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- เผยแพร่เมื่อ 26 ก.ย. 2023
- You've probably heard of CRISPR, the revolutionary technology that allows us to edit the DNA in living organisms. Biochemist and 2023 Audacious Project grantee Jennifer Doudna earned the Nobel Prize for her groundbreaking work in this field -- and now she's here to tell us about its next world-changing advancement. She explains how her team at the Innovative Genomics Institute is pioneering a brand new field of science -- precision microbiome editing -- that uses CRISPR in an effort to solve seemingly insurmountable problems like asthma, Alzheimer's and climate change.
This ambitious idea is part of the Audacious Project, TED's initiative to inspire and fund global change.
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• CRISPR's Next Advance ...
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#TED #TEDTalks #crispr #geneediting - วิทยาศาสตร์และเทคโนโลยี
This is so wonderful sounding, and yet at least a million things can go wrong in the hands of those who are not so interested in helping humanity.
So true…
The world need this but changing the cow's gut...you will need change the cow's DNA. Here in Brazil to help the 0 emissions of meat production the amazon forest needs help to reduce in half the cow's gut emissions .
Absolutely, it's natural to approach new technologies, especially something as transformative as CRISPR, with caution. We've seen in history that advancements can be used for both positive and negative outcomes.
However, progress in the field of science and technology is inevitable. As a society, our goal should be to foster open dialogue, robust ethical frameworks, and transparent regulations that ensure the responsible use of these technologies.
Fearing potential misuse can inhibit beneficial innovations, but being vigilant and proactive in our approach can maximize the benefits while minimizing risks. As with any tool, it's not about the tool itself but how we choose to use it.
She talked about the complexity of the microbiome being the problem, yet without first solving that, she’s going to carpet bomb them with a mutagenesis weapon known for mistargeting issues and call it precision microbiome editing. See how easily she dismissed the other approach: probiotics, prebiotics, fecal transplant? Calling this questionable is an understatement.
its already not in the hands of favor humanity
I’m a college student and I had the Opportunity to Met Her a week ago at a seminar she gave in San Diego. She was so genuine, and stupendously kind and sweet with everyone, specially with all the young students that wanted to take pictures with her.
Same, but in Seattle.
what is she a celebrity to you? get a life.
@@illygahPeople with a life admire and learn from others who have made great discoveries grounded in data and facts that will help humanity. Meanwhile, people like you want mylar balloons captured on drone footage to be proof of alien spacecraft. It’s perplexing that you reject others for admiring someone like Doudna.
Thats how they got you , wait for chimeras now
She is naive to how horrifically wrong things can/will go when this is in the wrong hands…
I wish she and her scientists peers got far more attention than pro athletes and entertainers and models.
Or loud mouth politicians, social media influencers, and zany business leaders :/
Humans crave entertainment so it will always be a high value job at the top level.
Not suggesting every job in entertainment is high value, but certainly for those that are valued within the space, the Hollywood celebs, top footballers etc. And this won't change.
Advertisers can't throw a bunch of money at scientists because it'd be an awful return on investment, and that's just how the cookie crumbles in capitalism I guess.
Sorry for Your loss.
Cmon now first of all scientists dont do it for fame, they have a passion for what they do. We all crave entertainment, so it’s impossible to not have, at the very least, sports. Imagine a world where everyone just hopped onto their computers to watch the latest scientific innovations, such a world wouldn’t work. Every industry is extremely crucial to this world except P*rn
To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.
She won the Nobel prize along with her female colleague! My hometown gal!
why are you bringing up gender into this? that only perpetuate the idea of man vs woman, etc...
But the fact you are pointing at it, perpetuates the idea of the idea of man vs woman etc...@@Danuxsy
@@itskittymedoes acknowledging reality contribute to its consequences?
How can you acknowledge reality if what you think is reality doesn't seem to exist in that way?@@LukeFG
@@Danuxsy Stop being cringe....
If only the good people who invented these technologies controlled how they were used.
Which has never been the case
Well said. I was just thinking something similar but couldn’t think of a concise statement.
that's why it's important we all vote, no matter where in world. solutions exist, many brilliant people invent technologies that can solve all our problems and many of them are already in existence. we just need to put people who will listen to the scientits in positions of power. In every country there is more us (citizens) then them (small amount of individuals who control). the power is all yours.
As citizens we always forget sciences are the foundation of our entire existence, scientists who want to do better cannot be overridden by governments, this is a lesson we still learn and will keep learning and improving on to better humanity forward.
We also forget as citizens we outnumber governments and bad actors in all forms 1000000:1 and have the power to arrest all forms of state organs via citizen arrest if they don't act in favour of our species or our fellow kin, the rights and power to boycott, overthrow and rehabilitate everyone to be better although there still needs to be a balance and not everyone acts in the betterment of our species sadly...
We cannot live in a complete dystopia, nor a complete utopia otherwise we would go extinct very quickly, along with Nature, our Earth and all other species of life... We can always look at the bad and negative side to things easily, but it's just as difficult but even easier to seek out the good things and positive change too. :)
It's not an invention, it's a discovery. Once you make a discovery, anyone can make it work.
The obvious incentive to profit rather than actually solve problems are made very clear with this presentation. Rather than looking at environment and other external conditions that cause disease/disorders (asthma) they are instead selling a product designed to change the organism at the very core. The tech is nonetheless impressive and has insane implications for the future if used correctly but we are not close to societal maturity to have such tech at our disposal.
Profiting and not solving problems are not mutually exclusive. In fact, it's unrealistic to think you can make large leaps in advancements without the need for major funding for R&D. I wish we could get over the "money equals bad" view because it's inevitable. Your idea of social maturity sounds like a naive utopia
I wouldn't blame the researchers, these people are geniuses that basically live in labs, but they're more or less forced to commercialize technologies or else most, if not all of their funding disappears. I wish we could live in a time where billionaires and governments and everyone else invested heavily in the natural sciences without an expectation of financial returns.
and we have many movies and series about that, aye
anyone still watching - `the boys`
@@Gruso57 yeah but he's not wrong. This tech is being pushed like it will be used to make the world better. In reality it's not curing the cause of disease, it's just a way more expensive, unnatural, and infinitely more complex bandaid.. Like pushing a vaccine for a flu-like disease instead of exercise and general health.
gainoffunction
Dr. Doudna is one of my heroes. Her work has the potential to do lots of good in the world if politicians don't let corporations screw it up.
What would corporate do to screw it up? They're just going to use it to help us edit the genes we want to keep or removed. I think the people will start requesting weird gene editing and because the corporations want money, they'll just do what the people say. I don't see how they will be the one to ruin it. It seems more like the people will be the one to ruin it.
Like the infamous quote, 'where is the money in people getting rid of disease'?
@@TheBann90tons of money in it. If someone patented a cure for cancer they would become a billionaire almost over night and would go down in history books as one of the most notable people in mankind.
To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.
Let’s hope politicians themselves don’t screw it up either. I’m surprised Crispr has been allowed to survive this long, not getting squelched by big pharma. My understanding is that big pharma kills off “cures” so they can continue making $$ to treat symptoms.
Whenever I hear, "Now we can do A without doing/getting/needing B...", I know that at some point in the future we'll be saying "... but we didn't know that we were going to cause C through Z".
Unfortunately you can't learn without doing it. As long as we're not omniscient we'll learn by iteration
Yes. That’s science. The same science that created cures and treatments for cancers and the phone you’re using. Everything comes at a cost.
@@SamSard like the researchers who decided to play with batshit and caused a pandemic…
Exactly. When we create new genetic code as of we were God, who knows what wiki happen? May I present the Covid “vaccine “ as Exhibit A.
Yep in the 90s they called most of the genome 'junk' dna... not now...
This amazing woman should be a household name like Steve Jobs and Elon Musk. Even her name ends in DNA. Jennifer was born to do this.
Steve Jobs should not be a household name.
nor should elon musk, literally two of the greatest hustlers of our time
nice finding, DNA...cool!
@@higgsboson9380 @kalla103 Too bad, they already are. Humanity is better for the companies and leadership of Steve Jobs and Elon Musk.
"Steve Jobs"… 😅 "Elon Musk"… 🤣
Sorry, but no.
Biggest take away here is metagenomics. If we can better understand the links between our health and and micro biome we could change our diets and environments to address these issues in the first place. Then small number of cases where that doesn’t work or time is too pressing due to life threatening illness we can use a tool like CRIsPR
I agree. Reducing cow farts is just a series of stepping-stones to what CRISPR can do in the future, like editing our own microbiomes. Metagenomics is key in understanding that, and doing so without wreaking havoc.
To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.
Going to guess the makers of Inhalers do not want this Asthma treamtment getting out. GSK Wouldn't like that.
The best comment on here
“CRISPR” IS EVOLUTIONARY!!!! Jennifer Doudna & Emmanuelle Charpentier gave it to us. Both internationally recognized in only 10 years! WOW . . . Thank you both!
Any hope for psychological disorders and depression
@@Ashish-nd3xjwith this, yes but it would take so much longer because these disorders are super complex since it pertains to the mind
4:52 “and show that they are safe and effective” Hear the voice change there.
Raise your hand if you can see a future bioweapon in this particular application of the crispr technology. 🖐️
I’m a bioinformatician, and I’m rooting for crispr all day. I hope really big brains are evaluating and creating solutions against what seem like inevitable use cases.
It was already used, what do you think the past few years was about. People are just walking over the cliff willingly.
@@krystalgardiner5591covid?
I’m eternally grateful to scientists like you that makes our world a better place
Wait until this science has it’s Oppenheimer moment…
To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.
Hope you like eating bugs.
How anyone of intelligence could possibly think something horrific isn't going to be created by accident or design is beyond my comprehension.
To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.
What is incredible time in mankind’s history we are privileged to live in.
Unfortunately the climate change brings changes no one ever has seen before. Mankind advances technology, but apparently can't give up its comfort or the power one thinks to own.
@@limonadovi Climate change has been happening for billions of years. Greenhouse gasses are what's creating all the problems for us now.
@@limonadovi I do hope climate change will just become a "Malthusian trap" and technology will just solve things you can stop the march of progress
🤢
Never before have so many promised so much to so few who still believe them.
Amazing scientist. I sent this to my kids to learn from her. So proud to know of her work.
she said it came to her in a dream. It's the dream who really deserves credit.
@@illygahit was her dream, not someone else, especially not yours.
@@ismailnyeyusof3520 some of my dreams are batshit crazy!
Just some.@@Magic-mushrooms113
I believe that Precision Microbiome editing is great but the example she gave with the reduced methane production in animals is promoting factory farming. In turn it will promote animal cruelty, deforestation, monocultures, soil degradation and a lot more.
The other examples sounded great to me and i hope that it will be focused on problems like these so that it will not only help to build a more resilient future for us as humans, but for the whole planet, with all of its inhabitants.
I remember driving down Hwy 5 in California, past the gigantic, famous feed lot. The stink went on for what seemed like miles.
I need 🍖.
I had a similar thought 🙂
Same. She’s focusing on those problems because they get more funding !!!
I have a relative who has always had a problem with their gut, specifically it’s a bacterial imbalance that causes him a lot of pain when he eats the wrong foods. I wonder if this is something that could be used to help him on the next couple years. There’s currently no cure for him, only staying away from 99% of foods keeps him from pain
Look Ivermectin and Bendezalo parisigt end dewormer . Herd red it might cure a lot of probloms .
Jennifer Doudna will be remembered for 1000s of years. Her work on crispr will change how we treat diseases also cure diseases and extend human life. This is still decades away,
but CRISPR is a game changer for humanity if used for good.
To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.
SHE WILL BE REMEMBERED AS A CONFUSED GEEK WHO PUSHED COMPLEX NONSENSE WHICH MADE NO SENSE
@robivan9263 How long have you been a bot?
Walter Isaacson's book on her is awesome, highly recommend.
Her book "The Code Breaker" is fantastic! Thank you for your work ❤️
It’s not her book
It’s about her.
it's not a good title. People don't like when things get broken. She shouldn't break things. She's a doctor, she should have called it "the code healer" or "the code doctor" or "the code decoder". The way she's titled the thing is suspicious and revealing. I don't think she respects nature or believes in the almighty.
@@illygah She's not a doctor.
@@illygahIntelligent ppl don't believe in deities.
An incredible scientist and human!
"Look at all these systemic problems we've created for ourselves. We've designed a new system for solving them all. Nothing could possibly go wrong."
Ticket prices for TED Vancouver were absurdly high. One would though they have a noble mission of sharing the knowledge, not just another elite club for super rich.
It all comes back to the money doesn’t it… we are all screwed
Is it gatekeeping or simple economics ie supply and demand? Was it sold out? What type of venue was it in? How many speakers? All these should be taken into account in my opinion
Thank you Jennifer from the heart ❤
Jen the dude doudna has the title of most impactful scientist this century.
It'll be amazing to see what comes from her tech.
I hope this doesn't go horribly, horribly wrong.
I hope everything doesn't go horribly horribly wrong
Well the odds of this technology being used as a weapon in one form or another is about 100%
It will dont worry
Any advancement in science and technology will always be misused unless we fix the animal within us first.
ahhh!! there we go.. found the aLaRmist!!
This sort of discovery gives me hope.
Thanks for sharing… I’ve given up and moved on to despairing for the planet and the human race. But by all means let’s go to Mars instead of building houses with solar panels and water collectors and give the homeless some human dignity… keep hoping for me though I appreciate it!
Thank you for your efforts
The main problem with scientists is who they work for. They discover wonders and turn those wonders over to the most ruthlessly self interested people on the planet. And none of them seem to notice the glaring moral fault.
Tbh. It happened before that. Research is incredibly expensive and the soul was sold long before the fully actualised discovery came to light. Psychopaths/sociopaths always rise to the positions of power
@@AQBPlays "Psychopaths/sociopaths always rise to the positions of power". Of course, this is part of the authoritarian method that civilization uses to create power.
@@AQBPlays They sure do within civilization. Other cultures have very little tolerance for them.
Im glad to hear good news about CRISPR research
They said the same thing with the “fusion energy” news a few months ago too.
Some are concerned with things going wrong but forget science has helped us in many ways. It helped create atomic energy that powers our homes. But it also ‘helped’ destroy two cities in WW2. It’s not about “what could go wrong?” But “what wrong doing will emerge from this?”
Can we have crispr get to work on male pattern baldness? I had a great head of hair in my 20’s! Looking forward to a midlife crisis muscle car and renewed head of hair. So if you guys could get right on that it would be great thanks!
Try finasteride and minox this stuff is far to cure mpb they will cure serious illnesses first
I don't believe we can solve the problems we have today with the same thinking that created them . Despite everything, an impressive step forward
No thinking created genetic disease.
haha
haha ur so wrong
There’s already a way to perfect one’s microbiome and it’s eating natural, whole foods. Works for all animals, and makes the ones which we consume much healthier for us too.
CRISPR editing at this scale will have disastrous results long term.
Living genius Jennifer Doudna and her colleagues
A fan of development, progress, understanding... but this one also came with an aftertaste of dystopian horror. When i heard those words, "...safe and effective..." i got chills.
It's because you've let fear mongering get to you
i hope you know that we are using crispr to work towards a cure of cancer. not saying this technology doesn't have ethical concerns. minimizing suffering for the humankind is always our priority, but whether that technology gets compromised by malicious people or used to contribute to a "dystopian society", is a question you should ask those in power rather than those who are merely doing research for the greater good.
@@sophialong640 whether or not its for the greater good we will see in the end. And if you're considering yourself to not be apart of those who are in power while in the forefront of this technology then I don't know what power is. Concerns would probably be better served welcomed rather than immediately shedding the weight and responsiblity to those in power.
@@Danfloww not sure if you've noticed, but our societies are not controlled by scientists but rather politicians and the rich. an example for elementary school kids: if scientists have been in power, then they won't be ignored for decades in the issue of climate change. by the way, the "concerns" that I'm talking about regard to "the misuse of technology" and the resulting dystopian future. i suggest you re-read my comment. do you think it's the scientists' intentions for tech to create a worse future for humanity? if not, then i suggest you to rewatch oppenheimer and see how the game of politics is played, and how this game does NOT give scientists say over their own tech once the military or whatever government body takes over this tech. yes concerns should be raised but it's no use if raised to those without power.
Gene editing entire biomes, what could possibly go wrong? What a terrible mess we are in.
These folks are trying to reduce suffering and improve the quality of life for people. It sounds like a worthwhile cause to me. This is certainly more effective than hoping for the best.
@@jerrybrown6169Well said, but the most important part is implementation and distribution of technology. That's just pure politics and would suggest technology will always be used for the worse, before maybe put to work for the best. So, a pretty sane response is to ask what can go wrong and then hamper those particular outcomes while facilitating better outcomes of using the technology. It's not like people did not ruin the world in the name of good before.
As an alternative to hoping for the best, as well as advanced gene editing of ecological systems, there is also just sustainable stewardship. You can revitalize desserts by making swales and planting trees, and stopping herding or at least swap to mega-herds cycles. Etcetera. There really would be no need to move with such zealous, under-precautionary speeds in science and technology if politics would implement existing knowledge properly.
Transplanting wild plants into "farms" what could go wrong?
.
Loading people into metal tubes and launching them into the sky, what could go wrong?
.
Injecting viruses into people to "prevent disease", what could go wrong?
.
Mining nitrogen and smearing it over plants rather than relying on nature, what could go wrong?
@MrMichiel1983 nothing political about my statement. Meddling with nature has unforseen, unpredictable outcomes. Politics just determine which group of people get f'd over, and which group of people get rich once the chips fall where they may.
Totally agree. We are playing God here. Man has managed to f*&k up Mother Nature in the name of progress before. Playing with genes and then releasing them into the environment could have devastating consequences.
Speaking of microbiomes. I remember having a bad ear infection because my dog (unbeknownst to me) was sleeping on my pillow while I was at work. Antibiotic didn't work, nor did drops. Then I saw a great gob of ear wax in my toddler's ear and I reasoned that it must be full of bacteria. So, knowing about microbiomes and fueled by a healthy dose of desperation, I got a Q-tip and put his earwax in my infected ear canal. Cured me within days.
The end looks like the begin of "I Am Legend" or other movies about zombie apocalypse
When Jennifer Doudna "Do-U-DNA" speaks, the world listens!
A genuine genius.
im sure crispr has great potential. but when someone talks about using gene technology to 'change the world' i get chills up my spine
because it's criminal in it's very suggestive nature. Are they going to ask the world for their feelings about it? Their permission to do so? Will they cease moving forward if the whole world speaks out against such a global move that is sure to have many unintended consequences? No, likely not. And, history repeats itself once again. A tiny group of people get funding and power and use it to do things THEY want to do. THEY think is good. They do not consider or respect that ALL of us live on this planet together and have a voice on these issues, because we may not have the same outlook that they do.
Incredible technology, but hopefully we can put in place code of ethics for this powerful technology. And with its advancement, the inherent wisdom to use this tool wisely across the globe.
The code of ethics will be warped by the desire for profit.
No thank, your "wise" is not necessarily what others would call wise. Just look at splitting the atom, not wise at all, and any benefit it promised never happened, all the dark and evil that could come of it has. I do not need you to tell me what I can do with my body. And no matter anyway because there will be no benefits from CRISPR till they can figure out how to keep it only available to the very wealthy anyway. In 2021 I had a problem that took me to the ER, they did a CT scan and ultrasound. Bloodwork. $16800. In 2022 the same problem happened and had to go to the ER again, $40 thousand. Same everything except cost. The VA paid but the point is if you cannot afford to break an arm or get a blood clot how the F*&^ are you going to afford this technology?
But there stock?
Not a chance. CRISPR technology can be mastered by a college student
Sounds like something you shouldn’t mess with. We are just fine the way we are now.
Great to see more good uses for CRISPR!
Astounding! Thank you. Carry on… Best wishes, health, joy, wellbeing… 🖖🏼
Fascinating! ❤
Great innovations are happening than ever before,hoping CRISPER may address many issues related to mankind in future both medically and environmentally, interesting discourse 🙏
Great innovations require daily interventions though, to remind our species that fiction isnt fact, and that praying is willful ignorance.
To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.
Ted talks are awesome. What sucks is they are held in a barbie doll dream world setting. These are people with the best of intentions. The real world is filled will all sorts of people with all manner of intent. Much of that is self interest.
Just listen. Don't look. It's a talk.
All my instincts say ... "proceed with caution."
Just the wording ("...a blueprint...") I was looking for- theorizing with a science-meets-biology-medicine LLM (A.I.). Had a need for a "blueprint" of my friends recent case of pronounced Alzheiemer's. In chats with said A.I....togehter with "persistent memory" (excluded in conventional chatGPTs)...I will theorize on Jennifer Doudna + Co's "precision microbiome editing" here and the new field of "bio *sonolithography* " . We should be able to...non-invasively "suggest" "to" the condition... back into pre-symptomatic states. eg. Robin Williams "Awakenings" but instead with lasting results.
Dr Doudna is da best ❤!!!
I love how the essence of being human is no longer literally the essence of existence that is DNA, but problem solving 😂😂😂
Be very careful to monitor arrogance in your disciplines! This is a phenomenal discovery. Use it wisely ❤️🙏
and we have many movies and series about that, aye
anyone still watching - `the boys`
So what you are saying is we need to weaponize this. Alright.
-CIA
In in one ear, out of the other. They are trying to play God and are opening Pandora's box. The Human species will be separated in 2, natural Humans and genetically modified ones.
I was put off that Dr. Doudna was wearing a shirt with an advertising logo. Then I read the comments of what a genuine person she is. It is a great lecture and hopefully this will help us all. Thanks!
The Doudna Lab logo? You're joking, right?
On,y if you can make money out of it for some capitalist millionaire
Amazing breakthrough, but with something this massive you can only imagine the politics involved. The funding, the legality, the bias, leaves no good invention unscathed.
We barely even started to understand the impact of micro biomes to an organisms health, but for sure we wanna edit it and play god. This kinda watches itself like the opening scene of some distopian movie
I noticed this too. If we only understand 1% of the microbiome, I feel like it's gonna take a long time to map the genomes of the other 99% of species of bacteria before we even start editing
Truly deserving Nobel Laureate👌🏻
100% agree. Jennifer Doudna and Emmanuelle Charpentier deserve all the praise and recognition they have received... The Broad (mit and harvard) need talented scientists like them on their staff!
Really ?
When quantum computers "unattainable" quantum threshold is achieved in my lifetime and then the bride and groom of A.I. and control of quantum entanglement marry...then 'Nobel prizes' will have to be redefined based on breakthrough after breakthrough.
Didn’t they get it already? At least her German co-constructor of CRISPR
@@hansludwig4732 Yes, she, along with Charpentier, received it in 2020.
10+ years of innovation - we are ready for it to make its way from theory to practice.
This is really good Science!!!
This technology is incredible but can we truly trust humanity to not abuse it
No we cannot. And as gene editing becomes designer-like it’ll only be available for the super rich and the disparity between rich & poor will widen even more.
@@vhscopyofseinfeld Pretty sure we're getting close to the tipping point of rebellion. History has shown that wealth disparity will only go so far before the guillotine comes out. While I don't believe the rich are as special as they're made out to be, I do suspect they are by and large well enough informed to try to avoid that tipping point.
Covid 19 showed we can't trust the military and the capitalists running the world.
*the rich who have access to this technology not to abuse it
"I had a dream that the meek inherited the Earth. It really shook me" You are humanity brother. Can we trust you?
A few comments:
1) Introducing a gene-modified organism into a cow's gut, whether of calf or adult, will only succeed if this organism is more fit in that environment that the competitors that will sooner or later also be present. If a more-fit competitor (for that environment) comes along, it will replace the "desired" strain as though it had never existed.
2) If the introduced organism IS more fit in a cow's gut than other competitors, it will inevitably spread through the herd, and into the wild. (It will be passed from cow to cow by natural means, whatever they are, just has gut flora have always been.) Is this something we really want? Gut-altered deer, buffalo, antelopes, ground hogs, grasshoppers, etc.? What would the ripple effects of this be?
Less embarrassing inadvertent farting on a crowded elevator?
This is an exceptional period in Science.Such exciting times .
This woman will go down in history !!!!
Classic case of the tail wagging the dog. Do we ever question to keep our unending consumption in check instead of modifying nature to produce more? Do we ever think about the downstream effects of these gene modifications on other aspects of nature? Instead of modifying the animal itself, why aren’t we asking the question of reducing use of these animals in the first place. Animals deserve that basic respect.
I have a degree in biotech and I've made GMOs. I also have been following the newest research in understanding the gut microbiome. We simply do not know enough about how the microbiome works to be going in and doing gene editing selectively in one of those species. We need to understand the system a whole lot better before we go tinkering with gene editing. This video needs to be taking place 30-40 years from now.
Ha!
‘Safe and effective’ she says
I'm sure nothing will go wrong with this technology that allows us to freely edit the basic code of life.
To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.
Read Jennifer’s book “a crack in creation” read about her dream meeting a pig faced Adolf Hitler
Amazing scientist in Dr. Doudna. Startalk opened my curiosity in crispr!
CRISPR as a technology has been hyped for the past 5 years as a game changer. The reality is that it is still early stages in trying to tame this beast. The reason there are not dozens of FDA approved drugs that use CRISPR is due to its volatility which makes it hard to harness. Still quite a long way to go for it to fulfill it's true potential.
Sophisticated technologies-life extension, nanotechnology, AI (AGI and ASI), information technology, the singularity, CRISPR gene editing, robotics, cryonics, mind uploading-must be in the hands of scientists and ethicists *_first_* and then in the hands of governments through regulation and law enforcement. 💕☮🌎🌌
Mind Duplication
@@m.a.4500 Absolutely! We should have the right to maximize our chances of getting infected and infect other people, especially those with an immune system too weak to get medical treatment or medical prevention. Freedom!!!
That is the same energy as the one that gets the survivors killed in a zombie movie
Absolutely not
Leaving technologies in the hands of government is how it has always ended up being politicized in the first place.
The list is endless: space tech, nuclear energy, vaccines
Nice set of words you have collected there.
Jennifer Doudna sure has exemplary and concise insights to share with audiences. Even the back of my neck I can feel the tips of my hairs rising.
Those are two of some of the strangest sentences I've ever seen paired together.
Love that science!
@@Novastar.SaberCombatget out more... ❤
This would be incredible for people with IBS…
They said they can cure sickle cells... i have a rare blood disorder i've had explained to me as Familial Hemolytic Spherosytosis.. I have had abnormal red blood cells since birth. Does anyone know if they could help me somehow? I always feel so tired...
feels like the opening scene to a zombie movie
More like I Am Legend. Curing cancer with an edited virus. Which by the way is one of the delivery methods for CRISPR, edited viruses to carry the payload to numerous cells
Fantastic and of course nothing could go wrong with such a powerful technology and it is fortunate that it can't be used for nefarious purposes.
Amazing!
"Your scientists were so preoccupied with whether they could, they didn’t stop to think if they should."
Doudna is such a brilliant human being
This, like all our tech we create, will be for rich folks only. Stem Cell, Lasik, invisalign, hormone therapy, advanced pharmaceuticals, and many other procedures are so far out of reach for most of us. Lasik is the cheapest of this tech and is still over $3000.00. That means 97% of humanity cannot have this, and it's been around for over 30 years. Greed always wins with the medical community, not helping folks.
Medical tourism. Lasik is far cheaper in india, mexico etc
You have a great point, but I think that perhaps you are thinking backwards. The problem isn’t that LASIK or any other medical treatment is too expensive, it is that many people are too poor to afford it. I think it would be more effective to focus on ensuring the poorer amongst us get more wealth, than to try and find further ways to cut the cost of shining powerful lasers into our eyes. In my opinion, it is worth spending the money and making sure medical treatment is done right.
But more importantly, I think perhaps you don’t quite appreciate how much cheaper most medical technology is these days, especially in genetics. The price for DNA sequencing has come down in price over a million times in the last 30 years, as have many others, so I think you many be overly pessimistic when you say “all tech” will be for rich folks only. Another example would be flying, which was extremely expensive 60 years ago, something only the rich could afford, but can now be afforded by most people on earth.
But do let me know if you don’t agree, I would love to discuss this further!
Thank You For Your
Phenomenal ✔
Global ✔
Outreach ✔ Support ✔
Helping ✔ People ✔ To Know Their
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is Priceless ✔ 🙏💜🌍💜🙏
How would you edit the child's microbiome?
I get that you can edit a dna sequence, but so you give them a food to eat which changes things?
scenario 1) We change microbioms to solve all our problems
scenario 2) We change microbioms to solve all our problems only to discover an exponentially cascading occurrence of new perplexing potentially devastating problems.
Last century the big technology was the transistor. This century it is microbiology.
@@Praisethesunson or is it AI or is it genomics or is it something else. I am glad to see molecular biology moving biology from the soft to the hard sciences.
Does anyone know if crispr can treat muscular dystrophy?
yes
@@MehdiL is there any information you can suggest ? Seems like I don’t know
Livestock are often dosed with antibiotics to alter their microbiomes to induce weight gain. Unsurprisingly, we can also gain weight when our microbiomes are altered by consuming said residual antibiotics. Meta management of microbiomes for weight control seems safer than say, unnaturally stimulating digestive hormone secretions by currently popular drug regimes.
I find it funny that the western diet destroys the gut biome of man, yet instead of solving the nutrition issue we work harder on creating technologies to manipulate the biome. Props to madame for the work she's doing but my minds eye sees how this could go wrong down the line
I hoped she would talk not just about CRISPR's applications, but also about its advancements. I heard a couple of years ago, they still had problems with achieving 100% accuracy and it was also really expensive to edit large parts of genome. Therefore it was limited to tiny, precise changes rather than complete bioengineering, that would take a long time with current methods. Also if you can, I would love to hear about those 0.50$ DNA tests, where you just drop a sample into a playing card sized sheet of plastic and a large grid of genes starts coloring based upon the presence and absence of genes. It sounded like a ground breaking invention as you could test for presence of hundreds of genes in humans in very short time and at large scale, possibly allowing us to sequence everyone's genome for possible disease predispositions, intellectual potential as well as genetic strength and endurance of patient's muscles. Sadly I didn't hear about it in years.
That’s some Theranos level pie in the sky.
There have been advancements in engineering CRISPR-Cas9 to be more specific. The best examples I can think of are nickases where they catalytically deactivate either the HNH or RucV endonuclease domain (each one cuts a single dna strand leading to coordinated double strand breakage) so that only a single cut is made. You can then dimerise this nickase cas9 and it increases the specificity through a longer reqired recongnition sequence, and any off target single strand breaks being much more readily repaired by the cell. There's also efforts looking into changing the PAM site requirements or base and prime editing where you add an effector deaminase which changes individual bases much more effectively. Prime editing is even cooler as you fuse a reverse transcriptase to Cas9 with a pegRNA (prime editing guide) which has the edited sequence of interest encoded on it for the reverse transcriptase to use. So there is lots of cool stuff going on, but I agree it would have been nice to find out more, as i've not kept fully upto date
Excellent.
exactly what i thought
Excited about the future but worried too
Corruption never sleeps and will inevitably control this technology.
Wonderful stuff. And when will this amazing technology trickle down to the average person, so that we may live more comfortable lives? Or... how much is it going to cost, in a world where dreams only come true for the mega wealthy?
Good news! You will be subjected to this tech in your corporate owned food supply.
I wonder if this can help cure psoriasis. That would be amazing!
The only cure for that is to end capitalism and live like they do in Star Trek 😄
@@Magic-mushrooms113 Or live like Cuba or North Korea. Most likely.
Fascinating ! thanks for sharing
Absolutely terrifying.
Diseases that kill millions?
1) In agricultural applications, gene-edited organisms could potentially escape into the environment and disrupt ecosystems.
2) There's concern that CRISPR could be used for nefarious purposes, such as creating bioweapons or dangerous genetically modified organisms.
3) The long-term effects of gene editing are not fully understood. Changes made to an organism's genome could have unforeseen consequences, and we may not discover these effects until years later.
We need to ensure that CRISPR gene editing is used for the benefit of society while minimizing risks and potential harm.
I wonder what if any significant differences there are in the gut microbiota between cattle that are kept in feedlots (ie dairies) where they spend their entire lives standing in feces and subsist on man made "feed" vs cattle that are raised in large open pastures and eat only grass. I would bet there are very significant differences and if we could sample and test them it would add valuable data about how gut microbiota interact both with the animal and with the food the animal consumes (less methane emissions?)
This doesn't even necessarily have to do with CRISPR, but there's actually been a lot of research done on how kids who grow up in more dirty environments or certain countries don't get diseases like ulcerative colitis, type 1 diabetes, or certain allergies. They think it's because their immune systems get more practice dealing with different things, so it's less likely to go haywire and attack things it's not supposed to, (i.e allergies.) I wonder if there will come a time when all babies and toddlers will receive a routine schedule of probiotic treatments at their pediatrician appointments, right along with their vaccines. Perhaps they'd put the bacteria in candy or drinks that they would give to the kids. And maybe CRISPR might be used to make some of these treatments or at least make them better.
That's what presumably probiotics are for.
The answer is even simpler - they live off the land. They aren't eating the trash that first world societies label as "food".
Yada yadacyada
What you are describing is called “vaccination” and sadly for some reason many of us don’t want it any more
It doesn't seem so farfatched, that one day we'll have monthly scans and balances :)
Thank you for your amazing work professor 🙏. If this can be used to cure intenstinal diseases like UC and Chron's it will lift immesurable suffering from the world 🙏🙏
That was what my mind first jumped to as well. Curing Crohn's Disease, or at least better controlling the symptoms would be so huge!
A friend of mine died two months ago of her intestinal/bowel disease at age 44. She left an 18 year old son. RIP Clara.
The strongest curse for humans is curiosity, each of us is born to make progress and we cannot escape that reality.