Hi I am a Pathologist and I should say that that video is one of the best, clear and easy to learn video of somatic recombination I have ever seen. You must be so clear in your concepts to make something like this. Excellent work. Hats off to you.
Just used this video for a presentation at University of Rochester School of Medicine, it's awesome! We wanted to point out one minor error for the sake of clarity - the big antibody, drawn at 2:17, has the structure of an IgG (with 3 constant regions). Armando is correct in stating that it is an IgM antibody, so the drawing should show 4 constant regions (with THREE constant regions before the hinge region, and 1 after the hinge region). Thanks! My class and my professor loved it!
I’ve been studying biology Olympiad tests, and my ability to ignore and unwillingness to learn the immune system so far has bit me in the butt hard right about 30 mins ago. Thanks for the video from 11 yrs later.
Also, thanks, your explanation made this MUCH easier to understand...everyone said immunology would be a breeze after biochem and cns. I got a 400 page book to learn in 2.5 weeks.
Thanks, this is great. The only thing is for VJ recombination of the light chain (around 6:30) you leave the leader segment in the complete spliced segment that makes up the final light chain.
I like the way you present your explanation of the topic, so easy to follow, fast paced (in a good way) and succinct. Good job, man - I will be visiting here a lot more in prep for my mid-sem.
Thank you, this is the best explanation ever. You are saving lives with these videos, I don’t know what I’d do without your explanations, (my lecturers are hmm useless sorry to say).Thank you infinite times. I’ll pass it forward.
if i receive at least a B on my immuno test by watching youtube videos the night before, then i am going to completely lose faith in most bio professors. props on explaining fairly in depth material through simple and orderly depictions.
I'm not sure if you ment this but I guess after the dna recombination we still have a DNA which now is locked until class switch. After the recombined DNA is transkipted we get the RNA and splicing etc..
You don't describe RAG1/RAG2, recombination signal sequences, the "turns" (12/23 rule), or the addition of nucleotides after splicing. Those are really important to this process.
If this is an M antibody, should there be 4 constant regions without the hinge? I only see 3 constant regions in the final AB. I know this is a minor detail. BTW, amazing videos!! Clear and concise voice, talented artwork!!
this video literally saved my soul but i do have one question. since an igm antibody has 4 constant regions, and the big antibody drawn in 5:01 only has 3, is that an error? Also, why was the second C region colored in with red... does it not participate as a constant region subunit, and thats why there were only 3 drawn in the antibody?
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Hi I am a Pathologist and I should say that that video is one of the best, clear and easy to learn video of somatic recombination I have ever seen. You must be so clear in your concepts to make something like this. Excellent work. Hats off to you.
Felt the same +1000 thanks a lot
its not "somatic recombination" that is something else entirely. It is antibody recombination, of the antibody Fc structure
Just used this video for a presentation at University of Rochester School of Medicine, it's awesome!
We wanted to point out one minor error for the sake of clarity - the big antibody, drawn at 2:17, has the structure of an IgG (with 3 constant regions). Armando is correct in stating that it is an IgM antibody, so the drawing should show 4 constant regions (with THREE constant regions before the hinge region, and 1 after the hinge region).
Thanks! My class and my professor loved it!
I’ve been studying biology Olympiad tests, and my ability to ignore and unwillingness to learn the immune system so far has bit me in the butt hard right about 30 mins ago. Thanks for the video from 11 yrs later.
OMG....I don't have words to explain how beautifully you're explaining the whole stuffs...hats off..
1,5 hour lecture explained in 7min. Appreciate it man!
I'm glad I've found such a clear presentation. Thanks to you I have now a chance to pass the next exam !
Thank you so much for this video, I am a biomed student and I always found this topic so confusing
you saved my ass on med school immunology! thank you!
hi. im on med sch also. hows your med day ? nice to know you
Saving students since 2012. Armando Hasudungan.
3 years into my med lab science degree and Armando is still rescuing me!! Thanks for these excellent immunology videos.
This has been great thank you. My prof introduces all the terms in an alphabet soup-like lecture, and you put it all together and make it make sense
Also, thanks, your explanation made this MUCH easier to understand...everyone said immunology would be a breeze after biochem and cns. I got a 400 page book to learn in 2.5 weeks.
I will try to scan it one day, its a big piece of paper, so it needs orienting, cutting and editing. Will take a while.
thanks
Just wanna let u know that these videos are awesome and people like me are still using it and more students will keep using it forever
I love the fact that you use pictures and a flowchart. It's so difficult to just read it, some need to see it! Thank you from the visual learner.
I really hope you pass!
got my inmuno final on friday if i pass i'm posting u on every single univerity group i know!!! thak you so much!!
did you pass
@@andrewm2786 did you pass?
@@buqbooQ yeah I'm an emergency medicine resident now thanks
@@andrewm2786 that’s great super proud of you doc!!
Thanks, this is great. The only thing is for VJ recombination of the light chain (around 6:30) you leave the leader segment in the complete spliced segment that makes up the final light chain.
Hey man, try watching it on massive screen with quality setting on 720p. And the printed version, I will try to upload picture next week:)
The image is no longer there :(
May God bless you, for putting this complex stuff so simplistically.
o m g you have no idea how much this saved my life
I like the way you present your explanation of the topic, so easy to follow, fast paced (in a good way) and succinct. Good job, man - I will be visiting here a lot more in prep for my mid-sem.
Excellent ❤
I'm a master degree student of genetic from Iran and I say hello to you🖐
Omg this is just perfect... Just look at your drawing so clean and perfect 😀... I really want to make notes like this ❤️❤️❤️... Thanks for the video.
Thank you, this is the best explanation ever. You are saving lives with these videos, I don’t know what I’d do without your explanations, (my lecturers are hmm useless sorry to say).Thank you infinite times. I’ll pass it forward.
If I pass my immunology test it will solely be because of you!
This video and you are a masterpiece!! This was so helpful!! :) Thank you for taking the time out to educate the world!
A great video.. definitely had to rewind many times to understand some points. You talk alittle too fast for me 😂 but you saved my life
I wish you could teach all my science classes! So helpful!
Em, Armando te quiero. Mil gracias.
thank you so much! been trying to figure out this bit about Ab diversity for so long. thanks for making it simple!
Hard work. Good video and great content.
i passed!! got an 8 (out of 10) thanxs to you!!!!!! so very happy :) i shared you everywhere i know of lol
thanks for helping me understand this process easily!
Splendid and TO THE POINT Explanation...very useful for basics and quick revision...
hen 720p was the highest quality :) good old days
Need more people so spread this video more
yep, it's on his facebook page
You just blew my mind❤️
during light chain recombination, at the last stage after intron removal, the J segment is removed as well so only V and C remains in the end product.
Thank you so much sir very helpful 🙂❤️
Bless you this helped so much!
Video starts at 0:34
Overpriced med school education can be replaced by youtube videos. Thanks for making sense of this:)
thank you very clearly explained.
Your videos are really brilliant and helpful. Thanks !
th-cam.com/video/pTeK3avkbuo/w-d-xo.html
this guy is great. helped ridiculously
Really helpful...thank you sir
100x better than my lecture in grad. school
Omg this video was awesome!!!!!!
God bless you
Thank you
Amazing job thx 🥺
Love this guy 💚
That was quite useful! Thank you so much!
thank you so much for your effort...amazing
thank you so much
You are a hero!!
Thank you very clear explanation
This was amazing!!!!! Thank you so much!!!
Great video!! So Helpful
You're amazing! Thanks for the video!!
if i receive at least a B on my immuno test by watching youtube videos the night before, then i am going to completely lose faith in most bio professors. props on explaining fairly in depth material through simple and orderly depictions.
wonderful work i love it thank you
Thank you !!
I'm not sure if you ment this but I guess after the dna recombination we still have a DNA which now is locked until class switch. After the recombined DNA is transkipted we get the RNA and splicing etc..
Very helpful video!!
Thank you very much😊
You don't describe RAG1/RAG2, recombination signal sequences, the "turns" (12/23 rule), or the addition of nucleotides after splicing. Those are really important to this process.
thank you soo much. this is golden !!!
really helpful video.
amaaaaaziing, thank youu!!
Thank you SO much!
If this is an M antibody, should there be 4 constant regions without the hinge? I only see 3 constant regions in the final AB. I know this is a minor detail. BTW, amazing videos!! Clear and concise voice, talented artwork!!
This is so helpful! Thankyou
wonderful!! thanks so much
Hi,
This video is fantastic. Thank you!
Amazing
This is so perfect! Thank you!!!!
thank you so much
thank you. The video was really helpful!
Thank uu so much it helped me a lot
Thanks
this video literally saved my soul but i do have one question. since an igm antibody has 4 constant regions, and the big antibody drawn in 5:01 only has 3, is that an error? Also, why was the second C region colored in with red... does it not participate as a constant region subunit, and thats why there were only 3 drawn in the antibody?
Thank you sir.
very nice presented but you showed DJ rearrangement in DNA and VDJ in RNA.please explain
well done
Thank you so much!!!
awesome
incredible!!!! thank you!!!!!
Thank you!
It’s wrong to say somatic recombination occurs in B cells . It occurs in both b and T cells
can you give a lecture about corona virus
Thanks dude, you rock
Amazing !
perfect
THANKS.
great.thanks a lot
Very useful.