3D Printed Bioreactors Enable Cell Growth | The Cool Parts Show Ep. 70
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- เผยแพร่เมื่อ 13 มิ.ย. 2024
- The Southwest Reasearch Institute is using 3D printing to more efficiently grow billions of cells! By 3D printing bioreactor scaffolds, they are able to create unique geometries with larger surface areas leading to more cell growth. One drawback to this method is that it generates extremely large file sizes. Implicit modeling offers a potential solution.
One of the next frontiers in medicine is to treat diseases not through chemistry but through biology, using cells engineered to fight the disease. But it takes a lot of cells to accomplish this, and therefore a lot of surface area for the cells to grow on. Industrializing bioengineering demands space-efficient means to cultivate cells, entailing a surface-area challenge even greater than, say, the surface-area needs of improved heat exchangers. One organization at the forefront of this work is the Southwest Research Institute, which has developed a bioreactor employing a geometrically complex cell-growth scaffold only possible through 3D printing. The geometry is so complex, the computer processing challenges of modeling the digital file pose an obstacle to scaling up the cell-growth hardware. A segment of this episode with Metafold discusses implicit modeling as a potential alternative for mathematically defining the most complex 3D printed geometries.
This episode of The Cool Parts Show brought to you by Carpenter Additive. www.carpenteradditive.com/
FOR ALL ACCESS MEMBERS: Metafold CEO Elissa Ross goes on to describe another promising win that will come from more effective modeling of geometrically complex 3D printed forms: metamaterials. To what extent can material “properties” come from geometry rather than the material itself?The Cool Parts Show All Access is a free subscription for fans of the show. Sign up and watch this month's exclusive Extra here: www.additivemanufacturing.med...
LEARN MORE ABOUT:
The Southwest Research Institute
www.swri.org/
Implicit Modeling
www.additivemanufacturing.med...
Metafold
www.metafold3d.com/
Geometrically complex heat exchanger made through 3D printing
• 3D Printed Heat Exchan...
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00:00 3D Printing for Bioreactors and Regenerative Medicine
00:52 Bioreactor Scaffolds for Growing Stem Cells
01:57 How Growing Cells Works and What are the Challenges
05:50 3D Printing Provides a Solution
07:49 The Challenge with Creating 3D Printed Scaffolds
10:57 Industrial Scale Cell Growth
13:41 Summary of 3D Printed Bioreactor Scaffolds
14:25 Why Scaling Up is so Difficult
16:24 How Implicit Modeling Works
17:46 How Implicit Modeling Could Solve this Challenge
19:44 How is Metal Powder for 3D Printing Made?
#3dprinting #manufacturing #bioengineergaming - วิทยาศาสตร์และเทคโนโลยี
📺More from Metafold on implicit modeling and metamaterials in The Cool Parts Show All Access. Watch the All Access extra here: www.additivemanufacturing.media/kc/cool-parts/articles/implicit-modeling-and-metamaterials-the-cool-parts-show-all-access?
Those of us who grew up with the demoscene are so proud to see SDFs finding new places to be awesome.
Enjoyed this episode very much! Keep them coming! Very cool and informative show you've got going on here!
Keep up the great work guys I watch every video
Thank you for watching and for your kind words!
If you're not already a member of The Cool Parts Show All Access, check out our site w/ extra videos for each episode: www.additivemanufacturing.media/kc/cool-parts/allaccess? This episode's All Access extra features Elissa from Metafold further discussing implicit modeling and metamaterials. Stay Cool!!
I had a similar challenge with modeling a complicated repetitive structure. I managed to do it with Matlab as an implicit parametric model and directly export as a mesh.
The original mesh was 9GB. After some reduction, it reached 2GB and I was able to print it on SLA printer.
The metafold solution is great for such application, I would like to give it a try.
Surprising software challenges. Like using fractals (not polygons) for video game creation. Cool part. Cool show!
This is one of the most interesting topics I've come across in a long long time. Great job guys.
Glad you enjoyed it!
Elissa from Metafold talks more about implicit modeling and metamaterials in The Cool Parts Show ALL ACCESS extra here: www.additivemanufacturing.media/kc/cool-parts/allaccess? We hope you enjoy that one, too. Stay Cool!
I cannot express my happy reaction to see the future evolving with these designs and ideas. Thanks you two for forwarding these fantastic inventions. I love this channel
This reminds me of some free software Maker's Muse reviewed long ago called Structure Synth. A mathematical/programmed approach to creating geometry. I forget who said it (maybe Carl Bass of Autodesk?), but it was along the lines of: "Our designs aren't constrained to our imaginations, but the tools we have to realize them with." They went on to show how you could trace the development of CAD software by industrial design, with things getting softer-edged and more complex over time. I wonder if someone might develop a GAN based AI tool to compress geometry while maintaining feature detail. Or perhaps a variant of H.264 where instead of compressing frames of an image, it is layers of the print... how about it Science?
If you can map the gene instructions and reproduce them, probably 3d printing the proteins, you can probably insert those genes in a bacteria or crop to harvest them that way way. Even if not, cell farming should be the new economy/microbusinesses, making many traditional jobs expendable now, though could be partly automated too.
In AEC we do something like that, too.
IFC and similar, most BIM software handle implicit models.
Parts, we call it elements, geometry are predefine by its category.
Some building models 'parts' are in thousand. Large scale project could imply million of parts.
Thus we don't do surface model, mostly.
Though best practice workflow tend to break these models down into manageable pieces. Before we 'assembly' it into full building models.
It never bother me how 3d printing software handle these data. This is a very interesting subject.
Thank you for the video.
Someone get this guy a ntop license!
ntop usually require high end hardware, and is currently limited by the hardware itself. apart from that, ntop also struggles with the same problem of importing large files.
I think this is the most nuts video you guys have put together. And then you give us a bonus showing how metal powders are made.
you guys are the shizz
Epic
Could be a good way if just manipulate the Gcode, observing the symmetries!
This is so fascinating. It reminded me that I should send you my research paper on my open source 3D printed tissue biofabrication platform, the 'bIUreactor'. It would use the cells from something like the bioreactor from SWRI to make 3D tissues. I'll send it shortly!
Thanks, Lester. We received your email and have linked to your research in the episode blog post (www.additivemanufacturing.media/articles/ultra-complex-3d-printed-scaffolds-enable-cell-growth-the-cool-parts-show-70?) Interesting work!
@@AdditiveManufacturing Thank you!
can't we use foam commercially readily available instead of 3D printing ?
The goal is to ensure a layer of cell growth exactly one cell deep, with no cell allowed to grow atop another. Foam is flexible - it could be compressed or bent in a way that might let cells overlap. Also, random geometry produces varying surface area - difficult to layer cells onto the surface consistently. The scaffold geometry here is an intricate form, but it offers a regular, repeating geometry.
Awesome application for 3d printing. Re: slicing. You only need to slice one repeating section and make a script that changes the layer name? Seems very solvable. Obv implicit modeling is much more elegant though.
It looks like they have to print it sideways, so they can't just stack the repeating pattern (I had the same thought).
A fish tank filter!!!
You could just say… 3D printing SVG
Fan tip: your videos could benefit from breaking it up into sections.
Noted! Thanks!
That sure looks like Blender on the screen
They are designing and producing the stl files incorrectly for this application. The design should be done algorithmically NOT using cad.