i am a medical student myself,& i honestly owe u due to your crystal clear xplanations. your speed,the precision of concepts & the accuracy summed up with ur confident presentation is what makes this immunology concept amazing! b4 my xams,it was a life saviour! so thank youuu
I'm just paying the University for degree, whereas you make me understand each and every concept clearly. Thank you sir. Lots of respect from Kolkata ☆
I opened kuby book I was confused with how this switching taking place but within a mints I got the concept Thnks sir for your precious vedios n hardworking✨👑 I admire n thank ful for u everytime I comes here to serch any topics ❤️💎
thank you so much shomu your selfless action of spreading knowledge among the dummies. We are very gratefull to you and not to mention you are just awesome in terms of expression and are really an expert.
Sir ur videos are one of the most informative and easy to grasp on. But the only think u r lacking is your video setup, the lights ,the angle and editings. If you can improve this u ll get lots of view and subscribers from around the world.
My answer is probably a bit late and I can only guess but as far as I know when IgD is produced, IgM is also produced, seems like IgD definitely cannot be produced if IgM isn't since they sit in the same region. Also since the frequency of IgD is below 1% i think there must be a specific pathway that somehow overgoes the immunoglobulin becoming an IgM. I know this is not really an answer to your question, just my thoughts.
You didn’t listen carefully then.. there is a small chance of recombination between the blue dots. Then if it’s between M&D, there will be IgD. And if both are cleaved together only IgM will be produced which has the highest concentration by the way
its a really smart learning... watched not almost all but huge no. is there.. nd all r great.. thnk u for this tutorial .. hope u will give notes on your google + or your website..
@@shomusbiologyofficial mere class m net ka syllabus padaya jata h. . Achhe se samjh m nahi aata but aapka lecture attend krne k bad sbb smjh m aa jata h 😊😊😊☺☺
Plz get understand somatic hyoermutation and somatic recombination( vdj )..bcz I think both process are different but mostly it is mixed in all online videos..
Hai Sir.. I got with one doubt. What if a New Antibody needs to be produced from the Cleaved part of DNA during the previous Antibody production... How will the cleaved DNA part (of variable or Constant region) be used again for a new Antibody synthesis?
Okay so just I make sure, when the plasma cell makes antibodies they all have same vdj sequence because they all are specific to one antigen right? But the type switching happens on the constant region.
I have a quick question. For the constant region recombination, there seems to be no recombination site between M and D. So how can IgD be expressed if it seemed to be masked by IgM. thanks
Sir you said that hey will always recombine at those fixed positions. If thats the case IgD will never be formed, because between M and D there is no recombination site. Isn't it sir?
I have a doubt 1) is the both variations occur simultaneously or one at a time 2) is this possible to convert or switch form antibody into another type?
Hi, first I really like your videos but I have 2Q: 1.Why does a class switch occure later in the course of an immune response? 2.When does clonal expansion not occur?
Idk how much this man gets paid but it should be at least the amount of an amazing doctor because he has saved my life multiple times
Don't worry, He earns more than a doctor, He is the best biology teacher in our West Bengal.
Agreed
One of the best since my childhood
i am a medical student myself,& i honestly owe u due to your crystal clear xplanations. your speed,the precision of concepts & the accuracy summed up with ur confident presentation is what makes this immunology concept amazing!
b4 my xams,it was a life saviour! so thank youuu
I'm just paying the University for degree, whereas you make me understand each and every concept clearly. Thank you sir. Lots of respect from Kolkata ☆
Thank you so much for appreciating my efforts. Stay tuned
I opened kuby book I was confused with how this switching taking place but within a mints I got the concept
Thnks sir for your precious vedios n hardworking✨👑
I admire n thank ful for u everytime I comes here to serch any topics ❤️💎
Thank you. All the best
Once again a brilliantly clear lecture making it easier to understand this complex subject, thank you so much!
+Dawn Horan glad it helped. All the very best
No one can explain in such a excellent way.. thanku
You're welcome
2 days away form my biology exam and you saved my life!! THANK YOU SIR!!
Sir you saved my semester really thankful to you ☺️
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thanks shomu after 7 years you are still #1
Thank you so much for appreciating my efforts
You are the Avenger for biology students ❤❤Thanks sir
You're welcome. Glad to hear that you're getting benefit from my lectures
Best biology channel on TH-cam
Thank you so much for appreciating my efforts
Literally you are very hardworking guy..one thing that I can learn from you is Consistency..Hats off to you..
Thank you so much for appreciating my efforts
thank you so much shomu your selfless action of spreading knowledge among the dummies. We are very gratefull to you and not to mention you are just awesome in terms of expression and are really an expert.
The best explanation of Antibody diversity
Thank you
This is what i was searching for ..
And free finally got from my best.....
Glad to hear that you are getting benefit from the videos
Just before my exam.. It was awesome. Love from Bangladesh
Thank you so much for appreciating my efforts
Great sir... Even in kuby it's hard to understand bt sir u made it more interesting.. Goona b very helpful in my coming exams..
Thank you. Glad you liked my lectures
I don't like immunology ..... but I try to understand it .Your explanation is nice and simple to helpe me alot ,,, Thank you
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Big thanks your sir❣️If i haven't seen this video I will never understand vdj recombination thanks legend of microbiology.
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Shomu sir aapki..ek..baat..bahut ..achha lgta h..yhi..ki..
That is about it...
Ha ha..
Really i like it...and hatts off u
you’re so good at explaining things, thank you for clarifying this, just wondering if you have a video on T cell receptor diversity?
You just saved me for my final exam mister.
Much appreciations 🙏🏻
Thank you
First comment
I m BS Biotechnology student of 4th semester
Explanation is oxm
I HV no words 💓
Love from Pakistan
sir i just started to see your video from this month. and i m loving the way u explain
Glad to hear that you are getting benefit from
this is the best detaied mechanism explanation I could found. thank youu
You're welcome. Glad to hear that you're getting benefit from my lectures
Shomu thank you so much, I'm studying Biochemistry, your explanation help me so much. Best regards from Mexico City 🙏✨🔬⚗️
Thank you for appreciating my efforts. Glad to hear that you are getting benefit from the videos
Sir ur videos are one of the most informative and easy to grasp on. But the only think u r lacking is your video setup, the lights ,the angle and editings. If you can improve this u ll get lots of view and subscribers from around the world.
Ur explanations are superb but I lost at 17:17 😅...but I got the main chunk of my topic ..thank u so much ..
You're welcome
My best teacher ❤️❤️
Thank you
Unbelievable explanation!!
Thank you. Glad you liked my lectures
Thankx alot you are the solution of my all study related problems again thankx alot alot of prayers for you
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This video was soo helpful, Thank you so much Sir.
You're welcome. Glad to hear that you're getting benefit from my lectures
You made it much easier! Thank you
U helped me a lot... and thank u so much sir... keep uploading ❣️
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Respect level up !!! After seeing this video.
Thank you. Glad you liked my lectures
Genius ...thnks alot from kashmir
u r the best sir👍
Thank you
How you teach soooo soo well. It just get straight into the mind. Thank you so much sir.☠🤍🤍
Thank you
my immunology teacher suggested me to watch thiz video:)...nd its amzaing sir...
You are the best. I have learned a lot from you
Glad to hear that you are getting benefit from the videos
May I ask something, Sir? How B cell creates IgD when Mu and delta segment always cleaved together? Thank you
My answer is probably a bit late and I can only guess but as far as I know when IgD is produced, IgM is also produced, seems like IgD definitely cannot be produced if IgM isn't since they sit in the same region. Also since the frequency of IgD is below 1% i think there must be a specific pathway that somehow overgoes the immunoglobulin becoming an IgM. I know this is not really an answer to your question, just my thoughts.
You didn’t listen carefully then.. there is a small chance of recombination between the blue dots. Then if it’s between M&D, there will be IgD. And if both are cleaved together only IgM will be produced which has the highest concentration by the way
Very well explained Sir! Thank you!....Stay blessed!
Thank you so much for appreciating my efforts
Why did it get so much more difficult in the last two minutes :(
exactly .. i also could not understand the VDJ part ...
@@sahelidas244 Same here brother .
Keep watching this part again and try to draw the same step by step. It's not that difficult.
@@viveksinghchauhan7496 *Sister*
Because he plagiarized it.
wow it's so clear now ,thank you
You're welcome
I'm watching the vedio in 2020 it's so easy to understand. Thank you
Thank you Sir this was very helpful👌
You're welcome
It was very well explained !! Thank u so much
You're welcome. Glad to hear that you're getting benefit from my lectures
thank you ~ you are
my teacher -from korea-
You're welcome
its a really smart learning... watched not almost all but huge no. is there.. nd all r great.. thnk u for this tutorial .. hope u will give notes on your google + or your website..
+Shukla Mahak thank you. Glad you liked my lectures
bhai korechen ki? apni tokhon 10k subscription e chhilen..... hats off
Thank you so much for appreciating my efforts
Very well explained sir😊
You're welcome
According to the blue dots you made on the board, IgD will never be made as it'll never be joint directly after variable region. Then How is IgD made?
IgD is expressed alongside IgM in immature B cells. So it is already there as a B cell receptor
I found this really helpful :) but I have a question: what makes the D and J regions ( and also the V and D regions) come together?
RAG(recombination activating genes) 1&2 are the protien complexes which are responsible to bring V&D...,D&J to come together..
Variable diversity joining
thank you sir, that was really healpful, i have difficulty to understand that TDT part , and how it cleave the unnecessary part of the gene
so so so briliant. thanks so much
You're welcome
It really helped.thank you😊
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Clearly explained Sir. Thank you very much.
You are the best
Thank you
You're welcome
As the title says it produces antibodies of different class but can you please clarify would they be of different subclasses as well?
Thanks a lot Brother ❤
You're welcome 😊
धन्यवाद 🙏🙏😍
Thank you. Glad you liked my lectures
@@shomusbiologyofficial mere class m net ka syllabus padaya jata h. . Achhe se samjh m nahi aata but aapka lecture attend krne k bad sbb smjh m aa jata h 😊😊😊☺☺
I have exam... this video helped me a lot.. thank you ☺️ sir
You're welcome
Thank you so much. ❤️❤️❤️❤️
You're welcome. Glad to hear that you're getting benefit from my lectures
Brilliant ❤️
Thank you
Plz get understand somatic hyoermutation and somatic recombination( vdj )..bcz I think both process are different but mostly it is mixed in all online videos..
Hai Sir.. I got with one doubt. What if a New Antibody needs to be produced from the Cleaved part of DNA during the previous Antibody production... How will the cleaved DNA part (of variable or Constant region) be used again for a new Antibody synthesis?
Brilliant!
Thank you
Love youuuuu! ❤
Thank you
Thank you sm!! Very clear
You're welcome
thanks a lot shomu....ur lectures have been helpfull to me olwz
Simply excellent........
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thankyou proff ❤
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Beautifully explained. Thank you!
You're welcome
Okay so just I make sure, when the plasma cell makes antibodies they all have same vdj sequence because they all are specific to one antigen right? But the type switching happens on the constant region.
I have a quick question. For the constant region recombination, there seems to be no recombination site between M and D. So how can IgD be expressed if it seemed to be masked by IgM. thanks
Nice one Sir...
You're welcome
dada, there is another topic called " GERM LINE DNA SEGMENT" in antibody diversity mechanism. Can you explain that?
Sir you said that hey will always recombine at those fixed positions. If thats the case IgD will never be formed, because between M and D there is no recombination site. Isn't it sir?
I have a doubt
1) is the both variations occur simultaneously or one at a time
2) is this possible to convert or switch form antibody into another type?
ur new surcriber from Pakistan,u did great job☺
thnxx fr making it..
+Benish Shah thank you. Glad you liked my lectures
☺
Sir,really amazing ...well defined !!...
You're welcome
thank you so much for this video
You're welcome
clear explanation sir
Sir u r the best ❤🙌
this video helped me a lot sir
Thanks a lot sir the video solved all my doubts and confusions
Hi, first I really like your videos but I have 2Q: 1.Why does a class switch occure later in the course of an immune response? 2.When does clonal expansion not occur?
Sir why tcr don't goes undergeo somatic mutations
This legend!!!!!!
Thank you
Is the last part explained have any detailed vedio
superb explanation sir...
It was really a nice video,it’s been beneficial to me,thank you so much please
You're welcome
Great sir..
Thanku so much ❤
You're welcome. Glad to hear that you are getting benefit from the videos
If the recombination is from blue dots between M&D, G, E, A then how is igD produced ? As there is no blue dot between M and D (please reply).
A Really good video.. Thanks a lot sir !
You're welcome
U r just awesome....😀😀😀
there is no recombinant site between g and d, so how does igd produce？
Very informative lecture, Thank you very much
i would have failed without this, thank you :'|
You're welcome. Glad to hear that you're getting benefit from my lectures
where can I find the link to the animation of VDJ recombination