Tiny Conspiracies - Bonnie Bassler (Princeton/HHMI)
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- เผยแพร่เมื่อ 2 มิ.ย. 2024
- www.ibiology.org/microbiology...
Did you know that bacteria can "speak" to each other and make decisions as a group? Dr. Bassler explains how bacteria use chemicals to communicate in a process called quorum sensing. By identifying these chemicals, scientists may be able to hamper, or improve, quorum sensing and generate new antibiotic or probiotic therapies. - วิทยาศาสตร์และเทคโนโลยี
Beautiful lighthearted delivery of complex information. You made it fun.
Professor Bassler- Bonnie - You are a gifted teacher. You are the model of what a teacher should be. You obviously enjoy your work, and you enjoy telling me about it in a way that I instantly grasp it and remember it. Vibrio fischeri - See? I remember even the name of the bacteria. How often do laymen come away from an impromptu visit to a biology lecture with the just-learned name of a bacteria imprinted in their minds?
I have long believed that we will eventually find all kinds of communication “circuits” in cells, bacteria, and even within the smaller parts of these. There must be feedback systems that aid in evolution itself, beyond the final test of sub-species survival. I think you may have revealed one of the most important systems. We have learned that octopi rewrite their RNA molecules and encode (apparently) something like genetic memory. Perhaps that has a role in evolution, too. But I encourage you to keep expanding your searches for more kinds of intra-cellular and inter-cellular (extra-cellular) forms of communication. I think science has been looking at process as random when in fact it’s very connected, very chatty, and very intelligent in ways we never dreamed of examining. This is incredible! Thank you so much for the video and your clear, concise way of communicating. There is something poetically just, here. Someone studying communication of any sort would be advised to understand communication on our macro-level, so that knowledge gets clearly and accurately conveyed to the recipient. You do Everyone else, take note!
Thank you. I like your clear lecture style. I didn't find myself stuck, trying to decipher sentence one, while you'd moved on to paragraph 20.
You know how to talk to laymen.
Check Out Gravity Light .
An excellent presentation. Better than anything on television! Dr. Bassler reminds me of a friend of mind who has a Phd in soil sciences: his enthusiasm is boundless and he makes dirt so very interesting. Question about inter-communication: do bacteria communicate with other bacteria to slow down or speed up their reproductive cycle? I can imagine scenarios where this could happen. But does it? Finally, we once again see that nature invented it first: networking, social media, and majority rule.
Awesome for the presentation and for giving credit to everyone at the end!
14 people voted down because they are sad that they don't have a vibrio fischeri bio-luminescence pouch and can be easily tracked by predators.
Votaron en contra porque son unos inútiles.
14 people were hunted down by predators because they cast a shadow, sad smh
I did not. I clicked up button.
when I was 12 we never had TH-cam how I wish I was 12 again... homework would be so easy
Thank you for such an interesting lecture, with such a clear and understandable presentation. Quorum sensing seems to have many potential medical applications, and may help us understand complex cellular interactions within large organisms. Absolutely fascinating.
Amazing to contemplate such a simple grouping of organic chemistry can lead to behaviors as complex as co operative tasking etc . . .life is a mind trip. Great presentation Dr Bassler.
Not only the most interesting subject, probably the most important.
Bonnie Bassler, you're the best, I love the way you do your lectures , wonderful, despit the fact that I'm so bad at english, I can clearly understand your lectures, I cant wait for your next one, it's become kind of endophine generator for me
Excellent lecture and very informative, I love Dr. Bassler's passion to the topic and bacteria. Please keep up the good work!
Ah! The world of scientists! They like to share their knowledge, their achievements, with interested laymen.
Of course we laymen too shall need raise to the occasion to have some basic background awareness of the involved topic.
Thanks m'am for this enlightening tour of the 'friendly' bacterias inside me & how they do what they do.
NO! WE ARE NOT DOOMED! Brilliantly presented brilliant communication of bacterias could prepare a brilliant post antibiotics future for us. Just listening you has giving a sense of brilliance of light to me. The only darkness moment my heart felt was when I heard the algorithms of me/us and others are so embedded in us even in our and all bacterias, now and since life existed! I sad to my self "Gosh we are doomed! No way there will be peace on earth!". Then my hopeful heart started beating again with the brilliance of your joyful endeavour of making science. And then seeing the gang of the lab, I sad humans will manage to be different and one day we will realize there is only us the earth's dwellers and only by thinking this way we can prevent our vulnerable home from heading towards the bleak end of loosing breath. Thanks for being you friends 😊
"Quorum sensing"
Democracy, Jim, but not as we know it.
Ones and zeros. Two words. Language.
Thank you. Great passion.
Fantastic explanation and delivery. Thank you!
this is a great presentation and the background illustrations make it easy to understand.
I love this lady. Intelligence is so attractive. Fantastic! Thanks
Fascinating ! And so we’ll communicated, thank you for your work
Such a great lecture. I hope millions of people see this. When Pasteur invented the method of cooking milk to prevent bacteria, he started the world on a road that classified bacteria as all bad, and this lecture i hope will start to turn that back around. We see more and more probiotic products sold, and i think over time people will realize that this quorum stuff is "the" important thing, because many bacteria are opportunistic, and sense which way things are going, and so keeping balance and not having them all pounce on us is very important for health. At some point the human body becomes a computer programming problem to study. I am sure that once you have 10 signals you are basically dealing with cellular algorithms. In a cell with only 2 types of sensors that is a pretty simple organism, but what happens when where are 10 inputs. That means 2^10 behaviors, which is 1024. It will be fascinating to see how many sensors they find. And i am still waiting for them to find the "chi" that the chinese talk about so much, the invisible energy that organisms possess, and can be projected from one person to another. That isn't chemical but some kind of radio, so there is another electromagnetic aspect of the cells that hasn't been discovered yet.
Wow, that's actually something new for me.
I like the way the scientist explain the whole idea and some outputs, so we know more than "how", but also "what is about". Thank you for the lesson.
Amazing. Very interesting. Very clear. Very original content. This is true for the whole channel
What a fantastic lecturer!
Wonderful speech! Thank you!
That was great. Thanks Bassler Labs
Thank you Prof Bonnie. I enjoy your way and the content of your presentation. I will tell our children and grand children to watch it to increase their knowledge and understanding.
She also has a Ted Talk on this, in which she goes a little more in-debth on the vibrio fischeri.
Amazing lecture
Cool! That was very interesting. Good luck to you, too.
Your presentation skills are exceptional! I would love to learn more from you.
Wow! This is really an amazin mechanism. It seems to be a precursor to the molecules used in orientation and differentiation messaging in animals.
Stunning idea to use it as a weapon against malignamlnt bacteria.
Shame i am in my fifries already. That would really be a great field to work in.
Keep up the good work. I love it!
A brilliant and interesting talk - thanks!
Very interesting and well explained.
Very interesting video. Thank you.
Amazing content, thanks for this!
How this may well produce a beneficial therapy is many of the bacteria in your gut are not "good" or "bad", but rather they behave beneficially in under favorable gut conditions and detrimentally under unfavorable gut conditions. And often, Bacteria will be doing both beneficial and detrimental things at the same time, just to different extents. Many existing therapies tend to nullify all or all of a group of bacteria during treatment. This is why after treating some gut / systemic infections, patient need a transplant of good gut bacteria. There is a saying in biology...You can never do just one thing. Biology tends to be very highly interconnected; do one little thing, and it will likely cause multiple other things. A therapy that results from this experimentation may be able to halt precisely the detrimental actions of a particular group of bacteria without interfering with the beneficial actions.
¡Grandee!
¡Me encanta lo que hace Ud.!
Thank you for sharing...
I love her. Good presentation
I love your passion for science, your support of your colleagues and your great sense of humor! Plus I learned quite a bit. This immediately makes me think of "My Octopus Teacher" and all the amazing shapes and colors of this amazing creature. It's clear the octopus isn't "thinking about" changing shape or color it's instantaneous. So, is it all one giant, tiny conspiracy of bacteria performing the endless dance?
Excellent ... well done ...
Just outstanding....I understood this...amazing.
Love it! Thank you.
10x more bacteria than me! That's a huge garden to take care of, really.
Wow you are great at teaching! I wish my mom was like you. In addition to being a great scientist, I think you'd be a great mom. Capable of teaching kids a ton!
This is amazing!!!!
Saw this on the Research Channel years ago as a lecture at HHMI. Edge had a question one year: What do you believe but can't prove. Mine was that every living thing on this planet is aware of itself and its surroundings. Haven't seen anything to disabuse me of that belief.
A very informative lecture thank you
This. Is. F-ing. AWESOME. Real science, fcking love it. Thnx for the video. More thnx for the content of video.
So incredibly important. Their language is simple and we can fake them out.
Quorum sensing helps explain how Tg can act like a group mind to control its host. Toxoplasma Gondii, the road rage parasite, cause of all shooters in my opinion and a whole lot more.
Thank you Bonnie Bassler.
Maybe this is what happens when women do science? We actually move forward.
@@garyha2650 That's a ridiculous opinion. Just because you've heard of one thing doesn't make it the explanation of every thing of another thing, it just means you've only heard about one thing. What about the homicide+suicide rates found in people with lyme disease? And what about people infected with plain old human nature? We move forward when anyone does science, we don't move forward when you think what you already know is enough to explain something way bigger than what zero minutes research is enough to explain.
@@annoloki Actually I've done over a year of research on Toxo. And you?
Galileo had ridiculous opinions according to some.
Tg also explains trolls (hyperjudgementalism, hair-trigger temper, loss of empathy that goes with Tg eating GABA) and is the only one of its kind with genes to produce dopamine, one mechanism for controlling its host via that expectation/reward pathway. Dr. Flegr is one source of human studies, shows Tg correlation with schizophrenia, suicide, even tattoos/piercings, promiscuity among females and a whole lot more. One would have to do more than zero minutes of reading to know ... -- stop -- ... ok, hey, take it easy, it's gonna be a great day, nice meeting you annoloki.
The vulgarity, adds nothing to your position and lacks reason or merit.
My watch later list is getting way to jam packed.
i love this so much thank you !!
great. what you found sounds very similar to the neuro-transmitter messaging system I researched decades ago.
curing disease, bacteria universal language, you are right, it might explain how our human cells evolve talk to eachother, human cells talking with bacteria, may be like frogs can be a good sign that the pond is healthy, some group of bacteria could be a good sign of our health, its beautiful, thank you Bonnie
This is one explanation for cancer and vindicates the theories from the early 1900s that stated that cancer is ultimately the condition of cells that should be communicating ceasing do so. As a result, they lose track of the fact they belong to a collective, and behave individualistically, growing a new colony and essentially a new organ. Luckily, if our immune systems are well fed and our inflammation reduced or eliminated so that signals can get through all layers of tissue, most of the time, our brain in coordination with our good cells prevent any wayward rebels from making it far, using the collection of phytochemicals they have collected from our diet, as well as the tricks they have learned from previous infections. If this system breaks down, we can develop allergies by attacking stuff that we shouldn't due to false associations in the immune system, and then inflammation, and then cancer.
That was considered a fringe theory for almost an entire century, but now science mainstream is shifting towards it recently.
9:00 How is this not trending at number one!🥰
Very impressive lecture! I am studying QS molecules too. Someday, I would like to talk with you.
Well, that was exciting.
This BLEW MY MIND! boom
Is there any winding twisting road that would have led from quorum-sensing to in-group preference in animals?
but is it really communicating with them or programming them? wonderful presentation.all the best.
Mysterious and magical. For sure
Thank you.
Godspeed, folks.
I was wondering if anyone knows how to grow bioluminiscent bateria or maybe even algae? I tried before but it failed, but i would like to try again so does anyone have any tips or ideas of what kind of fish to use best and where i kind find those fish. what sea are they from etc?
Floral wars, a germ signal corps. Great angle Bonnie real potential.
I'm so glad there are people smarter than me !
Question: From an evolutionary perspective, wouldn't it be more advantageous for a bacteria to develop the ability to "read" the environment for the universal communications molecule, but not create autoinducer 2 themselves? This way they could remain a silent "spy", able to read the environment for other bacteria, able to compare the ratio of autoinducer 2 to autoinducer 1, but without tipping off other species of their presence? Any bacteria that could mask their presence to other species would presumably have an advantage.
Such smart squids.
Very interesting analysis well presented. ... Fascinating idea that even bacteria are bilingual when most Americans can't even cope with the concept of California being bilingual.
can we genetically tag bacteria groups w bioluminiscence ?
Hey, they "don't" make bio lectures that "aren't" boring.
Excellent work and wonderful presentation, by the way I imagine that the bacteria specific chemical "WORD" for quorum sensing may be used to identify the presence of that specie in a culture ....
The maximum resolution of this video is only 480, and it’s really too bad.. we can barely see any clear things..
They will evolve, and that might lead to bugs that are more resistant to attack than our current superbugs.
Fantastic lecture, so well presented and with such enthusian. Well done, an admirable job. If I could make one comment, why speak of animals, plants and humans. Slightly redundan it seems,, since humans are nnimals, yes? Still, I guess given the unfortunate fact that in the US there is a sizabe number of people for whom biology and evolution are anathema, some caution is necessary.
Cellular DNA & RNA, cell types & structures are distinguishable. Human DNA is not the same as a plant or other animal. We have different cells, but our human DNA is common in all humans. But on closer examination our personal DNA is a further confirmation of both our humanity AND of our uniqueness.
At some scale, sense or context you are not wrong. Yeah.
****
But in microbiology, similarity and differences in pattern matching are real and v important.
Bonnie Bassler is a brilliant, beautiful, passionate, warm, funny, scientist, teacher, researcher, presenter, human being, woman, earthling, TH-camr etc..
All these words to describe her are true, different but in overlapping contexts, the categories or quality might be important or not.
WOW It all just happen on its own
What de you know about the VIRUS? Could be asociation betwen fungus- bacteria- virus.. for be in safe? I mean they make a team for help common? Its posible?
Japan is trying to discharge radioactively contaminated water into the sea, and I'm curious about this part.
Darwing knew what he was creating. Same goes for genius of geniuses The Shining Einsteing.
I was tested and was found was this horrible Helicobacter pylori (H. pylori) it made my taste bud go crazy and still after treatment thing don't taste the same
Very informative ... but why am I missing bacteria in my gut ... and have all sorts of digestions issues!!! I'm afraid to eat food ...
Steve Humphries I don't think you're being serious so don't eat. However if you are serious take probiotics
maybe English isn't her native language, but she misuses "shadow", she means "silhouette".
The squid uses counter-illumination, to hide it's silhouette when predators look up towards it's body, so the squid lights the bottom of itself to match the moonlight, and starlight behind it.
en.wikipedia.org/wiki/Counter-illumination
FTA:
"Marine animals of the mesopelagic (mid-water) zone tend to appear dark against the bright water surface when seen from below. They can camouflage themselves, often from predators but also from their prey, by producing light with bioluminescent photophores on their downward-facing surfaces, reducing the contrast of their silhouettes against the background. "
link.springer.com/article/10.1007/s00227-003-1285-3
FTA:
"Prior hypotheses have assumed that sepiolid squids in general utilize the bioluminescence produced by their V. fischeri symbionts for counterillumination, a behavior that helps squid camouflage themselves by matching down-welling moonlight via silhouette reduction."
I thought bacteria produce toxins as a bi-product of metabolism or eating not from communucating.
Number of bacteria cells in our body is about the same as number of our cells, not 10:1.
feedback mechanism
All babies have their own babies/ pets
This is going to be the ultimate human life hack. "give me the pill to activate the: "want to study, work out every day and be healthy" i need a boost"
The squid illuminates himself to became invisible? 🤔 🤔 🤔
Molecule chain = language. Mind lit up.
Handy template for use by all future generations:
•Scientists once believed______________;
•But we now know_____________________.
It will never not be applicable.
Which simply means, at all times retain a HEALTHY skepticism. It’s the flux in which scientific knowledge advances.
Reserve your FAITH for God (NOT religion); and your SKEPTICISM for science.
And thus avoid basic category mistakes.
Leaving aside the debunked "10 to 1" claim... that intra-species chemical is curious as they're way too similar to be coincidental... looks like it could be a driving force for speciation.... once a bacteria splits with a mutation on the gene producing the chemical, it becomes "cut off" from the rest of the group, causing it to begin a new group which will behave differently, and thus, react to future evolutionary pressures differently, driving a widening in the original genomes from the point of the original split with the mutation. Although I guess there would have to be some overlap if that were the case, where the receptor gene is duplicated allowing for a mutation on that gene first, so when the chemical producing gene is mutated, it already has a receptor for it... then gradually, it would lose the gene for the pre-mutation receptor... or something!
I was into this until the common knowledge fail at around 4 minutes. Bacterial to human cells are about 1:1, not 10:1. Of course the deep-dive study that revealed that "common knowledge" to be false is pretty recent, but still... Kinda hard to watch the rest and assume the information is legitimate :-/
🗽
Yo! I'm bugging!
Nitrous oxide induces a behavioral response (laughter) when it is detected by several brain regions.
I am guessing that production of nitrous oxide by some brain cells is associated with our becoming consciously aware of something that we were, up to that point, only subconsciously aware of.
Comedy is related to surprise.
The behavioral response associated with our sense of humor provides its own quorum-sensing function: When many people laugh, we have a different psychological response than if we hear one person laugh.
Fix civilization:
gaiabrain.blogspot.com/2015/12
@Sparkle Plenty Have you tried a whole lung-full? The low concentration you might get at the dentist doesn't induce laughter.
(Any idea why it's called 'laughing gas'?)
Hmmm, 4 billion years. That means, according to scientists, that based on our sun's shrinkage rate, that it would have been bigger than the orbit of the 1st 3 planets, yes, including Earth. Not sure how that adds up in their minds.
Italians subtitles?
4:36 A single giant boulder with a thousand little pebbles stuck to it is still considered "a boulder", not "a bunch of pebbles".
Bacteria can communicate with other through words Have group behaviors. Have One piece of DNA. They eat and split into two halves. A Human has 100 more bacterial cells in and around him then human cells. They protect you and do jobs for you that you can’t do. They are essential for you to live. You inherit them from your parents. They have a symbiotic relationship with other organisms. Humans squids.
They can also all make the same molecule and communicate with other species of bacteria.
Can stop communication to stop spreading of illness or expedite communication of good bacteria
Great subject, but I see some major mistakes. The theme, of the mistakes, is something like an interest in making progress, having understanding, causing us to underestimate complexity, like "aha! the earth is flat!". Start with this question and a reason for that question: 1) why are you so certain that a "cell" is a meaningful term, and what exactly is a cell that our body is not a "cell" and 2) (reason for question) look at your language when you say "the bacteria recieves and enzyme and "knows" to turn on and turn off genes ))))....... in other words, great work, yes bacteria communicate, but look deeper into the _scope_ of _what you do not know_ then you well see a bit better what a "bacteria" really is, which is much, much more than what you call a "cell"