simply and understandably! The enzyme reads the strand from 3' to 5' but the new one is made from 5' to 3' carbon + since the helicase continues to open up the DNA and the ''lagging'' strand is making DNA in the other direction, it simply needs new primers from time to time to catch up with the replicaton fork!
Your videos are helping greatly in lockdown ❤️
Love from Bangladesh 👍
Dhonnobaad!
He's very clear on explaining about the DNA I like this guy
Thanks for making me understand what I couldn't understand for 3 days❤️💯
I have watched so many videos on DNA Replication is this was so helpful!!! its crazy how I can watch 5 videos and not understand and watch yours and totally get it thank you very much!
This is the best replication video I have ever seen.
OMG! Helped me a lot! Thank you! This is the best DNA replication explanation after all.
파킨슨 이기려고유튜브합니다
This is probably the best way to teach anything. Dave you have made such a complicated process look like a child's play. I wish I could teach like you. Your appearance, choice of words, voice undulation, vocal clarity and above all the eye contact; all are immensely powerful and magnetic. Keep inspiring and enlightening us. I wish you all the best.
Thank you so much!! You just don't know how much this has helped me
I liked this video better than Khan Academy. By far the best and simple yet clearly explained!
You have just cleared my confusion . Bravo🎉❤
The best video I have watched on DNA replication. I just wished stuff on Telomerase and telomere were added here.
Hats off to you! Best video on this topic that I have seen as car as I can remember
I didn't understand the thing with the leading- and lagging strand. But now I do(At least much better) than i did before, because of this video.
Thank you!!
This is the best replication vedio
Thank you!! You saved me a lot of time. Wish my Cytogenetic teacher explained this well.
Amazing.. just discovered your channel hours before a test.. and I am so grateful to you. It cleared a lot of my doubts. Thank you so much. :)
This is what help me to pass my exam. Thanks a lot.
THANK YOU, this is such a great explanation. I kept reading my book over and over but was still confused, thank God for your video :')
This video cleared my confusion.... I enjoyed it
fantastic and the language simply superb
Thank you sir ....this was a difficult topic for me before I watched your video....it made easy for me to learn....🙂....it is the best video on DNA replication 👍
Thank you for such explanation.Your explanation is great.
Loved your explanation! Very easy to follow! Thank you so much!
Hooray!
A super cute teacher who actually speaks English.