Great Video! Sorry for the intrusion, I would appreciate your opinion. Have you heard about - Senarper Wordless Supremacy (probably on Google)? It is an awesome one of a kind product for stop aging and improve your life minus the hard work. Ive heard some unbelievable things about it and my work colleague finally got excellent results with it.
I really appreciate how you just give the facts, I love learning about the affects of drugs on the brain but so many videos are packed with bias. Like, even if I agree that you shouldn’t do heroine I still wanna know how it works😂
Couldn’t agree more. Just show me the science and leave all the rhetoric please. Same thing when trying to learn functions of government. No one just tells you the functions, they have to throw in their pseudophilosophy with it
Wow, I couldn't find a more precise and informative video about it. I searched "effect of nicotine in the brain" and found exactly that! Thank you very much
Thanks! The most difficult part about it is deciding what the most essential info to include is, and what can be left out. That's especially tough with a drug like nicotine. It not only has a long list of effects, but those effects can also change drastically with dose.
@@neurochallenged Yes; I have been studying GABA axis; My notion - which I have above 7-σ Covariance & Correlation - are not accepted practice; There is a wall sized chart just to schematically portray what is known
@@neurochallenged Ever thought of making a video on kratom? Many doctors say it's good for opioid withdrawal, but I'd really like to know the effects on the brain!
Does everyone in the beginning. That's the very reason we kept doing it in the beginning. Unfortunately that doesn't last forever and by the time you no longer get that effect you're hooked. I been trying to quit nicotine for over a year after smoking/vaping for almost 30 years. It's not easy to stop. And just for reference, I'm also an ex opiate junky. And as suck I can say with full confidence that quiting heroin and other opiates (clean now from that stuff almost 9 years) quiting those substances was far easier than quitting nicotine. An interesting fact about nicotine though is it's actually not that harmful. What's harmful is the way you ingest it. Cigarettes are definitely bad. Vaping is debatable because we don't really know how harmful it could be because it hasn't been around long enough, but I'm sure it's probably much safer than cigarettes. I keep bouncing back and forth between the two. Actually quit smoking for over a year with vaping and then for some dumb reason went back because I started hanging out with smokers again. Long story short, be careful messing with this stuff. It didn't destroy my life near as much as opiates, but it's definitely hard to stop once you been doing it for awhile, even if you really want to. I'm not gonna tell you what to do because we all have to make those decisions for ourselves. But I did want to put a warning out there from someone who knows and is still dealing with it.
@@craigdaubbeats-rapinstrume9185 I take full responsibility for my vaping. I’m aware of the risks and because of that I stay mindful with my use. People go through little disposables in 2 days where it takes me almost a month to go through it lol
500k+ views!! Concrats! I think the science and studies and common interest on nicotine have advanced greatly in the last 5 yrs from this vid so I'd LOVE to get a fresh, 2.0 version of this same vid! And I'm sure I'm not the only one. Keep up the good work! xDDD Personally I use the pouches as a tool to relax the mind/body. 1-4x per day but then when I feel it doesn't "work for me" I take a 1-3 day pause and my body resets without any withdrawal symptoms - as far as I can tell.. :P
I started nicotine (I don't smoke cigarettes) when I had a stressful week with my assistant manager. He was not qualified for the job and my boss chose to hire him after chatting with him at a bar. I started using it so much and made me feel better for a bit. I am still doing it and it has been one ride. Edit: I forgot the time frame it has been a year and a half since I started.
I read that nicotine, somewhat enhanced by the low level radioactivity of tobacco activates once dormant vestigial neurons. Which is part of why nicotine addiction is so difficult to overcome. While most drugs act as agonists on existing neurons and other less potent agonists can used to satiate cravings, the neural receptors acted on by nicotine only respond to nicotine since the body no longer processes the natural agonists that act on those neurons.
It's bizarre that our society strongly discourages relatively safe methods of nicotine usage, while treating TV/media consumption, fast food, soda, sexual hookups, etc as things that people are going to inevitably do. All those behaviors are more destructive than vaping or smokeless tobacco use. Meanwhile, nicotine boosts mental alertness, testosterone, and work drive. Our ancestors in the 1500s loved tobacco so much that it spread across the globe, and many geniuses who contributed to our modern world, like Isaac Newton or the US founding fathers, were regular users. Using tobacco can be an intelligent and deliberate choice.
Nicotine has been demonized. In its raw form, it is harmless at the right dosages. People like to associate nicotine with tobacco use that contains additives and carcinogens that WILL cause negative effects.
I'm glad there's actually a video that explains how nicotine actually works. When you try searching for something like this all you get is a bunch of anti-smoking propaganda stuff that's about how your brain gets addicted to nicotine and so on I'm not denying the science that it's addictive or not though
As someone who has used nicotine since they where 13 (and I was one of the first few in school who started that early, most didn't start until they where 17) this was rather informative and frankly I'd rather this be presented in school instead of what we got the whole time. I've made some bad choices and weed helped me get away from long-term nicotine use. That said nicotine is like caffeine for me
I wonder how long does the nicotinic acetylcholine receptors to down regulate back to their original levels, and become "normal", if that even is possible. If someone knows studies done on this topic let me know. Yes I'm also aware that it depends on many factors like how long the use has been, dosage etc. Just wondering because I quit using dip about a year ago after about 7 years of continious use, and have noticed still cravings sometimes.
It took me several years after deciding to quit smoking weed to actually not want it anymore. I started with one year of cold turkey. Not smoking any weed, only allowing regular cigarettes. I grew my own marihuana as an incentive to stay sober until I had my own harvest to smoke. I wasn't completely sober that year, I drank alcohol and had the occasional joint at parties, but other than that I was doing really well. Then, when the harvest was ready, I had an ounce that I smoked up pretty quickly. My "normal" usage before the cold turkey was daily, so I'd always smoke a joint before going to bed for about four years. With my harvest, I got back to the old habit, even though I didn't want to. I took it as a period to profoundly appreciate that feeling of being stoned and being grateful of having something to smoke that I cultivated myself. After that, I decided it was time to turn the page and stop smoking weed for good. That took about two years of going on and off, with which I mean I struggled significantly being sober. I tried to get my kicks from other things, like sex, adrenaline rushes. Looking back on it, I got into some borderline sociopathic behavior. My environment took it pretty well tho, because they knew I was trying to get rid of this addiction. I think I've been fine with being sober for about 15 months now (had my last ciggy in Summer 2021). I haven't smoked nor craved weed or cigarettes for about a year now and my mates got mad at me for not wanting to go to the coffeeshop last time we went to Amsterdam lol. I decided to go cold turkey in 2014, so that's almost 8 years for me to get rid of it. That's kinda crazy. Sorry for the amazement, but I never thought out how long this journey has been until I wrote this comment down lol
As someone that never smoked in my life, last year I tried nicotine pouched, and I liked the effect it gave me, I took more to get that high, now 11 months after I don't get the high at all, but I'm addicted, when I don't get it I get a crazy headache (like a concussion type migraine), one of there nicotine pouches is equivalent to 20 cigarettes in terms of nicotine, and I take around 10/14 a day, srsly don't start
It was around the same with me, try making time frames to when you can put your next one in, and get these time frames away from each other with time, this means you taking less pouches a day, I got off this way, might help man
man i smoke pipe, weed, cigars use pouches and snuff. Im not addicted to any of that and its not even difficult to stay clean for 2 or 4 years. But 10 pouches are you crazy i use like 5 a month. I am doing this for more then 15 years and recently i buy only my 4 box. 10-14 a day that is almost box a day. Also you can get addicted to almost anything, its not the substance but dosage. But congratulation you developed a nicotine addiction, you make your body super sensitive so if you abstinence for several years 1-2 pouches and you are back were you started
I used to smoke a pack of cigs a day while dipping a half can a day. Then I quit smoking and was dipping a can a day lol. I quit dipping for like a year and then I tried it again and felt absolutely no buzz.
Have you ever tried quitting coffee? It has the same effect. Once I quit for a few days to get on a certain purge, and I got this ringing headache and I didn’t understand. Second time I stopped drinking coffee in the evening, again the headache, now at that evening time. But it passes. It always does. Just get through the initial discomfort and it will fade.
The thing is, its so addictive because it works so well for whatever situation that prompted it. Depression? Trauma? Breakup? Impossible task? Self medicating ADHD? It will help you, and will continue to do so for a few days, making EVERY situation better, good, bad doesn't matter. But then one day it doesn't. It only works once. But once is all it takes. The horrible part is, since gene promotion/upregulation has brought about so many receptors, is that when an addict relapses, it is often stronger in effect. Best case scenario: Your receptors in your stomach go top-fuel drag and give you an experience akin to that scene from the exorcist. You are now disgusted by the mere thought of nicotine, for now at least. You have a 30% chance of you actually stopping in response to this. Worst: That narrow "theraputic" index is bullseyed, and it's bliss, even better than that first time, for about 30 mins. Finishing that assignment (You should really start it btw) is worse than whatever trauma started you on nicotine. You chase that same glorious buzz for the next 4 weeks until you repeat the cycle.
Trying to Quit traditional tobacco cigarettes and now I have purchased a Juul 2 Device to limit my use of conventional cigs. Wish me luck on my now lifelong nicotine addiction. 9th April 2022
Yes, typically. Nicotine is something of an anomaly. When it activates acetylcholine receptors, it also causes desensitization of the receptor (i.e. the receptor becomes less- or non-responsive). It's thought that this desensitization is associated with an increase in the number of nicotinic acetylcholine receptors, although the exact mechanism of this still isn't fully understood.
@@sylocin Yes, it's thought that receptors become desensitized during the day due to regular smoking, which promotes short-term tolerance. But they regain sensitivity overnight due to abstinence from nicotine.
In truth, cigarettes are designed to last for the length of time it takes for your receptors to desensitize. At that point, it takes roughly 45 minutes for them to resensitize, during which time the receptors are not responsive. As your body craves nicotine, it upregulates to compensate for the lack of nicotine, but this only causes you to need more and intensifies your withdrawal craving.
@@neurochallenged I thought having more receptors would mean the postsynaptic neuron becomes more sensitive? And conversely, receptor downregulation causes desensitization?
@@jamalrell7642 In Russia teenagers just buy Vapes out of the vending machines in city centre here in Moscow because you do not need ID Russian cops could care less if you use nicotine or alcohol as long as you’re a male but if you’re a female this can be looked down upon your better off getting caught with a little cocaine then any Ganja ( Weed 🇺🇸 )
I only smoke Ganja 💨🍃🇷🇺, I stay away from alcohol especially but I got arrested 7 times in 2020 alone for smoking Ganja, while the cops could care less when people smoke tobacco and take shots then go on to be abusing their wife and children when Ganja smokers like myself just enjoy to be left alone in our stoned world. It’s stupid dude.
Another great video my friend! Might I suggest making the video 30 seconds longer to account for the intro? That was it's' 2 minutes of *_information_* Thanks again for these videos
When I first started using nicotine years ago I could take 2 or 3 milligrams and I felt great, zero tolerance but didn't get sick at all. Now I can't even handle a milligram and I'll take like 0.25 milligrams and that will have a good effect on me but it's not like it was when I was able to take more.
Vaping my 3mg ragnarok, going for 1.5mg prettysoon, Cheers vapors around the globe, we get rid of TAR, dont forget to practice sports to burn nicotine.
My notes: Nicotinic Acetylcholine receptors - throughout the whole NS Nicotine - agonist, changes in the polarity of the receptor, increase in acetylcholine - enhanced cognition and attention, noradrenaline - stimulation and arousal PNS - increase in sympathetic NS activity, secretion of catecholamines - adrenaline from adrenal glands desensitize -> more receptors
Hello there. What exactly gets desensitized? Is it the receptors themselves, and in what way? Do they get thicker or something so the electricity becomes less intense? And how does this go in hand with there being more receptors?
dopamine from what i understand is what makes you motivated, ready to move, and energetic when you have sufficent levels of it. ive used amphetamine (prescribed for adhd, highly dopaminergic) of course caffeine, and nicotine and amphetamine has the strongest boost in motivation and energy but nicotine is less strong then caffeine for me, even though nicotine is supposed to have more addictive potential then caffeine. we all have different chemistry i guess, ive also quit nicotine suddenly before and it is not nearly as difficult as quitting caffeine
@@thehandliesthandle Actually, i kept on using nicotine and now everytime i hit a vape for the first time i get a nice refreshing feeling. Im psychologically addicted, not that big deal, i only vape when i go out with friends
@@dienosorpo i also have cravings for nicotine, but thats more or less all it is. i wont panic if i run out of nicotine, i feel like theres an arbitrary stigma attached to nicotine because its associated with the tobacco plant which is more addictive then plain nicotine
Currently I dip smoke cigarettes I use puff bars 😂 I quit smokeing but now I use puffs and dip but I been dipping since I was 5 years old and that's not even cap
what I need to know is: can you ever go back to normal if your acetylcholine receptors have become desensitized / more have been added? Will they reset themselves if the abuse of nicotine stops?
I have recently developed a slight left sided peripheral vision loss due to smoking nicotine vapes. Do you think this damage is permanent or will it restore over time?
i once have something similar. It was cause by extreme blood pressure pushing against optic nerve. But it was when i was deadlifting 385 pounds and this vision loss lasted only several minutes. Nicotine does increase blood pressure it will be good advice to visit doctor if its everything ok and you dont need medication for high blood pressure. If you are overweight have sedentary/inactive lifestyle and consume exes of caffeine. The other option is brain tumor. To answer directly its permanent damage if it dont go away in few hours. But it will heal and restore some of the vision but brain will fill out the gap if it is not too big. I would ask why you dont go to see doctor once you notice that but i think you are a american.
Heroin affects the brain similarly by creating more receptors to accommodate the flood of dopamine. Withdrawal is completely mental but can be felt in the entire body.
its the body response to all over stimulation. The body constantly trying to achieve chemical balance if body "loose" this ability well that is Parkinsons disease, epilepsy and seizures In short term you basically depleted the receptor chemicals for communication, in long term you burnt out/damage the receptor. That is also why body create more and the withdrawal symptoms are also part of neurons repair. Also clear answers are in mathematics (most of the time) in biology there is no clear or simple answer
A Harvard study has determined that nicotine is NOT addictive. Rather it is a separate chemical that the tobacco industry adds to their cigarettes that causes addiction.
i searched for a video that could dumb down what i read already, not repeat exactly what i’ve already read everywhere else 😪 why tf do they not teach us this important shit in school. it’s a set up i tell ya.
Good vid! Very factual. But I'm not smart enough to be able to use this info in a way that helps me decide if nicotine is harmful. My understanding (right or wrong) is that nicotine is comparable to caffeine as far as negative health effects. Anybody wanna comment?
If you are younger than 25, don't use! Even a brief exposure can alter your brain development. If you get addicted (use every day, once a week, dependent on it in some way), the damage has occured, resulting in impaired attention and ability to learn, memory problems too and lower impulse. Additional damage can occur as nixotine products increase blood pressure, which can impair blood circulation around the brain, causing brain damage on its own.
@@exposingreality6391 I would be very curious to see studies for this. Do you mind sharing the evidence for your claims? Furthermore, what do you mean with: "a brief exposure can alter your brain development?". A brief exposure to daylight in the morning, or briefly falling asleep, can also alter my brain development, no?
Body gladly make more stuff but there are very few mechanism that break down stuff. After time there will be some reduction but not by much. Also in any prolong use of any drug or substance you train your body so even after decades of abstinence and threshold decrease after few doses your tolerance is right back. Just like with alcohol tolerance even after years of abstinence few weekend and you again can drink the amount like nothing happened.
I don't understand, if there's more nicotinic receptors the more they smoke, then as they smoke, over time they will receive a larger dopamine rush per smoke right? But the opposite happens. In reality, they get tolerance and get less dopamine per smoke.
Hi can you please answer... could nicotine help with muscle memory? like using nicotine to improve nervous system and become a better guitar player for example? same with ritalin caffeine etc? plz thanks
very similar to the downregulation caused by psychiatric drugs. But it's kind of weird how psychiatric drugs can also desensitize the receptors but eventually caused down regulation, and why does nicotine cause up regulation? has this actually been proven by research?
like in long term or when high. I think long term no but not sure when high on nicotine. If it impair the function of amygdala and hippocampus then yes.
Its interesting to me how the withdrawal of nicotine can be compared to alcohol or benzodiazepine withdrawal because then the brain causes withdrawal due to the brain having to many GABA receptors.
If I start a cupcake and the secret ingredient is nicotine. Do I have to disclose that information. Even though nicotine is not considered a controlled substances. I will put on the warning ⚠️ lable that the cupcakes are very addicting
When first starting to use nicotine (never really) there is no positive effects. You just become dependent on the drug to function. This should be in the video!
This is waaaaaaaay too good of a video to have only 16k views
You like nicotine, don’t ya?
50k
@@telisahe5648 yeah do you not understand how time works?
Fax
Great Video! Sorry for the intrusion, I would appreciate your opinion. Have you heard about - Senarper Wordless Supremacy (probably on Google)? It is an awesome one of a kind product for stop aging and improve your life minus the hard work. Ive heard some unbelievable things about it and my work colleague finally got excellent results with it.
I really appreciate how you just give the facts, I love learning about the affects of drugs on the brain but so many videos are packed with bias. Like, even if I agree that you shouldn’t do heroine I still wanna know how it works😂
I hate when people give their whole life story 😂😂 just give us the info!!
we have the same brain
Couldn’t agree more. Just show me the science and leave all the rhetoric please. Same thing when trying to learn functions of government. No one just tells you the functions, they have to throw in their pseudophilosophy with it
@@AshadowsShadow its the most annoying shit
Heroin*
Wow, I couldn't find a more precise and informative video about it. I searched "effect of nicotine in the brain" and found exactly that! Thank you very much
I am always amazed that you can pack so much information in 2 minutes! Thank you!
Thanks! The most difficult part about it is deciding what the most essential info to include is, and what can be left out. That's especially tough with a drug like nicotine. It not only has a long list of effects, but those effects can also change drastically with dose.
@@neurochallenged luckily your effort is clearly visable! I can imagine it is really hard to pick the essentials.
@@neurochallenged
Yes; I have been studying GABA axis;
My notion - which I have above 7-σ Covariance & Correlation - are not accepted practice;
There is a wall sized chart just to schematically portray what is known
@@neurochallenged Ever thought of making a video on kratom? Many doctors say it's good for opioid withdrawal, but I'd really like to know the effects on the brain!
I played it on 2 times speed so 1 minute for me
Makes me feel spacey and dizzy 🥴
Does everyone in the beginning. That's the very reason we kept doing it in the beginning. Unfortunately that doesn't last forever and by the time you no longer get that effect you're hooked. I been trying to quit nicotine for over a year after smoking/vaping for almost 30 years. It's not easy to stop. And just for reference, I'm also an ex opiate junky. And as suck I can say with full confidence that quiting heroin and other opiates (clean now from that stuff almost 9 years) quiting those substances was far easier than quitting nicotine.
An interesting fact about nicotine though is it's actually not that harmful. What's harmful is the way you ingest it. Cigarettes are definitely bad. Vaping is debatable because we don't really know how harmful it could be because it hasn't been around long enough, but I'm sure it's probably much safer than cigarettes. I keep bouncing back and forth between the two. Actually quit smoking for over a year with vaping and then for some dumb reason went back because I started hanging out with smokers again.
Long story short, be careful messing with this stuff. It didn't destroy my life near as much as opiates, but it's definitely hard to stop once you been doing it for awhile, even if you really want to.
I'm not gonna tell you what to do because we all have to make those decisions for ourselves. But I did want to put a warning out there from someone who knows and is still dealing with it.
@@craigdaubbeats-rapinstrume9185 stay strong on your journey brother
@@craigdaubbeats-rapinstrume9185 I use nicotine pouches called ZYN but I only use like once a day
Same
@@craigdaubbeats-rapinstrume9185 I take full responsibility for my vaping. I’m aware of the risks and because of that I stay mindful with my use. People go through little disposables in 2 days where it takes me almost a month to go through it lol
Such a good video! Short and concise. Straight to the point well done!
Finally, a video with actual information about nicotine and not a scare video to put kids in line
yeah some of us are studying😭
Watching this while hitting my vape
same
Same💀💀💀
Sammeeeee
sameeeeeeeeeee
Same dude
First buzzes feel dizzy but after a bit I begin to feel lethargic
that is the CO poisoning after nicotine high
Beautifully explained! Crisp and clear!! 👏
You explain it so well. Do you know by what mechanism does nicotine suppress hunger?
I have never subscribed to a channel faster
literally the only video you can find that explains what nicotine actually does, as opposed to just 'smoking bad, don't do it'.
Insteresting, but 2 minutes is not enough. I need MORE!
500k+ views!! Concrats! I think the science and studies and common interest on nicotine have advanced greatly in the last 5 yrs from this vid so I'd LOVE to get a fresh, 2.0 version of this same vid! And I'm sure I'm not the only one. Keep up the good work! xDDD
Personally I use the pouches as a tool to relax the mind/body. 1-4x per day but then when I feel it doesn't "work for me" I take a 1-3 day pause and my body resets without any withdrawal symptoms - as far as I can tell.. :P
I started nicotine (I don't smoke cigarettes) when I had a stressful week with my assistant manager. He was not qualified for the job and my boss chose to hire him after chatting with him at a bar.
I started using it so much and made me feel better for a bit. I am still doing it and it has been one ride.
Edit: I forgot the time frame it has been a year and a half since I started.
are you planning to quit?
@@mientone Of course
@@moseshilow6162 Did you quit?
Did you quit
Did you quit?
Next do the effects on body function like low blood flow and low testosterone blood pressure etc. I think we need to hear it
Thank you for doing my chem final for me
I read that nicotine, somewhat enhanced by the low level radioactivity of tobacco activates once dormant vestigial neurons. Which is part of why nicotine addiction is so difficult to overcome. While most drugs act as agonists on existing neurons and other less potent agonists can used to satiate cravings, the neural receptors acted on by nicotine only respond to nicotine since the body no longer processes the natural agonists that act on those neurons.
I think the process and pain/discomfort/anxiety of withdrawal is the death throws of a dying receptor. It is programmed to survive by all means
It's bizarre that our society strongly discourages relatively safe methods of nicotine usage, while treating TV/media consumption, fast food, soda, sexual hookups, etc as things that people are going to inevitably do. All those behaviors are more destructive than vaping or smokeless tobacco use. Meanwhile, nicotine boosts mental alertness, testosterone, and work drive. Our ancestors in the 1500s loved tobacco so much that it spread across the globe, and many geniuses who contributed to our modern world, like Isaac Newton or the US founding fathers, were regular users. Using tobacco can be an intelligent and deliberate choice.
l0l...................................
Nicotine has been demonized. In its raw form, it is harmless at the right dosages. People like to associate nicotine with tobacco use that contains additives and carcinogens that WILL cause negative effects.
hey pal, you just blow in from stupid town?
post some videos
Raising your blood pressure is never good for you. Watch your cognition decline when you don't have your adult binky constantly at your side, m0ron.
Exactly the video I was looking for
I'm glad there's actually a video that explains how nicotine actually works. When you try searching for something like this all you get is a bunch of anti-smoking propaganda stuff that's about how your brain gets addicted to nicotine and so on I'm not denying the science that it's addictive or not though
2minutes brief lecturer in university about 20 minutes 😂😂😂
U are superhero (suparman😁❤️🔥)
Dad: Did you smoke a cigarette?
Me: No! I just self-administered nicotine!
Good one, Athene!
As someone who has used nicotine since they where 13 (and I was one of the first few in school who started that early, most didn't start until they where 17) this was rather informative and frankly I'd rather this be presented in school instead of what we got the whole time. I've made some bad choices and weed helped me get away from long-term nicotine use. That said nicotine is like caffeine for me
Weed is literally worse than nicotine.
@@Steve-sz4bh
@@Steve-sz4bh not quite
@@Steve-sz4bh you're very not smart 🤓
But what exactly do you feel? I don't understand why people use it
I wonder how long does the nicotinic acetylcholine receptors to down regulate back to their original levels, and become "normal", if that even is possible.
If someone knows studies done on this topic let me know. Yes I'm also aware that it depends on many factors like how long the use has been, dosage etc.
Just wondering because I quit using dip about a year ago after about 7 years of continious use, and have noticed still cravings sometimes.
cravings are different from dependence.
It took me several years after deciding to quit smoking weed to actually not want it anymore.
I started with one year of cold turkey. Not smoking any weed, only allowing regular cigarettes. I grew my own marihuana as an incentive to stay sober until I had my own harvest to smoke. I wasn't completely sober that year, I drank alcohol and had the occasional joint at parties, but other than that I was doing really well.
Then, when the harvest was ready, I had an ounce that I smoked up pretty quickly. My "normal" usage before the cold turkey was daily, so I'd always smoke a joint before going to bed for about four years. With my harvest, I got back to the old habit, even though I didn't want to. I took it as a period to profoundly appreciate that feeling of being stoned and being grateful of having something to smoke that I cultivated myself. After that, I decided it was time to turn the page and stop smoking weed for good.
That took about two years of going on and off, with which I mean I struggled significantly being sober. I tried to get my kicks from other things, like sex, adrenaline rushes. Looking back on it, I got into some borderline sociopathic behavior. My environment took it pretty well tho, because they knew I was trying to get rid of this addiction.
I think I've been fine with being sober for about 15 months now (had my last ciggy in Summer 2021). I haven't smoked nor craved weed or cigarettes for about a year now and my mates got mad at me for not wanting to go to the coffeeshop last time we went to Amsterdam lol.
I decided to go cold turkey in 2014, so that's almost 8 years for me to get rid of it. That's kinda crazy. Sorry for the amazement, but I never thought out how long this journey has been until I wrote this comment down lol
It takes 90 Days to return to baseline.
As someone that never smoked in my life, last year I tried nicotine pouched, and I liked the effect it gave me, I took more to get that high, now 11 months after I don't get the high at all, but I'm addicted, when I don't get it I get a crazy headache (like a concussion type migraine), one of there nicotine pouches is equivalent to 20 cigarettes in terms of nicotine, and I take around 10/14 a day, srsly don't start
It was around the same with me, try making time frames to when you can put your next one in, and get these time frames away from each other with time, this means you taking less pouches a day, I got off this way, might help man
man i smoke pipe, weed, cigars use pouches and snuff. Im not addicted to any of that and its not even difficult to stay clean for 2 or 4 years. But 10 pouches are you crazy i use like 5 a month. I am doing this for more then 15 years and recently i buy only my 4 box.
10-14 a day that is almost box a day. Also you can get addicted to almost anything, its not the substance but dosage. But congratulation you developed a nicotine addiction, you make your body super sensitive so if you abstinence for several years 1-2 pouches and you are back were you started
I used to smoke a pack of cigs a day while dipping a half can a day. Then I quit smoking and was dipping a can a day lol. I quit dipping for like a year and then I tried it again and felt absolutely no buzz.
Quit.
Can't get around what ya got to go through!
Have you ever tried quitting coffee? It has the same effect. Once I quit for a few days to get on a certain purge, and I got this ringing headache and I didn’t understand. Second time I stopped drinking coffee in the evening, again the headache, now at that evening time. But it passes. It always does. Just get through the initial discomfort and it will fade.
Correct explanation. Especially the last part
The thing is, its so addictive because it works so well for whatever situation that prompted it. Depression? Trauma? Breakup? Impossible task? Self medicating ADHD? It will help you, and will continue to do so for a few days, making EVERY situation better, good, bad doesn't matter. But then one day it doesn't.
It only works once.
But once is all it takes.
The horrible part is, since gene promotion/upregulation has brought about so many receptors, is that when an addict relapses, it is often stronger in effect.
Best case scenario: Your receptors in your stomach go top-fuel drag and give you an experience akin to that scene from the exorcist. You are now disgusted by the mere thought of nicotine, for now at least. You have a 30% chance of you actually stopping in response to this.
Worst: That narrow "theraputic" index is bullseyed, and it's bliss, even better than that first time, for about 30 mins. Finishing that assignment (You should really start it btw) is worse than whatever trauma started you on nicotine. You chase that same glorious buzz for the next 4 weeks until you repeat the cycle.
Can you please discuss glycine receptors? :)
Trying to Quit traditional tobacco cigarettes and now I have purchased a Juul 2 Device to limit my use of conventional cigs. Wish me luck on my now lifelong nicotine addiction. 9th April 2022
Watching this after a smoke is my new postnut clarity
Dont agonists cause a downregulation? Because if more Nicotinic Receptors are made, theres more receptors for Nicotine to bind to.
Yes, typically. Nicotine is something of an anomaly. When it activates acetylcholine receptors, it also causes desensitization of the receptor (i.e. the receptor becomes less- or non-responsive). It's thought that this desensitization is associated with an increase in the number of nicotinic acetylcholine receptors, although the exact mechanism of this still isn't fully understood.
Neuroscientifically Challenged The desensitization is why I get really buzzed only during the morning?
@@sylocin Yes, it's thought that receptors become desensitized during the day due to regular smoking, which promotes short-term tolerance. But they regain sensitivity overnight due to abstinence from nicotine.
In truth, cigarettes are designed to last for the length of time it takes for your receptors to desensitize. At that point, it takes roughly 45 minutes for them to resensitize, during which time the receptors are not responsive. As your body craves nicotine, it upregulates to compensate for the lack of nicotine, but this only causes you to need more and intensifies your withdrawal craving.
@@neurochallenged I thought having more receptors would mean the postsynaptic neuron becomes more sensitive? And conversely, receptor downregulation causes desensitization?
Do one on modafinil
Congratz you did it in 1 minute
Went outside to smoke one of many cigarettes for the day, figured I better learn why I love this stuff so much.
What if I use small quantity Tobacco only twice a week ?
High schoolers wya 🤣
Man those kids are some fiens for this 😂
Right here
@@wafflepancake1407 you're just gonna snitch on yourself to the FBI like that?
@@jamalrell7642 In Russia teenagers just buy Vapes out of the vending machines in city centre here in Moscow because you do not need ID Russian cops could care less if you use nicotine or alcohol as long as you’re a male but if you’re a female this can be looked down upon your better off getting caught with a little cocaine then any Ganja ( Weed 🇺🇸 )
I only smoke Ganja 💨🍃🇷🇺, I stay away from alcohol especially but I got arrested 7 times in 2020 alone for smoking Ganja, while the cops could care less when people smoke tobacco and take shots then go on to be abusing their wife and children when Ganja smokers like myself just enjoy to be left alone in our stoned world. It’s stupid dude.
Another great video my friend! Might I suggest making the video 30 seconds longer to account for the intro? That was it's' 2 minutes of *_information_*
Thanks again for these videos
When I first started using nicotine years ago I could take 2 or 3 milligrams and I felt great, zero tolerance but didn't get sick at all. Now I can't even handle a milligram and I'll take like 0.25 milligrams and that will have a good effect on me but it's not like it was when I was able to take more.
how can i stop taking?
Bro how tf did u not build tolerance
@@abumujahid1434 nigga did it backwards 💀💀💀
Nicotine saved me from long term Covid weakness and tiredness. I feel normal again. So far no cravings and unfortunately no decrease in appetite.
Useful information thank you...👑🔥👑😎💰👍💰👍🔔👑🙏
Vaping my 3mg ragnarok, going for 1.5mg prettysoon, Cheers vapors around the globe, we get rid of TAR, dont forget to practice sports to burn nicotine.
Skating after vaping
Notice that he says “might” in almost every explanation so these “might” differ from person to person.
My notes:
Nicotinic Acetylcholine receptors - throughout the whole NS
Nicotine - agonist, changes in the polarity of the receptor, increase in acetylcholine - enhanced cognition and attention, noradrenaline - stimulation and arousal
PNS - increase in sympathetic NS activity, secretion of catecholamines - adrenaline from adrenal glands
desensitize -> more receptors
Based.
Thanks for the precise and concise explanation!
great drug, highly suggest using it 👍
Thank you all i need to know
Shouldn’t receptors eventually be downregulated because of too much signals?
So why do we have nicotine receptors?
Hello there. What exactly gets desensitized? Is it the receptors themselves, and in what way? Do they get thicker or something so the electricity becomes less intense? And how does this go in hand with there being more receptors?
Much better than Huberman waffling and repeating himself for two hours
Watching this with a fat dip in😂
You are so cool.
Disgusting!! When your lip and tongue turns black from cancer, I'm sure you won't be laughing then.
I don’t feel any dopamine from nicotine... I just feel dizzy, food makes me feel way more dopamine
You don't? After popping a nice snus in my lip I feel the buzz as well as a nice spike of dopamine
@@JudeTheTH-camPoopersubscribe my man
dopamine from what i understand is what makes you motivated, ready to move, and energetic when you have sufficent levels of it. ive used amphetamine (prescribed for adhd, highly dopaminergic) of course caffeine, and nicotine and amphetamine has the strongest boost in motivation and energy but nicotine is less strong then caffeine for me, even though nicotine is supposed to have more addictive potential then caffeine. we all have different chemistry i guess, ive also quit nicotine suddenly before and it is not nearly as difficult as quitting caffeine
@@thehandliesthandle Actually, i kept on using nicotine and now everytime i hit a vape for the first time i get a nice refreshing feeling.
Im psychologically addicted, not that big deal, i only vape when i go out with friends
@@dienosorpo i also have cravings for nicotine, but thats more or less all it is. i wont panic if i run out of nicotine, i feel like theres an arbitrary stigma attached to nicotine because its associated with the tobacco plant which is more addictive then plain nicotine
I didn’t understand anything and i was vaping during the vid😵💫
POV: you are using some sort of nicotine product while watching this video
Currently I dip smoke cigarettes I use puff bars 😂 I quit smokeing but now I use puffs and dip but I been dipping since I was 5 years old and that's not even cap
i’m chewing nicotine gums lol
Nicotine pouch and snus is in my lip
Could you do a comparison between freebase nicotene and salt nicotene?
what I need to know is: can you ever go back to normal if your acetylcholine receptors have become desensitized / more have been added? Will they reset themselves if the abuse of nicotine stops?
Nope, permanent brain chemistry changes. Enjoy your new homeostasis
I have recently developed a slight left sided peripheral vision loss due to smoking nicotine vapes. Do you think this damage is permanent or will it restore over time?
has it restored?
i once have something similar. It was cause by extreme blood pressure pushing against optic nerve. But it was when i was deadlifting 385 pounds and this vision loss lasted only several minutes. Nicotine does increase blood pressure it will be good advice to visit doctor if its everything ok and you dont need medication for high blood pressure. If you are overweight have sedentary/inactive lifestyle and consume exes of caffeine.
The other option is brain tumor.
To answer directly its permanent damage if it dont go away in few hours. But it will heal and restore some of the vision but brain will fill out the gap if it is not too big. I would ask why you dont go to see doctor once you notice that but i think you are a american.
It has gotten better, and my brain has adapted. But not restored 100%
@@Aismartin so no brain tumor, that is good news. Did you stop vaping?
@@scasny I like how you added “I think you are American” insinuating he has easy cheap access to healthcare 😂
Heroin affects the brain similarly by creating more receptors to accommodate the flood of dopamine. Withdrawal is completely mental but can be felt in the entire body.
Does this apply to smokeless tobacco also?
Yes---same drug, different method of delivery.
Zyn for the win!
Good thing I quit smoking and vaping. I am done with most psychoactive substances until I turn 25.
Try psychedelics. They are truly good.
Stay clean
@@theGuilherme36 no, they’re not. Learn to live life that gives natural high & bliss.
are nicotine receptors everywhere? like nicotine gets into the blood then binds into the receptors? how does it go from smoke to the brain
No bullshit no propaganda to quit smoking pure science just facts thank you
why nicotine in low concetration stimulate the receptor and in high concetration block the receptor please i want clear answer
its the body response to all over stimulation. The body constantly trying to achieve chemical balance if body "loose" this ability well that is Parkinsons disease, epilepsy and seizures
In short term you basically depleted the receptor chemicals for communication, in long term you burnt out/damage the receptor. That is also why body create more and the withdrawal symptoms are also part of neurons repair.
Also clear answers are in mathematics (most of the time) in biology there is no clear or simple answer
Only drug that makes you smarter. Insane
What's a good source of nicotine intake
A Harvard study has determined that nicotine is NOT addictive. Rather it is a separate chemical that the tobacco industry adds to their cigarettes that causes addiction.
If thats true whats the chemical?
i searched for a video that could dumb down what i read already, not repeat exactly what i’ve already read everywhere else 😪
why tf do they not teach us this important shit in school. it’s a set up i tell ya.
Whatchu need help with?
Watching this while I'm vaping
Any trooth to Tucker's Nicatine frees your mind where as THC is basically the imperious curse from Harry Potter argument?
Thanks
My question is can zyn nicotine salt pouches cause brain damage?
No they're safe
Nicotine is just weak. It doesn't give you euphoria or even elation. It just makes you woozy and then nothing else.
Do one on benzos
th-cam.com/video/D5Vsm_Daexg/w-d-xo.html
I just took a nicotine gum i need help i feel pukish and all and weird how do i get rid of it
Drinks. sugary drinks like orange juice and lay down you’re nic sick my friend also use a vape nic gum is shit
@@P3rtzel thanks bruv i just puked haha and i was god to go but thanks for this much love!
Good vid! Very factual. But I'm not smart enough to be able to use this info in a way that helps me decide if nicotine is harmful. My understanding (right or wrong) is that nicotine is comparable to caffeine as far as negative health effects. Anybody wanna comment?
If you are younger than 25, don't use! Even a brief exposure can alter your brain development. If you get addicted (use every day, once a week, dependent on it in some way), the damage has occured, resulting in impaired attention and ability to learn, memory problems too and lower impulse. Additional damage can occur as nixotine products increase blood pressure, which can impair blood circulation around the brain, causing brain damage on its own.
@@exposingreality6391 I would be very curious to see studies for this. Do you mind sharing the evidence for your claims? Furthermore, what do you mean with: "a brief exposure can alter your brain development?". A brief exposure to daylight in the morning, or briefly falling asleep, can also alter my brain development, no?
Say hypothetically you stop consuming nicotine, would the additional acetylcholine receptors your body created be removed?
Body gladly make more stuff but there are very few mechanism that break down stuff. After time there will be some reduction but not by much. Also in any prolong use of any drug or substance you train your body so even after decades of abstinence and threshold decrease after few doses your tolerance is right back.
Just like with alcohol tolerance even after years of abstinence few weekend and you again can drink the amount like nothing happened.
So this goes against what Dr. Ardis is saying and that nicotine can help people with long covid. More studies are definitely needed
Still didn't understand does the brain release nicotine ?
i'm no scientist, but the ending makes me hypothesize that tapering off might be easier. i prefer cold turkey though. get it over with.
got a zyn in the upper deckie feeling quite alert
I don't understand, if there's more nicotinic receptors the more they smoke, then as they smoke, over time they will receive a larger dopamine rush per smoke right? But the opposite happens. In reality, they get tolerance and get less dopamine per smoke.
I smoked a cigarette while watching this. 🚬
watching this while buzzed
Watching this to help me quit vaping>
I feel like it gives me low blood pressure, I get super relaxed, no buzz tho because I don’t use it pften
What. It _upregulates_ acetycholine? I didn't expect such a 'harmful' chemical to do that.
Hi can you please answer... could nicotine help with muscle memory? like using nicotine to improve nervous system and become a better guitar player for example? same with ritalin caffeine etc? plz thanks
Good medicine!
Big brain
very similar to the downregulation caused by psychiatric drugs. But it's kind of weird how psychiatric drugs can also desensitize the receptors but eventually caused down regulation, and why does nicotine cause up regulation? has this actually been proven by research?
Does nicotine affect learning?
like in long term or when high. I think long term no but not sure when high on nicotine. If it impair the function of amygdala and hippocampus then yes.
I know some people with adhd who use nicotine patches to be able to concentrate better
Its interesting to me how the withdrawal of nicotine can be compared to alcohol or benzodiazepine withdrawal because then the brain causes withdrawal due to the brain having to many GABA receptors.
Can the brain undo those extra receptors or am I fucked for life, not being able to think or do anything when off nicotine?
If I start a cupcake and the secret ingredient is nicotine. Do I have to disclose that information. Even though nicotine is not considered a controlled substances. I will put on the warning ⚠️ lable that the cupcakes are very addicting
Nicotine is fun but it's an expensive addiction and kinda pointless after a few months.. Also FUCK CIGGIES
When first starting to use nicotine (never really) there is no positive effects. You just become dependent on the drug to function.
This should be in the video!
That's quite a broad, vague statement to make. Why do you think so many people use nicotine?
@@InLightVFX Because they get hooked? Social stress?
Scofield you missed the part where he mentions that this drug may increase dopamine levels
@@32starsandsugar Does it really tho? Have studies been done on newbies? Idk
@@VeganYeshua Google Scholar will help