Another great video! Just a note, at 40.50 you mention that the slide should say "pro-coagulative, instead of anti-coagulative" but the slide is correct.. also at end of the paragraph it says that "warfarin necrosis" is treated with FFP... you can also administer Vitamin K to reverse the effects of Warfarin! or maybe give them LMWH?
Just a note to the Vit K comment... It will take a much longer time to reverse the effects because replacing Vit K will allow the enzyme, epoxide reductase, to begin to work. Intuitively, the physiologic effect is down stream and therefor delayed. You're correct in the statement about warfarin's pro-coagulative effect; to expand on this, it happens because warfarin blocks the action of protein C and protein S before reducing the levels of the clotting factors in the blood. I've heard both ways, depending on the source, of how to fix the issue. The first being to start Heparin or LMW heparin at the same time because it takes three days for the warfarin to "start working". The second being what Dr. Bolin said, start it three days after. I guess, depending on the clinical picture could warrant one over the other. Thanks for the videos, Dr. Bolin!
Are you PowerPoints available for the public? I love your videos but I would like to be able to follow along with your videos while making notes on the PowerPoint. Thank you so much.
Another great video! Just a note, at 40.50 you mention that the slide should say "pro-coagulative, instead of anti-coagulative" but the slide is correct.. also at end of the paragraph it says that "warfarin necrosis" is treated with FFP... you can also administer Vitamin K to reverse the effects of Warfarin! or maybe give them LMWH?
Just a note to the Vit K comment... It will take a much longer time to reverse the effects because replacing Vit K will allow the enzyme, epoxide reductase, to begin to work. Intuitively, the physiologic effect is down stream and therefor delayed.
You're correct in the statement about warfarin's pro-coagulative effect; to expand on this, it happens because warfarin blocks the action of protein C and protein S before reducing the levels of the clotting factors in the blood. I've heard both ways, depending on the source, of how to fix the issue. The first being to start Heparin or LMW heparin at the same time because it takes three days for the warfarin to "start working". The second being what Dr. Bolin said, start it three days after. I guess, depending on the clinical picture could warrant one over the other.
Thanks for the videos, Dr. Bolin!
Thank you for these videos. They are also a good review for SBB (Specialist in Blood Bank) students!! :)
Thank you Dr Bolin!
Thank you so much ❤❤❤❤
Are you PowerPoints available for the public? I love your videos but I would like to be able to follow along with your videos while making notes on the PowerPoint. Thank you so much.
you said we diagnosis hemophilia baesd on symptoms as ecchymosis but as you mentioned we dnt have ecchymosis in hemophilia
I know from history, the son Alex of last Russian Tsar Nicolay had Hemophilia due to mom.
thank you bro!
excellent
@14:25 you said you can get haemophilia from your father?
I think its the opposite
sar im. lokesh solur sar ples com adres