Geraldine Seydoux (Johns Hopkins / HHMI) 2: How to Polarize the Cytoplasm

แชร์
ฝัง
  • เผยแพร่เมื่อ 18 ธ.ค. 2024

ความคิดเห็น • 11

  • @numericalcode
    @numericalcode 2 ปีที่แล้ว +1

    Great illustration of the scientific method at work. Hypothesis generation from theory with empirical test. Well done!

  • @corneliusprentjie-maker6715
    @corneliusprentjie-maker6715 4 ปีที่แล้ว

    This video was a bit above my comprehension. And you talk about it so effortlessly, while dressed in style.
    It is a curious thing how matter dances... i thought and there at the end it is...
    Culture comes full circle.
    We dance the stories of importance we try to understand and we try to relate(tell) and just find joy and function in... the dance.
    Tack & Merci.
    To have found all this you guys remind me of the determination and work-ethic and determination of Barbara McClintock.
    Hope that is a compliment.

  • @hraqhraq
    @hraqhraq 3 ปีที่แล้ว +1

    Basically those membrane proteins (PAR) control the cytosol protein pool distribution through speed control by phosphorylations and de-phosphorylations which affect their aggregation and De-aggregation. Also Note that these proteins (PAR) do the job internally unlike the Surfaceome proteins which main function are detection from outside the cell and then cytosolic signaling.

  • @Thomas-vq5pb
    @Thomas-vq5pb 6 ปีที่แล้ว +2

    Bravo, super interesting

  • @rogerscottcathey
    @rogerscottcathey 4 ปีที่แล้ว

    The sperm tail in the human zygote is sequestered after the first cell division. It remains sequestered in that first daughter cell. I assumed it played a role in trophoblast differentiation.

  • @archanathakur9743
    @archanathakur9743 5 ปีที่แล้ว

    thanks alot professor .

  • @udanbug
    @udanbug 6 ปีที่แล้ว

    Let me start by saying that these two lectures were quite revealing and I learned a lot. However, what kept going through my mind is "where are all the electrostatic forces"? Biology isn't just chemical, but electrochemical in nature. I guess I'm just wondering if anyone has approached these problems from this angle? Perhaps this could answer a lot of the how and why questions of the process.
    Thank you for some awesome videos. :)

    • @corneliusprentjie-maker6715
      @corneliusprentjie-maker6715 4 ปีที่แล้ว

      Are you hinting than chemical and biochemical reactions are complicated dances of electomagnetic particle debris of various size and combination?
      as example:
      the complexity of a (what i call) a protïen string... that ends up being repeatedly. mechanically influenced by polarity changes in the environmet?
      *perhaps i've been watching too many videos hehe
      I think and wonder, do you propose a good angle :)
      *I thinknyou do.
      wish i knew more.
      The previous video was more easily understandable for a layperson. glad someone is figuring out the complexities wonder and mistery of things contextualizing it... Hypothesizing anew... and unraveling... questions... re-alighting appreciation of life.
      You guys deserve some wine!
      -and a safari!

    • @udanbug
      @udanbug 4 ปีที่แล้ว

      @@corneliusprentjie-maker6715 I had to go back and watch this again, and I'm not sure what I was thinking when I wrote this comment 2 years ago. She does explain the how and why for the 'movement' of the Mex-5. However, this leaves another question. Why does the Par-1 concentrate on one side of the zygote?
      Yeah, there's one like me in every crowd. :D

    • @Eldering
      @Eldering 7 หลายเดือนก่อน

      @@udanbug If you want to revisit it again then I think the answer to your question why Par1 is on one side is discussed in the other video, part 1.

  • @李凯-v3t
    @李凯-v3t 7 ปีที่แล้ว

    👍👍👍