Dr. Michele LeRoux (MIT): Pseudomonas aeruginosa survives with a gut reaction using their T6SS
ฝัง
- เผยแพร่เมื่อ 22 มิ.ย. 2024
- www.ibiology.org/microbiology...
When we think about bacteria, we don’t really think about the sufferings and struggles they go through when they fight to keep their homes. Dr. Michele LeRoux explains how bacteria interact with one another as they compete for environmental resources. She focuses on the Type Six Secretion System (T6SS), a protein complex in the membrane of some strains of bacteria that is used to fight and outcompete other bacteria. Studying this system in Pseudomonas Aeruginosa, she discovered that when these bacteria encounter other bacteria with T6SS, they are able to increase the amount of activated T6SS in their membranes. She noticed that Pseudomonas Aeruginosa could sense the death of sibling bacteria, which would activate their defense system. This novel immune response mechanism in bacteria provides insight on the bacterial responses to harmful cues.
Speaker Biography:
Dr. Michelle LeRoux completed her Bachelor's degree in Molecular Biology at Colgate University, NY. She joined the Molecular and Cellular Biology doctorate program at University of Washington, where she worked with Dr. Joseph Mougous and studied bacterial social behavior and interspecies warfare. She joined Dr. Michael Laub’s lab at MIT as a postdoctoral associate and continues studying the molecular mechanisms of bacterial life. - วิทยาศาสตร์และเทคโนโลยี
I have to say, as a 48 yr old diabetic mom who has been struggling with the spread of pseudomonas aeruginosa from otitis externa for the last month, I found your research very informative and hopeful. The evolutionary aspect was fascinating and the lysis findings were brilliant! It may not be able to help me but it shows great promise for the future. I hope, based on your very important dicoveries, that more funding will come for the fight against pseudomonas aeruginosa. I am thankful that there are people like you and your team working on helping us try to win the fight. Great work!
what's up with your profile pic. explain
The presentation is clear and to the point. The analogies are helpful, as is seeing these ideas in a broader evolutionary context. Keep up the great work!
Pseudomonas
A brilliant presentation of some brilliant research!
This is wonderful. Very inspiring. Thank you for a great presentation.
Impressive research and very good presentation. Thank you, it was very helpful. I am looking forward for more good news.
Very interesting, I really enjoyed listening to your project! I hope we can get some more news about what kind of proteins are activated during cellular lysis.
Wow! that was perfect. good job!
Thank you! I love this presentation, I might get to do undergraduate research on Pseudomonas and this really helped me understand the thought process of which questions should be asked and ways to test things.
Awesome presentation!
Yes briliant ideas put to work
Great talk and great PhD research. It must have been a lot of fun.
Really informative!! Thank you!
Great work, on great bacteria.
I had thiz illness i nearly died from it was in hospital for 2 months what an awful illness to have it affected my organs im so lucky to be alive God is good❤
Jean Louw hi im the same situation im suffering
aRe u heal now?
@@areinecvstodio228 please, reply how you treated it?
@@alexh4037 hi Alex. Have you found any solutions yet?
How did you treated it?
@@areinecvstodio228 I am alive and healed now yes, they had taken a sputum test and that revealed I had pseudenomas aereginosa it was a battle well there was nothing they could do as the antibiotics they gave me through the iv drip was not working what they did do was see what anti biotics I was resistant to via blood tests and that's what actually healed me. It was a nasty virus can't believe how bad it was and that just from digging in the soil tHat day or it couldve been from my pool i would never know, I hope you are ok please let me know.
Great work!
Really interesting research. Hopefully this will lead to us being able to save people.
Thank you for your astonishing efforts and contribution to the subject and this area
I have a question regarding your research:
You have been able switching defence system and sensors of Pseudomonas during your tests!
can your method/system be implied or infected in already existing Pseudomonas in our body/wounds/lungs ?
So we can turn them into non-aggressive type while having treatment
Thank you again
Best Regards
Marvelous!, thanks for sharing this awesome project with us, truly appreciated, thank you again.
incredible!
Excellent
very amazing
i'd like to see any research into bacteriophages and its potential to combat antibiotic resistance
This is a very interesting research topic and very well presented talk. The impression from the talk of Pseudomonas having sensors receiving signals from lysed cells to trigger T6SS module suggests this system is applied when it is on defense side. How about the offense system? Assume Pseudomona attacks first, yet there probably won't be enough signals for activating T6SS initially, therefore there may be another pathway/module for that.
When you say : "It is ALMOST impossible for CF patient to get rid of pseudomonas".... you mean there is still a POSSIBILITY that they actually CAN GET RID OF IT?
Can you tell me more about this please?
Does anyone know if these causes scaring?
Doc i got this infection from a surgery couple weeks ago. Im still dealing with it now.they did a culture to find correct antibiotic . It came back yesterday put me on cipro. With all that said. I have a suggestion for an experiment that i think you may like. I woukd at least like to know the results of it.
Simulate surgical environment with this live bacteria in procedure. Heres my idea of controlling these infections in the surgery room. See how this particular bacteria responds to uv light exposure during surgery. In hvac industry ive recommended uv light installation inside heating and air equipment. This light kills many different types of bacteria . Although you cant look at the light as it will burn youre eyes. But under a shield over the subject surgical area this may be something worth looking into. Ive personally witnessed this light killing various types of spores and other bacterias. Why could this not also work inside surgical environment over a target area. Maybe change the nano watt to one works for this . But im not sure how this bacteria will respond to that light..
Anthony Poole
hello, finally you treated it?
So, how am I going to disable the Pseudomonas from detecting the danger signals sent out by Pseudomonas cells at war with competing bacteria, as you did in movie 3 at 23:39 ? I have been living in hell for several months, you have to tell me!!!
hello, I also fighting against this bacteria for a long time! If you treated it, please write me what kind of antibiotic did you use?
@@alexh4037 hi I’m in the same boat. Did you find something that cured you. Very interested to know. Tired of being ill
Any freind who recovered?
Pls tell us
@farazzafar159 number sand me please
My favorite bacteria
How?
It looks like Pseudomonas is still the grim reaper along with it's cousin Golden staff. They may not get you today but tomorrows another story.
I really hopethis gets you somewhere and nearer to winning this battle you don,t seem to have an answer to. From a selfish sufferer
Thank you for wasting half hour of my time to not know how to fight this bacteria.
6:50 💉 I got pseudomonas during orthopedic surgery. I' m told it is commonly found in sneakers. It snuck into my leg ! Had to give myself IV antibiotics for 6 weeks. Surgeons had Zero 7 on when they put the peripherally inserted cardiac catheter in. But I duress
Hi currently struggling with this. Did you have a uti? What type of antibiotic did they put you on?
@@Jsia2021 yes i am ,now how are you
@@parathcena5480 I'm ok. I took ciprofloxacin 500 mg for 14 days and it went away
@@Jsia2021 What are the problem you faced While you have that bacteria
@@parathcena5480 I was asymptomatic. Luckily my doctors found it early during a urine test.
Injects like a bacteriophage would when it infects a bacteria?
A fairly common flesh-eating bacteria
Thanks
You are looking beautifull