Phenomenal video!!! Thank you for drawing the connection between linkage disequilibrium and haplotypes. The absence of this connection increases confusion when texts explain LD blocks (haplotypes) that ARE associated with diseased alleles. It’s easy to question “just because two alleles are linked doesn’t mean a diseased allele is nearby, right?”, but the fact that linkage disequilibrium creates haplotypes/LD Blocks makes this much more reasonable to understand how these haplotypes can indicate diseased states. Having this said, without actually genotyping the intervening exons and introns… how can we say for certainty the haplotype is pure to the reference and isn’t experiencing an alternative mutation?
This was amazing!! I'll have a genetics exam soon and this will be part of the material! You explained it really well, I enjoyed listening to it and I think I actually understood this subject quite well :))
Great video...concepts are introduced and explained with amazing clarity..thank you
Phenomenal video!!! Thank you for drawing the connection between linkage disequilibrium and haplotypes. The absence of this connection increases confusion when texts explain LD blocks (haplotypes) that ARE associated with diseased alleles. It’s easy to question “just because two alleles are linked doesn’t mean a diseased allele is nearby, right?”, but the fact that linkage disequilibrium creates haplotypes/LD Blocks makes this much more reasonable to understand how these haplotypes can indicate diseased states. Having this said, without actually genotyping the intervening exons and introns… how can we say for certainty the haplotype is pure to the reference and isn’t experiencing an alternative mutation?
Thank u very much I was reading a paper and this helped understand what they were talking about
Glad to hear it
I really appreciate this video. Finally I feel like things are coming together. Thanks! :)
Thank you, comments like this mean a lot to me
Thank you so much. The video was clear and precise and helped me understand the concepts 🔥
This was amazing!! I'll have a genetics exam soon and this will be part of the material! You explained it really well, I enjoyed listening to it and I think I actually understood this subject quite well :))
Thank you for the kind words :) I'm glad you found this helpful
Amazing explanation.. hope you can do more videos
This video is amazing, cheers mate.
Thank you! Great video.
Very well-explained...
Thank you
thanks mate, great video! love the scottish accent :D
Awesome video! Thanks a lot
What is your accent?
Scottish
@@behaviouralgenomics438 Very nice and unique, also boosts the learning capacity of the audience i guess😉