The pros and cons of GWAS

What are genome wide association studies (GWAS)? In this video, learn about GWAS and the information we can gain from them but also there current limitations. Using obesity as an example, we will then look at how information from GWAS could be applied to the generation of polygenic risk scores which have potential therapeutic value as predictors and treatment of different genetic conditions.
Timestamps
00:27 - What are GWAS
02:06 - The pros
03:52 - The cons
07:55 - Polygenic risk scores

[@nikhilkumar8606]

I really like your video but it is difficult to understand when the audio says something and some other thing is being written on board.
Thank you

[@KARINEMOOSE]

This is really well done and so helpful! I'm about to start a graduate program in Bioinformatics, your videos are really helping me get up to speed what I need to know. Thank you so much!

[@TheSheekeyScienceShow]

Thanks, good luck with your grad program!

[@KARINEMOOSE]

@@TheSheekeyScienceShow Thank you! ❤️

[@susankanjira6098]

All the best in your career, Bioinformatics is fun

[@KARINEMOOSE]

@@susankanjira6098 Thank you so much! It's challenging right now, but these types of channels are really helping me get through :)

[@susankanjira6098]

@@KARINEMOOSE Kikiki they always do. Once you understand the stuff you will really love it.

[@KS-ve3zf]

Very helpful video! Thanks a lot! :) I do have a suggestion: Maybe it's better not to be constantly drawing and improving the drawing while you're explaining something because that can actually be quite distracting.. (for example: at 4 minutes - 5 minutes)

[@TheSheekeyScienceShow]

Thank you for the feedback! I agree, i hope my quality has improved since then but it is something i try to stay aware of!

[@KS-ve3zf]

@@TheSheekeyScienceShow Ahh alright! I had not watched your more recent videos, this was the first one I came across. Just checked your most recent one on COVID-19. Great improvement indeed! Keep it up :) Love from a Dutch student

[@TheSheekeyScienceShow]

Thank you! 😊

[@BFS4321]

Great intro on GWAS! Thank you!!! ❥

[@Foxhound_Chief_Razgriz]

Very helpful video. I do have one question though. When a paper say something such as "In the case of CACNA1C, the index risk polymorphism for BD (rs1006737) is located in the third intron", is that rs with the numbers the polygenic risk score? Thank you in advance.

[@TheSheekeyScienceShow]

Thanks! And rs stands for reference SNP, its an identifier used in databases and is separate from the risk score!

[@aggern299]

thanks!

[@claudiataylor4389]

This is so good! so informative and helpful

[@candyfloss9054]

Hey where did you get this data from ? Thank you love your video x

[@TheSheekeyScienceShow]

Glad you liked it. I compiled the info from multiple sources + my own opinions but this nature review is a good overview Benefits and limitations of genome-wide association studies. Nat Rev Genet 20, 467-484 (2019). doi.org/10.1038/s41576-019-0127-1

[@candyfloss9054]

The Sheekey Science Show awesome thank you very much x

[@regozs]

Very informative and well-made video

[@jinxcoursevent8375]

Good video ! continue

[@TheSheekeyScienceShow]

Thank you!