1.Gc involve in the metabolism of carbohydrate, protein and fat. Alson involve in bodies immune function i-e work against infection. they stress hormones. 2.Cotisone have keto grouo at C11 position and hydrocortisone have OH group at C11 which enhance the GC activity 4 folds. basically cortisone is metabolised into hydrocortisone. 3. prednisolone is synthesized by hydrocortisone (having OH on C11) by the addition of double bond b/w C1&2 and prednisone is synthesized by cortisone (having keto group at C11) by the addition of same double bond b/t C1&2. 4.Betamethasone have CH3 group at C16 and F group at C9 in prednisolone structure (double bond at C1&2) and beclomethasone have CH3 group at C16 and Cl group at C9 in prednisolone structure. 5. fludrocortisone is commercially available MC having 800 times more activity of MC because of presence of F group at 9th position in hydrocortisone.
Samreen nasir 38 Qno:1 Glucocorticoids regulates the metabolism of carbohydrates,protein and fats and also provide anti inflammatory effect and resist the infection. Qno:2 In cortison keton group is present at C11 while in hydrocortisone hydroxyl group is present at C11. Qno:3 By the addition of double bond between C1 and C2 cortison convert into Prednisone And by the addition of double bond between C1 and C2 hydrocortisone convert into prednisolone. Qno:4 In the structure of baclomethason addition of chlorine at C9 whereas in structure of betamethason addition of flourine at C9. Qno:5 By the substitution of flourine at C9 in hydrocortison formed fludrocortisone. Fludrocortisone enhance bht mineralocorticoid and glucocorticoid activity.
Sanober Bozdar Roll no:40 Qno:1 They function in response to regulate body metabolism. Qno:2 cortisone contain ketone group at C11 position while hydrocortisone contain OH group at C11 position. Qno:3 Cortisone can be converted into prednisone and hydrocortisone is converted into prednisolone by natural C- 11 keto group and C- 11 OH group by the double bond at C1 and C 2. Qno:4 Beclomethane is color derivative and beclomethasone is Flouro derivative of hydrocortisone. Qno:5 Fludrocortisone contains Flourine at C9 position that increases the both GC and mineralocorticoid activity.
1_Gc causes the regulation of carbohydrates, protein, fat metabolism. 2_Cortisone contains ketone group C11 & ahydrocortisone contains OH group at C11. 3_By introducing additional double bond at C1 & C2 Prednisone is synthesized. By introducing an additional double bond at C1 g C2 in hydrocortisone prednisolone is synthesized. 4_Beclomethysone methyl group is present at C16 & Cl is present at C9 position .While Beclomethysone methyl group is present at C16 &F is present on C9. 5_Fludocortisone contains F at C9 which enhance both glucocorticoids & mineralocorticoid's activity.
1) GC regulate metabolism of carbohydrates, protein and fats and also enable body to resist infection and stress. 2) cortisone contains 3 keto groups at 3,11and 20 postion .and 2 OH groups at17 and 21 position. While hydrocortisone is reduced form of cortisone and it is formed when keto group at C 11of cortisone is replaced with OH group . So it has 2 keto groups at 3 and 20 position while 3 OH groups at 11,17 and 21 position. 3) when there is addition of double bond between c1 and c2 of Cortisone, Prednisone is synthesized. With the addition of double bond between c1 and c2 of hydrocortisone, Prednisolone is synthesized. 4) In beclomethasone at c9 cl is present while in betamethasone at c9 F is present.
1.G.C are used to regulate the proteins, fats, and carbohydrates metabolism and mainly released in response of hypoglycemia .G.C are involved in immunity response and inflammation , also in the operation of processes that enable the body to resist stress and infection so that's why they are called stress hormone. 2. Cortisone contain keto group at Carbon no .3, 11, 20 and hydroxyl group at carbon no.17 ,21while hydrocortisone contain hydroxyl group at carbon no. 11, 17, 21 and keto group at carbon no. 3 ,20. 3. when unsaturation occur at carbon.no 1,2 the potency increases 4 times and thus G.C activity become increased and here is formation of new synthetic derivative is taking place. When cortisone naturally occurring carbon 11 keto group is converted into prednisone because of additional presence of double bond at carbon no. 1,2 . when hydrocortisone naturally occurring carbon 11 hydroxyl group is converted into predisolone due to additionally presence of double bond at carbon no. 1 and 2nd . 4.Betamethasone is derivative of hydro cortisone .In betamethasone the methyl group or OH group is substituted at carbon no .16 and fluorine is attached with carbon no.9 position. This substitution can enhance the G.C activity. Beclomethasone the methyl group is present at same carbon no. 16 but at carbon no. 9 the chlorine atom is substituted so this derivative increase the G.C activity, lipophilicity,bronchial tissue absorption and duration of action. 5.when halogenation occur at carbon no .6 it causes less G.C and M.C activity but when halogenation occur at carbon no .9 or when fluorine is attached at carbon no.9 it increases 800 times M.C and 11 times G.C activity so here a new derivative is formed by this halogenation called fludrocortisone.once the fludrocortisone is made the interconversion of OH group into keto group is inhibited because the hydrocortisone and cortisone are interconvertable with each other.
Q no:1 They regulate way the body's metabolism works Q no:2 Cortisone (contains OH group at C11) is a reduced form of hydrocortisone (contains OH group at C11) Q no:3 Prednisone is created by adding extra double bonds to the C1 C2 positions of cortisone by adding a second double bond at position C12 of hydrocortisone the formation of prednisolone Q no: 4 Betamethasone has fluorine at C9 while beclomethasone has chlorine at C9 The hydrocortisone derivative fludrocortisone is more intense than hydrocortisone
1. Regulate the carbohydrates, protein and fat metabolism. Enables the body to resist infections and stress. 2. cortisone have 3 keto groups and Hydrocortin have 2 keto groups. 3. Cortisone can be converted to prednisone and Hydrocortisne is converted into prednisone by natural C-11 keto group and C -11 OH group by the double bond at C1 and C2. 4.Beclomethane is color derivative and beclomethasone is Flouro derivative of hydrocortisone. 5. Flourocortisone is derivative of Hydrocortisone and more potent .
W slam sir 1)GC regulate carbohydrate fat and protein metabolism and also enable body to resist infection and stress. 2) cartisone contain 3keto groups at C 3, 11 and 20 position and 2 OH groups at C 17 and 21 position while hydrocortisone is reduced form of cortisone and formed when keto group at C 11 is replaced with OH so it has 2 keto groups at C 3 and 20 position while 3 OH groups at C11 17 and 21 position. 3)when there is addition of double bond b/w c1 and c2 of cortisone prednisone is synthesized. With the addition of double bond b/w c1 and c2 of hydrocortisone prednisolone is synthesized. 4) Beclomethasone have chlorine at C9 position while betamethasone have fluorine at c9 position. 5) fludrocortisone contain fluorine at C9 position that increases the both GC and mineralocorticoid activity.
Farzana soomro 1: Glucocorticoid are mainly involved bin metabolism of carbohydrates , fats, protein .they are also involved in inflammation and immunity response.they are also know as stress hormones . 2: cortisone presence of double bond at 4,5 position presence of ketone group at carbon no:3,11,20, 2 hydroxy group at carbon no:17,21, hydrocortisone . presence of 3 hydroxyl group at carbon no. 11,17 ,21 .2 ketone group at carbon no: 3 and 21 . 3: cortisone can be converted in Prednisone by the addition of unsaturation at carbon no.1,2 Prednisone can be synthesized by addition of unsaturated at carbon no. 1,2 4: betamethasone contain methyl group at carbon 16 and it contain chloride at c-9 5:flurocortisone .the halogen process i-e introduction of fluorine at c-9 the new derivative form in know as fudrocortiaone .
1 Glucocorticoids are mainly involved in metabolism of carbohydrates,fats and proteins.They are also involved in inflammation & immunity responses, they are also known as stress hormones 2. Cortisone: Presence of double bond at 4,5 position, presence of keto group at Carbon no 3,11,20, 2-hydroxy group at carbon no 17,21. Hydrocortisone: Presence of 3-hydroxyl group at carbon no 11,17,21. 2-ketone group at carbon no 3&20. 3. Corisone can be converted in prednisone by the addition of unsaturation at carbon no 1,2. Prednisolone can be synthesized by addition of unsaturation at carbon no 1,2 4. Betamethasone contains methyl or hydroxyl groups at C-16 and it contains Fulorine at C-9 Beclomethasone contains methyl group at C-16 & it contains Chlorine at C-9 5. Fludrocortisone: The halogenation process i.e introduction of fluorine at C-9 the new derivative form is known as fudrocortisone.
Sonia Rollno45 Ans1:These steroid regulate the carbohydrates, proteins,and the fat metabolism that enables the body to resist infections and stress. Ans2: Cortisone have 3 ketogroup and hydrocortisone have 2 keto groups. Ans3: Cortisone can be converted into Prednisone and hydrocortisone can be converted into prednisolone by natural (C11 keto group and C11 OH group) presence of double bond C1 and C2. Ans4:In betamethasone structure there is methyl group at C16 position and fluorine at C9 position whereas Beclomethasone methyl group at C16 position and cl at C9 position. Ans5: fludrocortisoneis derivative of hydrocortisone and more potent.
1)The main & important function of glucocorticoids is They mainly involves the metabolism of d/f pathways like;carbohydrates, protein and fat and also provides antiinflammatory & immulogical effect. 2) cortisone have 3 keto group at C3,11,20 positions & have OH groups at C17,21 positions while hydrocortisone have 2 keto groups at C3,20 positions and have 3OH groups at C11,17,21 positions. 3) By addition of double bond at C1 & C2 position in cortisone Prednisone can be synthesized, by adding double bond at C1& C2 position as hydrocortisone prednisolone can be synthesized. 4) beclomethasone have chlorine at C9 position, while betamethasone have flourine at C9 position. 5) fludrocotisone & F is present at C9 position.5_fludrocortisone contain F at C9 position which enhance the both glucocorticoids & mineralocorticoid activity. Roll no 23 Joti Kumari
1- Regulate the carbohydrates, protein and fat metabolism. Enables the body to resist infections and stress. 2- Cortisone have 3 keto groups and Hydrocorton have 2 keto group. 3- Cortisone can be converted into prednisone and hydrocortisone is converted into prednisolone by natural C- 11 keto group and C- 11 OH group by the double bond at C1 and C 2. 4- Beclomethasone is cholor derivate and beclomethasone is Fluoro derivative of hydrocortisone. 5- Flurocortisone is derivative of hydrocortisone and more potent.
Shweta 44 1) glucocorticoid are responsible of metabolism of protein ,fat, carbohydrates nd also involved in immunity nd inflammation response 2) in cortisone structure there is ketone group at c12 position due to reduction Hence hydrocortisone shows greator GC activity than cortisone 3) by introduction of additional double bond at c 1,2 in cortisone Prednisone is synthesized By introduction of additional double bond at c1,2 in hydrocortisone predinisolone is synthesized 4) beclomethasone contain chlorine at c9 nd betamethasone contain flourine at c9 5) flufocortisone is derivative of hydrocortisone nd it is more potent
1. GC regulates the metabolism of carbohydrates, proteins and fats in response to hypoglycemia. They also have important role in infection and immunity responses inside the body. 2. In cortisone structure there is a keto group at C 11 position while in hydrocortisone structure there is hydroxy group at C11 position due to reduction. Hence hydrocortisone shows greater GC activity than cortisone. 3. By additional introduction of double bond at C 1 and 2 position in cortisone , Prednisone is synthesized. By additional introduction of double bond at C 1 and 2 position in hydrocortisone , prednisolone is synthesized. 4. In betamethasone, there is Substitution of methyl group at C 16 position and substitution of flourine at C9 position . In beclomethasone, substitution is made at C 9 position with chlorine atom and methyl group remains same at C 16 position. 5. When flourine atom is introduced at C 9 position, fludrocortisone is produced and this will also inhibit the interconversion of OH group to keto group at C11 position.
Asma umer roll no 7 Ans 1. Their function is to regulate the body metabolism. Ans 2. Hydrocortisone is reduced form of cortisone. Ans 3. By the introduction of additional double bonds at C1,2 in cortisone. Prednisone is synthesised . By introduction of additional hydrocortisone. Prednisolone is synthesised. Ans 4. Beclomethasone contains chlorine at C9 and betamethasone contains fluorine at C9. 5. Fluodrocortisone is the derivative of hydrocortisone and it is more potent.
Mahnoor Ali, Roll # 24. Question #01: Function of Glucocorticoids: They regulate the carbohydrates, proteins, and the fat metabolism and are intimately involved in the operation of the processes that enable the body to resist infections and stress. Question #02: ✓Hydrocortisone differs from cortisone in that it contains OH group at C-11 position, while cortisone contains a keto group at C-11 position. ✓Hydrocortisone is basically reduced form of cortisone and is more active as compared to cortisone. Question #03: Prednisone can be synthesized by introducing a double bond at the C-1 and C-2 positions of cortisone. Similarly, prednisolone can be synthesized by incorporating a double bond at the C-1 and C-2 positions of hydrocortisone. Question #04: Beclomethasone is 9α-chloro derivative of betamethasone. It means that it contains a Chlorine atom at 9th position. While Betamethasone contains Fluorine atom at C-9 position. Question #05: Introduction of Fluorine at C-9 in Hydrocortisone creates a new derivative, that is called Fludrocortisone.
1. They function in response to regulate body metabolism. 2. Reduction of cortisone results in formation of hydrocortisone. 3. Adding double bond to cortisone for prednisone and to hydrocortisone form predinisolone. 4. Beclomethasone contains Chlorine while betamethasone contains fluorine. 5. Addition of fluorine at C-9 in cortisone forms fludocortisone.
Mahnoor Rehman Roll no : 25 Glucocorticoid regulate the metabolism of carbohydrates ,proteins and the fats also known as stress hormones Q:2 Ans: Hydrocortisone is the reduced form of cortisone in hydrocortisone at C-11 (OH group) is present while in cortisone (ketone group )is present at C-11 position Q:3 Ans:cortisone is converted to prednisone by introduction of unsaturation at C1 and C2 Hydrocortisone is converted to prednisolone by additional double bond between C1 and C2 Q:4 Ans :beclomethasone contain Cl at C9 position usually formed by 9 alpha chlorination of Beclomethasone . While betwmethasone contain F at C9 position Q:5 And : Halogenation at carbon 9 produces Fludrocortisone with greater glucocorticoid and mineralocorticoid activity .
Amber Roll no: 01 Answers: 1: Glucocorticoids regulate carbohydrate, protein and lipid metabolism and involved in inflammation and immune responses. 2: Cortisone contain keto group at three positions (carbon no: 3,11,20) and OH group at carbon no 17 and 21 whereas Hydrocortisone is reduced form of Cortisone, keto group at C11 is converted into OH group. Hydrocortisone contain 2 ketone groups at carbon no 3 & 20 and three OH group at carbon no 11, 17 and 21. 3: Addition of unsaturation or Double bond b/w C1 and C2 in Cortisone, cause the conversation of Cortisone into Prednisone. Hydrocortisone is converted into prednisolone by addition of unsaturation b/w C1 and C2. 4: Betamethasone is 9alpha fluoro-16Betamethyl derivative of Hydrocortisone whereas Beclomethasone is 9alpha chloro derivative of Betamethasone. 5: Fludrocortisone is a derivative of Glucocorticoid I which fluorination is occured at 9 position on ring B, which inhance its activity.
Aneeta Lohana 04 1) regulate the carbohydrates proteins and fat metabolism . Enables the body to resist infections and stress . 2) cortisone have 3 keto group and hydrocortisone have 2 keto groups . 3) Cortisone can be converted into prednisone and hydrocortisone into prednisolone by natural C-11 keto group and C-11 OH group by the double bond at c1 and c2.. 4) beclomethasone is chloro derivative and betamethasone is Fluoro derivative of hydrocortisones.. 5) fludfocortisone is derivative of hydrocortisone and more potent .
Tabinda zameer Roll no 46 1)glucocorticoids regulates the carbohydrates ,proteins and fat metabolism and enables the body to resists infections and stress. 2)cortisone have 3 keto groups and hydrocortin have 2 keto groups 3) cortisone can be converted to prednisone and hydrocortisone is converted into prednisone by natural C-11 keto group and C-11 OH group by the double bond at C1 and C2 4) beclomethasone is color derivative and beclomethasone is Fluoro derivative of hydrocortisone . 5)Fludrocortisone contains fluorine at C9 position thất increases the both GC and mineralocorticoid activity.
1) regulate the carbohydrates proteins and fat metabolism . Enables the body to resist infections and stress . 2) cortisone have 3 keto group and hydrocortisone have 2 keto groups . 3) Cortisone can be converted into prednisone and hydrocortisone into prednisolone by natural C-11 keto group and C-11 OH group by the double bond at c1 and c2.. 4) beclomethasone is chloro derivative and betamethasone is Fluoro derivative of hydrocortisones.. 5) fludfocortisone is derivative of hydrocortisone and more potent .
Sameet fatima Roll no 37 Q:1 Ans Function of glucocorticoids is to regulate the carbohydrates, protein, and fat and involved in the operation of the processes that enable the body to resist infections and stress. Q:2 Ans • Hydrocortisone is the reduce form of cortisone and is more active • Hydrocortisone contain OH group at C-11 meanwhile cortisone contain keto group at C-11. Q:3 Ans Addition of double bond at C-1 and C-2 position of cortisone and hydrocortisone will lead to the formation of prednisone( by cortisone) and prednisolone( by hydrocortisone). Q:4 Ans Beclomethasone contain chlorine at C-9 and betamethasone contain flourine at C-9. Q:5 Ans Flourination at C-9 on ring B in prednisolone will form fludrocortisone.
Shumaila dahri roll no 43 1 glucocorticoids involves in the metabolism of many pathways eg carbs protein fats 2 cortisone has double bond at 4'5 And keto group has 3 20 11 position 3 Prednisone synthesized by addions of double bond between C1 and C2 4 Beclomethasone contain chlorine at 9 C And betamethsone contain fluorine at 9c 5 Fludocartisone has halogen at C9 position which increases its glucocorticoid and minrilocarticoid
W salam sir Saira majeed roll no 36. Ans:downregulate the immune system, decrease symptoms of autoimmune disorders, modify the body's stress response, regulate metabolism, increase blood glucose, and treat skin disorders. Ans:cortisone is a harmone produced by adrenal cortex its anti inflammation and anti allergic. Hydrocortisone is harmone produced by adrenal cortex used to treat inflammation from eczema. Ans: by introducing double bond in C1 Prednisone is synthesized by unsaturation between C1 and 2 hydrocortisone is converted in Prednisolon. Ans:Beclomethasone has the same structure as betamethasone apart from the replacement of the 9α-fluoro group with a 9α-chloro group. Ans: adding flourine group at carbon 9 having increase GC and mineralocorticoid activity.
Humera Nasir Roll no:19 Q1: Glucocorticoids are mainly involve in regulation of different metabolic pathways like metabolism of carbohydrates and fats. Q2:In hydrocortisone structure at C-11 position OH group is present whereas in cortisone at C-11 position ketone group is present. Q3:By the introduction of unsaturation double bond between C-1and C-2 cortisone converted into Prednisone and by the additional unsaturation between C-1and C-2 hydrocortisone converted into prednisolone. Q4:Beclomethason has additional Cl atom at C-9 position. Betamethasone has F atom at C-9 position. Q5:When halogenation or halogen atom are substitute at C-9 position then fludrocortison will formed and it has greater glucocorticoids and mineralocorticoids activity.
Maryam aziz Roll no 26 1) Glucocorticoids regulates carbohydrates, proteins and fats metabolism and also involved in producing resistance to infections and stress 2)cortisone contain double bond at carbon 4 and 5, keto group at carbon 3, 11& 20 position and OH group at 17,21 carbon Whereas hydrocortisone contain keto group at carbon 11 and OH group at 11 21 and 17 carbon 3)By addition of double bond between C1 and C2 in cortisone it is converted into prednisone and By addition of double bond between C1 and C2 in hydrocortisone it produces prednisolone 4)Betamethsone contains flourine at C9 position whereas beclomethasone contains Chlorine at C9 position 5)fludrocortisone contain fluorine which increases its Glucocorticoids and mineralocorticoids activity
YusRa shaikh Roll no Ans 1 the function of glucocorticoids is to regulate the body metabolism Ans 2 hydrocortisone is the reduced from of cortisone. Hydrocortisone hydroxy group is present st carbon no 11 instead of ketone Ans 3 by reduction (adding of double bond between C1 and C2 Ans 4 beclomethasone contain Cl at C9 position while betamethasone contain f at C9 position Ans 5 fludrocortisone is commercially available mineralocorticoid it contain f at C9 position which enhance its both mineralocorticoid and glucocorticoid activity
Mehwish Arain Roll no 28 Ans# 1: Glucocorticoids functions is to regulate the metabolism of carbohydrates, fats and protein. Also provide anti- inflammatory and immunological effects. Ans # 2 : Cortisone contains ketone group at Carbon no11 whereas in Hydrocortisone this reduce to hydroxy (OH) group at carbon 11 due to this reduction hydrocortisone has more Glucocorticoid activity than cortisone. Ans #3 By the introduction of additional double bond b/ w 1,2- carbon atoms in cortisone and hydrocortisone structure this leads to the formation of prednisone and prednisolone respectively. Ans #4: the difference between the structure is the only difference in the halogen atom betamethasone is 9alpha fluoro-16 beta Methyl derivative of hydrocortisone & beclomethasone is 9alpha- chloro derivative of betamethasone. Ans 6: Fludrocortisone is mineralocorticoid form by the substitution of fluorine at carbon 9 in hydrocortisone which enhance the 800 time Mineralocorticoid and 11 times glucocorticoid activity .
Dua Aftab Roll no 12 Ans.1 Glucocorticoids are mainly involved in regulation of diff metabolic pathways like metabolism of carbohydrates,proteins,fats. Also they have important role in the inflamation and immunity responses of the body. Ans.2 glucocorticoid activity of cortisone is less than hydrocortisone -reduced form of cortisone has keto group at C-11 while hydrocortisone has OH group at C-11 Ans.3 by introduction of double bond between C-1 and C-2 of cortisone it canbe converted into prednisone While prednisolone is formed by introduction of double bond between C-1 and C-2 of hydrocortisone. Ans.4 betamethasone contain flourine at C-9 while beclomethasone has Chlorine atom at C-9 Ans.5 flourination at C-9 on ring B enhances glucocorticoid and mineralocorticoid activity. *Fludrocortisone is only mineralocorticoid which is commercially available.
Name Areesha Rind Roll no 05 1 They function in response to regulate body metabolism. 2 Reduction of cortisone results in formation of hydrocortisone. 3 Adding double bond to cortisone for problems and to hydrocortisone from prednisolone. 4 Betamethasone contains chlorine while Betamethasone of fluorin at c -9 in cortisone forms fludrocortisone
Hafsa qureshi Roll no 16 Qno:1 Glucocorticoids regulates the metabolism of carbohydrates,protein and fats and also provide anti inflammatory effect and resist the infection. Qno:2 In cortison keton group is present at C11 while in hydrocortisone hydroxyl group is present at C11. Qno:3 By the addition of double bond between C1 and C2 cortison convert into Prednisone And by the addition of double bond between C1 and C2 hydrocortisone convert into prednisolone. Qno:4 In the structure of baclomethason addition of chlorine at C9 whereas in structure of betamethason addition of flourine at C9. Qno:5 By the substitution of flourine at C9 in hydrocortison formed fludrocortisone. Fludrocortisone enhance bht mineralocorticoid and glucocorticoid activity.
Asma ujjan Roll No:06 Q1: Ans: Their function is to regulate body metabolism Q2: Ans:Hydrocortisone (Contains OH group at C11) is reduced form of cortisone ( Contains keto group at C11) Q3: Ans:By introduction of additional double bond at C1,2 in hydrocortisone:-prednisolone is synthesized By introduction of additional double bond at C1,2 in hydrocortisone:-prednisolone is synthesized Q4: Ans: Beclomethasone Contains chlorine at C9 and Betamethasone contains Fluorine at C9 Q5: Ans: Fludrocortisone is the derivative of hydrocortisone and it is more potent
Sawera Mushtaque ahmed Roll no 42 Answer 1) Glucocorticoid involves in metabolism of carbohydrates ,protein and fats. They also have an important role in the inflammation and immunity responses inside the body Ans 2) HYDROCORTISONE : is the reduced form of cortisone .In Hydrocortisone ,Hydroxy group is present at C-11 instead of ketone due to this reduction ,hydrocortisone has more GLUCOCORTICOID activity than cortisone . Ans 3) PRESNISOLONE. By adding a double bond solution in the C1 C2 positions in the hydrocortisone ,prednisolone can be synthesized. Ans 4) BECIOMETHASONE contains chlorine at c-9 position while BETAMETHASONE contains fluorine at C-9 position . The difference between these structure is the only difference in the halogen atom . Ans 5) FLUDROCORTISONE is commercially available MINERAL OCORTICOID ,it contains flourine at C-9 position which enhances its both MINERAL OCORTICOID(800 times more ) and GLUCOCORTICOID (11 times more ) Activity .
Sapna Nusrat roll no 41 Q:01 Ans: Glucocorticoids are types of steroids regulate the carbohydrates, protein and fat's metabolism and are involved in the different processes of body which prevent the body from infections and stresses. Q:02 Difference Between Cortisone as Hydrocortisone. Ans: 1) Cortisone is naturally occurring glucocorticoid. Position of ketone group in Cortisol is at C3, 11 and 22 C, means contain three ketone group in it's chemical structure. And 2 hydroxyl group Present at carbon 17 and 21. 2) Hydrocortisone is reduced form of Cortisone because Keto group at C-11 position is converted into Hydroxyl group then hydrocortisone is formed, position of ketone group is at C-11. Biologically activity of hydrocortisone is greater than cortisone. Q:03 Synthesization of Prednisone and Prednisolone. Ans : A) In Cortisol's chemical structure C1 and C2 double bond potency increases 4 times and directly increases the Glucocorticoid activity through this C-11 keto group is converted into Prednisone. So Presence of additional double bond and additional unsaturation between C1 and C2 synthesizes the Prednisone. B) Hydrocortisone ( Natural C-11 hydroxy group ) is converted into Prednisolone. Then Unsaturation occurs at C1=C2 . All is the great role of additional double bonds between C1 and C2. Q:04 Difference Between Beclomethasone and Betamethasone Ans: Beclomethasone is the 9alpha chloro derivative of betamethasone. And Betamethasone 9Alpha Flouro-16 Beta Methyl deirvative of hydrocortisone. Q:05 Ans: Fludrocortisone is a Mineralocorticoid with high salt retention and is commercially available. It enhances both mineralocorticoid and glucocorticoid activity with chemical structure aspect at 9 position on Ring B.
Q-1 Regulate body metabolism. Q-2 Cortisone has 4,5 double bond & keto group= 3,11, 20C - position. Hydrocortisone has double between 4 & 5 C 3 carbonyl. Q-3 Prednisone is synthesised from cortisone by only additional double bond between C1 & C2. Prednisolone is synthesised from hydrocortisone by only additional double bond between C1 & C2. Q-4 Beclomethasone contain chlorine at 9C Betamethasone contain fluorine at 9C. Q-5 Fludrocortisone is a derivative of hydrocortisone and it is more potant.
Ghulam fatima (20) Ans 1: They regulate metabolism of carbohydrates, fat, proteins They also release in hypoglycemia Also involved in body infections and stress Ans 2: In cortisone there is O (ketone group) at C 11 whereas in hydrocortisone C 11 is substituted with OH Ans 3: By addition of double bond between C 1 and C 2 Ans 4: In betamethasone C 9 contain F whereas in beclomethasone C 9 contain Cl instead of F Ans 5: fludrocortisone is commercialy available mineralocorticoid which contain F at C 9 that inc its both GC and MC activity
Q1# Glucocorticoids causes the regulation of the carbohydrates, protein and fat metabolism,and enable the body to resist infections and stress. Q2# Cortisone contain ketone group at C 11 position and hydrocortisone contain OH group at C11 position. Q3# By introduction of additional double bond at C1 &2 in cortisone Prednisone is synthesized. By introduction of additional double bond at C1 and C2 in hydrocortisone prednisolone is synthesized. Q4# Beclomethasone methyl group is present at C16 position & Cl is present at C9 position. While in betamethasone methyl group is present at C16 position and F is present at C9 position. Q5# Fludrocortisone contain F at C9 position which enhances both glucocorticoid and mineralocorticoid activity.
Nimra khalid Ans 1 Functions They regulate the carbohydrates, protein and fat metabolism. They involve in operation of the process that enable the body to resist infection and stress. Ans 2 In cortisone 3,11,20 at C-position = 3 keto group 17,21-C = OH gruop In hydrocortisone 11,17,21 = 3 OH group 3,20 = keto group Ans 3 Prednisone can be synthesize by addition of unsaturation at C-no 1 and 2 in cortisone. Prednisolone can be synthesize by addition of unsaturation at C-1 and C-2 in hydrocortisone. Ans 4 Betamethasone contain Fluorine at C-9. Beclomethasone contain chlorine at C-9 Ans 5 Addition of fluorine at C-9 in cortisone to form fludrocortisone.
Quiz Answers: 1. Regulation of Metabolism 2. Hydrocortisone is the reduced from of cortisone. in hydrocortisone, Hydroxy group is present at Carbon no 11 instead of ketone. 3. By Reduction. (addition of double bond between C1 and C2) 4. Beclomethasone contain Cl at C9 position while Betamethasone contain F at C9 position. 5. Fludrocortisone is commercially available Mineralocorticoid , it contain F at C9 position which enhance its both Mineralocorticoid and glucocorticoid activity.
Naila Ali Ans1: Glucocorticoids cause the regulations of the carbohydrates, protein and fat metabolism,and enable the body to resist infection and stress. Ans2:Cortisone contain ketone group at C 11 position and hydrocortisone contain OH group at C 11 position. Ans3: By introduction of additional double bond at C1&2 in cortisone Prednisone is synthesized. By introduction of additional double bond at C1 and C2 in hydrocortisone prednisolone is synthesized. Ans4: Beclomethasone methyl group is present at C16 position &C16 position.While in betamethasone methyl group is present at C16 position and F is present at C9 position. Ans5: Fludrocortisone contain F at C9 position which enhance both Glucocorticoids and mineralocorticoid activity.
Ans:1 G.C involves in metabolism of carbohydrates, proteins, fats b/c they are mainly released in response of hypoglycemia, which acts as a stimuli for the released of G.C. They have an also important role in the inflammation and immunity responses inside the body. Also known as stress hormone. Ans:2 In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11. In cortisone 3 keto group is present at C-3,11,20 and 2 hydroxyl group present at C-17,21. In hydrocortisone 2 ketone group are present at C-3,20 and 3 hydroxyl group present at C-11,17,21. Ans:3 In G.C un saturation is present at the 4th,5th C-atom but we synthesize new derivative with maximum G.C activity in. Comparison to naturally occurring, so we introduced new un saturation at C-1,2 which increases potency of G.C 4 times in comparison to naturally occurring G.C. Cortisone can be converted into prednisone and additional un saturation of C-1,2 of hydrocortisone can be converted into prednisolone. Ans:4 Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group CH3 at C-16 position and Fluorine (F) at C-9 position while in beclomethasone methyl CH3 group is same at C-16 position but at C-9 Chlorine (cl) group is attached. Ans:5 During synthesis of different types of new derivative halogenation reaction was done at the different position in chemical structure of G.C, like it was done at C-6 but halogenation at C-6 produces G.C or M.C with lesser biological activity but when halogenation like (F) atom introduce or substituted at C-9 then new derivative form c/d fludrocortisone and its activity is 800 times more M.C and 11 times more G.C activity then previous. Fludrocortisone contain additional F atom which is halogen at C-9 and due to this F or halogen at its activity is increase and this cause inhibition of metabolism of or reconversion of hydrocortisone into cortisone b/c hydrocortisone & cortisone are interconvertable to one another due to metabolism reactions.
1. Glucocorticoids used to regulate the proteins , fats and carbohydrates metabolism and enable the body to resist infection and stress. 2. Cortisone contain keto group at carbon no: 11 position while hydrocortisone contain OH group at carbon no:.11 position. 3. In cortisone there is additional double bond at carbon no : 1,2 to synthesized the prednisone while in hydrocortisone there is additional double bond at carbon no :1,2 to synthesized the predisolone. 4. Betamethasone contain methyl group at carbon no:16 position and Flourine atom is present at carbon no :9 while in Beclomethasone OH group is present at carbon no : 16 position and chlorine atom is present at carbon no : 9. 5. flourination is taking place when FL is present at carbon no :9 position that can enhance both glucocorticoids and mineralocorticoids activity. Mineralocorticoids activity increases 800 times while glucocorticoids activity increases 11 times .when FL is present at carbon no : 9 position it inhibit the reaction conversion of OH group into keto group.
Noor e Sehar Roll no:33 Ans:1 Glucocorticoids also known as stress hormone involve in the metabolism of carbohydrates,proteins, and fats. They are also involved in inflammation and immunity responses. Ans:2 Hydrocortisone:presence of 3-hydroxyl group at carbon no:11,17,21 and 2-ketone group at carbon no:3 and 20. Cortisone:presence of double bond at 4,5 position,presence of keto group at carbon no:3,11,20 and 2-hydroxy group at carbon no:17 and 21. Ans:3 Prednisone can be synthesized by adding a double bond at C1,C2 position in cortisone. Prednisolone can be synthesized by adding double bond at C1,C2 position in hydrocortisone. Ans:4 Beclomethasone have clorine at C-9 while Betamethasone have flourine at C-9. Ans:5 It is commercially available mineralocorticoid which contain Fluorine at carbon no:7 which enhance both glucocorticoid and mineralocorticoid activity.
Rabia Roll no: 35 ANSWERS 01: Glucocorticoid helps in the metabolism of carbohydrates, protein and fats. It also perform inflammatory response in body. 02: Hydrocortisone is reduced form of cortisone. In hydrocortisone hydroxy group is present at C11. Hydrocortisone has more glucocorticoid activity than cortisone. 03: Prednisolone can be formed by addition of double bond at C1 and C2 position in hydrocortisone. Prednisone is formed by addition of double bond at C1 and C2 position in cortisone. 04: In BECIOMETHASONE chlorine is present at C 9 position while in BETAMETHASONE flourine is present at C 9 position. 05: It is commercially available mineralocorticoid which contain flourine at carbon 7 which increases both glucocorticoid and mineralocorticoid activity.
Mehnaz Gul unar ROLL no#27 Ans:1 the main function inside the body they are mainly involve in the regulation different metabolism pathway like metabolism of carbohydrates,protein,fats and enable and important role in the inflammation and immunity responses in the body they also known stress harmone. Ans:2cortisone have 3 keto group at C3,11,20 positions and have OH group at C17,21 position while Hydrocortisone have 2 keto group at C3 ,20 position and have 3 OH group at C11,17,21. Ans :3 By adding a double bond at C1,C2 positionin cortisone ,prednisone can be synthesized. By adding a double bond at C1,C2 position in hydrocortisone , prednisolone can be synthesized. Ans :4 Beclomethasone have chlorine at C9 position while Betamethasone have flourine at C9 position. Ans :5 Fludrocortisone contains Flourine at C9 position that increases the both GC and mineralocorticoid activity.
Amna Mehmood Roll no 02 Q#1 Glucocorticoid involves in the metabolism of carbohydrates, proteins and fats also have a inflammatory effect and resist the infection. Q#2 Hydrocortisone (contains OH group at C11) is reduced form of cortisone(contain keto group at C11). Q#3 Cortisone can be converted into prednisone and hydrocortisone can be converted into prednisolone by natural (C11 keto group and C11 OH group) presence of double bond at C1 and C2. Q#4 Beclomthasone contain chlorine at C9 and betamethasone contain flourine at C9. Q#5 Fludrocortisone is derivative of hydrocortisone and it is more potent.
Anoosha Qureshi Roll no 03 1. Their function is to regulate the body metabolism. 2. Hydrocortisone (contains OH group at C11) is reduced form of Cortisone (contains keto group at C11). 3. Adding double bond to cortisone for prednisone and to hydrocortisone form predinisolone. 4. the difference between the structure is the only difference in the halogen atom betamethasone is 9alpha fluoro-16 beta Methyl derivative of hydrocortisone & beclomethasone is 9alpha- chloro derivative of betamethasone. 5. Fludrocortisone: The halogenation process i.e introduction of fluorine at C-9 the new derivative form is known as fudrocortisone.
Name : Fiza Majeed Roll no :15 Ans :01 Glucocorticoids regulate the metabolism of carbohydrates, fats & protein & also enables the body to resist stress & infections. Ans :02 Cortisone have 3 keto group at 3,11,20 position & 2 OH group at 17 & 21 position. Hydrocortisone is reduced form of cortisone & have 2 keto group at 3 & 20 position & 3 OH group at 11,17 & 21 position. Ans :03 Prednisone is synthesized when there is a addition of double bond between C1 & C2 of cortisone. Prednisolone is synthesized when there is addition of double bond between C1 & C2 of hydrocortisone. Ans :04 Beclomethasone is chloro derivative & betamethasone is fluoro derivative of hydrocortisones. Ans :05 Fludrocortisone contains fluorine at C9 position that increases the activity of both Glucocorticoids & mineralocorticoid.
Sania akhtar Roll no 39 Q1 Main function of glucocorticoids are •Mainly involved in regulation of metabolism of carbohydrates,protein and fats •important role in inflammation and immunity responses inside the body also known as stress hormones Q2 In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11 In cortisone 3 ketone group is present at C-3, 11,20 and 2 hydroxyl group present at C 11,17, 21. Q3 In G.C saturation is present at the 4th, 5th C atom but we synthesize new derivative with maximum G.C activity in comparison to naturally occurring,so we introduce new unsaturation at C-1,2 which increase potency of G.C 4 times in comparison to naturally occurring G.C Cortisone can be converted into Prednisone and additional un saturation at C-1,2 of hydrocortisone can be converted into Prednisolone. Q4 Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C 16 position and fluorine at C 9 position while in beclomethasone methyl group at C 16 position but at C 9 chlorine group is attached with it Q5 Fluorination at the 9 position on ring B enhances both glucocorticoid and mineralocorticoid activity
Ans 1 GC regulates the carbohydrates,proteins and fat metabolism and are involved in the processes that enables the body to resist infection and stress. Ans 2 Cortisone have 3 keto groups at C 3,11,20 positions and have 2 OH groups at C 17,21 positions while Hydrocortisone have 2 keto groups at C 3,20 positions and have 3 OH groups at C 11,17,21 positions . Ans 3 By adding a double bond at C1,C2 position in cortisone, prednisone can be synthesized . By adding a double bond at C1,C2 position in hydrocortisone,prednisolone can be synthesized. Ans 4 Beclomethasone have chlorine at C9 position while Betamethasone have flourine at C9 position. Ans 5 Fludrocortisone contains Flourine at C9 position that increases the both GC and mineralocorticoid activity .
Ans1. Gc regulates the carbohydrates, proteins and fat metabolism and are involved in the processes that enables the body to resist infection and stress. Ans2. Cortisone have 3 keto group at C3,11,20 positions and have 2 OH grous at C 17,21 positions while hydrocortisone have 2 keto group at C 3,20 positions and have 3 OH groups at C11,17,21 positions. Ans3.By adding a double bond at C1,C2 position in cortisone , prednisone can be synthesized. By adding a double bont at c1, C2 position in hydrocortisone, prednisone can be synthesized. Ans4. Beclomethasone have chlorine at C9 position while betamethadone have flourine at C9 position. Ans5. Fludrocortisone contains flourine at C9 position that increases the both GC and mineralocorticoid activity.
Ans:1 G.C involves metabolism of carbohydrate, protein, fats b/c they are mainly released in response of hypoglycemia, which acts as a stimulus for the released of G.C. they have an also important role in the inflammation and immunity response inside the body.also known as stress hormone. Ans2 In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11 In cortisone 3 ketone group is present at C-3, 11, 20 and 2 hydroxyl group present at C 11,17, 21. Ans 3 In G.C saturation is present at the 4th ,5th C atom but we synthesize new derivative with maximum G.C activity in comparison to naturally occurring, so we introduce new unsaturation at C-1,2 which increase potency of G.C 4 times in comparison to naturally occurring G.C Cortisone can be converted into Prednisone and additional un saturation at C-1,2 of hydrocortisone can be converted into Prednisolone. Ans 4 Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C 16 position and fluorine at C 9 position while in beclomethasone methyl group at C 16 position but at C 9 chlorine group attached.
W. Salam sir. 1 glucocorticodss caused the regulations of carbohydrates proteins nd fat metabolism . 2 cortisone contain ketone grouo c11 nd hydrocortison contain oH group at c11. 3. By introducing additional double bond at c1 nd c2 Predinsone is synthesisend. By introducing additional double bond at c1 nd c2 in hydrocirtisone predinsolone is synthesised. 4. beclomethasone methyl group is present at c16 nd Cl is present at C9 positions. While beclomethasone methyl gruop is persent at c16 nd F is present at c9. 5.fludorocortisone contain F at c9whivh enhance both glucocorticoid nd mineralocorticoid activity.
Sahar Aslam Roll no 46 1) they function in response to regulate body metabolism 2) reduction of cortisone results in formation of hydrocortisone 3) adding double bond to cortisone for prednisone and to hydrocortisone form predinisolone 4) beclomethasone contains chlorine while betamethasone contains fluorine 5) Addition of fluorine at C-9 in cortisone forms fludocortisone
Bibi Amna 08 Ans.1 Glucocorticoids regulate the carbohydrate protein and the fat metabolosm and are intimately involved in the operation of the processes that enable the body to resist infections and stress.. Ans.2 Cortisone contain keto group at carbon no.11 position whereas hydrocortisone contain oH group at carbon no.11 position.. Ans.3 When there is addition of double bond b/w c1 and c2 of cortisone prednisone is synthesized. -And when there is addition of double bond b/w c1 and c2 of hydrocortisone prednisolone is synthesized.. Ans.4 Beclomethasone have chlorine at the c9 position whereas beta-methasone have flourine at the c9 position.. Ans.5 Fludrocortisone contain F at c9 position which enhance the activity of glucocorticiods and mineralocorticoids..
Walaikum Assalam Sir! Iram Mehboob Malik Roll No# 22 ANSWERS: Q#1- GLUCOCORTICOID involves in Metabolism of Carbohydrates, Proteins and Fats. They also have an important role in the Inflammation and Immunity responses inside the body. Q#2- HYDROCORTISONE is the reduced form of CORTISONE. In Hydrocortisone, Hydroxy group is present at C-11 instead of Ketone due this reduction, Hydrocortisone has more GLUCOCORTICOID activity than Cortisone. Q#3- PREDNISONE •By Adding a Double Bond at C-1, C-2 Position In CORTISONE, PREDNISONE can bs Synthesized. PREDNISOLONE •By Adding Double Bond at C-1, C-2 Positions in HYDROCORTISONE, PREDNISOLONE can be synthesized. Q#4- BEClOMETHASONE contains CHLORINE at C-9 Position While BETAMETHASONE contains FLOURINE at C-9 Position. The difference between these Structures, is the only difference in the HALOGEN Atom. Q#5- FLUDROCORTISONE is commercially available MINERALOCORTICOID, It contains FLOURINE at C-9 Position which enhance its both MINERALOCORTICOID (800 times More) and GLUCOCORTICOID (11 times more) Activity.
Ans#1 The regulate the metabolism of carbohydrates,fats,proteins and they release in hypoglycemic condition and also involved in body infections and stress Ans#2 In cortisone there is ketone group at carbon no 11 whereas in hydrocortisone carbon no 11 is substituted with OH group Ans#3 By addition of double bond between carbon no 1 and 2 Ans#4 In betamethasone carbon 9 contain f whereas in beclomethasone carbon 9 cintains cl instead of f. Ans#5 Fludrocortisone is commercially available mineralocorticoid which contains f at carbon no 9 that includes it's both GC and MC activity
Anum Zardari roll:06 1. Their function is to regulate the body metabolism. 2. Hydrocortisone (contains OH group at C11) is reduced form of Cortisone (contains keto group at C11). 3. by introduction of additional double bonds at C1,2 in cortisone:- Prednisone is synthesized. by introduction of additional double bond at C1,2 in hydrocortisone:- prednisolone is synthesized. 4. Beclomethasone contains chlorine at C9 & Betamethasone contains fluorine at C9. 5. Fludrocortisone is the derivative of hydrocortisone and it is more potent.
*Duaa Zehra_11* *Quiz Answers* *A1: Functions of Glucocorticoids:* -Metabolism of carbohydrate, protein, fats as they are mainly released in response to hypoglycemic conditions. -Resist body from infections and stress. *A2: Difference Between Cortisone & Hydrocortisone:* Hydrocortisone is a reduced form of cortisone. *=> Cortisone* ---> 3 keto group is present at 3, 11, 20 and 2 hydroxyl groups present at C17, 21. *=> Hydrocortisone* ---> 3 hydroxyl group present at C11,17, 21 and 2 keto group at C 3, 20. *A3: Synthesis of Prednisone & Prednisolone from Cortisone & Hydrocortisone:* In GC saturation is present at the 4th ,5th atom of carbon. However, for synthesizing new derivatives with maximum GC activity in comparison to naturally occurring, we introduce new unsaturation at C1,2 which increases potency of GC 4 folds. Cortisone can be converted into prednisone by this way and additional unsaturation at C1,2 of hydrocortisone can be converted into prednisolone. *A4: Difference Between Betamethasone & Beclomethasone:* Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C16 position and fluorine at C9 position whereas in beclomethasone chlorine is attached at C9 position and methyl at C16. *A5: Fludrocartisone:* Fludrocartisone is derivative of prednisolone obtained by fluorination in prednisolone at C9.
Ans1: Glucocorticoids are responsible for metabolism of carbohydrates, proteins and fats and are also involved in immunity and inflamation responses. Ans2: If we see structure of cortisone, there is ketone group on 11carbon whereas in hydrocortisone OH group is on 11carbon. Ans3: Prednisone can be synthesized from cortisone by unsaturation of double bond between carbon no: 1 and 2 by unsaturation of double bond between carbon no: 1 and 2, hydrocortisone will converted to prednisolone. Ans4: In beclomethasone, there is chlorine at carbon no:9 whereas betamethasone is synthesized by fluorination at carbon no: 9. Ans5: By fluorination in prednisolone at carbon no:9, a derivative is formed which is known as fludrocortisone.
Name MurkBhutto Roll no31 Q1 Glucocorticoids have a pivotal role in the glucose, protein, and fat metabolism of the body. Q2 Ans:CORTISONE: A hormone produced by the adrenal cortex, one of the Glucocorticoids. It is also made synthetically for use as an anti inflammatory and anti allergy agent. CHEMICAL FORMULA:C21H28O5. HYDROCORTISONE: A steroid hormones produced by the adrenal cortex and used medinically to treat inflammation resulting from eczema and rheumatism. CHEMICAL FORMULA:C21H30O5 Q3 Ans By reduction (addition of double bond between C1 and C2). Q4 Ans BECLOMETHASONE: Contain Cl at C9 position. BETAMETHASONE:Contain F at C9 position. Q5 Ans Fludrocortisone contain F at C9 which enhance both Glucocorticoid and mineralocorticoid activity.
Ans: 1- Glucocorticoids regulate the carbohydrates, protein and fat metabolism,and enable the body to resist infections and stress. 2- cortisone contain ketone group at C 11 position and hydrocortisone contain OH group at C11 position. 3- By introduction of additional double bond at C1 &2 in cortisone Prednisone is synthesized. By introduction of additional double bond at C1 and C2 in hydrocortisone prednisolone is synthesized. 4- in beclomethasone methyl group is present at C16 position & Cl is present at C9 position. While in betamethasone methyl group is present at C16 position and F is present at C9 position. 5- Fludrocortisone contain F at C9 position which enhances both glucocorticoid and mineralocorticoid activity.
Ans:1: Glucocorticoids are responsible for metabolism of carbohydrates, proteins and fats and are also involved in immunity and inflammation responses....
1-Regulate the carbohydrates, protein and fat metabolism. Enables the body to resist infections and stress. 2. cortisone have 3 keto groups and Hydrocortin have 2 keto groups. 3. Cortisone can be converted to prednisone and Hydrocortisne is converted into prednisone by natural C-11 keto group and C -11 OH group by the double bond at C1 and C2. 4.Beclomethane is color derivative and beclomethasone is Flouro derivative of hydrocortisone. 5. Flourocortisone is derivative of Hydrocortisone and more potent .
Muqadisa Ahmed Roll no 30 Qno:1 Glucocorticoids regulates the metabolism of carbohydrates,protein and fats and also provide anti inflammatory effect and resist the infection. Qno:2 In cortison keton group is present at C11 while in hydrocortisone hydroxyl group is present at C11. Qno:3 By the addition of double bond between C1 and C2 cortison convert into Prednisone And by the addition of double bond between C1 and C2 hydrocortisone convert into prednisolone. Qno:4 In the structure of baclomethason addition of chlorine at C9 whereas in structure of betamethason addition of flourine at C9. Qno:5 By the substitution of flourine at C9 in hydrocortison formed fludrocortisone. Fludrocortisone enhance bht mineralocorticoid and glucocorticoid activity.
Ans 1 GC regulates the carbohydrates,proteins and fat metabolism and are involved in the processes that enables the body to resist infection and stress. Ans 2 Cortisone have 3 keto groups at C 3,11,20 positions and have 2 OH groups at C 17,21 positions while Hydrocortisone have 2 keto groups at C 3,20 positions and have 3 OH groups at C 11,17,21 positions . Ans 3 By adding a double bond at C1,C2 position in cortisone, prednisone can be synthesized . By adding a double bond at C1,C2 position in hydrocortisone,prednisolone can be synthesized. Ans 4 Beclomethasone have chlorine at C9 position while Betamethasone have flourine at C9 position. Ans 5 Fludrocortisone contains Flourine at C9 position that increases the both GC and mineralocorticoid activity .
Ans:1 G.C involves metabolism of carbohydrate, protein, fats b/c they are mainly released in response of hypoglycemia, which acts as a stimulus for the released of G.C. they have an also important role in the inflammation and immunity response inside the body.also known as stress hormone. Ans2 In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11 In cortisone 3 ketone group is present at C-3, 11, 20 and 2 hydroxyl group present at C 11,17, 21. Ans 3 In G.C saturation is present at the 4th ,5th C atom but we synthesize new derivative with maximum G.C activity in comparison to naturally occurring, so we introduce new unsaturation at C-1,2 which increase potency of G.C 4 times in comparison to naturally occurring G.C Cortisone can be converted into Prednisone and additional un saturation at C-1,2 of hydrocortisone can be converted into Prednisolone. Ans 4 Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C 16 position and fluorine at C 9 position while in beclomethasone methyl group at C 16 position but at C 9 chlorine group attached. Ans5 By flourination in prednisolone at C 9, a derivative is formed which is known as fludrocortisone
Ans:1 G.C involves metabolism of carbohydrate, protein, fats b/c they are mainly released in response of hypoglycemia, which acts as a stimulus for the released of G.C. they have an also important role in the inflammation and immunity response inside the body.also known as stress hormone. Ans2 In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11 In cortisone 3 ketone group is present at C-3, 11, 20 and 2 hydroxyl group present at C 11,17, 21. Ans 3 In G.C saturation is present at the 4th ,5th C atom but we synthesize new derivative with maximum G.C activity in comparison to naturally occurring, so we introduce new unsaturation at C-1,2 which increase potency of G.C 4 times in comparison to naturally occurring G.C Cortisone can be converted into Prednisone and additional un saturation at C-1,2 of hydrocortisone can be converted into Prednisolone. Ans 4 Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C 16 position and fluorine at C 9 position while in beclomethasone methyl group at C 16 position but at C 9 chlorine group attached.
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1.Gc involve in the metabolism of carbohydrate, protein and fat. Alson involve in bodies immune function i-e work against infection. they stress hormones.
2.Cotisone have keto grouo at C11 position and hydrocortisone have OH group at C11 which enhance the GC activity 4 folds.
basically cortisone is metabolised into hydrocortisone.
3. prednisolone is synthesized by hydrocortisone (having OH on C11) by the addition of double bond b/w C1&2 and prednisone is synthesized by cortisone (having keto group at C11) by the addition of same double bond b/t C1&2.
4.Betamethasone have CH3 group at C16 and F group at C9 in prednisolone structure (double bond at C1&2) and beclomethasone have CH3 group at C16 and Cl group at C9 in prednisolone structure.
5. fludrocortisone is commercially available MC having 800 times more activity of MC because of presence of F group at 9th position in hydrocortisone.
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Samreen nasir 38
Qno:1
Glucocorticoids regulates the metabolism of carbohydrates,protein and fats and also provide anti inflammatory effect and resist the infection.
Qno:2
In cortison keton group is present at C11 while in hydrocortisone hydroxyl group is present at C11.
Qno:3
By the addition of double bond between C1 and C2 cortison convert into Prednisone
And by the addition of double bond between C1 and C2 hydrocortisone convert into prednisolone.
Qno:4
In the structure of baclomethason addition of chlorine at C9 whereas in structure of betamethason addition of flourine at C9.
Qno:5
By the substitution of flourine at C9 in hydrocortison formed fludrocortisone. Fludrocortisone enhance bht mineralocorticoid and glucocorticoid activity.
Sanober Bozdar
Roll no:40
Qno:1 They function in response to regulate body metabolism.
Qno:2 cortisone contain ketone group at C11 position while hydrocortisone contain OH group at C11 position.
Qno:3 Cortisone can be converted into prednisone and hydrocortisone is converted into prednisolone by natural C- 11 keto group and C- 11 OH group by the double bond at C1 and C 2.
Qno:4 Beclomethane is color derivative and beclomethasone is
Flouro derivative of hydrocortisone.
Qno:5 Fludrocortisone contains Flourine at C9 position that increases the both GC and mineralocorticoid activity.
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1_Gc causes the regulation of carbohydrates, protein, fat metabolism.
2_Cortisone contains ketone group C11 & ahydrocortisone contains OH group at C11.
3_By introducing additional double bond at C1 & C2 Prednisone is synthesized.
By introducing an additional double bond at C1 g C2 in hydrocortisone prednisolone is synthesized.
4_Beclomethysone methyl group is present at C16 & Cl is present at C9 position .While Beclomethysone methyl group is present at C16 &F is present on C9.
5_Fludocortisone contains F at C9 which enhance both glucocorticoids & mineralocorticoid's activity.
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1) GC regulate metabolism of carbohydrates, protein and fats and also enable body to resist infection and stress.
2) cortisone contains 3 keto groups at 3,11and 20 postion .and 2 OH groups at17 and 21 position.
While hydrocortisone is reduced form of cortisone and it is formed when keto group at C 11of cortisone is replaced with OH group .
So it has 2 keto groups at 3 and 20 position while 3 OH groups at 11,17 and 21 position.
3) when there is addition of double bond between c1 and c2 of Cortisone, Prednisone is synthesized.
With the addition of double bond between c1 and c2 of hydrocortisone, Prednisolone is synthesized.
4) In beclomethasone at c9 cl is present while in betamethasone at c9 F is present.
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1.G.C are used to regulate the proteins, fats, and carbohydrates metabolism and mainly released in response of hypoglycemia .G.C are involved in immunity response and inflammation , also in the operation of processes that enable the body to resist stress and infection so that's why they are called stress hormone.
2. Cortisone contain keto group at Carbon no .3, 11, 20 and hydroxyl group at carbon no.17 ,21while hydrocortisone contain hydroxyl group at carbon no. 11, 17, 21 and keto group at carbon no. 3 ,20.
3. when unsaturation occur at carbon.no 1,2 the potency increases 4 times and thus G.C activity become increased and here is formation of new synthetic derivative is taking place. When cortisone naturally occurring carbon 11 keto group is converted into prednisone because of additional presence of double bond at carbon no. 1,2 .
when hydrocortisone naturally occurring carbon 11 hydroxyl group is converted into predisolone due to additionally presence of double bond at carbon no. 1 and 2nd .
4.Betamethasone is derivative of hydro cortisone .In betamethasone the methyl group or OH group is substituted at carbon no .16 and fluorine is attached with carbon no.9 position. This substitution can enhance the G.C activity.
Beclomethasone the methyl group is present at same carbon no. 16 but at carbon no. 9 the chlorine atom is substituted so this derivative increase the G.C activity, lipophilicity,bronchial tissue absorption and duration of action.
5.when halogenation occur at carbon no .6 it causes less G.C and M.C activity but when halogenation occur at carbon no .9 or when fluorine is attached at carbon no.9 it increases 800 times M.C and 11 times G.C activity so here a new derivative is formed by this halogenation called fludrocortisone.once the fludrocortisone is made the interconversion of OH group into keto group is inhibited because the hydrocortisone and cortisone are interconvertable with each other.
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Q no:1
They regulate way the body's metabolism works
Q no:2
Cortisone (contains OH group at C11) is a reduced form of hydrocortisone (contains OH group at C11)
Q no:3
Prednisone is created by adding extra double bonds to the C1 C2 positions of cortisone by adding a second double bond at position C12 of hydrocortisone the formation of prednisolone
Q no: 4
Betamethasone has fluorine at C9 while beclomethasone has chlorine at C9
The hydrocortisone derivative fludrocortisone is more intense than hydrocortisone
1. Regulate the carbohydrates, protein and fat metabolism.
Enables the body to resist infections and stress.
2. cortisone have 3 keto groups and Hydrocortin have 2 keto groups.
3. Cortisone can be converted to prednisone and Hydrocortisne is converted into prednisone by natural C-11 keto group and C -11 OH group by the double bond at C1 and C2.
4.Beclomethane is color derivative and beclomethasone is
Flouro derivative of hydrocortisone.
5. Flourocortisone is derivative of Hydrocortisone and more potent .
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W slam sir
1)GC regulate carbohydrate fat and protein metabolism and also enable body to resist infection and stress.
2) cartisone contain 3keto groups at C 3, 11 and 20 position and 2 OH groups at C 17 and 21 position while hydrocortisone is reduced form of cortisone and formed when keto group at C 11 is replaced with OH so it has 2 keto groups at C 3 and 20 position while 3 OH groups at C11 17 and 21 position.
3)when there is addition of double bond b/w c1 and c2 of cortisone prednisone is synthesized.
With the addition of double bond b/w c1 and c2 of hydrocortisone prednisolone is synthesized.
4) Beclomethasone have chlorine at C9 position while betamethasone have fluorine at c9 position.
5) fludrocortisone contain fluorine at C9 position that increases the both GC and mineralocorticoid activity.
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Farzana soomro
1: Glucocorticoid are mainly involved bin metabolism of carbohydrates , fats, protein .they are also involved in inflammation and immunity response.they are also know as stress hormones .
2: cortisone presence of double bond at 4,5 position presence of ketone group at carbon no:3,11,20, 2 hydroxy group at carbon no:17,21, hydrocortisone . presence of 3 hydroxyl group at carbon no. 11,17 ,21 .2 ketone group at carbon no: 3 and 21 .
3: cortisone can be converted in Prednisone by the addition of unsaturation at carbon no.1,2 Prednisone can be synthesized by addition of unsaturated at carbon no. 1,2
4: betamethasone contain methyl group at carbon 16 and it contain chloride at c-9
5:flurocortisone .the halogen process i-e introduction of fluorine at c-9 the new derivative form in know as fudrocortiaone .
1 Glucocorticoids are mainly involved in metabolism of carbohydrates,fats and proteins.They are also involved in inflammation & immunity responses, they are also known as stress hormones
2. Cortisone: Presence of double bond at 4,5 position, presence of keto group at Carbon no 3,11,20, 2-hydroxy group at carbon no 17,21.
Hydrocortisone: Presence of 3-hydroxyl group at carbon no 11,17,21. 2-ketone group at carbon no 3&20.
3. Corisone can be converted in prednisone by the addition of unsaturation at carbon no 1,2.
Prednisolone can be synthesized by addition of unsaturation at carbon no 1,2
4. Betamethasone contains methyl or hydroxyl groups at C-16 and it contains Fulorine at C-9
Beclomethasone contains methyl group at C-16 & it contains Chlorine at C-9
5. Fludrocortisone: The halogenation process i.e introduction of fluorine at C-9 the new derivative form is known as fudrocortisone.
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Sonia
Rollno45
Ans1:These steroid regulate the carbohydrates, proteins,and the fat metabolism that enables the body to resist infections and stress.
Ans2: Cortisone have 3 ketogroup and hydrocortisone have 2 keto groups.
Ans3: Cortisone can be converted into Prednisone and hydrocortisone can be converted into prednisolone by natural (C11 keto group and C11 OH group) presence of double bond C1 and C2.
Ans4:In betamethasone structure there is methyl group at C16 position and fluorine at C9 position whereas Beclomethasone methyl group at C16 position and cl at C9 position.
Ans5: fludrocortisoneis derivative of hydrocortisone and more potent.
1)The main & important function of glucocorticoids is They mainly involves the metabolism of d/f pathways like;carbohydrates, protein and fat and also provides antiinflammatory & immulogical effect.
2) cortisone have 3 keto group at C3,11,20 positions & have OH groups at C17,21 positions while hydrocortisone have 2 keto groups at C3,20 positions and have 3OH groups at C11,17,21 positions.
3) By addition of double bond at C1 & C2 position in cortisone Prednisone can be synthesized, by adding double bond at C1& C2 position as hydrocortisone prednisolone can be synthesized.
4) beclomethasone have chlorine at C9 position,
while betamethasone have flourine at C9 position.
5) fludrocotisone & F is present at C9 position.5_fludrocortisone contain F at C9 position which enhance the both glucocorticoids & mineralocorticoid activity.
Roll no 23
Joti Kumari
1- Regulate the carbohydrates, protein and fat metabolism. Enables the body to resist infections and stress.
2- Cortisone have 3 keto groups and Hydrocorton have 2 keto group.
3- Cortisone can be converted into prednisone and hydrocortisone is converted into prednisolone by natural C- 11 keto group and C- 11 OH group by the double bond at C1 and C 2.
4- Beclomethasone is cholor derivate and beclomethasone is Fluoro derivative of hydrocortisone.
5- Flurocortisone is derivative of hydrocortisone and more potent.
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Shweta 44
1) glucocorticoid are responsible of metabolism of protein ,fat, carbohydrates nd also involved in immunity nd inflammation response
2) in cortisone structure there is ketone group at c12 position due to reduction
Hence hydrocortisone shows greator GC activity than cortisone
3) by introduction of additional double bond at c 1,2 in cortisone Prednisone is synthesized
By introduction of additional double bond at c1,2 in hydrocortisone predinisolone is synthesized
4) beclomethasone contain chlorine at c9 nd betamethasone contain flourine at c9
5) flufocortisone is derivative of hydrocortisone nd it is more potent
1. GC regulates the metabolism of carbohydrates, proteins and fats in response to hypoglycemia. They also have important role in infection and immunity responses inside the body.
2. In cortisone structure there is a keto group at C 11 position while in hydrocortisone structure there is hydroxy group at C11 position due to reduction. Hence hydrocortisone shows greater GC activity than cortisone.
3. By additional introduction of double bond at C 1 and 2 position in cortisone , Prednisone is synthesized.
By additional introduction of double bond at C 1 and 2 position in hydrocortisone , prednisolone is synthesized.
4. In betamethasone, there is Substitution of methyl group at C 16 position and substitution of flourine at C9 position .
In beclomethasone, substitution is made at C 9 position with chlorine atom and methyl group remains same at C 16 position.
5. When flourine atom is introduced at C 9 position, fludrocortisone is produced and this will also inhibit the interconversion of OH group to keto group at C11 position.
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Asma umer roll no 7
Ans 1.
Their function is to regulate the body metabolism.
Ans 2.
Hydrocortisone is reduced form of cortisone.
Ans 3.
By the introduction of additional double bonds at C1,2 in cortisone. Prednisone is synthesised .
By introduction of additional hydrocortisone. Prednisolone is synthesised.
Ans 4.
Beclomethasone contains chlorine at C9 and betamethasone contains fluorine at C9.
5. Fluodrocortisone is the derivative of hydrocortisone and it is more potent.
Mahnoor Ali,
Roll # 24.
Question #01:
Function of Glucocorticoids:
They regulate the carbohydrates, proteins, and the fat metabolism and are intimately involved in the operation of the processes that enable the body to resist infections and stress.
Question #02:
✓Hydrocortisone differs from cortisone in that it contains OH group at C-11 position, while cortisone contains a keto group at C-11 position.
✓Hydrocortisone is basically reduced form of cortisone and is more active as compared to cortisone.
Question #03:
Prednisone can be synthesized by introducing a double bond at the C-1 and C-2 positions of cortisone. Similarly, prednisolone can be synthesized by incorporating a double bond at the C-1 and C-2 positions of hydrocortisone.
Question #04:
Beclomethasone is 9α-chloro derivative of betamethasone. It means that it contains a Chlorine atom at 9th position.
While Betamethasone contains Fluorine atom at C-9 position.
Question #05:
Introduction of Fluorine at C-9 in Hydrocortisone creates a new derivative, that is called Fludrocortisone.
1. They function in response to regulate body metabolism.
2. Reduction of cortisone results in formation of hydrocortisone.
3. Adding double bond to cortisone for prednisone and to hydrocortisone form predinisolone.
4. Beclomethasone contains Chlorine while betamethasone contains fluorine.
5. Addition of fluorine at C-9 in cortisone forms fludocortisone.
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Mahnoor Rehman
Roll no : 25
Glucocorticoid regulate the metabolism of carbohydrates ,proteins and the fats also known as stress hormones
Q:2
Ans:
Hydrocortisone is the reduced form of cortisone in hydrocortisone at C-11 (OH group) is present while in cortisone (ketone group )is present at C-11 position
Q:3
Ans:cortisone is converted to prednisone by introduction of unsaturation at C1 and C2
Hydrocortisone is converted to prednisolone by additional double bond between C1 and C2
Q:4
Ans :beclomethasone contain Cl at C9 position usually formed by 9 alpha chlorination of Beclomethasone .
While betwmethasone contain F at C9 position
Q:5
And : Halogenation at carbon 9 produces Fludrocortisone with greater glucocorticoid and mineralocorticoid activity .
Amber
Roll no: 01
Answers:
1: Glucocorticoids regulate carbohydrate, protein and lipid metabolism and involved in inflammation and immune responses.
2: Cortisone contain keto group at three positions (carbon no: 3,11,20) and OH group at carbon no 17 and 21 whereas Hydrocortisone is reduced form of Cortisone, keto group at C11 is converted into OH group. Hydrocortisone contain 2 ketone groups at carbon no 3 & 20 and three OH group at carbon no 11, 17 and 21.
3: Addition of unsaturation or Double bond b/w C1 and C2 in Cortisone, cause the conversation of Cortisone into Prednisone.
Hydrocortisone is converted into prednisolone by addition of unsaturation b/w C1 and C2.
4: Betamethasone is 9alpha fluoro-16Betamethyl derivative of Hydrocortisone whereas Beclomethasone is 9alpha chloro derivative of Betamethasone.
5: Fludrocortisone is a derivative of Glucocorticoid I which fluorination is occured at 9 position on ring B, which inhance its activity.
Aneeta Lohana 04
1) regulate the carbohydrates proteins and fat metabolism . Enables the body to resist infections and stress .
2) cortisone have 3 keto group and hydrocortisone have 2 keto groups . 3) Cortisone can be converted into prednisone and hydrocortisone into prednisolone by natural C-11 keto group and C-11 OH group by the double bond at c1 and c2..
4) beclomethasone is chloro derivative and betamethasone is Fluoro derivative of hydrocortisones..
5) fludfocortisone is derivative of hydrocortisone and more potent .
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Tabinda zameer
Roll no 46
1)glucocorticoids regulates the carbohydrates ,proteins and fat metabolism and enables the body to resists infections and stress.
2)cortisone have 3 keto groups and hydrocortin have 2 keto groups
3) cortisone can be converted to prednisone and hydrocortisone is converted into prednisone by natural C-11 keto group and C-11 OH group by the double bond at C1 and C2
4) beclomethasone is color derivative and beclomethasone is Fluoro derivative of hydrocortisone .
5)Fludrocortisone contains fluorine at C9 position thất increases the both GC and mineralocorticoid activity.
1) regulate the carbohydrates proteins and fat metabolism . Enables the body to resist infections and stress .
2) cortisone have 3 keto group and hydrocortisone have 2 keto groups . 3) Cortisone can be converted into prednisone and hydrocortisone into prednisolone by natural C-11 keto group and C-11 OH group by the double bond at c1 and c2..
4) beclomethasone is chloro derivative and betamethasone is Fluoro derivative of hydrocortisones..
5) fludfocortisone is derivative of hydrocortisone and more potent .
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Sameet fatima
Roll no 37
Q:1
Ans
Function of glucocorticoids is to regulate the carbohydrates, protein, and fat and involved in the operation of the processes that enable the body to resist infections and stress.
Q:2
Ans
• Hydrocortisone is the reduce form of cortisone and is more active
• Hydrocortisone contain OH group at C-11 meanwhile cortisone contain keto group at C-11.
Q:3
Ans
Addition of double bond at C-1 and C-2 position of cortisone and hydrocortisone will lead to the formation of prednisone( by cortisone) and prednisolone( by hydrocortisone).
Q:4
Ans
Beclomethasone contain chlorine at C-9 and betamethasone contain flourine at C-9.
Q:5
Ans
Flourination at C-9 on ring B in prednisolone will form fludrocortisone.
Shumaila dahri roll no 43
1 glucocorticoids involves in the metabolism of many pathways eg carbs protein fats
2 cortisone has double bond at 4'5
And keto group has 3 20 11 position
3 Prednisone synthesized by addions of double bond between C1 and C2
4
Beclomethasone contain chlorine at 9 C
And betamethsone contain fluorine at 9c
5
Fludocartisone has halogen at C9 position which increases its glucocorticoid and minrilocarticoid
W salam sir
Saira majeed roll no 36.
Ans:downregulate the immune system, decrease symptoms of autoimmune disorders, modify the body's stress response, regulate metabolism, increase blood glucose, and treat skin disorders.
Ans:cortisone is a harmone produced by adrenal cortex its anti inflammation and anti allergic. Hydrocortisone is harmone produced by adrenal cortex used to treat inflammation from eczema.
Ans: by introducing double bond in C1 Prednisone is synthesized by unsaturation between C1 and 2 hydrocortisone is converted in Prednisolon.
Ans:Beclomethasone has the same structure as betamethasone apart from the replacement of the 9α-fluoro group with a 9α-chloro group.
Ans: adding flourine group at carbon 9 having increase GC and mineralocorticoid activity.
Humera Nasir Roll no:19
Q1: Glucocorticoids are mainly involve in regulation of different metabolic pathways like metabolism of carbohydrates and fats.
Q2:In hydrocortisone structure at C-11 position OH group is present whereas in cortisone at C-11 position ketone group is present.
Q3:By the introduction of unsaturation double bond between C-1and C-2 cortisone converted into Prednisone and by the additional unsaturation between C-1and C-2 hydrocortisone converted into prednisolone.
Q4:Beclomethason has additional Cl atom at C-9 position.
Betamethasone has F atom at C-9 position.
Q5:When halogenation or halogen atom are substitute at C-9 position then fludrocortison will formed and it has greater glucocorticoids and mineralocorticoids activity.
Maryam aziz
Roll no 26
1) Glucocorticoids regulates carbohydrates, proteins and fats metabolism and also involved in producing resistance to infections and stress
2)cortisone contain double bond at carbon 4 and 5, keto group at carbon 3, 11& 20 position and OH group at 17,21 carbon
Whereas hydrocortisone contain keto group at carbon 11 and OH group at 11 21 and 17 carbon
3)By addition of double bond between C1 and C2 in cortisone it is converted into prednisone and By addition of double bond between C1 and C2 in hydrocortisone it produces prednisolone
4)Betamethsone contains flourine at C9 position whereas beclomethasone contains Chlorine at C9 position
5)fludrocortisone contain fluorine which increases its Glucocorticoids and mineralocorticoids activity
YusRa shaikh
Roll no
Ans 1 the function of glucocorticoids is to regulate the body metabolism
Ans 2 hydrocortisone is the reduced from of cortisone. Hydrocortisone hydroxy group is present st carbon no 11 instead of ketone
Ans 3 by reduction (adding of double bond between C1 and C2
Ans 4 beclomethasone contain Cl at C9 position while betamethasone contain f at C9 position
Ans 5 fludrocortisone is commercially available mineralocorticoid it contain f at C9 position which enhance its both mineralocorticoid and glucocorticoid activity
Mehwish Arain
Roll no 28
Ans# 1: Glucocorticoids functions is to regulate the metabolism of carbohydrates, fats and protein. Also provide anti- inflammatory and immunological effects.
Ans # 2 : Cortisone contains ketone group at Carbon no11 whereas in Hydrocortisone this reduce to hydroxy (OH) group at carbon 11 due to this reduction hydrocortisone has more Glucocorticoid activity than cortisone.
Ans #3 By the introduction of additional double bond b/ w 1,2- carbon atoms in cortisone and hydrocortisone structure this leads to the formation of prednisone and prednisolone respectively.
Ans #4: the difference between the structure is the only difference in the halogen atom betamethasone is 9alpha fluoro-16 beta Methyl derivative of hydrocortisone & beclomethasone is 9alpha- chloro derivative of betamethasone.
Ans 6: Fludrocortisone is mineralocorticoid form by the substitution of fluorine at carbon 9 in hydrocortisone which enhance the 800 time Mineralocorticoid and 11 times glucocorticoid activity .
Dua Aftab
Roll no 12
Ans.1 Glucocorticoids are mainly involved in regulation of diff metabolic pathways like metabolism of carbohydrates,proteins,fats. Also they have important role in the inflamation and immunity responses of the body.
Ans.2 glucocorticoid activity of cortisone is less than hydrocortisone
-reduced form of cortisone has keto group at C-11 while hydrocortisone has OH group at C-11
Ans.3 by introduction of double bond between C-1 and C-2 of cortisone it canbe converted into prednisone
While prednisolone is formed by introduction of double bond between C-1 and C-2 of hydrocortisone.
Ans.4 betamethasone contain flourine at C-9 while beclomethasone has Chlorine atom at C-9
Ans.5 flourination at C-9 on ring B enhances glucocorticoid and mineralocorticoid activity.
*Fludrocortisone is only mineralocorticoid which is commercially available.
Name Areesha Rind
Roll no 05
1 They function in response to regulate body metabolism.
2 Reduction of cortisone results in formation of hydrocortisone.
3 Adding double bond to cortisone for problems and to hydrocortisone from prednisolone.
4 Betamethasone contains chlorine while Betamethasone of fluorin at c -9 in cortisone forms fludrocortisone
Hafsa qureshi
Roll no 16
Qno:1
Glucocorticoids regulates the metabolism of carbohydrates,protein and fats and also provide anti inflammatory effect and resist the infection.
Qno:2
In cortison keton group is present at C11 while in hydrocortisone hydroxyl group is present at C11.
Qno:3
By the addition of double bond between C1 and C2 cortison convert into Prednisone
And by the addition of double bond between C1 and C2 hydrocortisone convert into prednisolone.
Qno:4
In the structure of baclomethason addition of chlorine at C9 whereas in structure of betamethason addition of flourine at C9.
Qno:5
By the substitution of flourine at C9 in hydrocortison formed fludrocortisone. Fludrocortisone enhance bht mineralocorticoid and glucocorticoid activity.
Asma ujjan
Roll No:06
Q1:
Ans: Their function is to regulate body metabolism
Q2:
Ans:Hydrocortisone (Contains OH group at C11) is reduced form of cortisone ( Contains keto group at C11)
Q3:
Ans:By introduction of additional double bond at C1,2 in hydrocortisone:-prednisolone is synthesized
By introduction of additional double bond at C1,2 in hydrocortisone:-prednisolone is synthesized
Q4:
Ans: Beclomethasone Contains chlorine at C9 and Betamethasone contains Fluorine at C9
Q5:
Ans: Fludrocortisone is the derivative of hydrocortisone and it is more potent
Sawera Mushtaque ahmed
Roll no 42
Answer 1)
Glucocorticoid involves in metabolism of carbohydrates ,protein and fats. They also have an important role in the inflammation and immunity responses inside the body
Ans 2)
HYDROCORTISONE : is the reduced form of cortisone .In Hydrocortisone ,Hydroxy group is present at C-11 instead of ketone due to this reduction ,hydrocortisone has more GLUCOCORTICOID activity than cortisone .
Ans 3) PRESNISOLONE.
By adding a double bond solution in the C1 C2 positions in the hydrocortisone ,prednisolone can be synthesized.
Ans 4) BECIOMETHASONE contains chlorine at c-9 position while BETAMETHASONE contains fluorine at C-9 position . The difference between these structure is the only difference in the halogen atom .
Ans 5) FLUDROCORTISONE is commercially available MINERAL OCORTICOID ,it contains flourine at C-9 position which enhances its both MINERAL OCORTICOID(800 times more ) and GLUCOCORTICOID (11 times more ) Activity .
Sapna Nusrat roll no 41
Q:01 Ans: Glucocorticoids are types of steroids regulate the carbohydrates, protein and fat's metabolism and are involved in the different processes of body which prevent the body from infections and stresses.
Q:02 Difference Between Cortisone as Hydrocortisone.
Ans: 1) Cortisone is naturally occurring glucocorticoid. Position of ketone group in Cortisol is at C3, 11 and 22 C, means contain three ketone group in it's chemical structure. And 2 hydroxyl group Present at carbon 17 and 21.
2) Hydrocortisone is reduced form of Cortisone because Keto group at C-11 position is converted into Hydroxyl group then hydrocortisone is formed, position of ketone group is at C-11.
Biologically activity of hydrocortisone is greater than cortisone.
Q:03 Synthesization of Prednisone and Prednisolone.
Ans : A) In Cortisol's chemical structure C1 and C2 double bond potency increases 4 times and directly increases the Glucocorticoid activity through this C-11 keto group is converted into Prednisone. So Presence of additional double bond and additional unsaturation between C1 and C2 synthesizes the Prednisone.
B) Hydrocortisone ( Natural C-11 hydroxy group ) is converted into Prednisolone. Then Unsaturation occurs at C1=C2 . All is the great role of additional double bonds between C1 and C2.
Q:04 Difference Between Beclomethasone and Betamethasone
Ans: Beclomethasone is the 9alpha chloro derivative of betamethasone.
And Betamethasone 9Alpha Flouro-16 Beta Methyl deirvative of hydrocortisone.
Q:05
Ans: Fludrocortisone is a Mineralocorticoid with high salt retention and is commercially available. It enhances both mineralocorticoid and glucocorticoid activity with chemical structure aspect at 9 position on Ring B.
Q-1
Regulate body metabolism.
Q-2
Cortisone has 4,5 double bond & keto group= 3,11, 20C - position.
Hydrocortisone has double between 4 & 5 C 3 carbonyl.
Q-3
Prednisone is synthesised from cortisone by only additional double bond between C1 & C2.
Prednisolone is synthesised from hydrocortisone by only additional double bond between C1 & C2.
Q-4
Beclomethasone contain chlorine at 9C
Betamethasone contain fluorine at 9C.
Q-5
Fludrocortisone is a derivative of hydrocortisone and it is more potant.
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Ghulam fatima (20)
Ans 1: They regulate metabolism of carbohydrates, fat, proteins
They also release in hypoglycemia
Also involved in body infections and stress
Ans 2: In cortisone there is O (ketone group) at C 11 whereas in hydrocortisone C 11 is substituted with OH
Ans 3: By addition of double bond between C 1 and C 2
Ans 4: In betamethasone C 9 contain F whereas in beclomethasone C 9 contain Cl instead of F
Ans 5: fludrocortisone is commercialy available mineralocorticoid which contain F at C 9 that inc its both GC and MC activity
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Q1# Glucocorticoids causes the regulation of the carbohydrates, protein and fat metabolism,and enable the body to resist infections and stress.
Q2# Cortisone contain ketone group at C 11 position and hydrocortisone contain OH group at C11 position.
Q3# By introduction of additional double bond at C1 &2 in cortisone Prednisone is synthesized.
By introduction of additional double bond at C1 and C2 in hydrocortisone prednisolone is synthesized.
Q4# Beclomethasone methyl group is present at C16 position & Cl is present at C9 position.
While in betamethasone methyl group is present at C16 position and F is present at C9 position.
Q5# Fludrocortisone contain F at C9 position which enhances both glucocorticoid and mineralocorticoid activity.
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Nimra khalid
Ans 1
Functions
They regulate the carbohydrates, protein and fat metabolism.
They involve in operation of the process that enable the body to resist infection and stress.
Ans 2
In cortisone
3,11,20 at C-position = 3 keto group
17,21-C = OH gruop
In hydrocortisone
11,17,21 = 3 OH group
3,20 = keto group
Ans 3
Prednisone can be synthesize by addition of unsaturation at C-no 1 and 2 in cortisone.
Prednisolone can be synthesize by addition of unsaturation at C-1 and C-2 in hydrocortisone.
Ans 4
Betamethasone contain Fluorine at C-9.
Beclomethasone contain chlorine at C-9
Ans 5
Addition of fluorine at C-9 in cortisone to form fludrocortisone.
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Quiz Answers:
1. Regulation of Metabolism
2. Hydrocortisone is the reduced from of cortisone. in hydrocortisone, Hydroxy group is present at Carbon no 11 instead of ketone.
3. By Reduction. (addition of double bond between C1 and C2)
4. Beclomethasone contain Cl at C9 position while Betamethasone contain F at C9 position.
5. Fludrocortisone is commercially available Mineralocorticoid , it contain F at C9 position which enhance its both Mineralocorticoid and glucocorticoid activity.
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Naila Ali
Ans1:
Glucocorticoids cause the regulations of the carbohydrates, protein and fat metabolism,and enable the body to resist infection and stress.
Ans2:Cortisone contain ketone group at C 11 position and hydrocortisone contain OH group at C 11 position.
Ans3:
By introduction of additional double bond at C1&2 in cortisone Prednisone is synthesized.
By introduction of additional double bond at C1 and C2 in hydrocortisone prednisolone is synthesized.
Ans4:
Beclomethasone methyl group is present at C16 position &C16 position.While in betamethasone methyl group is present at C16 position and F is present at C9 position.
Ans5:
Fludrocortisone contain F at C9 position which enhance both Glucocorticoids and mineralocorticoid activity.
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Ans:1
G.C involves in metabolism of carbohydrates, proteins, fats b/c they are mainly released in response of hypoglycemia, which acts as a stimuli for the released of G.C. They have an also important role in the inflammation and immunity responses inside the body. Also known as stress hormone.
Ans:2
In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11.
In cortisone 3 keto group is present at C-3,11,20 and 2 hydroxyl group present at C-17,21.
In hydrocortisone 2 ketone group are present at C-3,20 and 3 hydroxyl group present at C-11,17,21.
Ans:3
In G.C un saturation is present at the 4th,5th C-atom but we synthesize new derivative with maximum G.C activity in. Comparison to naturally occurring, so we introduced new un saturation at C-1,2 which increases potency of G.C 4 times in comparison to naturally occurring G.C.
Cortisone can be converted into prednisone and additional un saturation of C-1,2 of hydrocortisone can be converted into prednisolone.
Ans:4
Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group CH3 at C-16 position and Fluorine (F) at C-9 position while in beclomethasone methyl CH3 group is same at C-16 position but at C-9 Chlorine (cl) group is attached.
Ans:5
During synthesis of different types of new derivative halogenation reaction was done at the different position in chemical structure of G.C, like it was done at C-6 but halogenation at C-6 produces G.C or M.C with lesser biological activity but when halogenation like (F) atom introduce or substituted at C-9 then new derivative form c/d fludrocortisone and its activity is 800 times more M.C and 11 times more G.C activity then previous.
Fludrocortisone contain additional F atom which is halogen at C-9 and due to this F or halogen at its activity is increase and this cause inhibition of metabolism of or reconversion of hydrocortisone into cortisone b/c hydrocortisone & cortisone are interconvertable to one another due to metabolism reactions.
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1. Glucocorticoids used to regulate the proteins , fats and carbohydrates metabolism and enable the body to resist infection and stress.
2. Cortisone contain keto group at carbon no: 11 position while hydrocortisone contain OH group at carbon no:.11 position.
3. In cortisone there is additional double bond at carbon no : 1,2 to synthesized the prednisone while in hydrocortisone there is additional double bond at carbon no :1,2 to synthesized the predisolone.
4. Betamethasone contain methyl group at carbon no:16 position and Flourine atom is present at carbon no :9 while in Beclomethasone OH group is present at carbon no : 16 position and chlorine atom is present at carbon no : 9.
5. flourination is taking place when FL is present at carbon no :9 position that can enhance both glucocorticoids and mineralocorticoids activity. Mineralocorticoids activity increases 800 times while glucocorticoids activity increases 11 times .when FL is present at carbon no : 9 position it inhibit the reaction conversion of OH group into keto group.
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Noor e Sehar
Roll no:33
Ans:1
Glucocorticoids also known as stress hormone involve in the metabolism of carbohydrates,proteins, and fats. They are also involved in inflammation and immunity responses.
Ans:2
Hydrocortisone:presence of 3-hydroxyl group at carbon no:11,17,21 and 2-ketone group at carbon no:3 and 20.
Cortisone:presence of double bond at 4,5 position,presence of keto group at carbon no:3,11,20 and 2-hydroxy group at carbon no:17 and 21.
Ans:3
Prednisone can be synthesized by adding a double bond at C1,C2 position in cortisone.
Prednisolone can be synthesized by adding double bond at C1,C2 position in hydrocortisone.
Ans:4
Beclomethasone have clorine at C-9 while Betamethasone have flourine at C-9.
Ans:5
It is commercially available mineralocorticoid which contain Fluorine at carbon no:7 which enhance both glucocorticoid and mineralocorticoid activity.
Rabia
Roll no: 35
ANSWERS
01: Glucocorticoid helps in the metabolism of carbohydrates, protein and fats. It also perform inflammatory response in body.
02: Hydrocortisone is reduced form of cortisone. In hydrocortisone hydroxy group is present at C11. Hydrocortisone has more glucocorticoid activity than cortisone.
03: Prednisolone can be formed by addition of double bond at C1 and C2 position in hydrocortisone.
Prednisone is formed by addition of double bond at C1 and C2 position in cortisone.
04: In BECIOMETHASONE chlorine is present at C 9 position while in BETAMETHASONE flourine is present at C 9 position.
05: It is commercially available mineralocorticoid which contain flourine at carbon 7 which increases both glucocorticoid and mineralocorticoid activity.
Mehnaz Gul unar
ROLL no#27
Ans:1 the main function inside the body they are mainly involve in the regulation different metabolism pathway like metabolism of carbohydrates,protein,fats and enable and important role in the inflammation and immunity responses in the body they also known stress harmone.
Ans:2cortisone have 3 keto group at C3,11,20 positions and have OH group at C17,21 position while Hydrocortisone have 2 keto group at C3 ,20 position and have 3 OH group at C11,17,21.
Ans :3 By adding a double bond at C1,C2 positionin cortisone ,prednisone can be synthesized. By adding a double bond at C1,C2 position in hydrocortisone , prednisolone can be synthesized.
Ans :4
Beclomethasone have chlorine at C9 position while Betamethasone have flourine at C9 position.
Ans :5
Fludrocortisone contains Flourine at C9 position that increases the both GC and mineralocorticoid activity.
Amna Mehmood
Roll no 02
Q#1
Glucocorticoid involves in the metabolism of carbohydrates, proteins and fats also have a inflammatory effect and resist the infection.
Q#2
Hydrocortisone (contains OH group at C11) is reduced form of cortisone(contain keto group at C11).
Q#3
Cortisone can be converted into prednisone and hydrocortisone can be converted into prednisolone by natural (C11 keto group and C11 OH group) presence of double bond at C1 and C2.
Q#4
Beclomthasone contain chlorine at C9 and betamethasone contain flourine at C9.
Q#5
Fludrocortisone is derivative of hydrocortisone and it is more potent.
Anoosha Qureshi
Roll no 03
1. Their function is to regulate the body metabolism.
2. Hydrocortisone (contains OH group at C11) is reduced form of Cortisone (contains keto group at C11).
3. Adding double bond to cortisone for prednisone and to hydrocortisone form predinisolone.
4. the difference between the structure is the only difference in the halogen atom betamethasone is 9alpha fluoro-16 beta
Methyl derivative of hydrocortisone & beclomethasone is 9alpha- chloro derivative of betamethasone.
5. Fludrocortisone: The halogenation process
i.e introduction of fluorine at C-9 the new derivative form is known as fudrocortisone.
Name : Fiza Majeed
Roll no :15
Ans :01
Glucocorticoids regulate the metabolism of carbohydrates, fats & protein & also enables the body to resist stress & infections.
Ans :02
Cortisone have 3 keto group at 3,11,20 position & 2 OH group at 17 & 21 position.
Hydrocortisone is reduced form of cortisone & have 2 keto group at 3 & 20 position & 3 OH group at 11,17 & 21 position.
Ans :03
Prednisone is synthesized when there is a addition of double bond between C1 & C2 of cortisone.
Prednisolone is synthesized when there is addition of double bond between C1 & C2 of hydrocortisone.
Ans :04
Beclomethasone is chloro derivative & betamethasone is fluoro derivative of hydrocortisones.
Ans :05
Fludrocortisone contains fluorine at C9 position that increases the activity of both Glucocorticoids & mineralocorticoid.
Sania akhtar
Roll no 39
Q1
Main function of glucocorticoids are
•Mainly involved in regulation of metabolism of carbohydrates,protein and fats
•important role in inflammation and immunity responses inside the body also known as stress hormones
Q2
In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11
In cortisone 3 ketone group is present at C-3, 11,20 and 2 hydroxyl group present at C 11,17, 21.
Q3
In G.C saturation is present at the 4th, 5th C atom but we synthesize new derivative with maximum G.C activity in comparison to naturally occurring,so we introduce new unsaturation at C-1,2 which increase potency of G.C 4 times in comparison to naturally occurring G.C Cortisone can be converted into Prednisone and
additional un saturation at C-1,2 of hydrocortisone can be converted into Prednisolone.
Q4
Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C 16 position and fluorine at C 9 position while in beclomethasone methyl group at C 16 position but at C 9 chlorine group is attached with it
Q5
Fluorination at the 9
position on ring B enhances both
glucocorticoid and mineralocorticoid
activity
Ans 1
GC regulates the carbohydrates,proteins and fat metabolism and are involved in the processes that enables the body to resist infection and stress.
Ans 2
Cortisone have 3 keto groups at C 3,11,20 positions and have 2 OH groups at C 17,21 positions while Hydrocortisone have 2 keto groups at C 3,20 positions and have 3 OH groups at C 11,17,21 positions .
Ans 3
By adding a double bond at C1,C2 position in cortisone, prednisone can be synthesized .
By adding a double bond at C1,C2 position in hydrocortisone,prednisolone can be synthesized.
Ans 4
Beclomethasone have chlorine at C9 position while Betamethasone have flourine at C9 position.
Ans 5
Fludrocortisone contains Flourine at C9 position that increases the both GC and mineralocorticoid activity .
Ans1. Gc regulates the carbohydrates, proteins and fat metabolism and are involved in the processes that enables the body to resist infection and stress.
Ans2. Cortisone have 3 keto group at C3,11,20 positions and have 2 OH grous at C 17,21 positions while hydrocortisone have 2 keto group at C 3,20 positions and have 3 OH groups at C11,17,21 positions.
Ans3.By adding a double bond at C1,C2 position in cortisone , prednisone can be synthesized.
By adding a double bont at c1, C2 position in hydrocortisone, prednisone can be synthesized.
Ans4. Beclomethasone have chlorine at C9 position while betamethadone have flourine at C9 position.
Ans5. Fludrocortisone contains flourine at C9 position that increases the both GC and mineralocorticoid activity.
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Ans:1
G.C involves metabolism of carbohydrate, protein, fats b/c they are mainly released in response of hypoglycemia, which acts as a stimulus for the released of G.C. they have an also important role in the inflammation and immunity response inside the body.also known as stress hormone.
Ans2
In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11
In cortisone 3 ketone group is present at C-3, 11, 20 and 2 hydroxyl group present at C 11,17, 21.
Ans 3
In G.C saturation is present at the 4th ,5th C atom but we synthesize new derivative with maximum G.C activity in comparison to naturally occurring, so we introduce new unsaturation at C-1,2 which increase potency of G.C 4 times in comparison to naturally occurring G.C
Cortisone can be converted into Prednisone and additional un saturation at C-1,2 of hydrocortisone can be converted into Prednisolone.
Ans 4
Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C 16 position and fluorine at C 9 position while in beclomethasone methyl group at C 16 position but at C 9 chlorine group attached.
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W. Salam sir.
1 glucocorticodss caused the regulations of carbohydrates proteins nd fat metabolism .
2 cortisone contain ketone grouo c11 nd hydrocortison contain oH group at c11.
3. By introducing additional double bond at c1 nd c2 Predinsone is synthesisend.
By introducing additional double bond at c1 nd c2 in hydrocirtisone predinsolone is synthesised.
4. beclomethasone methyl group is present at c16 nd Cl is present at C9 positions.
While beclomethasone methyl gruop is persent at c16 nd F is present at c9.
5.fludorocortisone contain F at c9whivh enhance both glucocorticoid nd mineralocorticoid activity.
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Sahar Aslam
Roll no 46
1) they function in response to regulate body metabolism
2) reduction of cortisone results in formation of hydrocortisone
3) adding double bond to cortisone for prednisone and to hydrocortisone form predinisolone
4) beclomethasone contains chlorine while betamethasone contains fluorine
5) Addition of fluorine at C-9 in cortisone forms fludocortisone
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Bibi Amna 08
Ans.1 Glucocorticoids regulate the carbohydrate protein and the fat metabolosm and are intimately involved in the operation of the processes that enable the body to resist infections and stress..
Ans.2 Cortisone contain keto group at carbon no.11 position whereas hydrocortisone contain oH group at carbon no.11 position..
Ans.3 When there is addition of double bond b/w c1 and c2 of cortisone prednisone is synthesized.
-And when there is addition of double bond b/w c1 and c2 of hydrocortisone prednisolone is synthesized..
Ans.4 Beclomethasone have chlorine at the c9 position whereas beta-methasone have flourine at the c9 position..
Ans.5 Fludrocortisone contain F at c9 position which enhance the activity of glucocorticiods and mineralocorticoids..
Walaikum Assalam Sir!
Iram Mehboob Malik
Roll No# 22
ANSWERS:
Q#1- GLUCOCORTICOID involves in Metabolism of Carbohydrates, Proteins and Fats. They also have an important role in the Inflammation and Immunity responses inside the body.
Q#2- HYDROCORTISONE is the reduced form of CORTISONE. In Hydrocortisone, Hydroxy group is present at C-11 instead of Ketone due this reduction, Hydrocortisone has more GLUCOCORTICOID activity than Cortisone.
Q#3- PREDNISONE
•By Adding a Double Bond at C-1, C-2 Position In CORTISONE, PREDNISONE can bs Synthesized.
PREDNISOLONE
•By Adding Double Bond at C-1, C-2 Positions in HYDROCORTISONE, PREDNISOLONE can be synthesized.
Q#4- BEClOMETHASONE contains CHLORINE at C-9 Position While BETAMETHASONE contains FLOURINE at C-9 Position. The difference between these Structures, is the only difference in the HALOGEN Atom.
Q#5- FLUDROCORTISONE is commercially available MINERALOCORTICOID, It contains FLOURINE at C-9 Position which enhance its both MINERALOCORTICOID (800 times More) and GLUCOCORTICOID (11 times more) Activity.
Ans#1
The regulate the metabolism of carbohydrates,fats,proteins and they release in hypoglycemic condition and also involved in body infections and stress
Ans#2
In cortisone there is ketone group at carbon no 11 whereas in hydrocortisone carbon no 11 is substituted with OH group
Ans#3
By addition of double bond between carbon no 1 and 2
Ans#4
In betamethasone carbon 9 contain f whereas in beclomethasone carbon 9 cintains cl instead of f.
Ans#5
Fludrocortisone is commercially available mineralocorticoid which contains f at carbon no 9 that includes it's both GC and MC activity
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Anum Zardari roll:06
1. Their function is to regulate the body metabolism.
2. Hydrocortisone (contains OH group at C11) is reduced form of Cortisone (contains keto group at C11).
3. by introduction of additional double bonds at C1,2 in cortisone:- Prednisone is synthesized.
by introduction of additional double bond at C1,2 in hydrocortisone:- prednisolone is synthesized.
4. Beclomethasone contains chlorine at C9 & Betamethasone contains fluorine at C9.
5. Fludrocortisone is the derivative of hydrocortisone and it is more potent.
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*Duaa Zehra_11*
*Quiz Answers*
*A1: Functions of Glucocorticoids:*
-Metabolism of carbohydrate, protein, fats as they are mainly released in response to hypoglycemic conditions.
-Resist body from infections and stress.
*A2: Difference Between Cortisone & Hydrocortisone:*
Hydrocortisone is a reduced form of cortisone.
*=> Cortisone* ---> 3 keto group is present at 3, 11, 20 and 2 hydroxyl groups present at C17, 21.
*=> Hydrocortisone* ---> 3 hydroxyl group present at C11,17, 21 and 2 keto group at C 3, 20.
*A3: Synthesis of Prednisone & Prednisolone from Cortisone & Hydrocortisone:*
In GC saturation is present at the 4th ,5th atom of carbon. However, for synthesizing new derivatives with maximum GC activity in comparison to naturally occurring, we introduce new unsaturation at C1,2 which increases potency of GC 4 folds. Cortisone can be converted into prednisone by this way and additional unsaturation at C1,2 of hydrocortisone can be converted into prednisolone.
*A4: Difference Between Betamethasone & Beclomethasone:*
Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C16 position and fluorine at C9 position whereas in beclomethasone chlorine is attached at C9 position and methyl at C16.
*A5: Fludrocartisone:*
Fludrocartisone is derivative of prednisolone obtained by fluorination in prednisolone at C9.
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Ans5
By flourination in prednisolone at C 9, a derivative is formed which is known as fludrocortisone
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Ans1: Glucocorticoids are responsible for metabolism of carbohydrates, proteins and fats and are also involved in immunity and inflamation responses.
Ans2: If we see structure of cortisone, there is ketone group on 11carbon whereas in hydrocortisone OH group is on 11carbon.
Ans3: Prednisone can be synthesized from cortisone by unsaturation of double bond between carbon no: 1 and 2
by unsaturation of double bond between carbon no: 1 and 2, hydrocortisone will converted to prednisolone.
Ans4: In beclomethasone, there is chlorine at carbon no:9 whereas betamethasone is synthesized by fluorination at carbon no: 9.
Ans5: By fluorination in prednisolone at carbon no:9, a derivative is formed which is known as fludrocortisone.
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Ans:3: Prednisone can be synthesized from cortisone by by unsaturation of double bond between carbon no 1 and 2 ..
Name MurkBhutto
Roll no31
Q1 Glucocorticoids have a pivotal role in the glucose, protein, and fat metabolism of the body.
Q2
Ans:CORTISONE: A hormone produced by the adrenal cortex, one of the Glucocorticoids. It is also made synthetically for use as an anti inflammatory and anti allergy agent.
CHEMICAL FORMULA:C21H28O5.
HYDROCORTISONE: A steroid hormones produced by the adrenal cortex and used medinically to treat inflammation resulting from eczema and rheumatism.
CHEMICAL FORMULA:C21H30O5
Q3
Ans By reduction (addition of double bond between C1 and C2).
Q4
Ans BECLOMETHASONE: Contain Cl at C9 position.
BETAMETHASONE:Contain F at C9 position.
Q5
Ans Fludrocortisone contain F at C9 which enhance both Glucocorticoid and mineralocorticoid activity.
Ans: 1- Glucocorticoids regulate the carbohydrates, protein and fat metabolism,and enable the body to resist infections and stress.
2- cortisone contain ketone group at C 11 position and hydrocortisone contain OH group at C11 position.
3- By introduction of additional double bond at C1 &2 in cortisone Prednisone is synthesized.
By introduction of additional double bond at C1 and C2 in hydrocortisone prednisolone is synthesized.
4- in beclomethasone methyl group is present at C16 position & Cl is present at C9 position.
While in betamethasone methyl group is present at C16 position and F is present at C9 position.
5- Fludrocortisone contain F at C9 position which enhances both glucocorticoid and mineralocorticoid activity.
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Ans:2: If we see structure of cortisone there is ketone group on carbon no 11 whereas in hydrocortisone OH group is on carbon no 11.....
Ans:1: Glucocorticoids are responsible for metabolism of carbohydrates, proteins and fats and are also involved in immunity and inflammation responses....
Ans:4:flourination in prednisolone at C 9, a derivative is formed which is known as fludrocortisone....
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W\salam sir
1-Regulate the carbohydrates, protein and fat metabolism.
Enables the body to resist infections and stress.
2. cortisone have 3 keto groups and Hydrocortin have 2 keto groups.
3. Cortisone can be converted to prednisone and Hydrocortisne is converted into prednisone by natural C-11 keto group and C -11 OH group by the double bond at C1 and C2.
4.Beclomethane is color derivative and beclomethasone is
Flouro derivative of hydrocortisone.
5. Flourocortisone is derivative of Hydrocortisone and more potent .
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Muqadisa Ahmed
Roll no 30
Qno:1
Glucocorticoids regulates the metabolism of carbohydrates,protein and fats and also provide anti inflammatory effect and resist the infection.
Qno:2
In cortison keton group is present at C11 while in hydrocortisone hydroxyl group is present at C11.
Qno:3
By the addition of double bond between C1 and C2 cortison convert into Prednisone
And by the addition of double bond between C1 and C2 hydrocortisone convert into prednisolone.
Qno:4
In the structure of baclomethason addition of chlorine at C9 whereas in structure of betamethason addition of flourine at C9.
Qno:5
By the substitution of flourine at C9 in hydrocortison formed fludrocortisone. Fludrocortisone enhance bht mineralocorticoid and glucocorticoid activity.
Ans 1
GC regulates the carbohydrates,proteins and fat metabolism and are involved in the processes that enables the body to resist infection and stress.
Ans 2
Cortisone have 3 keto groups at C 3,11,20 positions and have 2 OH groups at C 17,21 positions while Hydrocortisone have 2 keto groups at C 3,20 positions and have 3 OH groups at C 11,17,21 positions .
Ans 3
By adding a double bond at C1,C2 position in cortisone, prednisone can be synthesized .
By adding a double bond at C1,C2 position in hydrocortisone,prednisolone can be synthesized.
Ans 4
Beclomethasone have chlorine at C9 position while Betamethasone have flourine at C9 position.
Ans 5
Fludrocortisone contains Flourine at C9 position that increases the both GC and mineralocorticoid activity .
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Ans:1
G.C involves metabolism of carbohydrate, protein, fats b/c they are mainly released in response of hypoglycemia, which acts as a stimulus for the released of G.C. they have an also important role in the inflammation and immunity response inside the body.also known as stress hormone.
Ans2
In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11
In cortisone 3 ketone group is present at C-3, 11, 20 and 2 hydroxyl group present at C 11,17, 21.
Ans 3
In G.C saturation is present at the 4th ,5th C atom but we synthesize new derivative with maximum G.C activity in comparison to naturally occurring, so we introduce new unsaturation at C-1,2 which increase potency of G.C 4 times in comparison to naturally occurring G.C
Cortisone can be converted into Prednisone and additional un saturation at C-1,2 of hydrocortisone can be converted into Prednisolone.
Ans 4
Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C 16 position and fluorine at C 9 position while in beclomethasone methyl group at C 16 position but at C 9 chlorine group attached.
Ans5
By flourination in prednisolone at C 9, a derivative is formed which is known as fludrocortisone
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Ans:1
G.C involves metabolism of carbohydrate, protein, fats b/c they are mainly released in response of hypoglycemia, which acts as a stimulus for the released of G.C. they have an also important role in the inflammation and immunity response inside the body.also known as stress hormone.
Ans2
In cortisone ketone group is present at C-11 and in hydrocortisone hydroxyl group present at C-11
In cortisone 3 ketone group is present at C-3, 11, 20 and 2 hydroxyl group present at C 11,17, 21.
Ans 3
In G.C saturation is present at the 4th ,5th C atom but we synthesize new derivative with maximum G.C activity in comparison to naturally occurring, so we introduce new unsaturation at C-1,2 which increase potency of G.C 4 times in comparison to naturally occurring G.C
Cortisone can be converted into Prednisone and additional un saturation at C-1,2 of hydrocortisone can be converted into Prednisolone.
Ans 4
Betamethasone is derivative of hydrocortisone. In betamethasone structure there is methyl group at C 16 position and fluorine at C 9 position while in beclomethasone methyl group at C 16 position but at C 9 chlorine group attached.
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