CRSP Stock On Wild Ride After FDA's Historic Approval. These Gene Editing Treatments Could Be Next.
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- เผยแพร่เมื่อ 7 ธ.ค. 2023
- Biotech stocks could be at a major turning point after FDA approval of the first gene editing drug using CRISPR technology to treat sickle cell disease.
Government approval of these groundbreaking treatments could generate an unprecedented wave of medical innovation. But gene editing therapies aren’t without risk, and questions remain about the safety and cost effectiveness of these experimental treatments.
On this episode of Growth Stories, we dive into the science of gene editing treatments and how the boom in gene therapy drug approvals could transform the healthcare industry.
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I wonder how many members of congress and the FDA just happened to own the stock…
You've got the order of events mixed up. "I wonder how many members of congress found out about the approval before it was publicly announced and then bought stock"
I wonder how many idiots like you keep looking for any reason to believe in a conspiracy theory. I invested in this company when their stock was still just OTC. I read their financial statements and 8K’s all the time. Very few of us investors that believed in them. They received very little grant money and only after they accumulated a lot of data. But of course, now you want everything for free after their staff and scientists earned less than the national average for years. Yes, now you entitled socialists finally appreciate what they did and want to take advantage of it without giving any compensation.
3.5million per treatment... Is there a cure for greed yet?
I think in this case the high price is the combination of the chemo, what is essentially a marrow transplant, and the small market size. The smaller market size means less people need to shoulder the cost of R&D and opportunity costs.
Very apt, analysis!
As time goes the cost will come down I am sure....
socialist revolution (but not those rainbow coloured FAKE freaks)
It’s called Jesus, the only cure for all sin.
GOLDEN age for modern medicine alright with emphasis on GOLDEN. More like golden age for curing and perfecting rich people.
Why did you not use the shorter and more to the point saying "LET THEM EAT CAKE!" After all who do those poors think they are demanding healthcare which is private for obscene profit for a reason! To keep those poors working for you for next to nothing. @@Avrakadavra1418
Let's be clear, the cost of producing these therapies, now that the foundational scientific research is complete, amounts to only a few dollars.
The million-dollar price tags attached to them are not even intended to recover research and development costs, which have been partially funded through taxpayer-supported academic institutions, philanthropic donations, and the dedicated work of scientists.
Rather, these extraordinary price tags are driven by pharmaceutical companies' focus on profits over people. Each person cured means one less source of ongoing revenue. Let that sink in - cures destroy repeat business.
The tax payers paid for all of this research to be done, it’s ours, we should control the patents, not some capital owners that figured out how to rig the system and rip us off. The funny thing is cures are also profitable, but what’s not profitable is preventative care. It would be nice if we didn’t have contaminated water and food pumped with junk so we didn’t succumb to these diseases in the first place, but that would hurt profits.
Let's hope that most people are just trying to help out of purity of heart.
Bingo!
that's why we need socialism oriented hackers and scientists. they sould find their data, make it public so everyone can make it in the garrage, like they have done with insulin open source project
Whats exciting about this technology is it will be accessible to the general public eventually, there are already citizen scientists/biohackers doing their own CRISPR experiments.
i know all about this, but great video Alexis. i hope you spread knowledge and hope to more people.
The discovery stage of CRISPR that goes from its study as a biological phenomenon to its conception as a mechanism that can be used as a genomic editing tool took place mainly in American universities with public funding from federal agencies such as the Department of Energy and the National Science Foundation.Feb 7, 2023
I can't think of a better way to spend money.
Your point?
@@ConnoisseurOfExistence capitalism needs gov't support to do the heavy lifting.
Yup and now we need to give all that technology to private companies so they can charge us 1 million dollars for it & then have government subsidizes insurance to cover the cost
We definitely need to nationalize the entire industry.
@@jensoneemaybe the college could have paid for it they charge enough.
Energy will flow more ,Clean more cells live longer, create a Larger Magnetic Field, Keep going
Aging is another big killer
You have to take it as it comes....
Once you become immortal you effectively stop living. Let’s not.
@@apothecurioWhy does it have to be immortal? What’s wrong with wanting to live 200 years or whatever a person wants? If someone stops aging, they don’t become immortal, they just don’t die or suffer from aging anymore.
@@DynamicUnreal A mortal extension would yield absolutely disastrous for the well being of humankind and the earth. There are far more insightful ways to use this tech.
@@apothecurio How so? Explain yourself.
👏🏼👏🏼. Great video … very informative yet concise.
But can they reverse male pattern baldness..thats what is important
i just don't trust the FDA
is this treatment work for thalassemia trait person???
At least 15,000 patients across the world have received CAR T cells, and dozens more clinical trials using this approach are in progress,
Six treatments are fully FDA approved.
Success averages 55 to 65% across the board. The modified cells don't last long.
Thank you, I got excited for a second. 55% ain't great...
How long does it last?
@@jeanwonnacott2718 it just came out let time get better lol
@@jeanwonnacott2718It’s better than zero.
If I understood it correctly, he had to get chemo before the gene editing? So will we get better methods of treatment that don’t involve chemo as a prerequisite?
It's essentially a bone marrow transplant. The chemo is how we currently do it. Although in this case I'm betting they could develop a virus that specifically targets the marrow. That virus could deliver the edits. I'm guessing the reason they aren't doing that is because it would be more difficult to get approval for. It's safer to perform the gene therapy outside the body then reinsert.
That's fascinating! @@Imaboss8ball I imagine this virus delivery method will become more feasible over time as the world moves forward with this stuff.
next time together with boosters chemo will try to be mandatory ;) only thing day can get is white waxy substance, a DNA vaccine, right in their back
I feel investors should be focusing on under-the-radar stocks, and considering the current rollercoaster nature of the stock market, Because 35% of my $270k portfolio comprises of plummeting stocks which were once revered and i don't know where to go here out of devastation.
Safest approach i feel to tackle it is to diversify investments. By spreading investments across different asset classes, like bonds, real estate, and international stocks, they can reduce the impact of a market meltdown
A lot of folks downplay the role of advisors until being burnt by their own emotions. I needed a good boost to stay afloat, hence I engaged the services of a true market strategist to help rejuvenate my $700k portfolio and boost performance and returns by 40% in a little over four years.
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I'm being guided by *Kaitlin Rose Sternberg* who is widely recognized for her competence and expertise in the financial market. She has a thorough understanding of portfolio diversification and is regarded as an authority in this field.
I just googled her and I'm really impressed with her credentials; I reached out to her since I need all the assistance I can get. I just scheduled a caII.
DNA is inception code if you debugged linux kernel except this is orders of magnitude more complex. Knock on effects might be dire.
1:13 she has an Alvin Kamara shrine behind her?? Wtf lol. Die hard saints fan i suppose
It has taken a long time for gene therapy to actually work. I wonder when it will treat common chronic diseases.
Considering the multi million dollar price tag it won't matter for most people. Better leave the city and grow your own food, will probably prevent a lot of diseases due to awful diets with GMO.
There are gene therapies in the pipeline for type 1 diabetes. I hope we have something that works in the next 10 years
Long after militaries have learned to target specific ethnic groups.
@@mikemondano3624 is that a dark premonition or a death wish?
@mikemondano3624 Do you think any whites will be alive by then?
We could just invest in preventing illnesses, but that would hurt corporate profits and there’s no market for that.
Yah imagine nobody got sick anymore. The whole multi trillion dollar medical industry would collapse. This world is disturbing and evil.
@@zerovalue5106 no, most people in the world despise the logic of our economic system, which is why violence, propaganda and coercion is used to maintain it. It’s something that only benefits the ruling class, capitalists, within a capitalist economic system. Under almost any other economic systems conceivable, this dynamic makes no sense at all.
U can’t prevent genetic diseases. The only way to get them out of the population without intervention would be to tell people who have it to stop having kids and you can’t really do that. And even then they could still pop back up through random mutations
can your big brain tell us how to prevent genetic diseases?
See your separation spread of like H2O I just use it for an example do you think you learn the principles of hot and cold to produce inside out of the correct ratio development of DNA which placed side it's supposed to be on in the flow or the heartbeat of directions of blood
Cool breakthrough
Rubbish
@@trulyso734 why?
Nice
Gene editing is the best thing
Thought this was gonna take longer wow
This could be wonderful! Rarely do medical co do cures just continual treatments & prescriptions
You must be an easy to dupe kind of a person
I'm actually happy my covid shot helped others. I knew it would but I had no idea how much.
Sounds like fallen angel technology. It says in the Greek Bible that the nations are deceived by Pharmikia. Hummm...
I wish humans could code genes just like in programming language. Wish humans could reset genetic code into "default" and remove all errors caused by mutations from pollution,chemicals, stress and etc...
That’s why I want to get my Genome mapped now. That way as your DNA creates errors as you get older, you can go back and reset it to when you were younger.
@@MrCarRamrodthat's a good idea but it doesn't matter if you don't take DNA methylation and histone modifications into account and epigenetics is a much younger concept than editing DNA and genes are only half responsible for the expression of proteins and molecules that make the body work. While we can edit segments of DNA that are mutated as you mentioned, there's no guarantee that the proper epigenetic data is imprinted for those edited segments to work. We're still in the infancy of reasurch about how DNA works.
No such thing because okraina is a scam. Delusion about futzing with genes is bound screw things up
You can….its all in the mind
bio systems are much more complex and non deterministic and it's good so
Once approved the real test begins in mass on large numbers of humans and only after 10 years of data will I try a new drug
is it useful for Parkinson's Disease that is not genetic based?
Try serrapeptase, which is an enzyme that eats loose protein in the body, including the plaques for PD, and look into sulforaphane to seal the leaky gut associated with PD
Something for DEL Lymphoma PLEASE!
Gene experiments sure have changed the life insurance industry.
Too right
Everybody together now.. Kaching.... oops where did everyone go..
Thanks. Grey hair/beard.
She said “theoretically”?
Let's go!!!!
How come no one cares to mention the ultimate goal and holy grail of gene therapy, longevity?
Or cash.
I look forward to this, it would cure my clotting disorder 😳
The World Will Never Be Same
As The Human beings Will Be Changed For Ever
In a good way...
"We are not only men of science: we are men of hope."
- Dr. Jonas Venture
My shoulder pain no more
But can it cure idiocy? Because that is very much needed right now.
It will enhance it. There is no free lunch
Unintended consequences will likely be disregarded.
100%
#ban gene editing
drugs should be a non profit Government organization . Profit driven communal needs HAVE TO public owned!!
This all ready being used by local biohackers this allows anyone with enough knowledge to work on themselves not just billion dollar companies.
Meanwhile, the planet is on fire.
Long time I have no shoulder pains
For "the right patients" is all I needed to hear 😡 when will the world catch up
Ok thats cool and all, but when am I gona get my catboy hrt spine shots? I just wanna be a lil kitty man.....
Do they make it ex-vivo to sell those chemotherapy drugs? There are better ways.
Jitta score: 2,26/10
Daqui a 100 anos vai ser testada e
Humanos
Crazy
“and..it will change business models”…not if wall street has something to say.
They should try it on vagal paraganglioma... yaknow about a 1 in 200 million tumor that can cause all kinds of problems for those of us that are 1 of the lucky 10 in the us.(at least that was the count according to the last oncologist that backed away as fast as he could.... to know this is a direct gene abnormalitie and no one is willing to help... tell that to my now 5 year old when he is about 13 to16 when I die from it. 11 years from diagnosis... 80%mortality to even get a simple sample unless you live on alpha and beta blockers.... lol yeah let's live like we are totally insane while the government wants to say your okay to go to work... so you get nothing for over 30 years of your time... disenfranchised....my middle name anymore ..but I will say this my son will have no doubt I fought to stay here for him and it's to him the apologies need to go to 🖕
I will be saying no
So happy for the billionaires who can actually afford it.
Gene Editing is trash. The human body is perfect without these poisons being oushed on us. Enough!!!
Time and nature already naturally does gene editing, that's called mutation, it's not different it's just a quicker way to adapt to the environment which is the point of mutations.
Heart disease, cancer, diabetes. Weight loss prevents/treats all 3.
Weight loss also needs treatment. Obesity is a disease. Maybe different causes for different people, but a disease that should have treatment available regardless for anyone who should want it.
Obesity is not a disease. I've seen this way to many times in my 60 years.
It's a disorder. Not a disease.
Glad I had med training before all the false information started coming out.
Word trickery.
“Mark of the beast” being a body part engineered from an animal was implied.
Going to be a $1000 stock soon
I really hope this can cure psoriasis soon. 😔
Look up Dr Shawn baker. The carnivore diet. Says it cures a lot of people
Heart issues , cancer and diabetics …. A cure ! Crazy times we live in …. Wow
Nope, they'll just dangle it in front of you, they don't make $$$off healthy people.
Heart disease plaque build up is not one gene. That kind of disease cannot be cured with genes. Diabetes type 2 is largely a life style disease.
what the point of these life saving stuff when the company is going to price it at a point where the average person can't afford it ..
Because you pay for it thru your working wages, and the elite profit from the tech. It was never meant for you to begin with. If you notice, most of the CRISPR videos are here to encourage INVESTMENTS. They just need your funding.
Evolution takes a long time to sort out the good from the bad, what is working what is not, what increases survivability and which may decrease it. Do we have already the foresight to look down the line of generations, what the combinations of changes manifesting in our genepool would do to us?
Evolution is selection for reproduction, not fitness or even survival.
Prophecy worries could apply to anything.
Everything is a probability assessment, even the next moment.
We'll fix it when that time comes. Until then, IT IS UNETHICAL TO NOT USE THIS TECHNOLOGY TO HELP HUMANITY
You're mixing Evolution with Natural Selection. Changes that have occurred due to both have brought many species to extinction.
I'm sure the experts researching this stuff haven't thought of such a possibility from a random pleb on the internet who's got no idea.
@@ZenTheMC Don't sell yourself short. While not everyone may lack insights and manners, you still may produce viable thoughts. Just keep trying.
All focus on a financial model first. Impruvments to humans life second! 😢
10th dimensions please and you will be super
$3 Million for one gene therapy tailored to one person's genetic makeup? Its probably generic to all sufferers, but they will say it's individual to make money.
Cost of therapies will decrease 10% per year so by 2040 it will be cheap
Nothing will be cheap in 2040.
@@mikemondano3624 What you're saying goes against common patterns and logic. How many people could afford smartphones when they first came out? How many people have them now? Please learn how supply and demand, technological innovations, and economic growth actually works.
@@ZenTheMC One example in a totally different context. The world will be in disarray and survival will be our total focus by 2040. Governments will be bankrupt from responses to disasters and only life will be cheap.
Gene editing has been approved for years by Dr Fauci.
5:45 oh thats lovely. Try to cure one thing and manifest another. Why does that sound familiar.
Imagine the possibilities with such mutations. Does this finally make the zombie apoc a legitimate possibility, haha..ha...
There is no patent, there is no stock, there is only me. Hopefully I can train others. If not, it's the Garden of Eatin'. Wanna go for a gene drive? It's not a question.
Bogota🎉
Let's hope that bioengineers don't wield this power like a child who's found his dad's gun.
Too late dark labs already going full force
They already did, and unleashed it on the world.
Going to make 15 years or more
I don't understand the man. CRISPR-Cas9 editing would only operate on his somatic cells. But he thinks his next generation won't carry the gene.
The stock is moving like normal. Idk wtf these people are talking about there is no breakout or anything like that happening right now.
only the rich get to llve
More hells planned?
👍🏾
Good news thank you
Million per patient 😂
Right now, yes. Like every new technology. Also, would you want generation 1 of a new drug or therapy? I would rather have generation 10 which is orders of magnitude cheaper and less risk-averse.
If it works well it'll be for the rich. So most of you shouldn't get to excited.
🎉
👍
This is the second time a company tried to sell this type of medicine 💊 The first company went bankrupt because it was to expensive to produce, the treatment is complicated and also expensive. Last of all the patients don't have the money to pay for it. I'm referring to the cure for sicle disease
Pretty sure someone at home could make this medication. Gene therapy drugs are pretty simple. It's similar to antibiotics instead of aspirin. You use bacteria/viruses to hold and deliver the genes to be edited. The benefits of that is that it's easy to create more in a bioreactor.
They're advertising like this in the hope that investors would invest in their company so that it wouldn't be impossible to produce due to how expensive it is. You act like everyone is coming together to screw over the common people. If this works, they'll make even more money, and these rich folks want to remove their hereditary disease too
@@Imaboss8ball Nah this treatment requires chemotherapy and a bone marrow transfusion so it's not only gene therapy
@@Dave_of_Mordor I have this disease that's why I read about it, I'm the target group. It makes sense they went bankrupt since this disease is found in low income countries. It's a shame but also implies that there is a need for further development to find the correct price point.
They will never allow this because there is no money in a cure
no, I'm NOT asking what CRSPR and Gene therapy is, it's about as old news as god....why do all these YT clips always assume everyone is as dumb as a rock ?
Caveat emptor.
As if pharmaceutical companies would shoot for a one time dose 🤣
What do you think that would cost then, so it stays economical?
THERANOS PART 2 GET READY GUYS
Eternal life is offered by our maker and designer and His son, Jesus Christ the Lord. We are not going to from our own technology achieve it. The wages of sin is death, and we all live in its shadow without faith in Jesus. Repent and trust Christ.
Hard to say if this will be good or bad. But time will tell.
Obviously good for patients
It will be bad.
@@jdsguam Pessimistic fallacy. It will be amazing for humanity.
@@jdsguamyou’re not the one dealing with a long term disease so I’m not surprised your ignorant self is quick to say it’ll be bad
Capitalism at its maximum expression, we repeat the cases of insulin and epinephrine again. Science, especially that related to medicine, must be at the service of everyone.
The discovery stage of CRISPR that goes from its study as a biological phenomenon to its conception as a mechanism that can be used as a genomic editing tool took place mainly in American universities with public funding from federal agencies such as the Department of Energy and the National Science Foundation.Feb 7, 2023
The funny part is, that the issue is government red tape, not capitalism. If it was capitalism, there would be dozens of companies selling the stuff for cheaper and cheaper... But one or two companies usually end up holding the patents or are allowed to manufacture the products, thus not allowing competition.
@@Ryan-wx1bi so, you're saying there should be no regulation. people, companies who create a product, medicine, music, shouldn't be able to profit from it. they should give it away. the scientists who discovered insulin gave it to their university. the university sold it to businesses. now it costs hundreds of dollars, but wait, biden has decided, and passed a law, to force the price down to 35$. but you want it to be hundreds of dollars? i can't follow your logic.
@@Ryan-wx1bithey don't have tech to do it they would definitely do it, why you don't do it?? you don't have knowledge and equipment. we need socrevolution!
@@NionXenion-gh7rf Because companies hold onto patents and other companies can't legally make copies of the medicine/vaccine etc.
Please send me the proper form. I'd like to order a bespoke baby.
When you are playing God
You do not end up being God.
1.6 million per patient, seems it will be for rich
11:00
14:30 three big killer
My vision is someday not so far,we can edit genes and make people so smart that even a 10 year old can solve quantum physics
It's obscene that these companies are trying to make such exorbitant profits off the suffering of children. Look at videos of girls with Rett Syndrome and explain how a drug company CEO says "We should maximize our profits helping these children". IT'S OBSCENE!!!
There would be NO advancement in medicine if it weren’t for profits. I believe these companies lose their patents after so many years on the market allowing generic equivalents to be available.
These are one time shots, how are companies going to pay their years of drug development without a high price?
Fight them with A.I
It the therapy genuinly help the kid what is obsene about that?
The obvious answer is a system like Canada has, where our taxes fund the healthcare needs of the population, meaning you don't have to be rich to get the care you need to live. Especially as the gap grows between the rich and poor, having healthcare funded in this way is the only answer.
G1 #whospink?
I'm unimpressed and underwhelmed by the snail's pace in rolling out this "groundbreaking research" SO MUCH SO that I'm inclined to believe this is another ploy by pharmaceutical companies and nothing more.
Blame the over-regulation and fearmongering from anti-tech folk. Innovation can only occur at the rate it's allowed to by policy.
@@ZenTheMCvery true
have you been paying attention?
Crispr discoverer’s name is not pronounced dow-dinna it’s pronounced Dow-D-N-A 😏