B's. Stop seeking fake supplements after videos made by shills like this one. Your problem is excess carbohydrates and amino acids deficiency. Become carnivore and do some fasting too. That's all you need and will be really effective instead of palliative.
I have been taking 1 g of NAC and one gram of glycine daily in the morning for the last 6 months. I had been referred to a specialist about the signs of non-alcoholic fatty liver syndrome, but in the blood tests I did since I started taking glynac, this is no longer being shown in my blood tests. I realize this is just anecdotal but this is the only thing I changed and it seems to have had a very positive effect. I am 61
Wow. Glad to hear it's been helping you. That's pretty good evidence I'd say. As you mentioned it could be something else but blood tests are far better than someone saying "I feel better". I really appreciate you sharing your story here. Very interesting to read. Thanks again.
I just turned 66 and have been taking GlyNAC for a couple of months now. About four grams a day divided into morning and evening. Due to the fact that I've also been taking NMN for over a year now, along with other supplements to support that, I can't say that I've seen any major differences except for one. My mood has stabilized and I've become calmer. NMN did that also but GlyNAC has taken it down another notch as well. Noticed it right away. I work in a job that can produce a lot of stress at times. Now I find that, while I still do experience some stress , the intensity of it is much lower. It's funny because after a lifetime of getting all worked up about things that when it doesn't happen my brain gets confused. It wants to get all agro but can't and it actually feels somewhat disappointing. I wouldn't have it any other way and maybe someday that feeling will go away.
I just bought a glynac supplement that is 600mg NAC and 70mg glycine. Is that ok? Should it not be 1:1? Confused. Help! There is also 20mcg of selenium.
I’m 71 years young and have been taking glycine for years now. Since glycine is sweet to taste I use it to sweeten coffee or tea. Usually at the rate of 4 gms/day in two doses. Tastes sweet and no tummy upset like xylitol. Just started taking NAC at the rate of 4 gms/day as well.
@@Nandymon That is not a high dose at all. Some people take much more. Each person is different and has different needs and tolerances. Splitting an amount into different times of the day is good. More likely to be taken up and utilized. Also, remember that different sexes, different weight individuals, different exercise regimens and different diets and lifestyles all have an effect on what a given person needs and tolerates best. 👍 It is also true that a person should be mindful of how much they take so they can be consistent.
72 here, I take 4 grams of Glycine/600mg of NAC just before bed. After waking I repeat. 16th week now. Also taking NMN and C-60 on alternate days. I have been walking faster and walking more. Have started walking before sunrise even. Gym several times a week. Do not feel my age.
I started taking nac over a year ago after hearing it would fix my sciatic damage that had me limping for over a year it has completely healed I do not have any more pain I took 600mg every night I also noticed less pain and inflammation on my spinal cord injury
I started taking NAC about 10 days ago. I bought the powder and it tastes terrible. I would suggest buying capsules. For the glycine, I just take my collagen peptides, maybe just a little extra. While whey protein has equal and smaller amounts of both glycine and cysteine, collagen peptides has over a gram of glycine in every tablespoon. Over 4 grams of glycine per 18 gram protein serving.
66 here. I eat a diet of mostly primary animal foods, meat, dairy, fruit, some nuts is the bulk, with some fermented foods. I dropped almost all supplements except amino acids: 4.5g NAC, 8g glycine, 2.5g Taurine, 6g creatine, split that in half and take one half in the morning, one half in the evening. My mood is brighter, energy is fairly stable all day, absence of really black moods or extreme downs, exercise seems a bit easier...all in all I'd say I get a definite boost from this. About four months in now. The most noticeable is cognition...things just seem to work better overall in terms of mental rapidity, access of memory and responding to events.
Thanks for sharing your own experience. I really like what you're doing. Very healthy habits for sure. I love that you're seeing cognitive benefits. I have to say the thought of that kind of decline haunts me once in a while. I'd like to avoid it if at all possible. Thanks again.
69. Just received a package from China yesterday. Mixed the gly+nac together. Also taking NMN and Resveratrol. Also started Ashwaganda and Rhodeola Rosea yesterday and first night in years had numerous very clear dreams. Suspect that was the Ashwaganda.. I am going to the gym almost every day. Ashwaganda doesn't mix with water so I mix it with sour cream and cream 😎
im 70 and have been taking Glycine and NAC for about 6 month, and I walk everyday. My gait beats much younger people, I always have to pass everyone. also have been sleeping better and more relaxed throughout the day. I can easily sleep 9 hours with a nap. Also lost weight im 5¨2 and 100 lbs, I wasn't this weight since I was 9 or 10!!!
I’m going to add glycine to my morning NAC intake. I went through premature menopause at 40 and am now 45. I’ve never taken hrt, only NAC and vitamin d with probiotics every morning. I haven’t noticed any ageing of my skin. People always assume I’m 10 years younger at least. Could be genetics but I swear by NAC. I can’t wait to add glycine to my daily supplements!
I'm 73 and happy to learn the specifics of this study. I had taken glycene with NAC but I'd given up on it. Now I know that 1) my dosage was too small for my body weight and 2) not to expect results until 16 weeks. I just ordered capsules with a higher dosage in greater quantities. I heard that these supplements are best taken on an EMPTY STOMACH. But the manufacturer suggests taking them WITH FOOD. What is your take on that?
Hi thanks for watching and thanks for sharing your own experience here. My approach would be to take it on an empty stomach and if I feel any gut issues try taking it with food. Hope that helps.
I took NAC for a 6 months and gradually increased the dosage to 3X 600 mg, at this dose it dried up all lubrication between my joints and I had Severe gout like symptoms. quitting NAC for a week fixed this.
@@george6252 yes agree learned it the hard way. But back then I was under tremendous stress and NAC + Mucuna was helping me getting things done, its easy to get carried away.
Yeah, I'm taking 8 grams of each per day, nac and glycine, 3grms in morning, 3 in afternoon, 2 at night. My gait has increased and I have plenty of energy.
You should spend some time on pub med. More is not always better with antioxidants, taking too much NAC can go the complete opposite direction. You should be careful. Peer reviewed studies show that excessive dosing with NAC/ in combination with other antioxidants can produce oxidative stress. The person hosting this channel is derelict and ignorant to chime in with you that this is a good idea. Do your homework. I have one and a half kilos of NAC in my refrigerator, I am clearly an avid fan… I take 800 mg with 2 g of glycine twice a day. I also take 2 g of taurine, NMN, and other things too numerous to list here, YOU HAVE TO DO A LOT OF RESEARCH TO FIGURE THE BALANCE THAT WORKS HERE. Your system, your organs still have to process these things. They can be good for helping the kidneys, eliminate toxins, but too much is literally burdensome on the kidneys, and does the exact opposite. SPEND FIVE MINUTES ON AN AI APP AND SIMPLY ASK, “CAN I TAKE TOO MUCH NAC OR OTHER ANTIOXIDANTS? WHAT ARE THE GUIDELINES?” AND YOU’LL BE SET.
@@JTJaredTaylor no, it is not awesome at all, it is ignorant and according to peer-reviewed research, this can be toxic, cause serious oxidative stress,. And you should be doing your duediligence and correcting this person.
Regarding the extremely high dosage of 8 grams (8,000 mg) of N-Acetylcysteine (NAC) per day, as recommended by the TH-cam channel host, this is a concerning and potentially dangerous level that is not supported by peer-reviewed research. According to the available scientific evidence: 1. Recommended Dosage of NAC: - The typical recommended daily dosage range for NAC supplements is 600-1,800 mg, divided into 2-3 doses. (1) - Dosages above 2,000 mg per day are generally not advised without medical supervision. (1) 2. Potential Risks of Excessive NAC: - Very high doses of NAC, such as 4,000 mg or more per day, have been associated with adverse effects such as nausea, vomiting, diarrhea, and abdominal pain. (2) - Excessively high doses of NAC can potentially lead to an imbalance in the body's oxidative state, potentially causing more harm than good. (3) - The antioxidant properties of NAC can become pro-oxidant at extremely high doses, leading to increased oxidative stress and inflammation. (3) 3. Importance of Maintaining Oxidative Balance: - Moderate levels of oxidative stress are essential for the body's natural defense mechanisms and cellular signaling processes. (4) - However, excessive oxidative stress can damage cells, proteins, and DNA, leading to various health problems. (4) - The "line" between beneficial and harmful effects of antioxidants like NAC is not absolute and can vary based on individual factors, dosage, and duration of use. (3) In summary, the recommendation of 8 grams (8,000 mg) of NAC per day is significantly higher than the established guidelines and poses a serious risk of causing more harm than good due to the potential for disrupting the body's delicate oxidative balance. This dosage is not supported by peer-reviewed research and should be strongly discouraged. Consulting a healthcare professional is advisable before starting any high-dose supplement regimen. References: (1) Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A review on various uses of N-acetyl cysteine. Cell journal, 19(1), 11. (2) Aldini, G., Altomare, A., Baron, G., Vistoli, G., Carini, M., Borsani, L., & Sergio, F. (2018). N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research, 52(7), 751-762. (3) Bouayed, J., & Bohn, T. (2010). Exogenous antioxidants-Double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative medicine and cellular longevity, 3(4), 228-237. (4) Sies, H. (2015). Oxidative stress: a concept in redox biology and medicine. Redox biology, 4, 180-183.
Glycine is not rate limiting to GSH production normally, may be under some circumstances. They have not done the needed comparative study that compares NAC vs NAC + Glycine needed to really know if the glycine is additive to the NAC. In older people, it's possible, but that depends on factors like P intakes etc. It will also take higher doses of glycine than people may realize. BTW, whey is liklye superior to any of those due to glu-cys moiety which is rare in nature in anything but tiny amounts.
I'm 65 and became interested in these precursors to improve liver function, which appears to have worked. 2 years ago, I was plagued with cramps and fatigue. D3 was another element of my recovery. I'm now supplementing heavily with a much wider range of vitamins, chelated minerals, aminos, berberine, Taurine, R-ALA and a lot more. I have felt better and better. In my case, it seems I was depleted in many things. But these two were the first, and made an obvious difference.
That's awesome to hear. I'm glad you've been able to find things that have been so helpful. It's a great feeling to be able to say, "I have felt better and better." Thank you for sharing your own personal experience.
The thing is, NAC works on its own. Glycine is an abundant non-essential amino acid in food. This is not a single compound, but a mix of two compounds. If you could not synthesize glycine, even if you synthesized 1/10th of what you need, that would cause serious problems. And if you synthesized only half what you need, then that might mean that you should just eat 40-60 additional grams of protein per day that the normal minimum. But supplementing glycine is sort of odd because sure you can take as much as 4 grams per day (again there is no minimum nutritional requirement normally) but every 25 grams of protein will contain approximately 1 gram of glycine (and it can be synthesized also). So even 4 grams is a dose that would easily be replicated by increasing overall protein significantly less than 100 g per day. So the question is do glycine supplements work on their own? Does adding glycine to NAC work better than NAC?
Yes. I believe it does from what I have seen, read and experienced. Also, remember that people don’t always digest things as efficiently as they get older. And many people don’t take in as much protein as they should. And glutathione is not as plentiful to do it’s job in the body as we get older. Glutathione is a tripeptide made up of NAC, Glycine and Glutamic acid. Having the building blocks available helps guarantee that the body can make all the glutathione it needs for repairs, etc. Add in Creatine, taurine and a few other amino acids and nutrients and you will find the energy level and mental focus definitely improves. You might add Co q 10 also. It’s absolutely necessary for the mitochondria in the cells.
I've heard Glycine and NAC can be more effective when taken with Taurine... would be grateful for a list of things that can be taken at the same time as Glycine and NAC to deliver optimal health and wellbeing outcomes please?
Taurine has some pretty strong research. It would be hard to list all of the things that are good to take. I can share my current "longevity stack" if that helps. I am currently taking NMN, Creatine, TMG, GlyNAC, Collagen, Whey Protein, hyaluronic acid, saw palmetto (my hair is falling out), vitamin D, vitamin K2, magnesium. I also try to get at least 2 tablespoons of olive oil each day as well as 1 tablespoon of psyllium husk. I've also been taking omega-3's but have put that on pause for a little bit because I'm getting ready to start an experiment to see how much I can raise my omega-3 index. But normally I try to take omega-3's every day as well. I also need to mention that taking a bunch of supplements without following a healthy diet isn't going to help much. Regular exercise is also hugely important as well as good sleep. Hope that helps.
Glycine makes you tonnage sleepy, so keep that in mind as far as when you take it. I have been using GlyNAC about 4 times a week for several months. Honestly, I have felt zero effects, other than sleepy due to glycine.
I do Not take GlyNac. But I do take Glycine, Taurine, Methionine & EAA's (essential aminos - all 9) in free form and feel amazing. I also take small amounts of acetylated GSH.
Can you cite the Glutathione study? Have you tried Glutathione?? (Diminished oxidant/antioxidant) As a 45 yr old with a physical job/lifting running long distance 5 days week i rely on Gluta. Taking sublingually is key the feeling like a needed b12 shot not to mention recovery. I suppose if your sedentary glutathione wouldnt provide much and be a detriment. I would relegate glutathione as a more potent efficient glynac protocol.
I want to try it for the same reason. Actually I bought it few months ago after having C19 and it helped a lot with my lungs. Also I wanted to recover from the weakness I felt. I was also previously diagnosed with chronic fatigue syndrome.
You're very welcome. Thanks for watching. In the studies that I've seen and particularly the one that showed so many benefits they used a 1 to 1 ratio. That seems to be the most common recommendation.
Great question. You'd have to check for different options and choose one you're most comfortable with. I see that Labcorp offers a test that measures levels of Glutathione also called GSH. Ideally you would do the test then take GlyNAC for a period of time and follow that up with another test. This could tell you if it's been effective and if you need to increase the dose etc. Hope that helps.
Interesting. I've heard that NAC is actually helpful for treating respiratory issues. I wonder if the phlegm in your throat was due to a mild respiratory irritation. Just thinking out loud. Thanks for sharing your own personal experience. I'm sure it will be helpful to others.
Been taking Glynac for last few years, age 62. Seems to be helping…been a gym rat since teenage so bit hard to tell… I can tell you is does NOT help avoid BHP, sorry ( had a lot of trouble with that until surgery). General energy and fitness, perhaps a help. Question: Often hear that TMG is part of this for sake of “methylation”. Honestly don’t understand what really that is nor why necessary but I toss in a few TMG as well daily. Could you comment on this..is TMG important for Glynac to work? Thank you
Do you know that you can buy large bags of glycine very cheaply the bag will last 6 months or so. The NAC I have only found it in capsules but if you want a cheaper product get your glycine very cheap in a bag it’s just like fine like sugar crystals.
Do they need to be chemically bound together to increase efficacy or can I just wolf down a load of glycine and NAC as seperate pills but taken at the same time? Please and thank you
I believe wolfing down works! The studies I've seen they gave participants both Glycine and NAC but as separate supplements NOT chemically bound. Many people choose to buy them in bulk separately and then just take them together at what ever time the choose during the day.
I’m not taking GLYnak; I’m just not consuming outlandish amounts of sugars, starchy, advanced glycated end products overly processed foods. Fasted for 5 days exercised daily 45 min walk went from about 189 to 174.03. Still 2 days left in my fast. I don’t let the medical industry decide how much I weigh. I let Physics determine that.
Has anyone had GlyNAC raise their BP? I find it gives me a ton of energy for exercise but has raised my BP by 30 points.😟 It's supposed to lower it.😎 I buy it by the kilo from a lab in China. I am 69 and take about half a teaspoon of GlyNAC and same of Ashwaghanda plus Rhodiola Rosea daily. Can notice the difference in the gym if I miss one day.
Hi, Thanks for sharing. I haven't noticed that myself. Maybe someone else will comment. If I understand correctly Ashwagandha is also supposed to help regulate blood pressure.
@@JTJaredTaylor Yes , your right . But one could get the idea that the doctor maybe don't know , and therefore to better be save , would say I wouldn't recommend it ! 🙃 Which is cool , but doesn't help a lot . This field is so new that I guess its almost impossible even for doctors to keep up . I have taken NAC earlier because of a TH-cam video that suggested it could reverse grey hair 😀 , actually I think it worked a little ! My question was because I thought about giving my old mother (83) it , but she takes pills for high blood pressure !
Tried NAC for a few days and had to stop, as it completely flattened out my mood…couldn’t get excited about anything. Anyone here experiencing the same effect..and if so, is there a way around it! Cheers!!
Sorry to hear it. I can't say I experienced that but thanks for sharing your experience. I'm interested in hearing what other people say. Thanks again.
@@JTJaredTaylor Thanks…wish it wasn’t this way, however perhaps trying at a different dose will result in a different or no unwanted side effect. Will post if I notice a difference. Cheers!
Taking it daily made my chest tight, throat feel tight. But, taking a pinch every now and then completely got rid of afib and heart palps and pvc !! I take it sparingly.
I tried NAC 500mg 8hr later I was breaking out in hives throwing up and having cold chills. I still would like to try it, has any one else had a bad reaction and could I possibly take less or combine it with something to avoid this. I’m cereus what causes this reaction in some people. Thanks if anyone knows this.
Hey Dan, Is it possible that the reaction was caused by something else? If not that sounds like an allergic reaction. The research says NOT to keep taking it if you have such a reaction. I don't think I'd want to risk that. At the very least consult with a doctor. I personally haven't had that issue and I recently took straight NAC at a pretty high does. 6000mg several days in a row. I was taking it in an effort to prevent getting sick. I ended up with mild side effects but it gives you an idea about a range of tolerance. Here's a video about that. th-cam.com/video/hF3mQFCSc-8/w-d-xo.html Hopefully others can help shed more light on this for you as well.
I have read that it tends to lower blood pressure that is why they recommend that people on high blood pressure lowering medication should not take Glynac because it may lower blood pressure too much
Great question. There is research that indicates NAC may actually lower blood pressure. Here's one example. www.ncbi.nlm.nih.gov/pmc/articles/PMC2721729/ That said, if you're taking medication you would want to be sure there are not any drug interactions. I'm certainly not qualified to give you the best answer there. I'd highly recommend you check with your doctor or pharmacist. Sorry I can't give you a more clear answer on this.
Age unheard of across the globe Nac glycine Massive amino acids and eat living foods only I grow as a organic master Not one wrinkle No grey hair My gal pal 38 My daughters🎉 31 and 33 No weights 58 by 31 Vvvvvvvv stacked Just went through Genetic testing External age Not my words The viking is 38 Wtf 8:318:358:36 the challenges that each cell needs at different the challenges that each cell needs at 30 seasons plus dat🎉 The hammer
No. Glycine is an amino acid. A building block for proteins. Where people might get confused is when going on a calorie restricted diet studies have shown that the addition of glycine helps prevent muscle loss. If someone hears "fat loss" and "glycine" together they may think it means glycine helps you lose fat by lowering the impact of carbohydrates. But it's the lowering of calories and or carbohydrates that does it. Not the glycine. I hope I'm answering your question. I hope it helps.
@JTJaredTaylor the talk was about Glynac. The first part of the word was a shorthand of the word glycine, i was asking what the second part nac was....? I have since looked this up
@JTJaredTaylor yes but there are a lot of people talking about it. It is a lot of reading. Could you recommend a recent source on the subject as it is of interest? I've begun taking a glycine supplement (a company called Nutra 1300mg per serving) and a hydrolyzed multi collagen supplement (company called codeage) 2000mg per serving. I'm taking this daily as from 25.03.24. Any pointers in the right direction would be appreciated.
Yes you can. Many people chose to do that. And it's more affordable. Just make sure it's third party tested for quality and purity and manufactured to GMP standards and you should be fine.
Nope. They mention that topic in the study. Once people stopped taking GlyNAC unfortunately the benefits diminished. 6:03 in the video references that topic. Hope that helps.
My understanding is that it's perfectly fine to take it when you're younger but it's just that you will notice improvements more the older you are since glutathione levels decline as you age. Hope that helps.
I want to ask you, I purchased NOW brand glycine and NAC powder Glycine is about 4~5g per day NAC is about 2g per day Divide the above amount into two portions and eat once in the morning and evening But after taking it for 2 to 3 weeks, I almost always feel tired, weak, dizzy, feel uncomfortable in my heart, have a sore neck, and feel unwell. Does anyone else feel the same? Is it because the body is adjusting? Will it improve if I continue to eat it?
It would appear to be too powerful for you right now. Maybe have a break and retry with smaller dose of Glycine by itself first , and then NAC on own to see which one is not right for you , right now .
I took glycine in the day time once and experienced similarly.. so tired and fatigued all day .. now I take nac 600 mg in the morning and glycine 3gms at bedtime and sleep like a baby !
I appreciate your video but want to comment that a lot of health related videos, including yours, have the phrase, “As we age..” as if that fact is what causes a decline in glutathione or any and everything else. Is it the event of aging or a continued accumulation of toxins in our body from the air, food, and water? Why not say instead, as toxins bio accumulate in our bodies, glutathione or whatever, declines?
Thanks for watching and thanks for sharing your thoughts. Great question. The reason people (including myself) say "As we age..." is because that is the most straightforward and accurate way to say it. Think of it this way. There is a reason professional athletes (in most sports) are considered too old by the time they reach their mid-thirties. It's not that toxins from food air and water have accumulated in their body, it's that as we get older things in our body change. Yes, we are still being exposed to toxins but healthy kidneys and a healthy liver will be removing most toxins and waste from your body. Our bodies change as we get older. For example your fast twitch muscle fibers start to atrophy at a faster rate especially after we reach our late 20's. These muscle fibers are responsible for explosive movement, power and speed. Hormone levels change. Testosterone levels decline in men and estrogen levels decline in women. This is one reason TRT or hormone replacement therapy has become so poplar. Bone density changes (becomes less dense). Your Vo2Max (cardio fitness) declines. Your body's ability to process protein and turn it in to muscle declines. You can still do it, but your body becomes less efficient at it. It becomes harder and harder to build muscle and strength. Stomach acid declines so foods are not digested as easily. Collagen levels start to decrease around your mid 20's and continue to decline every year, which is why we start to see wrinkles sometime in our 30's. Cells become older and stop dividing. NAD levels decline and as mentioned in the video Glutathione levels naturally begin to go down. The list goes on and on. We have to work at restoring or preventing or preserving these things much harder as we age, whereas when we're younger, we don't have to worry about it because all of these things are either improving or maintaining. That all changes later in life and it happens for the most part a little at a time over time. This is why people say "as we age.. this begins to happen etc" because that is really what's happening. I sure hope that helps answer your question. Thanks again.
Glycine is a great replacement for sugar on grapefruit. Snack on 3 brazil nuts for the selenium and luthium needed to make glutathione along with NAC. I buy bulk powder of both I encapsulate the NAC in 00 capsules 'cos it tastes real bad The glycine can be added to a stack with magnesium citrate, niacin and vit C or used as above.
I started taking glynac about 4 months ago l, i am 46 about the right age to start ( lucky its been discovered in time!) i feel a lot better generally but as i eliminated sugar and ultra processed foods from my diet and started eating fermented food every day its difficult to say which improvement has come from what. I guess at 46 my glutathione levels wouldn't have been as low as someone in there 60's so it would have less impact on me, the great thing is they don't have to decline with time anymore!
I'm sure it's a combination of all those things. Like a puzzle made up of many small pieces that all fit together. Thanks for sharing. Glad to hear you're feeling better!
I've been taking NAC for a while now, probably a few years. I just added glycine. Thing is, things can get a little expensive especially with some of the other supplements I take so I try to save by taking only 600 mg a day of the NAC. Is that enough? I see some studies where people are taking huge amounts and that would be too expensive for me. I'm a relatively petite 41-year-old woman but I am quite active if that makes a difference.
Yeah it does get expensive right? It's frustrating. I have a lot more to learn but the studies that show significant benefits were using pretty high doses. It seems a little prohibitive for most people. That said, my feeling is that "some" is better than nothing. Some benefit is better than no benefit. We all need to do the best we can with what we have to work with. If 600 mg is what you can do then that's what you can do. In my view it's still better than 0 mg. Honestly I wouldn't be too concerned about it. The more I study and the more I learn about health and longevity in general, the more I believe that the fact that you're "quite active" will help you more than any supplement. Just do the best you can. That may not be the answer you're looking for but I hope it helps.
GlyNAC is digested and absorbed by your body allowing your body to build glutathione and regulate how much goes to which cells and when. Liposomal Glutathione passes right by your bodies ability to regulate it and goes straight to the cells. The issue is you run the risk of jamming your cells with too much at the wrong times which can cause reductive stress and may actually accelerate aging rather than slow it down. Hope that helps.
Of course you can but do you need to? The studies suggest that glutathione levels begin to decline in our mid-40's. We're all different so giving an exact age is impossible but you likely have some time yet. Taking GlyNAC at your age will be safe but you'll likely not experience the same benefits as someone in their 40's 50's 60's and beyond. Hope that helps.
Does anyone have any idea what is causing my Nasal Congestion? I'm taking NAC 600mg twice a day. Glycine 500mg 3 x daily, NMN 500mg once daily, Taurine 500mg 2x daily and 1500mg mg Spermidine. Could any of these causing my severe nasal congestion? Thank you for any help.
Do you sleep with an old or down pillow or comforter? I got rid of mine and it went away pretty quickly. Could be dairy. I only use raw. Could be animals or other allergies. Look in to quercetin?
Perhaps. I would imagine there is research that attempts to answer the cancer question. I haven't heard huge concerns along those lines but it would be really good to see the research.
The study which I have read, indicates that in mice when given Glynac at a later age, because it stops senescent cells in the lungs which is good but also senescent cells have on advantage. Because senescent cell are the cells way of stopping mutating cells becoming cancerous they turn them into senescy cells that no longer divide. Problem is when Glutathione the end product of Glynac is increased in older mice it stops senescent cells being senescent and they become cancerous, this occurred only in the lungs in one tenth of the mice with a certain gene. Humans share many of illnesses with mice that is why it has attracted attention. The paradox about this is that too many senescent cells because they are inflammatory often do cause cancers in people, as well as heart disease, dementia and many other illnesses
What is GlyNACET? Its proportion of GLYCINE to NAC is 10:1, but claims x20 bioavailability compared to Ordinary NAC. The video here is 2 months ago but your most recent is about taking plain ole NAC for an illness. NAC, GlyNAC, GlyNACET is confusing! NAC 0:600, GlyNAC 600:600 (donotage), GlyNACET 1050:100.
Great question. I haven't researched GlyNACET yet so I'm not the best person to answer that question. Something simple (plain ole NAC) can still be helpful. I made the video about NAC because I was wanting to learn more about it, in and of itself. I just happened to be doing some research on it when I started feeling sick. I thought it would be a good time to try it out for myself and why not make a video about it while I'm in the process. I'll have to check out GlyNACET. Thank you.
I'm sure the study is true, as you reprt, but did the reseachers just go to GNC or Walmart for the GlyNAC, or use a pharmeceutical grade? If the latter, then you're lying by ommission of the only fact that matters to us consumers. Correct?
That's a great question. What was the actual quality of the GlyNAC they used and what do we have available to us? Not sure if they outline that in the study or not. Probably need to take a closer look. It's linked in the description. The one I get is pure GlyNAC (Glycine + NAC). I wouldn't be interested in other options. The good thing is regular consumers like you and I, have more access to that kind of quality than ever before. Which is pretty cool.
Don't take my word for it. There are plenty of studies that anyone can find and review themselves. I've linked to one in the description of this video.
You sound just like that guy who puts on makeup and talks to children…I see him on Odins Men sometimes. You look like him too. Have you heard that before?
@@aeiou8287 Several research studies looking at these 2 compounds were released earlier this year and they showed tremendous benefits in lab rats and in humans, so there is a renewed interest in them right now, but they've been around for ages.
Regarding the extremely high dosage of 8 grams (8,000 mg) of N-Acetylcysteine (NAC) per day, as recommended by the TH-cam channel host, this is a concerning and potentially dangerous level that is not supported by peer-reviewed research. According to the available scientific evidence: 1. Recommended Dosage of NAC: - The typical recommended daily dosage range for NAC supplements is 600-1,800 mg, divided into 2-3 doses. (1) - Dosages above 2,000 mg per day are generally not advised without medical supervision. (1) 2. Potential Risks of Excessive NAC: - Very high doses of NAC, such as 4,000 mg or more per day, have been associated with adverse effects such as nausea, vomiting, diarrhea, and abdominal pain. (2) - Excessively high doses of NAC can potentially lead to an imbalance in the body's oxidative state, potentially causing more harm than good. (3) - The antioxidant properties of NAC can become pro-oxidant at extremely high doses, leading to increased oxidative stress and inflammation. (3) 3. Importance of Maintaining Oxidative Balance: - Moderate levels of oxidative stress are essential for the body's natural defense mechanisms and cellular signaling processes. (4) - However, excessive oxidative stress can damage cells, proteins, and DNA, leading to various health problems. (4) - The "line" between beneficial and harmful effects of antioxidants like NAC is not absolute and can vary based on individual factors, dosage, and duration of use. (3) In summary, the recommendation of 8 grams (8,000 mg) of NAC per day is significantly higher than the established guidelines and poses a serious risk of causing more harm than good due to the potential for disrupting the body's delicate oxidative balance. This dosage is not supported by peer-reviewed research and should be strongly discouraged. Consulting a healthcare professional is advisable before starting any high-dose supplement regimen. References: (1) Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A review on various uses of N-acetyl cysteine. Cell journal, 19(1), 11. (2) Aldini, G., Altomare, A., Baron, G., Vistoli, G., Carini, M., Borsani, L., & Sergio, F. (2018). N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research, 52(7), 751-762. (3) Bouayed, J., & Bohn, T. (2010). Exogenous antioxidants-Double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative medicine and cellular longevity, 3(4), 228-237. (4) Sies, H. (2015). Oxidative stress: a concept in redox biology and medicine. Redox biology, 4, 180-183.
this was in response to a comment posted by somebody else, which you agreed with and said "awesome" when they said they were taking 8 g of NAC a day. You are either ignorant or reckless to condone such a thing, if you were a doctor you should have your license revoked for putting that in writing.
This is a game changer for newly diagnosed Parkinson's patients, my tremor is virtually gone and no more nightmares
Awesome! Thanks for sharing. I'm sure it will be helpful for others to see your comment here. Thank you.
B's. Stop seeking fake supplements after videos made by shills like this one. Your problem is excess carbohydrates and amino acids deficiency. Become carnivore and do some fasting too. That's all you need and will be really effective instead of palliative.
Congratulations.
That is great news.
As I read various comments I am very interested in the results people have that have improved their life.
I have been taking 1 g of NAC and one gram of glycine daily in the morning for the last 6 months. I had been referred to a specialist about the signs of non-alcoholic fatty liver syndrome, but in the blood tests I did since I started taking glynac, this is no longer being shown in my blood tests. I realize this is just anecdotal but this is the only thing I changed and it seems to have had a very positive effect. I am 61
Wow. Glad to hear it's been helping you. That's pretty good evidence I'd say. As you mentioned it could be something else but blood tests are far better than someone saying "I feel better". I really appreciate you sharing your story here. Very interesting to read. Thanks again.
You need 3D ultrasound to conclude on NAFLD or fatty liver reversal. Your LFT, liver enzymes & lipids can be in normal range even with fatty liver.
I just turned 66 and have been taking GlyNAC for a couple of months now. About four grams a day divided into morning and evening. Due to the fact that I've also been taking NMN for over a year now, along with other supplements to support that, I can't say that I've seen any major differences except for one. My mood has stabilized and I've become calmer. NMN did that also but GlyNAC has taken it down another notch as well. Noticed it right away. I work in a job that can produce a lot of stress at times. Now I find that, while I still do experience some stress , the intensity of it is much lower. It's funny because after a lifetime of getting all worked up about things that when it doesn't happen my brain gets confused. It wants to get all agro but can't and it actually feels somewhat disappointing. I wouldn't have it any other way and maybe someday that feeling will go away.
That's interesting and something I haven't heard yet about GlyNAC. Thank you so much for sharing. I'm glad you're seeing positive results.
I've heard around 9 gm per day, you dose may be too low and ineffective
66 and working a stressful job? Hats off to you sir 👏 👒
Im only taking glycine (just glicine) for 25 days and feel more calm to, im liking it alot
I just bought a glynac supplement that is 600mg NAC and 70mg glycine. Is that ok? Should it not be 1:1? Confused. Help!
There is also 20mcg of selenium.
I’m on it. I’m in my 50’s and deliver pkgs. I’m impressed how great I feel
I’m 71 years young and have been taking glycine for years now. Since glycine is sweet to taste I use it to sweeten coffee or tea. Usually at the rate of 4 gms/day in two doses. Tastes sweet and no tummy upset like xylitol. Just started taking NAC at the rate of 4 gms/day as well.
Thanks for sharing. I'll have to try using glycine as a sweetener. Thanks again.
Oooh, that's a lot of NAC per day, be careful, there are ? about long term use at high doses and toxicity!
it's not NAC she's taking glycine only
@@Nandymon
@@Nandymon
That is not a high dose at all. Some people take much more. Each person is different and has different needs and tolerances. Splitting an amount into different times of the day is good. More likely to be taken up and utilized.
Also, remember that different sexes, different weight individuals, different exercise regimens and different diets and lifestyles all have an effect on what a given person needs and tolerates best. 👍
It is also true that a person should be mindful of how much they take so they can be consistent.
I am 70yrs. What started you on glycine to begin with? I have taken a couple years, am starting to take with NAC
I am feeling fantastic on NAC. My energy has improved dramatically. I have motivation again. Its wonderful
Awesome! Thanks for sharing your own experience. I'm sure this will be helpful to others.
32 and have been taking this for about a year now. Trying to start young and keep my youth long term. Also take nmn and a bunch of other supplements
I’ve been taking knack for three years. Only recently heard about glycine. Now I’m taking both.
72 here, I take 4 grams of Glycine/600mg of NAC just before bed. After waking
I repeat. 16th week now. Also taking NMN and C-60 on alternate days.
I have been walking faster and walking more. Have started walking before sunrise even.
Gym several times a week. Do not feel my age.
That's awesome. Thank you so much for sharing your personal experience.
👍👍👍👍
Sir, nac is n acetyl cysteine right?
@@Viv8ldiyes
I started taking nac over a year ago after hearing it would fix my sciatic damage that had me limping for over a year it has completely healed I do not have any more pain I took 600mg every night I also noticed less pain and inflammation on my spinal cord injury
Awesome! Thank you so much for sharing your own experience. So glad it helped you.
I started taking NAC about 10 days ago. I bought the powder and it tastes terrible. I would suggest buying capsules. For the glycine, I just take my collagen peptides, maybe just a little extra. While whey protein has equal and smaller amounts of both glycine and cysteine, collagen peptides has over a gram of glycine in every tablespoon. Over 4 grams of glycine per 18 gram protein serving.
66 here. I eat a diet of mostly primary animal foods, meat, dairy, fruit, some nuts is the bulk, with some fermented foods. I dropped almost all supplements except amino acids: 4.5g NAC, 8g glycine, 2.5g Taurine, 6g creatine, split that in half and take one half in the morning, one half in the evening. My mood is brighter, energy is fairly stable all day, absence of really black moods or extreme downs, exercise seems a bit easier...all in all I'd say I get a definite boost from this. About four months in now. The most noticeable is cognition...things just seem to work better overall in terms of mental rapidity, access of memory and responding to events.
Thanks for sharing your own experience. I really like what you're doing. Very healthy habits for sure. I love that you're seeing cognitive benefits. I have to say the thought of that kind of decline haunts me once in a while. I'd like to avoid it if at all possible. Thanks again.
Excellent plan.
You kept the best and most useful.
Thank you for this video. I really appreciate all the information. Yes I’m taking it now.
You're very welcome. I'm glad you liked the video. Thanks for watching and thanks for letting me know. I really appreciate it.
69. Just received a package from China yesterday. Mixed the gly+nac together. Also taking NMN and Resveratrol. Also started Ashwaganda and Rhodeola Rosea yesterday and first night in years had numerous very clear dreams. Suspect that was the Ashwaganda.. I am going to the gym almost every day. Ashwaganda doesn't mix with water so I mix it with sour cream and cream 😎
im 70 and have been taking Glycine and NAC for about 6 month, and I walk everyday. My gait beats much younger people, I always have to pass everyone. also have been sleeping better and more relaxed throughout the day. I can easily sleep 9 hours with a nap. Also lost weight im 5¨2 and 100 lbs, I wasn't this weight since I was 9 or 10!!!
Awesome! Thanks for sharing your own personal experience Susan! I'm sure this will be helpful to others.
How many mg/g of each do you take? Thanks
I’m going to add glycine to my morning NAC intake. I went through premature menopause at 40 and am now 45. I’ve never taken hrt, only NAC and vitamin d with probiotics every morning. I haven’t noticed any ageing of my skin. People always assume I’m 10 years younger at least. Could be genetics but I swear by NAC. I can’t wait to add glycine to my daily supplements!
Awesome! Thanks for sharing your own personal experience.
How are u feeling after adding in Glycine? Ty
Still waiting for delivery!
I'm 73 and happy to learn the specifics of this study. I had taken glycene with NAC but I'd given up on it. Now I know that 1) my dosage was too small for my body weight and 2) not to expect results until 16 weeks. I just ordered capsules with a higher dosage in greater quantities. I heard that these supplements are best taken on an EMPTY STOMACH. But the manufacturer suggests taking them WITH FOOD. What is your take on that?
Hi thanks for watching and thanks for sharing your own experience here. My approach would be to take it on an empty stomach and if I feel any gut issues try taking it with food. Hope that helps.
I took NAC for a 6 months and gradually increased the dosage to 3X 600 mg, at this dose it dried up all lubrication between my joints and I had Severe gout like symptoms. quitting NAC for a week fixed this.
You were taking way too much. I take 600 mg/Glycine before bed same waking . That's it.
That's good to know. Thanks for sharing your own personal experience.
@@george6252 yes agree learned it the hard way. But back then I was under tremendous stress and NAC + Mucuna was helping me getting things done, its easy to get carried away.
600 mg is not even spitting n the ocean as far as dose. Everybody is different and responds differently to…..
How do you know NAC has dried up your lubrication between your joints? Gout is from stress and poor diet.
Yeah, I'm taking 8 grams of each per day, nac and glycine, 3grms in morning, 3 in afternoon, 2 at night. My gait has increased and I have plenty of energy.
Awesome. So taking a higher dose like they did in the study. Makes sense. Glad it's going well for you. Thanks for sharing.
You should spend some time on pub med. More is not always better with antioxidants, taking too much NAC can go the complete opposite direction. You should be careful. Peer reviewed studies show that excessive dosing with NAC/ in combination with other antioxidants can produce oxidative stress. The person hosting this channel is derelict and ignorant to chime in with you that this is a good idea. Do your homework. I have one and a half kilos of NAC in my refrigerator, I am clearly an avid fan… I take 800 mg with 2 g of glycine twice a day. I also take 2 g of taurine, NMN, and other things too numerous to list here, YOU HAVE TO DO A LOT OF RESEARCH TO FIGURE THE BALANCE THAT WORKS HERE. Your system, your organs still have to process these things. They can be good for helping the kidneys, eliminate toxins, but too much is literally burdensome on the kidneys, and does the exact opposite. SPEND FIVE MINUTES ON AN AI APP AND SIMPLY ASK, “CAN I TAKE TOO MUCH NAC OR OTHER ANTIOXIDANTS? WHAT ARE THE GUIDELINES?” AND YOU’LL BE SET.
@@JTJaredTaylor no, it is not awesome at all, it is ignorant and according to peer-reviewed research, this can be toxic, cause serious oxidative stress,. And you should be doing your duediligence and correcting this person.
Regarding the extremely high dosage of 8 grams (8,000 mg) of N-Acetylcysteine (NAC) per day, as recommended by the TH-cam channel host, this is a concerning and potentially dangerous level that is not supported by peer-reviewed research.
According to the available scientific evidence:
1. Recommended Dosage of NAC:
- The typical recommended daily dosage range for NAC supplements is 600-1,800 mg, divided into 2-3 doses. (1)
- Dosages above 2,000 mg per day are generally not advised without medical supervision. (1)
2. Potential Risks of Excessive NAC:
- Very high doses of NAC, such as 4,000 mg or more per day, have been associated with adverse effects such as nausea, vomiting, diarrhea, and abdominal pain. (2)
- Excessively high doses of NAC can potentially lead to an imbalance in the body's oxidative state, potentially causing more harm than good. (3)
- The antioxidant properties of NAC can become pro-oxidant at extremely high doses, leading to increased oxidative stress and inflammation. (3)
3. Importance of Maintaining Oxidative Balance:
- Moderate levels of oxidative stress are essential for the body's natural defense mechanisms and cellular signaling processes. (4)
- However, excessive oxidative stress can damage cells, proteins, and DNA, leading to various health problems. (4)
- The "line" between beneficial and harmful effects of antioxidants like NAC is not absolute and can vary based on individual factors, dosage, and duration of use. (3)
In summary, the recommendation of 8 grams (8,000 mg) of NAC per day is significantly higher than the established guidelines and poses a serious risk of causing more harm than good due to the potential for disrupting the body's delicate oxidative balance. This dosage is not supported by peer-reviewed research and should be strongly discouraged. Consulting a healthcare professional is advisable before starting any high-dose supplement regimen.
References:
(1) Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A review on various uses of N-acetyl cysteine. Cell journal, 19(1), 11.
(2) Aldini, G., Altomare, A., Baron, G., Vistoli, G., Carini, M., Borsani, L., & Sergio, F. (2018). N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research, 52(7), 751-762.
(3) Bouayed, J., & Bohn, T. (2010). Exogenous antioxidants-Double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative medicine and cellular longevity, 3(4), 228-237.
(4) Sies, H. (2015). Oxidative stress: a concept in redox biology and medicine. Redox biology, 4, 180-183.
Glycine is not rate limiting to GSH production normally, may be under some circumstances. They have not done the needed comparative study that compares NAC vs NAC + Glycine needed to really know if the glycine is additive to the NAC. In older people, it's possible, but that depends on factors like P intakes etc. It will also take higher doses of glycine than people may realize. BTW, whey is liklye superior to any of those due to glu-cys moiety which is rare in nature in anything but tiny amounts.
It is IN FACT a rate limiting factor
How could it not be additive since both are needed to produce glutathione?
i am 76 this shit works believe it
Have been using glynac 1yr feeling great, have copd do not to use injaler,gym3 4 days a week, 80yrs young, u should try it.
Awesome! Thanks for sharing Harold. Glad you're feeling great!
I'm 65 and became interested in these precursors to improve liver function, which appears to have worked. 2 years ago, I was plagued with cramps and fatigue. D3 was another element of my recovery. I'm now supplementing heavily with a much wider range of vitamins, chelated minerals, aminos, berberine, Taurine, R-ALA and a lot more. I have felt better and better. In my case, it seems I was depleted in many things. But these two were the first, and made an obvious difference.
That's awesome to hear. I'm glad you've been able to find things that have been so helpful. It's a great feeling to be able to say, "I have felt better and better." Thank you for sharing your own personal experience.
The thing is, NAC works on its own. Glycine is an abundant non-essential amino acid in food. This is not a single compound, but a mix of two compounds. If you could not synthesize glycine, even if you synthesized 1/10th of what you need, that would cause serious problems. And if you synthesized only half what you need, then that might mean that you should just eat 40-60 additional grams of protein per day that the normal minimum. But supplementing glycine is sort of odd because sure you can take as much as 4 grams per day (again there is no minimum nutritional requirement normally) but every 25 grams of protein will contain approximately 1 gram of glycine (and it can be synthesized also). So even 4 grams is a dose that would easily be replicated by increasing overall protein significantly less than 100 g per day. So the question is do glycine supplements work on their own? Does adding glycine to NAC work better than NAC?
Yes. I believe it does from what I have seen, read and experienced.
Also, remember that people don’t always digest things as efficiently as they get older. And many people don’t take in as much protein as they should. And glutathione is not as plentiful to do it’s job in the body as we get older.
Glutathione is a tripeptide made up of NAC, Glycine and Glutamic acid. Having the building blocks available helps guarantee that the body can make all the glutathione it needs for repairs, etc.
Add in Creatine, taurine and a few other amino acids and nutrients and you will find the energy level and mental focus definitely improves. You might add Co q 10 also. It’s absolutely necessary for the mitochondria in the cells.
It's so amazing what benefits 2 amino acids can have.
It really is, isn't it?
I have even my Mother taking NAC w/ TMG...for many many years now....I use the glycine pwder in my drink as it tastes sweet...
I've heard Glycine and NAC can be more effective when taken with Taurine... would be grateful for a list of things that can be taken at the same time as Glycine and NAC to deliver optimal health and wellbeing outcomes please?
Lions Mane and Niacin :)
NMN
Taurine has some pretty strong research. It would be hard to list all of the things that are good to take. I can share my current "longevity stack" if that helps. I am currently taking NMN, Creatine, TMG, GlyNAC, Collagen, Whey Protein, hyaluronic acid, saw palmetto (my hair is falling out), vitamin D, vitamin K2, magnesium. I also try to get at least 2 tablespoons of olive oil each day as well as 1 tablespoon of psyllium husk. I've also been taking omega-3's but have put that on pause for a little bit because I'm getting ready to start an experiment to see how much I can raise my omega-3 index. But normally I try to take omega-3's every day as well. I also need to mention that taking a bunch of supplements without following a healthy diet isn't going to help much. Regular exercise is also hugely important as well as good sleep. Hope that helps.
@@JTJaredTaylorsurprised you don’t take resvertrol with the NMN.
@@JTJaredTaylor
What in N & TMG?
Glycine makes you tonnage sleepy, so keep that in mind as far as when you take it. I have been using GlyNAC about 4 times a week for several months. Honestly, I have felt zero effects, other than sleepy due to glycine.
Yeah, a lot of people like to take glycine in the evening for that reason.
I do Not take GlyNac.
But I do take Glycine, Taurine, Methionine & EAA's (essential aminos - all 9) in free form and feel amazing. I also take small amounts of acetylated GSH.
Love it. Thanks for sharing. Glad it's helping!
Why take methionine?
Can you cite the Glutathione study? Have you tried Glutathione??
(Diminished oxidant/antioxidant) As a 45 yr old with a physical job/lifting running long distance 5 days week i rely on Gluta. Taking sublingually is key the feeling like a needed b12 shot not to mention recovery.
I suppose if your sedentary glutathione wouldnt provide much and be a detriment. I would relegate glutathione as a more potent efficient glynac protocol.
Anyone, please Question; have you heard of it helping Chronic Fatigue Sindrom?? TY
I want to try it for the same reason. Actually I bought it few months ago after having C19 and it helped a lot with my lungs. Also I wanted to recover from the weakness I felt. I was also previously diagnosed with chronic fatigue syndrome.
How much glycine compared to NAC should one take? I have NAC already and I'll be adding in glycine. Thank you for the very informative video!!
You're very welcome. Thanks for watching. In the studies that I've seen and particularly the one that showed so many benefits they used a 1 to 1 ratio. That seems to be the most common recommendation.
How to take? How much and when? I have been taking NAC for a while usually 600mg in the morning. 600 in the evening. Don’t know if I feel anything.
consider the vascular endothelial glycocalyx
Are there blood tests available to provide some sort of personalized feedback of supplement effectiveness...is one taking too much or too little?
Great question. You'd have to check for different options and choose one you're most comfortable with. I see that Labcorp offers a test that measures levels of Glutathione also called GSH. Ideally you would do the test then take GlyNAC for a period of time and follow that up with another test. This could tell you if it's been effective and if you need to increase the dose etc. Hope that helps.
I had constant phlegm always clearing my throat, started taking glyNAC and it went away.
Interesting. I've heard that NAC is actually helpful for treating respiratory issues. I wonder if the phlegm in your throat was due to a mild respiratory irritation. Just thinking out loud. Thanks for sharing your own personal experience. I'm sure it will be helpful to others.
@@JTJaredTaylor I had the mucus drip for years now gone.
I have this right now my entire life
Been taking Glynac for last few years, age 62. Seems to be helping…been a gym rat since teenage so bit hard to tell… I can tell you is does NOT help avoid BHP, sorry ( had a lot of trouble with that until surgery). General energy and fitness, perhaps a help.
Question:
Often hear that TMG is part of this for sake of “methylation”. Honestly don’t understand what really that is nor why necessary but I toss in a few TMG as well daily.
Could you comment on this..is TMG important for Glynac to work?
Thank you
Do you know that you can buy large bags of glycine very cheaply the bag will last 6 months or so. The NAC I have only found it in capsules but if you want a cheaper product get your glycine very cheap in a bag it’s just like fine like sugar crystals.
You make less money though promoting expensive brands of pills...
Is the GlyNac pill... the one that is an "ester".... a good option? (it's more convenient to take)
Do they need to be chemically bound together to increase efficacy or can I just wolf down a load of glycine and NAC as seperate pills but taken at the same time? Please and thank you
I believe wolfing down works! The studies I've seen they gave participants both Glycine and NAC but as separate supplements NOT chemically bound. Many people choose to buy them in bulk separately and then just take them together at what ever time the choose during the day.
I’m not taking GLYnak; I’m just not consuming outlandish amounts of sugars, starchy, advanced glycated end products overly processed foods. Fasted for 5 days exercised daily 45 min walk went from about 189 to 174.03. Still 2 days left in my fast. I don’t let the medical industry decide how much I weigh. I let Physics determine that.
Has anyone had GlyNAC raise their BP? I find it gives me a ton of energy for exercise but has raised my BP by 30 points.😟 It's supposed to lower it.😎 I buy it by the kilo from a lab in China. I am 69 and take about half a teaspoon of GlyNAC and same of Ashwaghanda plus Rhodiola Rosea daily. Can notice the difference in the gym if I miss one day.
Hi, Thanks for sharing. I haven't noticed that myself. Maybe someone else will comment. If I understand correctly Ashwagandha is also supposed to help regulate blood pressure.
Very interesting , do you know if the is any problem taken it for people with high blood pressure ?
Bw
It shouldn't but of course it's best to check with your doctor.
@@JTJaredTaylor
Yes , your right .
But one could get the idea that the doctor maybe don't know , and therefore to better be save , would say I wouldn't recommend it ! 🙃
Which is cool , but doesn't help a lot . This field is so new that I guess its almost impossible even for doctors to keep up .
I have taken NAC earlier because of a TH-cam video that suggested it could reverse grey hair 😀 , actually I think it worked a little !
My question was because I thought about giving my old mother (83) it , but she takes pills for high blood pressure !
Tried NAC for a few days and had to stop, as it completely flattened out my mood…couldn’t get excited about anything. Anyone here experiencing the same effect..and if so, is there a way around it! Cheers!!
Sorry to hear it. I can't say I experienced that but thanks for sharing your experience. I'm interested in hearing what other people say. Thanks again.
@@JTJaredTaylor
Thanks…wish it wasn’t this way, however perhaps trying at a different dose will result in a different or no unwanted side effect.
Will post if I notice a difference.
Cheers!
How much glycine should we take with say NAC 600mg if taken separately? Thanks 👍
My understanding is that a 1 to 1 ratio is generally recommended. So with 600mg NAC I'd also do 600mg glycine. Hope that helps!
I take glynac before bed and that results in my morning poop smelling like nac, a kinda chemical smell, really bad. Anyone else has this?
GlyNacLionsMane is my evening longevity drink, and quite tasty. 6 grams of Glycine according to studio.
Awesome! Thanks for sharing.
I subscribed
Taking it daily made my chest tight, throat feel tight. But, taking a pinch every now and then completely got rid of afib and heart palps and pvc !!
I take it sparingly.
I tried NAC 500mg 8hr later I was breaking out in hives throwing up and having cold chills. I still would like to try it, has any one else had a bad reaction and could I possibly take less or combine it with something to avoid this. I’m cereus what causes this reaction in some people. Thanks if anyone knows this.
Hey Dan, Is it possible that the reaction was caused by something else? If not that sounds like an allergic reaction. The research says NOT to keep taking it if you have such a reaction. I don't think I'd want to risk that. At the very least consult with a doctor. I personally haven't had that issue and I recently took straight NAC at a pretty high does. 6000mg several days in a row. I was taking it in an effort to prevent getting sick. I ended up with mild side effects but it gives you an idea about a range of tolerance. Here's a video about that. th-cam.com/video/hF3mQFCSc-8/w-d-xo.html
Hopefully others can help shed more light on this for you as well.
Do you know if either glycine or NAC have an affect on blood pressure.
I don't. I haven't researched that specifically. Sorry.
I have read that it tends to lower blood pressure that is why they recommend that people on high blood pressure lowering medication should not take Glynac because it may lower blood pressure too much
I take a hypertension medication, is it safe if I also take NAC?
Great question. There is research that indicates NAC may actually lower blood pressure. Here's one example.
www.ncbi.nlm.nih.gov/pmc/articles/PMC2721729/ That said, if you're taking medication you would want to be sure there are not any drug interactions. I'm certainly not qualified to give you the best answer there. I'd highly recommend you check with your doctor or pharmacist. Sorry I can't give you a more clear answer on this.
Age unheard of across the globe
Nac glycine
Massive amino acids and eat living foods only
I grow as a organic master
Not one wrinkle
No grey hair
My gal pal 38
My daughters🎉 31 and 33
No weights
58 by 31
Vvvvvvvv stacked
Just went through
Genetic testing
External age
Not my words
The viking is 38
Wtf 8:31 8:35 8:36 the challenges that each cell needs at different the challenges that each cell needs at
30 seasons plus dat🎉
The hammer
If I want to start today , but prefer to take one only for a start, which should I get first, glycine or NAC?
Are there anty carcbohydrates in Glycine?
No. Glycine is an amino acid. A building block for proteins. Where people might get confused is when going on a calorie restricted diet studies have shown that the addition of glycine helps prevent muscle loss. If someone hears "fat loss" and "glycine" together they may think it means glycine helps you lose fat by lowering the impact of carbohydrates. But it's the lowering of calories and or carbohydrates that does it. Not the glycine. I hope I'm answering your question. I hope it helps.
Im taking glycine just started what in the NAC bit?
Hi Martin, Sorry. I'm not quite sure what you're asking.
@JTJaredTaylor the talk was about Glynac. The first part of the word was a shorthand of the word glycine, i was asking what the second part nac was....? I have since looked this up
@@martinbennett9578 I see. Thanks. Were you able to find the information you needed?
@JTJaredTaylor yes but there are a lot of people talking about it. It is a lot of reading. Could you recommend a recent source on the subject as it is of interest? I've begun taking a glycine supplement (a company called Nutra 1300mg per serving) and a hydrolyzed multi collagen supplement (company called codeage) 2000mg per serving. I'm taking this daily as from 25.03.24. Any pointers in the right direction would be appreciated.
My glynac supplement is 1000 mg, 500 of each. Is this enough? The company is longevity box, fyi.
So I can take glycine and cysteine together do I get that righ?
Yes you can. Many people chose to do that. And it's more affordable. Just make sure it's third party tested for quality and purity and manufactured to GMP standards and you should be fine.
I just started this about two weeks ago. Does this mean that I need to take a break at 16 weeks?
Nope. They mention that topic in the study. Once people stopped taking GlyNAC unfortunately the benefits diminished. 6:03 in the video references that topic. Hope that helps.
Any thoughts on younger people taking nac? I'm not 45 but I have been taking nac anyways
My understanding is that it's perfectly fine to take it when you're younger but it's just that you will notice improvements more the older you are since glutathione levels decline as you age. Hope that helps.
I have ordered glycine... Then i Will order NAC another time...
A lot of people do just that. It is more affordable to order then separately.
I want to ask you,
I purchased NOW brand glycine and NAC powder
Glycine is about 4~5g per day
NAC is about 2g per day
Divide the above amount into two portions and eat once in the morning and evening
But after taking it for 2 to 3 weeks, I almost always feel tired, weak, dizzy, feel uncomfortable in my heart, have a sore neck, and feel unwell. Does anyone else feel the same? Is it because the body is adjusting? Will it improve if I continue to eat it?
Sorry to hear that. I haven't experienced that personally and need to do more research. Hopefully someone else can help. Thanks
It would appear to be too powerful for you right now. Maybe have a break and retry with smaller dose of Glycine by itself first , and then NAC on own to see which one is not right for you , right now .
I took glycine in the day time once and experienced similarly.. so tired and fatigued all day .. now I take nac 600 mg in the morning and glycine 3gms at bedtime and sleep like a baby !
It makes me feel good when i consume it, but Ive wondered if it gives me a hangover. I only do a small dose of like 600mg of each.
I appreciate your video but want to comment that a lot of health related videos, including yours, have the phrase, “As we age..” as if that fact is what causes a decline in glutathione or any and everything else. Is it the event of aging or a continued accumulation of toxins in our body from the air, food, and water? Why not say instead, as toxins bio accumulate in our bodies, glutathione or whatever, declines?
Thanks for watching and thanks for sharing your thoughts. Great question. The reason people (including myself) say "As we age..." is because that is the most straightforward and accurate way to say it. Think of it this way. There is a reason professional athletes (in most sports) are considered too old by the time they reach their mid-thirties. It's not that toxins from food air and water have accumulated in their body, it's that as we get older things in our body change.
Yes, we are still being exposed to toxins but healthy kidneys and a healthy liver will be removing most toxins and waste from your body. Our bodies change as we get older. For example your fast twitch muscle fibers start to atrophy at a faster rate especially after we reach our late 20's. These muscle fibers are responsible for explosive movement, power and speed.
Hormone levels change. Testosterone levels decline in men and estrogen levels decline in women. This is one reason TRT or hormone replacement therapy has become so poplar. Bone density changes (becomes less dense). Your Vo2Max (cardio fitness) declines. Your body's ability to process protein and turn it in to muscle declines. You can still do it, but your body becomes less efficient at it. It becomes harder and harder to build muscle and strength. Stomach acid declines so foods are not digested as easily. Collagen levels start to decrease around your mid 20's and continue to decline every year, which is why we start to see wrinkles sometime in our 30's. Cells become older and stop dividing. NAD levels decline and as mentioned in the video Glutathione levels naturally begin to go down. The list goes on and on.
We have to work at restoring or preventing or preserving these things much harder as we age, whereas when we're younger, we don't have to worry about it because all of these things are either improving or maintaining. That all changes later in life and it happens for the most part a little at a time over time. This is why people say "as we age.. this begins to happen etc" because that is really what's happening. I sure hope that helps answer your question. Thanks again.
Glycine is a great replacement for sugar on grapefruit.
Snack on 3 brazil nuts for the selenium and luthium needed to make glutathione along with NAC.
I buy bulk powder of both
I encapsulate the NAC in 00 capsules 'cos it tastes real bad
The glycine can be added to a stack with magnesium citrate, niacin and vit C or used as above.
Awesome stuff here. Thanks for sharing. I love grapefruit and I may just have to try that.
@@JTJaredTaylor just be mindful what else you take with the grapefruit as it can greatly enhance takeup 😉
I use magnesium glycinate with nac
I take L Glycine in the evening…And NAC through the day
Can I take them together?
How much should I take at age 83, have never taken it before and for how long should I take it?
100mcg per 1kg of body weight+1 NAC+1 PQQ per day for ever...
@@zoranpaunovic6701
What’s PQQ?
I started taking glynac about 4 months ago l, i am 46 about the right age to start ( lucky its been discovered in time!) i feel a lot better generally but as i eliminated sugar and ultra processed foods from my diet and started eating fermented food every day its difficult to say which improvement has come from what. I guess at 46 my glutathione levels wouldn't have been as low as someone in there 60's so it would have less impact on me, the great thing is they don't have to decline with time anymore!
I'm sure it's a combination of all those things. Like a puzzle made up of many small pieces that all fit together. Thanks for sharing. Glad to hear you're feeling better!
I actually am just talking glycine and Nac together for now.
Great! How's it going for you?
I've been taking NAC for a while now, probably a few years. I just added glycine. Thing is, things can get a little expensive especially with some of the other supplements I take so I try to save by taking only 600 mg a day of the NAC. Is that enough? I see some studies where people are taking huge amounts and that would be too expensive for me. I'm a relatively petite 41-year-old woman but I am quite active if that makes a difference.
From what I read 600mg a day is good for daily maintenance.
Yeah it does get expensive right? It's frustrating. I have a lot more to learn but the studies that show significant benefits were using pretty high doses. It seems a little prohibitive for most people. That said, my feeling is that "some" is better than nothing. Some benefit is better than no benefit. We all need to do the best we can with what we have to work with. If 600 mg is what you can do then that's what you can do. In my view it's still better than 0 mg. Honestly I wouldn't be too concerned about it. The more I study and the more I learn about health and longevity in general, the more I believe that the fact that you're "quite active" will help you more than any supplement. Just do the best you can. That may not be the answer you're looking for but I hope it helps.
@@JTJaredTaylor try it and find out I guess. I was taking NAD for a while but it made me feel tired so I stopped.
@@mhaas281 interesting. You're not the only one I've heard that from. We each have our own unique puzzle to solve don't we?
I switch to powder form for both plus taurine. Way cheaper.
It clears the brain fog associated with menopausal symptoms
Awesome!
Would you take this in conjunction with NMN?
Yes. I have and do. Keep in mind they are for different things. NMN for increasing NAD+ and GlyNAC for elevated Glutathione levels.
When you say glycine, does that mean betaine, or tmg?
No, just pure glycine. TMG or betaine is a form of glycine that has 3 methyl groups. It's a little different.
Why would Glynac be safe but not liposomal glutathione??
GlyNAC is digested and absorbed by your body allowing your body to build glutathione and regulate how much goes to which cells and when. Liposomal Glutathione passes right by your bodies ability to regulate it and goes straight to the cells. The issue is you run the risk of jamming your cells with too much at the wrong times which can cause reductive stress and may actually accelerate aging rather than slow it down. Hope that helps.
Causes urticaria?felt so.
Can I supplement with GlyNAC at 33 years old? or am I too young?
Of course you can but do you need to? The studies suggest that glutathione levels begin to decline in our mid-40's. We're all different so giving an exact age is impossible but you likely have some time yet. Taking GlyNAC at your age will be safe but you'll likely not experience the same benefits as someone in their 40's 50's 60's and beyond. Hope that helps.
Did the GlyNac reverse your graying?
Hope not! I like my silver.
@@lighterbeing I certainly don't. Have you used GlyNac for a while and have not seen any reversal of your graying?
Unfortunately I cannot comment on graying. My problem isn't graying but thinning and I don't know that it has slowed my hair loss at all...
Does anyone have any idea what is causing my Nasal Congestion? I'm taking NAC 600mg twice a day. Glycine 500mg 3 x daily, NMN 500mg once daily, Taurine 500mg 2x daily and 1500mg mg Spermidine. Could any of these causing my severe nasal congestion? Thank you for any help.
Do you sleep with an old or down pillow or comforter? I got rid of mine and it went away pretty quickly.
Could be dairy. I only use raw.
Could be animals or other allergies.
Look in to quercetin?
Oh. Also could be glysophate , it’s in all American wheat products.
There are also other studies bringing up cancer related to this, no ? I don't have the links but it's out there.
Perhaps. I would imagine there is research that attempts to answer the cancer question. I haven't heard huge concerns along those lines but it would be really good to see the research.
Related in what way ? Cause or cure ?
The study which I have read, indicates that in mice when given Glynac at a later age, because it stops senescent cells in the lungs which is good but also senescent cells have on advantage. Because senescent cell are the cells way of stopping mutating cells becoming cancerous they turn them into senescy cells that no longer divide. Problem is when Glutathione the end product of Glynac is increased in older mice it stops senescent cells being senescent and they become cancerous, this occurred only in the lungs in one tenth of the mice with a certain gene. Humans share many of illnesses with mice that is why it has attracted attention. The paradox about this is that too many senescent cells because they are inflammatory often do cause cancers in people, as well as heart disease, dementia and many other illnesses
love the spongebob memes
I had fun putting those in! I'm so glad someone appreciates it! My daughter is actually watching old spongebob episodes right now. 😊
What is GlyNACET? Its proportion of GLYCINE to NAC is 10:1, but claims x20 bioavailability compared to Ordinary NAC. The video here is 2 months ago but your most recent is about taking plain ole NAC for an illness. NAC, GlyNAC, GlyNACET is confusing! NAC 0:600, GlyNAC 600:600 (donotage), GlyNACET 1050:100.
Great question. I haven't researched GlyNACET yet so I'm not the best person to answer that question. Something simple (plain ole NAC) can still be helpful. I made the video about NAC because I was wanting to learn more about it, in and of itself. I just happened to be doing some research on it when I started feeling sick. I thought it would be a good time to try it out for myself and why not make a video about it while I'm in the process. I'll have to check out GlyNACET. Thank you.
BromNAC FTW
Bromelain + NAC
Is there a doctor on this planet that prescribes glutathione?
Do your research doc. The body requires ~15g glycine/day.
Supplementing with 12 g+ glycine per day is recommended.
Memo: glutathione is unstable. Liposomal glutathione is stable
You and others speak about grams…when many of us take tablets or capsules…. This is confusing…….
Good point. The bottle for your tablets or capsules should say how many grams of GlyNAC you're getting in each one.
GlyNAC affects spelling as well as muscle strenth.
Spelling???😂
@@piperuk5366 Yep, it's a banned substance at spelling bee championships
My half angel takes glynac, my half demos loves wine. At 59, I am doing fine, train, and look young. It is a go.
Bryan Johnson Blueprint, Ai will soon take the guess work out of it and all gurus and snake oil salesmen will soon be gone. Don't die, see you in 2500
I'm looking forward to Blueprint.
Unfortunately both JT and others don't address those of us who already take glutathione IN INJECTIBLE FORM, where absorption isn't an issue.
Good idea. Thanks. I'll have to look into that.
Why is everyone in the comments 70 years old?
Because people in their 70s will get the most benefit from Glynac
relax, Im 69
I'm sure the study is true, as you reprt, but did the reseachers just go to GNC or Walmart for the GlyNAC, or use a pharmeceutical grade? If the latter, then you're lying by ommission of the only fact that matters to us consumers. Correct?
That's a great question. What was the actual quality of the GlyNAC they used and what do we have available to us? Not sure if they outline that in the study or not. Probably need to take a closer look. It's linked in the description. The one I get is pure GlyNAC (Glycine + NAC). I wouldn't be interested in other options. The good thing is regular consumers like you and I, have more access to that kind of quality than ever before. Which is pretty cool.
Is everyone taking GlyNAC???? Im not.
"Gold standard"....was the study double blinded?
Yep.
EVERYONE is not taking it. Most people don't even know what it is. Folks, don't get your medical advice off the internet.
Sadly it's prob more dangerous to listen to doctors on the many many many so called medications they try to shovel into each person..
Says who ? You . Where's the scientific data proof. Eyes mind heart and soul wide open. NO FEAR !
Don't take my word for it. There are plenty of studies that anyone can find and review themselves. I've linked to one in the description of this video.
Meanwhile, you’re missing out on the benefits of glynac ☺️.
Lots of medical information on Glycerine and N Acetal Cysteine. Says Harvard for example. They are amino acids found in meat.
@@darrenvail8726 tks. I don't eat meat , I supplement HEAVY with NAC, GLYCINE, NAD . etc .
wtf are you talking about
You sound just like that guy who puts on makeup and talks to children…I see him on Odins Men sometimes. You look like him too. Have you heard that before?
Not yet. That's a new one. Is that a good thing?
go troll somewhere else
@@jackbouchez9573 I wasn’t trolling, I seriously wondered if it was the same person🤷🏻♀️
Ya he has a Winnie the Pooh type voice for sure. Easy to listen to.
Works great
No one is taking glynac.
What? Tons of people take these. However, most just buy them separately because it's much less expensive than combined ones like DoNotAge.
@dlg5485 it's the first time I heard about it.
@@aeiou8287 Several research studies looking at these 2 compounds were released earlier this year and they showed tremendous benefits in lab rats and in humans, so there is a renewed interest in them right now, but they've been around for ages.
Regarding the extremely high dosage of 8 grams (8,000 mg) of N-Acetylcysteine (NAC) per day, as recommended by the TH-cam channel host, this is a concerning and potentially dangerous level that is not supported by peer-reviewed research.
According to the available scientific evidence:
1. Recommended Dosage of NAC:
- The typical recommended daily dosage range for NAC supplements is 600-1,800 mg, divided into 2-3 doses. (1)
- Dosages above 2,000 mg per day are generally not advised without medical supervision. (1)
2. Potential Risks of Excessive NAC:
- Very high doses of NAC, such as 4,000 mg or more per day, have been associated with adverse effects such as nausea, vomiting, diarrhea, and abdominal pain. (2)
- Excessively high doses of NAC can potentially lead to an imbalance in the body's oxidative state, potentially causing more harm than good. (3)
- The antioxidant properties of NAC can become pro-oxidant at extremely high doses, leading to increased oxidative stress and inflammation. (3)
3. Importance of Maintaining Oxidative Balance:
- Moderate levels of oxidative stress are essential for the body's natural defense mechanisms and cellular signaling processes. (4)
- However, excessive oxidative stress can damage cells, proteins, and DNA, leading to various health problems. (4)
- The "line" between beneficial and harmful effects of antioxidants like NAC is not absolute and can vary based on individual factors, dosage, and duration of use. (3)
In summary, the recommendation of 8 grams (8,000 mg) of NAC per day is significantly higher than the established guidelines and poses a serious risk of causing more harm than good due to the potential for disrupting the body's delicate oxidative balance. This dosage is not supported by peer-reviewed research and should be strongly discouraged. Consulting a healthcare professional is advisable before starting any high-dose supplement regimen.
References:
(1) Mokhtari, V., Afsharian, P., Shahhoseini, M., Kalantar, S. M., & Moini, A. (2017). A review on various uses of N-acetyl cysteine. Cell journal, 19(1), 11.
(2) Aldini, G., Altomare, A., Baron, G., Vistoli, G., Carini, M., Borsani, L., & Sergio, F. (2018). N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why. Free Radical Research, 52(7), 751-762.
(3) Bouayed, J., & Bohn, T. (2010). Exogenous antioxidants-Double-edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxidative medicine and cellular longevity, 3(4), 228-237.
(4) Sies, H. (2015). Oxidative stress: a concept in redox biology and medicine. Redox biology, 4, 180-183.
this was in response to a comment posted by somebody else, which you agreed with and said "awesome" when they said they were taking 8 g of NAC a day. You are either ignorant or reckless to condone such a thing, if you were a doctor you should have your license revoked for putting that in writing.