This Causes Type 2 Diabetes Not Just Glucose or Fats
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- เผยแพร่เมื่อ 21 ต.ค. 2024
- This Causes Type 2 Diabetes Not Just Glucose or Fats
Dr. Barbara E. Corkey was given Banting Award from the American Diabetes Association (ADA) for the groundbreaking work in her 2011 lecture entitled: Hyperinsulinemia: Cause or Consequence. Let's review.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Monday, Apr. 14 2023
Frederick Banting - Wikipedia
en.wikipedia.o...
Barbara Corkey | Chobanian & Avedisian School of Medicine
www.bumc.bu.ed...
Banting Lecture 2011 | Diabetes | American Diabetes Association
diabetesjourna...
Insulin Resistance & Prediabetes - NIDDK
www.niddk.nih....
Banting Lecture 2011 | Diabetes | American Diabetes Association
diabetesjourna...
Bariatric Surgery for Type 2 Diabetes Reversal: The Risks | Diabetes Care | American Diabetes Association
diabetesjourna...
Bariatric Surgery to Treat Type 2 Diabetes
my.clevelandcl...
Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report | Diabetes Care | American Diabetes Association
diabetesjourna...
International Experts Outline Diabetes Remission Diagnosis Criteria | ADA
diabetes.org/n...
Nutritional basis of type 2 diabetes remission | The BMJ
www.bmj.com/co...
Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin - PubMed
pubmed.ncbi.nl...
Case Report: Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin - PMC
www.ncbi.nlm.n...
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years - PubMed
pubmed.ncbi.nl...
HbA1c Calculator - HbA1c
www.hba1cnet.c...
Insights from a general practice service evaluation supporting a lower carbohydrate diet in patients with type 2 diabetes mellitus and prediabetes: a secondary analysis of routine clinic data including HbA1c, weight and prescribing over 6 years - PMC
www.ncbi.nlm.n...
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - PubMed
pubmed.ncbi.nl...
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial - CORE Reader
core.ac.uk/rea...
(19) Reversing Type 2 Diabetes | Jason Fung - TH-cam
• Reversing Type 2 Diabe...
NIH study finds heavily processed foods cause overeating and weight gain | National Institutes of Health (NIH)
www.nih.gov/ne...
Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine | The American Journal of Clinical Nutrition | Oxford Academic
academic.oup.c...
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism1,2 - ScienceDirect
www.sciencedir...
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Excellent presentation.
To me, this is one of the most important health-related topics that we can discuss.
Controlling insulin levels (preventing hyperinsulinemia) is the key to preventing all of the most common modern diseases -- heart disease, cancer, diabetes, etc.
*EDIT:*
I was intending to type more but it was time for me to go read some bed-time stories to my son.
There were two major highlights for me:
1) It is mostly common knowledge that consuming carbohydrates (glucose/fructose) will elevate insulin levels,
but it also seems to be true that *non-glucose factors can also trigger insulin production:*
➖ Artificial sweeteners
➖ Iron consumption
➖ Reactive oxygen species
2) Mitochondrial damage (via ROS) can contribute to diabetes
Here is the paragraph that stood out to me:
_"Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. In high amounts ROS cause damage known as oxidative stress. However, ROS form as a natural byproduct of metabolism, and modest ROS production has important roles in cell signaling. Conditions that increase redox, as we found with stimulatory glucose and MOG, can lead to production of modest amounts of ROS in mitochondria. Thus, redox and ROS are candidate signals for basal insulin secretion, and we asked whether the putative signal was essential or sufficient."_
So, we see that mitochondria can be exposed to oxidative stress.
Sources include: carb consumption (glucose), ROS, MOG, etc.
This oxidative stress can damage mitochondrial function and contribute to type 2 diabetes.
"_impaired mitochondrial function is a cause of insulin insensitivity in myocytes and adipocytes as a result of insufficient supply of energy or defects in the insulin signaling pathway._
_...inhibition of respiration and oxidative phosphorylation by respiratory inhibitors or knockdown of genes involved in mitochondrial biogenesis can impair the differentiation of preadipocytes and response of adipocytes to insulin._
_...defective mitochondria also cause a decrease in adiponectin secretion that leads to decline glucose utilization of other tissues._
_...Taken together, we suggest that mitochondrial dysfunction plays a role in the pathophysiology of insulin insensitivity._
*Source:*
_Mitochondrial dysfunction in insulin insensitivity: implication of mitochondrial role in type 2 diabetes_
_Chih-Hao Wang, Ching-Chu Wang, Yau-Huei Wei_
In other words, it isn't just elevated insulin that contributes to diabetes;
Damaging mitochondria also contributes to diabetes.
We've got to seriously cut down on our carbohydrate intake.
And we need to cut out processed foods since they contain artificial sweeteners and ROS.
It's making more and more sense to my why ketogenic diets -- diets that heavily restrict carbohydrate consumption are so effective at treating type II diabetes.
Well said. Agreed.
Excellent discussion. This model has been known for many years. It is the basis for strategies that reverse T2DM. DrJason Fung described this in his a few years ago.
Lovely. Thank you. I think you’d enjoy having a chat with Harry Serpanos. He focuses on carnivore diet and mitochondrial health.
Keto diets are known to create insulin insensitivity even when it was not there before - as exposed by glucose tolerance tests. More or less transient. Just the effect of high glucose disappears in absence of glucose - which is trivial. When heavy in animal foods and extracted fats, as usual, keto causes inflammation. (Partial healing effects are bound to weight loss when achieved.)
On the other hand carb rich diets with oats or other whole grains, mainly plant based have great success reversing T2D. They do that all the time at PCRM e.g., even low fat.
Sports folkes consume lots of sugar. E.g. hundreds of grams during a road cycling race. But the body sucks it up an burns it, no T2D.
That makes carbs (as it) unlikely as cause. But special causes of inflammation (inc. over-weight and odd substances in food) and lack of anti-oxidants.
Fructose has no impact on insulin first and foremost. Type 2 diabetes is elevated blood sugar nothing else which is due to a chronic activation of the randle cycle... Go and learn about the randle cycle... Very interesting stuff!!!
It is time to put some light on this epidemic of insulin resistance. Thank you again Dr Been for the outstanding work you are doing
My pleasure.
Thanks as always Doc. You are generous with your time and thorough in your presentations.
My pleasure.
Processed salad dressings are a major source of emulsifiers.
Hmm I never thought of the impact of emulsifiers.
Salt, pepper, appelcider vinegar or lemon, kefir and ol will make nice dressings. You can add onions apples or spices as you want. Don't buy the industrial crab.
True plus soybean +/or canola oils, neither is good.
Miso makes tasty dressing.
Hence I never buy it.. we make our own in Southern Europe
@@vitalybroshchak4512 I don't live in the States. I don't eat fast food. It is not food tome
Just "WOW!"
Thanks again, DrBeen!
Thanks very much. Learned more today.
This is a researcher worth tracking long-term. How refreshing to see someone thinking outside the box and really evaluating accepted concepts and practices. I hope she is not closeted by big pharma. Keep up the good work Dr Been, in sharing and explaining everything! You are the best!
Thank you for these beginning lectures about diabetes. Since having long COVID I have had to strictly modify my diet as I started plummeting toward type 2 Diabetes. I have tried nutrition classes given by our hospital ( shockingly useless), the Plate Method ( useless), keto ( which did help begin to lower A1C), now, nearly a carnivore doing rotating intermittent fasting. Still, after 18 months (!) cannot get A1C below 6.1.... Your lectures are helping me understand the mechanics driving my insulin resistance and give me further strategies to refine my quest to lose weight as I have YET to lose any weight, therefore prolonging my situation. Thank you so much, I refer you to all my friends and doctors . God bless!
Thank you. Happy that some more strategies will be possible. Praying that you recover soon.
What about NAC mentioned at the beginning
Hi, I recently lowered my A1C by going plant based, reducing processed foods, saturated fats and coffee. Coffee can cause your body to raise cortisol levels and cause insulin resistance. In less than a year I went from 6.0 to 5.5. Going plant based will help you lose weight as well. I hope that helps ❤
I had that problem due to stress and PTSD. After watching Dr Been talk about berberine I decided to try it. It has had the most significant impact on
My life of any supplement I’ve ever taken. After 10 days no more cravings. Then I watched Glucose Goddess and started doing savory breakfasts and apple cider vinegar. Then I added intermittent fasting. I became much happier and less stressed and more focused. Now the weight just comes off effortlessly. It’s amazing. I can’t wait to see what my A1c is next time. I take 500 mg of regular berberine 3x a day. Try it.
I listened to this video three times. Each time I’ve learned more. Thank you for discussing it
You are welcome.
Always appreciate your gifts.
Imagine my surprise to sit down and watch this video as I ate an organic salad with extra virgin cold pressed olive oil and balsamic vinegar as dressing. Along with the salad I had a mushroom and cheese omelette made with home raised free range chickens. The omelette was topped with plain Greek yogurt and avocado.
After watching this talk you should have had double the enjoyment from your healthy food!
Excellent talk. It elevates the awareness that as we have more processed foods we are condemning ourselves to health problems. We may not understand all the mechanisms yet by which these detrimental effects take hold but we have enough evidence to aim for avoidance. Of course the ‘food industry’ when they become more exposed will fight against the evidence and probably suggest a solution which involves another additive to food to negate the damage caused by the original additives. I can see it now!
Lucky you, poor people don’t have so much of a choice in healthy eating, count yourself lucky and privileged
@@Buddhavibez if you knew the poverty my family came from you wouldn't make such a comment. I am blessed to be able to afford good food, it didn't come from luck.
@@davidcoalkey6074Excellent! Don't let anyone make you feel bad for your ability to purchase good quality food.
I am going to confess one thing: I must have had brain damages from a bunch of things like bad diet, lack of exercises (lately), vaccines( took everything available, for all diseases, not only covid), lack of sleep, stress, etc. I am feeling so overwhelmed with so much information that is piling up with all I have already to deal with in my everyday life (personal, family and professional issues) that I am feeling lazy, really lazy, dreaming with more direct and simple information like “dos and don’t dos”. A list, a simple and safe list. Last semester I’ve started a keto diet, but had to introduce a bit of carbs due to keto flue. Stopped the intake of sugar, breads and pastas, Diet Coke and my dearest chocolate. But than Christmas came. I am still struggling to cut it all again. Fasting 17 hours is easy, but other than that, it has been very difficult. And I feel just so lazy to try to understand these papers…🤦🏻♀️… I just heard of methylene blue. It might help. 😐 But thank you, professor. I am a new subscriber!
im no fan of keto i have learned a lot about dairy products i can not eat any of them anymore i have something like this but i wee calcium can not absorb any do not have parathyroid glands absorb vitamin d i just eat a little meal keep of processed food read labels or i can have hypocalcemia which can be serious to life very bad condition low levels of vitamin d and calcium
Carnivore is the historic solution for all of mankind
Great lecture . Please do more on the causes of diabetes , and what we can do to reverse diabetes and, high insulin level.
Will do!
Yes, especially since it is curable with diet change. I had type 2 diabetes. Now, my AIC levels are low without any medicines. Just changed diet - not too greatly and it worked. This is one disease causer that could be lessened with education. But, convincing a younger, thinner person to be careful is very difficult.
This is a silly thought but we need fewer work out gyms and more sugar reducing centers.
@@danmichael7335 , how long did it take for you to change your diet? Have your hemoglobin A1c be doable? What is a current? Mine HBA1c is 5.6% . My blood sugars have been going down as a bit losing weight and exercising. I expect it will be even lower in three months.
@@danmichael7335interested in diet change you made. My mom is not fat, pretty active but struggling with high blood sugar.
@@DrBeenMedicalLecturesI would appreciate if you include or explain all aspects of type 2 diabetes because not everybody is obese and have a sedentary lifestyle.
Thanks a lot from Brazil. Very important and necessary topic.
You are welcome!
Great concept for doctors and scientists, for a general T2D patient like me only learned sacarine and preservatives are agents of ROS.
Please make another discussion with tips on what are generally available tests and ways of choosing food to manage ROS.
Very well done. Will watch again because it is very new-information dense. I am sorry I did not learn of this years ago!
Thank you for learning these concepts.
What a brilliant explanation of this wonderful paper Mobeen, as I said earlier it enlights me why the ROS can be responsible for the entire process of inducing Hyperinsuliminia 🙏
Thank you 🙏
Very necessary information indeed! Eye-opening!
Thank you Dr. Barbara E. Corkey,
Thank you Drbeen!
Thank you for this. Without your video I never would have become aware of this study. It makes so much sense, more so than the on-going traditional models.
You are welcome.
Excellent! Clear information, helping us understand why processed foods are categorically troublesome.
Thank you!
Imagine having a plant based diet, not from whole foods but from things like beyond burgers, beyond sausage, soy based "egg" powder, pea protein shakes, muffins, cookies, breads, protein bars etc etc. All these foods products appeal to people wanting to eat healthy but many "products" are full of additives and processed
Great drawings,marvelous presentation of a groundbreaking paper about the major health crisis the world faces today. Thank you for taking the time. I remember you presenting the classical diabetes model a short time ago, underlying your statement that we all have things to learn from this paper. There was a misstatement at 30:55, where the paper showed an effect at 25 micro moles per liter, one thousand times less than the 25 mili moles per liter that at least I heard. Only mentioning this to emphasize the massive effect described and to assist your yearning toward being correct in all things. Thanks, Mobeen.
Post Script thought. This work can have a tremendous, positive impact on mental health, as too many people think their body is defective in the beta cell area and they they are failing and getting diabetes due to lack of will power. Changing the medical model can provide resolution of diabetes, as well as putting the lie to these incorrect, destructive thoughts.
Thank you for the important correction.
Yes, this model offers much more hope and control to the patient. And, everyone in general.
Thanks for the video 😊 The insulin level can also be influenced by problems with the cervical spine. Because the nucleus tractus solitary is located in the gray matter of our brain, and this also controls insulin production and can be severely affected by the atlas vortex. Here the insulin can rise or fall. In the end, a diabetes is diagnosed that is not real because the patient also feels symptoms. This was the case for me, since I've been doing sport for my cervical spine, all the symptoms have gone and the insulin level is completely normal again.
Where can I find more info on this? My cervical spine bothers me so much and I carry a great deal of muscle tension in my neck to upper shoulder area. And... I have type 2 diabetes.
@@Je-Lia Sounds like my problems. I got all problems from long sitting at work (nerd neck), wrong sports and temporary less sport. Google „The Role of the Vagal Nucleus Tractus Solitarius in the Therapeutic Effects of Obesity Surgery and Other Interventional Therapies on Type 2 Diabetes“ I can’t post links
@@Je-Lia if you invest some time you find more about this on Google, don’t let you distract by stupid doctors, if you have so much tension in this area the nerves get stressed and can’t do their work as they should. As you could imagine, if that happens over a long time, many organs and body functions don’t work as they should. This area can have so much more effects on your body, heart beat, blood pressure and breath can be effected if your atlas is not correct and irritate the nerves coming out of your brain that should control functions and organs.
@@Je-Lia I had circulatory problems, shortness of breath and cardiac arrhythmia, as well as severe glucose intolerance shortly before diabetes. Since my neck is ok again, my body has completely recovered in a few months. all symptoms are gone.
@@Je-Lia The first thing to check is posture-the balance of the front and back muscles of the upper body. if there is an imbalance due to sitting for a long time or training incorrectly, this will stress the opposing muscles. this leads to hardening and shortening. so balancing movement like yoga or something similar is very helpful. bad posture can be recognized by hunched shoulders, e.g. by shortened or too strong chest muscles compared to the upper back. the shoulder girdle works against it all day long and at some point it can't anymore.
Fascinating discussion as always Dr Mobeen. Many thanks!
My pleasure.
9:00min processed food, prepared food, pre-packaged food
Intermittent fasting, bariatic surgery
My personal experience causes me to suspect that it is mainly concintrated vegetable fat. I am talking of fat that is in normal doses is ok but if the oil is seperated from the vegetables like when it is made into forms like margerine. These are the things that cause insulin to become a problem because the body reacts. I say thins because at a very early age I suddenly lost taste for sugar. I am talking of hot drinks like coffee, suddenly I had to cease having sugar in my coffee, just lost the taste for it. My body had rejected sugar, it was having a reaction. I never developed diabeties 2 because of stopping the sugar at around 15 years of age although I was very active, extremely so. I am 67 now but have always put on belly fat very easily. I am convinced this is from my body getting easy sugar sources from foods and back when I was a teenager soon after my mother started giving us margerine instead of butter that is when the reaction first started. I remember this disctinctly but only now am able to link it to those things that cause it.
BRILLIANT!!! THANK YOU.
Pleasure.
Very interesting and important information
Agreed
Electro-magnetic pollution may be contributing to ROS. I personally am addressing this angle as well as OMAD to keep insulin level low.
Excellent video and review. Thank you. I share your channel name where I can. Maybe Google/YT will allow video and other links in comments again one day?
Drbeen, do you think that insulin may have a protective effect initially against the inflammation created by these foods and the ROS?
Any chance of a summary at the beginning please, as my time is very limited ❤
*You Did Not Choose To Be Classified As Diabetic, But You Can Choose To Fight Back Against Diabetes* 💪
Excellent lecture.Thank you so much.
Pleasure
Thank you so much Dr Been...
I love you Dr. Been! 🌹
Excellent presentation....Great explanation...Thanks Doc...
Most welcome!
Thank you.
You're welcome!
Trans fat is another reason too . Thanks doc 🙏
Pleasure
Thank you Dr Been!!
Welcome
Thank you for your fantastic videos.
I'd love to see you talk to Dr David Unwin and professor Ben Bikman about this subject.
I will reach out to them.
Imaging Dr. Been and Mr. Bikman reviewing a paper on hyperinsulinemia... 🤯
Thanks Bean :)
Pleasure
Just a great lecture.
Thank you
I like her new model. My understanding is that various organs in the body can become insulin resistance. Those Cells probably change the expression of the Glucose Transport Machinery. There are fewer Doors on the Cell Walls for Glucose to go thru. From a Control Perspective this make sense. So, type 2 diabetics have fewer insulin activated glucose transport door into their cells.
ChatGPT says GlyNAC and Vitamin C actually work together.
Good summary.
thank you so much
Welcome
Thank you
So...there is the new invisible coating "Apeel" on fruits and vegetables organics and others."Apeel" is mono- and diglycerides contain trans- fat,with promotes inflammation. There are other ingredients coming from the process of making the coating. In the light of the lecture, we have now a really bad new player on the market, not limited to US .
When you say glycerols, do you also mean dietary glycerine (e.g. vegetable glycerine used in some keto foods, and recommended to add to olive oil by my mum's dietitian)?
Seems to me, listening to the first quarter of video, that what you're saying is that we need to get back to the basics so to speak. We should be eating fresh foods that is, start growing and raising our own foods, harvest it and either can or freeze it for our later use. At least one of those things. Additionally, folks need to do more physical activity...physical labor. Nothing new, been saying it for years but not many will listen. Food processing and packaging needs to change. Gluttony is a problem as well. To much of a good thing makes it a bad thing...we can over do and under do and neither is a good thing. We need to get back to the natural foods, i.e., no processed and eliminate all these unneed additives in our foods.
Gluttony is often just a carbohydrate addiction. The body craves carbs like a drug.
It's been said that the process of sugar produces small amounts of alcohol as part of digestion..let's look carefully at that point. How much do diabetics make and what else processes breakdown of foods? Does insulin stop that at any measure? It's ( alcohol) against some ideas due the high sugar content. However the process as is cuts sugars and dissolves them for liquidity. It does aid digestion in another sense. The alcohol does contain cooling also. That in turn reacts to body heat or something about the mechanism . So I'd love to see the outcome of findings for the use and lack of . See the recent past says that vitamin K2 or D3 decreased as it's used or needed too much during virus . What can we learn about it if we didn't stay on the opposite findings to see more?
Be specific about fats!!!! Animal fats are the way out of the problem, not the problem.
Reactive Oxygen Species
Is this not what we call Free Radicals?
Yes
Try to find original German non wheat or corn bread. Usually there is no sugar and oil in it.
You can freeze it in portions.
Wheat bread will make less insulin spikes if you freeze it .
Except that in America it contains glyphosate
I just ate a banana in North America. How many bananas would I have eaten here in 1800? I suspect none.
Does sunlight UVB production of ROS also contribute to elevated insulin levels?
If it goes to pancreas then yes. I doubt it though.
I thought it sounded like to much vit d supplements may cause elevated insulin?
There is a recent abstract study that says vit d lowered the risk of diabetes.
I haven't got a clue why my previous comment isn't liked by either Dr Been or TH-cam.
Science Direct. Available online 14 April 2023, 121603
Particulate air pollution exaggerates diet-induced insulin resistance through NLRP3 inflammasome in mice.
Discussion
"Exposure to ambient PM2.5, even at levels deemed acceptable, has been associated with diabetes and insulin resistance in both humans and animals in the past few decades (Sun et al., 2009; Zhang et al., 2021; Eze et al., 2015; Bowe et al., 2018). As a leading environmental risk factor, the contribution of PM2.5 to the global health burden including metabolic diseases is rapidly rising (Collaborators, 2020)".
"Even at levels deemed acceptable" means in places that pollution isn't really really bad.
@@DrBeenMedicalLectures
@@DrBeenMedicalLectures You mentioned previously in the discussion of near infrared vs UVB that UVB may actually play a role in fighting infections. Does the UVB produced ROS in the skin only remain in the skin cells or does it also get transported via the blood throughout the body? I have an obese patient who has had normal glucose and A1c for the longest time, but only now has normal fasting glucose, but A1c of 5.9 along with fasting insulin of 84 and CRP of 7.0. Although she likely has elevated insulin levels due to the now evident A1c of 5.9, I am wondering if her insulin resistance is originating from multiple sources. If UVB is playing some role, I am wondering if I need to stress again balancing that out with near infrared sunlight exposure.
What about Tulsi tea viewed in this new paradigm? Does it increase insulin to decrease blood sugar (most of articles say this) or is it doing something else? If it triggers insulin release, then it would not be a good choice. I can't handle caffeine, so looking for alternatives to green tea Fung mentions. Thanks.
How about lecitin?
Ive been unable to get a straight answer on why diabetes goes into rapid remission after roux-en-y surgery. One italian surgeon speculated that it has to do with the piece of intestine that is removed and that it is responsible for certain specific anti intregrins. So if correct it could imply an over secretion that is putting the integrin - antiintegrin loop out of balance. However, this is an 8 year old theory and perhaps we know more now?
Please clarify the supplement monolaurin...I thought that was immune supportive, including anti viral ( lipid enveloped virus), helpful in lyme disease and H pylori. Is this the same substance you speak about early in this video?
Sir, 😊🙏😊
I have questions ⁉️
* Reactive oxygen species, free fatty acids are required more energy... And that's the main reason insulin are triggered... This is correct sir?
* Process food, long preservative may be also required more energy can it causes insulin production?
* Continuously consumption of this type of product it's courses continuously production of insulin and cells are filled with high glucose...body reached their hyperglycemia level and start immune response against beta cells?
2) sir very very important questions please note this it's make to solve diabetes problem
Question is, irone ( and same other minirals) case to insulin level high but vit c is required to irone metabolism is case reduce reactive oxygen species or reduce insulin level ...sir if irone is high and body start high insulin response then this actual problem is vitamin deficiency, sir is this correct scientifically and if this correct 💯 %
Than we found final conclusion
Diabetes is come from imbalance vitamin deficiency....
Not proper exercise
And not properly daily detoxification of body.
All this are important...
Because we consume process food, carbohydrate, fatty food.. they all wants high energy and this energy required every time differently...this energy graph some time is high or same time low. Energy use as per body requiredment and this depends on person's behaviour, their life style, food consumption,etc..we are not manually give drugs to maintain body's homeostasis (normal regular metabolic condition) levels.
If we give drugs and this perticular time body not required this (for example high ammount of process food or fatty food consume from patients and body wants very high energy to digest them and if we suppress this activity with help of drug...it courses reversely and body inhibit drugs ) body metabolic cycle is disturbed.....
In this condition body use vitamin and mineral as per their requirement..and maintain body's (homeostasis) normal regular metabolic condition ...
Sir I really like your videos, and is use full....thank you sir❤❤❤😊🙏😊
Should we be concerned with emulsifiers in skincare?
No.
Well those products must cause hypoglycemia then, right?
Fasting may be a simple benefit, a day or two a week , maybe learn to make your own sauces that need a whipping use a hand blender.🙂 Great video again
Maybe forcing water and oil together in a food product is just a bad idea to Begin with. 🤔
Adding the result of aerosol was thought pressure from the use of and breakdown of alcohol as I recall. The same deters fungi, mold, or yeasts . Why would that imbalance be critical after the point ? It's plausible theory . Yes common in high amounts could be food . But the other is the result of fresh foods compared . Since it was said Japan did they study of alcohol related or reversing possible meds, for drunk driving thought, why not utilize information if the one making it will allow the base education they learned ? We have much pushed toward the base points without whole issue . So, while I know alcohol can give a runny aspect, it's worth looking into for digestive aid and cell altering affects . Let's hope better understanding comes with the idea
Thank you for all this clearly presented information! I have been suffering from long covid and have only just discovered high does thiamine that has done wonders in a short amount of time. I'm curious to see if we can use substances like thiamine to protect ourselves from the oxidative stress. I know NAC is mentioned but it is not a magic bullet and finding the right dosage is hard at times. I have a relative who can't take it at all.
Also does this maybe change some of your thoughts on using berberine?
So monolaurin raises insulin levels? Did not know this. I thought it was good for immunity, which is what it says, but now this complication.
I must have a great pancreas. I've eaten so much sugar in my life that I wonder why I'm as healthy as I am. My body at 75 and soon to experience another birthday GOD willing doesn't do well in the cold weather conditions. Just can't seem to get warm. My (feeling well) body temperature is 97.7° but I always seem to feel cold. I feel cold at 70°. Should I take niacin for the warm all over feeling?
I don't understand 1 thing not all diabetic is obese and have a sedentary lifestyle. But most of the study's are made looking to obese people.
Dr Been, can children take NAC?
So we need iron and calcium...
Diabetes is caused by overcoming your personal fat threshold. Inflammatory mediators are released from overfilled fat cells which down stream cause liver and muscle insulin resistance. The pancreas responds with more insulin production as glucose piles up in the blood stream. Hyperinsulinemia is an effect not a cause.
There is DEFINITELY individual (and ancestral?) variability in fat threshold... over-abundance of any food group is likely to trigger the pancreas to release more insulin... it would just make sense from the body's perspective (store those nutrients).
Here in the US my kid's pediatrician insisted I gave iron supplements to my children for years and I declined. So all these children whose parents followed doctors orders might have been harmed. The medical system is a mess.
Same with melatonin for sleep. Do not medicate your children, just feed them non processed foods!!!
Thank you for this, a couple of questions. 1) How can the rapid “reversal” of type ii after bariatric surgery be explained, and is there something extraordinary about this compared to say, fasting? 2) Fe is implicated as a possible factor x, could this be the nature of the synthetic addition, or could it be that some people can’t methylate folate?
Fasting is the closest alternative to bariatric surgery. In both the interventions the curative mechanism is the drop in the insulin levels due to the lack of carbs and insulin triggering foods.
Iron generates ROS through fenton reaction. www.ncbi.nlm.nih.gov/pmc/articles/PMC3967355/
@@DrBeenMedicalLectures What about keto? Fat doesn't rise insulin too much. Could it be effective in normalising insulin levels? Keto is definitely easier to implement and has less side effects than fasting.
@@galladiel Depends on the amount of carbs you eat. Generally, restricting your carbs to less than 20 total grams per day will result in rapid reduction in insulin levels.
But some people still eat too many artificial sweeteners, and "keto" snacks that keep their insulin high.
Best bet is to do the zero-carb version of keto called "carnivore."
For me, fasting for 48 hrs does help reset the body. I haven’t tried fasting longer though. I generally do IF with OMAD, with breaks on the wknd. I do cook from scratch, rarely purchase pre prepared meals, I do try to prepare meals & freeze to make life easier (like making 3 meatloaf at one time, freezing 2). You don’t have to make a ton at one time, a couple extra every time you can really adds up.
@@chanchan5349 I regularly fast too, and (as far I know) have no problem controlling my insulin levels. What really astounded me about this talk was how quickly people recover from type ii after bariatric surgery - well before they lost weight. I was wondering if this had something to do with Ghrelin… this is why I asked the good doctor here. Furthermore, I question whether type ii can really be classified as a condition if it is indeed this easy and swiftly resolved. However, I’m guessing this swift recovery is only true for some people.
If you freeze bread it will lower the glycemic index. Sourdough has a lower glycemic index because it is made with a fermentation technique in the starter. It then should follow that if you freeze sourdough you will have a lower glycemic index. than frozen white bread for instance.
Toasting the frozen sourdough reduces GI too. Make sure it's real sourdough, check ingredients.
Carnivore diet or Keto and fasting works to correct DM2 for me
Anything which is pro-inflammatory and/or produces ROS can cause hyperinsulinemia, leading to insulin resistance, obesity , diabetes.
Excessive ROS levels causes increased insulin secretion, or fat formation.
Not clear about how people would not have been suffering low blood sugars if this theory were true. If secreting too much insulin, we would have hypoglycemia, and get fat as well. Or, perhaps if we ate high carbs, it would not have been noticed, in which case it was the right amount of insulin, wasn't it?
Sea water for diabetis.
Thank you for shedding kight! I wonder if the aluminium content (GRAS) which is a prevalent anticaking agent ( as well as sun screen, lotions, deodorants/antiperspiants, vaccines, pikls ( esp. buffered pharmceuticals are a trigger. There is no known biologic function or requiremebt for aluminium ( which is ALWAYS bound to silica in nature) hmmm.
Hmm thanks for that. Need to check that my silica supplement has been screened for aluminium...
It all seems pretty obvious. I think if a person thinks all this is not obvious has some issues in education.
It seems to me that technologies such as GMO wheat, preservatives, and plastic packaging, have saved millions of people from death by starvation and food poisoning from rotting food. So some people have problems. BUT THEY ARE ALIVE. Seems like a good trade to me. Hard to defend purely cosmetic things like food coloring though.
You have a good point. I think we can become more aware and careful for our health.
We do not need GMO wheat, we need more nutrition in foods. Eat less but more nutritious, in other words.
There was a famous story where US wheat was offered to African nations but they actually refused it, saying that it fills your belly with EMPTY nutrition. (if I find the link, I'll share)
GMO crops are also monocultivars, we are better off with more biodiversity, both for the environment and our own health. Putting our faith in one type of wheat (or soybean) for instance, is risky as if that species fails (pest etc), then we are in trouble. Different species mean less risk.
Moreover, GMO crops are sprayed with RoundUp and Glyphosate (originally approved as an antibiotic), which affects our microbiome and is implicated in cancers, immune issues and also ruining farmers' finances in poorer countries (e.g. India but not only). Many Indian farmers committed suicide after the GMO cotton they invested on kept failing year after year and they became so indebted to BigChem that they had to way out
GM farmers are forced to buy seeds from the BigChem companies every year and cannot save seeds from previous years as was traditionally done. Moreover, they are forced to buy glyphosate to get the seeds to germinate (more income for BigChem and more diseases for us). In first world countries, these crops damage organic farming and pollute our water table anyway (no matter what the claims of "biodegradable in the soil" stated on the label in our country).
If you want scientific info on the damage of glyphosate (which goes with GMO crops but is also used separately), please see Dr Seneff's excellent research on this.
@@pilatesfitness8766 People who are starving to death in poorer parts of the world need whatever is the lowest cost food that will keep them alive. General health to them is a luxury.
What makes you think those poor starving populations actually have money to spend on roundup or glyphosate or any other modern pesticides?
GMO wheat, especially those that are pest resistant without the need for additional chemicals, has its uses. Though perhaps not many uses to the developed world other than ethanol fuel production. And for that use I couldn't care less about glyphosate.
I wish people would stop peddling a black and white agendas and consider the cost/benefit of uses for technology. Nothing is 100% bad. Some uses are reasonable, some are not.
Huge
Inflammation...another EMF mechanism
💜
Cutting the stomach down to 10-15% sounds good except that then the person has to take a bunch of vitamins and minerals for the rest of their life which is something I wouldn’t be able to afford.
Vegetable Oil!
Factor X is trpv1 in the intestines that stimulate glucagon Ike peptide-1 (glp-1). glp-1 goes to the beta cell and causes insulin secretion.
I took oxcarbazepine that upregulates trpv1 and Trpv4 and took two 5 hour glucose tolerance tests (GRT). Each test showed 82 or so resting glucose, at 2 hours glucose high was 129 or 140. At hour 5 hypoglycemia of 46 and 52. The hypoglycemia worsened following the 5th hour. I stopped oxcarbazepine and 1 month later had a third GTT: resting fasting glucose 72, 2 hour glucose 223, no hypoglycemia followed.
I git insulin resistance from oxcarbazepine’s upregulation of TRPV1.
I now wear a continuous glucose monitor and my beta cell function has not recovered. I have been on a low carb diet since 2021. I do intermittent fasting.
TRPV1 also causes pancreatitis and colitis.
of trpv4 causes insulin secretion also and prolonged stimulation causes pancreatic beta cell dysfunction and cell death. Trpv4 causes cell death by ferroptosis.
Trpv4 is an oncogene for colorectal cancer and ovarian cancer.
TRPV1 stimulates antidiuretic hormone (adh) that causes water retention and is a natriuretic causing sodium loss. This leads to hypoosmolality and triggers trpv4.
Trpv4 on monocytes causes them to become M1 macrophages that release reactive oxygen species (ROS) ! and cayses the macrophages to become phagocytic and phagocytize oxidized LDL becoming foamy macrophages. Trpv4 also causes the break in the endothelial monolayer of the coronary arteries.
TRPV1 forces glucose into skeletal muscle cells independent of insulin and its receptor. The glucose is oxidized and then mitochondria make ROS in excess of its antioxidant capacity. This makes the cell insulin resistant.
Your engine will run well if u put good gasoline inside the tank. Forget water or burned french fries oil.
Isn't glucose an essential stuff for cell metabolism so that even if your diet contains zero glucose, like that of inuits, your body will make it anyways?
Most cells can metabolize fat (ketone bodies) instead of sugar. Some cell types, such as red blood cells or the retina, have no mitochondria and need sugar, which the liver produces on demand from protein (gluconeogenesis). There is therefore no reason to consume carbohydrates through food.
@@foghather nailed it. I'd add it's near impossible to not take in some carbohydrates no matter how hard you try.
Quit giving FALSE information! The retina has many cells with mitochondria!
Hmm…. Time to grow and buy locally grown Whole (real) foods)‼️
just eat meat
Go Vegan 🔉
that is still processed food
Thanks!
Thank you
Thank you 🙏
Pleasure