0:00 - Glycolysis 0:29 - Pyruvate to Acetyl-CoA by PDC (pyruvate dehydrogenase complex) 0:43 - Krebs Cycle, Citric Acid Cycle 1:11 - Central Metabolism 1:29 - Why go through central metabolism? ATP!! 1:53 - Reduced cofactors (more ATP through ETC) → ATPs for cells to survive 2:19 - Other monosaccharides can enter central metabolism 2:57 - What about Proteins (amino acids)? Glucogenic & Ketogenic AAs 4:23 - Excess nitrogens → Urea Cycle (in Liver) 5:58 - What about Fatty Acids? Beta-Oxidation (reduced cofactors & acetyl-CoA produced) 7:13 - Reversible Glycolysis → Gluconeogenesis 7:35 - Irreversible Reaction: Pyruvate to Acetyl-CoA 7:52 - Gluconeogenesis (genesis of new glucose molecules) 8:15 - Sources of carbons for glucose (for gluconeogenesis): lactate, glycerol 9:00 - Alpha-keto acids as a source of carbons for glucose? NOPE (Acetyl-CoA enters TCA cycle) 9:31 - Can we take proteins/amino acids to form glucose? Depends (Glucogenic vs. Ketogenic AAs) 12:05 - Using fatty acids to form glucose? Acetyl-CoA? No, BUT last 3-carbon molecules can be converted to glucose 12:40 - Importance of Acetyl-CoA (for fatty acid synthesis, phospholipids, triacylglycerides) 13:37 - Fed State (excess carbs & proteins stored as triacylglycerides) 15:04 - Serine + Palmitic Acid → sphingosine backbone → cerimide → sphingomyelin/cerebroside/ganglioside) 16:05 - Fasted State (breakdown of triacylglycerides) 16:54 - Fasted State (ketogenesis in liver): 3 Acetyl Co-A molecules converted to HMG-CoA 17:33 - Why forming ketoacids? (ketolysis: ketoacids to acetyl-CoA to enter TCA Cycle) 18:15 - HMG-CoA can be converted to Isoprene → build larger molecules (Fed State) 19:07 - Biosynthesis of Cholesterol 19:26 - Cholesterol used to create hormones 20:16 - Biosynthesis of amino acids 22:09 - Importance of Serine (Folate cycle, Methionine cycle; SAM - universal methyl donor) 23:20 - PAPS (universal sulfur donor) 23:55 - Glycosylation (monosaccharides from intermediates of glycolysis) 25:32 - Pentose Phosphate Pathway (PPP) 25:50 - NADPH cofactors - electron donor to build bond during anabolism 26:14 - Reduced glutathione (endogenous anti-oxidant) 27:21 - Free radicals produced from ETC 28:46 - Biosynthesis of nucleic acids 30:02 - Degradation of nucleic acids 30:47 - Biosynthesis of nuerotransmitters 32:05 - Biosynthesis of porphyrin ring (used for hemoglobin, myoglobin, cytochrome, ETC) 32:44 - Big picture - see the forest! (links in the description box for each pathway in detail) 33:22 - Limitations to central metabolism: Essential Vitamins (must be obtained from diet) 34:04 - Essential Minerals (must be obtained from diet) 34:42 - Our limitations to central metabolism - final note El fin! Now go get that 528 you guys 🏃♀️🏃♂️
I've taken biochem, sat in on biochem classes, and have been in an MCAT prep course and this was the BEST EXPLANATION I have ever had on these processes. I knew bits and pieces but this guy explained them in a way that had everything just click. I feel so empowered now! Biochem is amazing!
Not ONE college-level textbook ever explained the relationship between cellular metabolism all in one scoop. sure they gave you ONE diagram with vague descriptions, but they never connected it as a whole mechanism like you. It's really easier to understand the role of cellular respiration taking into consideration proteins/fatty acids/and sugars. THANK YOU SO MUCH for the time and dedication to this video, you explained all these really way and simplified (w/o dumbing it down) :)
Amazing summary, this approach should be the first class of every biochemistry class, unfortunately they dive into details and never give us the big picture. Essential video for first learners!
This might be the best explanation I have ever seen. Someone hire this guy. I mean seriously. Not only does he explain everything like a tenured professor at Harvard, but relates everything to the holistic vision of biochemical processes in our bodies. Unreal. Thank you!
I watched this to study for the MCAT. I watched this to study for biochem my first year of medical school. And here I am watching this my second year of medical school to study for endocrine. I pray I never have to watch this again, but thank you, this is the BEST explanation!
I HAVE BEEN STUDYING FOR THE MCAT FOR 4 MONTHS. I HAVE WATCHED MANY YT VIDEOS... ON MANY TOPICS (BELIEVE ME). THIS. THIS HANDS DOWN. THIS IS THE MOST INFORMATIVE, WELL-ORCHESTRATED, THOUGHTFUL, AND INTUITIVE VIDEO I HAVE WATCHED ON THIS TOPIC. AND OF ALL TOPICS, THIS HAPPENS TO BE THE HARDEST. YOUR CHANNEL DEFINITELY LIVES UP TO ITS NAME BRAVO
@@nikaylal No--I'm writing my personal statement and activities section right now and'll be applying this upcoming cycle for the first time. I ended up bombind CARS on the real deal (122) and got 3.72/509. MD or DO, I'll take it--not looking to apply a second cycle by any means. Cheers
This 30m video has tied together everything I've learned in all my years of schooling and a TON of my things that I never even thought of. This is gold bra!!
This is an amazing summary. I know everyone is saying it in the comments, but this video should literally have a million views. I have spent 20-30 minutes on just the first couple minutes to outline the steps of glycolysis for myself and man you are amazing. In the first 6 minutes, I am having total brain explosions just from the connections that you are putting together that I never quite got. Thank you so much. I always skip ads but not here
Wow... I never comment on TH-cam videos but this is everything and more that I've been looking for in my MCAT studying! I hope both sides of your pillow are cold at night
WOW WOW WOW WOW!!!! This video should have 1MILLION+ likes!!!!!!! This is sooooo gooood, if someone is able to put everything big picture together like this - you’ll master metabolism forever. Thank you!!!!!
Thank you so much for this video! I've been trying to figure out the details of metabolism for the last 2 weeks and you summarized it all so well in just 34 minutes. You are the best!
I am a non-trad and only took two bio courses after my Eng degree. I got 129 in BB thanks to this channel. Don't know how to thank you. I hope you make videos of more advanced concepts like IC-50 (as you promised, JK😜) or do greater things in medicine-related education. ❤❤🙏🙏🙏🙏
@periodtyt kaplan content review is best (altho Princeton review is more comprehensive for physics). Also khan academy is good. The most important tho is doing practice questions and then more practice questions
I've taken biochem in both undergrad and medical school and this is by far the best video I've seen! Keep simplifying the science and make more videos!
You are a god. There is no better way to make this kind of video, and I thank you eternally for every bit of energy you put into it. I could go on in detail
Instead of a biochemistry class, the professor should give every student 1 semester to watch this video at their own pace and ask whatever questions they want about it. Then at the end a final exam going over the content
Wow, I finally found someone putting this together. I am preparing for the MCAT and I have not taken biochemistry. I will watch all your videos and study them as my preparation biochem course. Thank you so much. I only wish the pink structures were more visible.
I am not sure why i think this way! I really think if you can just do 3 of this videos on Biochem, you will be my Biochem textbook and reference source. Esp for those prepping for professional school exams. Biochem needs to be taught by people like you who can help students make meaning and relevance out of them. Without this simplification and connection to the cell as a whole, Biochem becomes unnecessarily complex, irrelevant, and difficult. Thank you sir. You are great. Like Khan Academy, you need a place call Biochemistry Academy (taught by you) lol
You are a fuckin' GENIUS! I'm in medical school, and our biochemistry teacher is an asshole who doesn't know shit and only tells us to read his powerpoint files. You made it much easier to understand, thank you!
Wow this was so great! Is it suffice to just watch this 1 video and take detailed notes? or should I also watch all the separate videos you made? (first time learning metabolism)!
This videos purpose is to relate all the pathways, but does not go into enough detail on each individual pathway to be sufficient for the MCAT. Strongly strongly recommend “Kaplan MCAT biochemistry” it’s a great resource for MCAT. But this videos goal was to lay foundation to understand big picture.
![เจ็บที่ยังฮัก - ม่อน วรวิทย์ [ Official Mv ] จอนนี่มิวสิค](http://i.ytimg.com/vi/KALIGSRSjFs/mqdefault.jpg)
![เปิด อาณาจักร หมื่นล้าน "สาระตั้ม" l [Nickynachat]](http://i.ytimg.com/vi/3XE0nPF4YkQ/mqdefault.jpg)
0:00 - Glycolysis
0:29 - Pyruvate to Acetyl-CoA by PDC (pyruvate dehydrogenase complex)
0:43 - Krebs Cycle, Citric Acid Cycle
1:11 - Central Metabolism
1:29 - Why go through central metabolism? ATP!!
1:53 - Reduced cofactors (more ATP through ETC) → ATPs for cells to survive
2:19 - Other monosaccharides can enter central metabolism
2:57 - What about Proteins (amino acids)? Glucogenic & Ketogenic AAs
4:23 - Excess nitrogens → Urea Cycle (in Liver)
5:58 - What about Fatty Acids? Beta-Oxidation (reduced cofactors & acetyl-CoA produced)
7:13 - Reversible Glycolysis → Gluconeogenesis
7:35 - Irreversible Reaction: Pyruvate to Acetyl-CoA
7:52 - Gluconeogenesis (genesis of new glucose molecules)
8:15 - Sources of carbons for glucose (for gluconeogenesis): lactate, glycerol
9:00 - Alpha-keto acids as a source of carbons for glucose? NOPE (Acetyl-CoA enters TCA cycle)
9:31 - Can we take proteins/amino acids to form glucose? Depends (Glucogenic vs. Ketogenic AAs)
12:05 - Using fatty acids to form glucose? Acetyl-CoA? No, BUT last 3-carbon molecules can be converted to glucose
12:40 - Importance of Acetyl-CoA (for fatty acid synthesis, phospholipids, triacylglycerides)
13:37 - Fed State (excess carbs & proteins stored as triacylglycerides)
15:04 - Serine + Palmitic Acid → sphingosine backbone → cerimide → sphingomyelin/cerebroside/ganglioside)
16:05 - Fasted State (breakdown of triacylglycerides)
16:54 - Fasted State (ketogenesis in liver): 3 Acetyl Co-A molecules converted to HMG-CoA
17:33 - Why forming ketoacids? (ketolysis: ketoacids to acetyl-CoA to enter TCA Cycle)
18:15 - HMG-CoA can be converted to Isoprene → build larger molecules (Fed State)
19:07 - Biosynthesis of Cholesterol
19:26 - Cholesterol used to create hormones
20:16 - Biosynthesis of amino acids
22:09 - Importance of Serine (Folate cycle, Methionine cycle; SAM - universal methyl donor)
23:20 - PAPS (universal sulfur donor)
23:55 - Glycosylation (monosaccharides from intermediates of glycolysis)
25:32 - Pentose Phosphate Pathway (PPP)
25:50 - NADPH cofactors - electron donor to build bond during anabolism
26:14 - Reduced glutathione (endogenous anti-oxidant)
27:21 - Free radicals produced from ETC
28:46 - Biosynthesis of nucleic acids
30:02 - Degradation of nucleic acids
30:47 - Biosynthesis of nuerotransmitters
32:05 - Biosynthesis of porphyrin ring (used for hemoglobin, myoglobin, cytochrome, ETC)
32:44 - Big picture - see the forest! (links in the description box for each pathway in detail)
33:22 - Limitations to central metabolism: Essential Vitamins (must be obtained from diet)
34:04 - Essential Minerals (must be obtained from diet)
34:42 - Our limitations to central metabolism - final note
El fin! Now go get that 528 you guys 🏃♀️🏃♂️
Wow thank you! Appreciate it much!
@@sciencesimplified3890 This video was perfect for tying everything up to see the big picture. Thank you for your amazing lecture!
thank you!
THANK YOU💛
Man, you have no idea how much you helped me with my mid-term exam tomorrow. I haven't even watched the video yet, but I can already say thank you.
I've taken biochem, sat in on biochem classes, and have been in an MCAT prep course and this was the BEST EXPLANATION I have ever had on these processes. I knew bits and pieces but this guy explained them in a way that had everything just click. I feel so empowered now! Biochem is amazing!
I watch this once a week as part of my MCAT studying. Thank you for this gem
hey, struggling with Mcat ,any tips or site with free sample questions?
@@wycliffenyandika9017 Jack westin has practice questions
@@shannalyle2333 Thank you for responding,how do I link up with Jack Westin though ?
@@shannalyle2333 also I love all you music ,saved to my library for later 🤗
@@wycliffenyandika9017 lol glad you like it!
currently on the MCAT grind and praying for everyone here AAAAAA
Not ONE college-level textbook ever explained the relationship between cellular metabolism all in one scoop. sure they gave you ONE diagram with vague descriptions, but they never connected it as a whole mechanism like you. It's really easier to understand the role of cellular respiration taking into consideration proteins/fatty acids/and sugars. THANK YOU SO MUCH for the time and dedication to this video, you explained all these really way and simplified (w/o dumbing it down) :)
Amazing summary, this approach should be the first class of every biochemistry class, unfortunately they dive into details and never give us the big picture. Essential video for first learners!
I can't believe you don't have more followers. This was better than Khan academy.
This might be the best explanation I have ever seen. Someone hire this guy. I mean seriously. Not only does he explain everything like a tenured professor at Harvard, but relates everything to the holistic vision of biochemical processes in our bodies. Unreal. Thank you!
“So that’s pretty Cool!” Never change brother, you’re saving everyone in bio chem!
I watched this to study for the MCAT. I watched this to study for biochem my first year of medical school. And here I am watching this my second year of medical school to study for endocrine. I pray I never have to watch this again, but thank you, this is the BEST explanation!
I HAVE BEEN STUDYING FOR THE MCAT FOR 4 MONTHS. I HAVE WATCHED MANY YT VIDEOS... ON MANY TOPICS (BELIEVE ME).
THIS. THIS HANDS DOWN. THIS IS THE MOST INFORMATIVE, WELL-ORCHESTRATED, THOUGHTFUL, AND INTUITIVE VIDEO I HAVE WATCHED ON THIS TOPIC. AND OF ALL TOPICS, THIS HAPPENS TO BE THE HARDEST.
YOUR CHANNEL DEFINITELY LIVES UP TO ITS NAME
BRAVO
are you in med school now? :))
@@nikaylal No--I'm writing my personal statement and activities section right now and'll be applying this upcoming cycle for the first time. I ended up bombind CARS on the real deal (122) and got 3.72/509. MD or DO, I'll take it--not looking to apply a second cycle by any means.
Cheers
@@andersnelson6888 Good luck!! We're in this together
This 30m video has tied together everything I've learned in all my years of schooling and a TON of my things that I never even thought of. This is gold bra!!
This is hands down the best biochem video I've ever seen
I love this guys enthusiasm. Makes it easy to listen to.
This is an amazing summary. I know everyone is saying it in the comments, but this video should literally have a million views. I have spent 20-30 minutes on just the first couple minutes to outline the steps of glycolysis for myself and man you are amazing. In the first 6 minutes, I am having total brain explosions just from the connections that you are putting together that I never quite got. Thank you so much. I always skip ads but not here
I love how you just sound so stinkin excited over how cool all this chemistry is - really sets a positive atmosphere for me as a learner.
Wow... I never comment on TH-cam videos but this is everything and more that I've been looking for in my MCAT studying! I hope both sides of your pillow are cold at night
WOW WOW WOW WOW!!!! This video should have 1MILLION+ likes!!!!!!! This is sooooo gooood, if someone is able to put everything big picture together like this - you’ll master metabolism forever. Thank you!!!!!
Thank you so much, you should have more views. i'm definitely sharing this.
Without exaggeration, this is the best video on biochem I've ever watched.
Thank you so much for this video! I've been trying to figure out the details of metabolism for the last 2 weeks and you summarized it all so well in just 34 minutes. You are the best!
I am a non-trad and only took two bio courses after my Eng degree. I got 129 in BB thanks to this channel. Don't know how to thank you. I hope you make videos of more advanced concepts like IC-50 (as you promised, JK😜) or do greater things in medicine-related education. ❤❤🙏🙏🙏🙏
Hi! Do you happen to have any tips for the MCAT? What materials did you use to study to get your score? Thank you!
@periodtyt kaplan content review is best (altho Princeton review is more comprehensive for physics). Also khan academy is good. The most important tho is doing practice questions and then more practice questions
each minute of this video feels so heavy and packed w amazing and concise info. THANK YOU
i'm in love with this man he's gonna save my ass on this biochem midterm in two days
I've taken biochem in both undergrad and medical school and this is by far the best video I've seen! Keep simplifying the science and make more videos!
Which biochem is harder in undergrad or med school ?
You are a god. There is no better way to make this kind of video, and I thank you eternally for every bit of energy you put into it. I could go on in detail
Im watching on double speed and it’s still coherent
Instead of a biochemistry class, the professor should give every student 1 semester to watch this video at their own pace and ask whatever questions they want about it. Then at the end a final exam going over the content
A perfect correlation!!! Hats off to you.
best video about mcat on youtube
Wow, I finally found someone putting this together. I am preparing for the MCAT and I have not taken biochemistry. I will watch all your videos and study them as my preparation biochem course. Thank you so much. I only wish the pink structures were more visible.
You made extremely complex topic to extremely simplified. Thanks man! ❤️
Your voice is very engaging, it helps with concentrating and you explain everything very well :)
The Organic Chemistry Tutor may have a rival here.....and that's saying quite a lot.
I salute you, sir.
I am not skipping ads, this one is by far the best video of metabolic pathways!!!
You went straight to the point and had me hooked.
This is honestly the best, most understandable explanation/teaching of these pathways I've come across! Thank you so much!
Voice is crazy funny but information is condensed and accurate. Cool beans
Watching this the day before my MCAT. Pray for me
5/20 prayers lol
I'm sure you did great!! :)
@@itsmeashlib4394 got a 510! :)
@@priyarazdan4691 I'm so proud of you!! Keep shining! :)
Now in my second year of med school studying for STEP 1, coming back to this very same video
The best overview I've ever come across! THANK YOU!
AMAZING WAY OF EXPLAINING, THANK YOU!
you're a great guy and I really appreciate this content
This was so helpful to just tie in all the concepts together! Thank you so much
This is a biochemistry gem. Thank you for this.
man murdered these videos geez
the big picture way of explaining makes this so much easier
MAN THIS IS GOLD GOD BLESS YOU THANK YOU SO MUCH!!
Prayers to everyone here
absolute must watch video. everything is so clearly explained and logically put together, thank you!
This is a better explanation than the Princeton review damn I am impressed fr
Holy **** ! The channel should be named "Godly simplified science" ! Thank you, awesome work !
Perfect perfect perfect ! This is exactly what we need, a wholistic view on metabolism to get the big picture, thank you so much !
This is so neat. I wish all my professors can teach like you
This is a video with a very well explained biochemistry in 30 mins. Thank you!
Great video . Keep up the good work
This is such a brilliant overview of biochemistry. Wow!
This is insane. Bravo
this is the most informative biochemistry video I have ever watched. thank you for this
When you learn more in a 30 min video than an entire kaplan book
so true it is sad
this video saved me hours of content review, thank you so much for this!!!
Wow, really hands down. Super awesome
This is AWESOME. You rock, dude!!!
omg this is the best explanation ever. thank you so much!
This video is amazing! Thank you
never thought I would say this but biochem is so amazing. THANK YOU for your wholesome explanations🔥
I want to hug you. Thank you good sir for everything!
this was beautiful!!!! thank you!!
Dude you freaking are awesome.. so so helpful
Seriously awesome and invaluable review video. Many thanks!
Thank you so much. This overview is what I needed
Me too..r u medical student?
@@mehfoozsidd2133 ouch bro no response
This was by far the best video summarizing everything I need in biochemistry. Thank you
Wow! That was a great, amazing summary of biochemistry course.
Holy Jesus Bless this man. Years of biochem agony just came to an abrupt end. Bro you make me wanna call you daddy!
wow you've done an amazing job here. thanks a ton
Great level of hardwork has gone in here 💪
THANK YOU, sir!!! Keep making these wonderful videos!!!
YOOO you need 10 million subscribers. I'm not even kidding. But besides that, holy moly, you are incredible at explaining this subject.
thank you sooo much for this! my life has changed))
Wow! I have to agree with the other commenters here and say that this really helped. Thank you!
Great video I wish the quality and resolution little bit better so I can zoom in the video my eyes aren't that great .
THIS WAS GREAT! Thank youuu!!!
I love how you keep it simple cause I need that lol. Thanks so much for this vid
Great content to begin biochem 2 with! thank you!!!
A modern masterpiece.
There should really be a "But wait! There's more!" somewhere in this video. ;) Excellent job, thank you for the help!
Awesome videos. Just wish you would crop out the “undo paint stroke” portion, i can’t stop looking at that instead of your lecture.
It all makes sense now. Thanks 🙏
Thank You -- Great Job..!!
this video is absolutely amazing oh my god thank you so much
The inflections of your voice make this hard to listen to, but the content is just so good. Very concise.
u deserve head for this
Thank you for this amazing class
This was super helpful!!! Thank you!
this video is great, thank you!
I am not sure why i think this way! I really think if you can just do 3 of this videos on Biochem, you will be my Biochem textbook and reference source. Esp for those prepping for professional school exams. Biochem needs to be taught by people like you who can help students make meaning and relevance out of them. Without this simplification and connection to the cell as a whole, Biochem becomes unnecessarily complex, irrelevant, and difficult. Thank you sir. You are great. Like Khan Academy, you need a place call Biochemistry Academy (taught by you) lol
thanks, the best explanation i've ever seen!
God level. Thank you.
You are a fuckin' GENIUS! I'm in medical school, and our biochemistry teacher is an asshole who doesn't know shit and only tells us to read his powerpoint files. You made it much easier to understand, thank you!
great video. thanks!
Please do videos on nucleotide metabolism we love you sir
PURE EXCELLENCE!
Wow this was so great! Is it suffice to just watch this 1 video and take detailed notes? or should I also watch all the separate videos you made? (first time learning metabolism)!
This videos purpose is to relate all the pathways, but does not go into enough detail on each individual pathway to be sufficient for the MCAT. Strongly strongly recommend “Kaplan MCAT biochemistry” it’s a great resource for MCAT. But this videos goal was to lay foundation to understand big picture.
good stuff! kind of a beautiful process actually:)