In 1996, My dad was treated with Interferon-beta for a grawitz tumor in his kidney. 8 inches in diameter, had been labelled terminal. Yet the I-b reduced the tumor to size of a penny. Gave him a couple extra years, after which the cancer returned in the bones. Unfortunately I-b was ineffective in hard tissues. He passed in 2004.
I got diagnosed with hep c a couple years after this drug was approved by the FDA. I remember the big sigh of relief I experienced when my doctor told me that it seems like it cleared on its own and no further treatment is needed after further and subsequent retestings. Apparently about 20% to 35% of those infected with hep c can spontaneously recover. I consider myself very lucky.
Same here. My Hep C cleared itself and was told the same thing from my doctor that I should count myself incredibly lucky. Thank the universe that I didn't get HIV or AIDS or something like that.
I kinda forgot, mostly because headlines were like "cure found, it costs $100k, not a joke or typo", nobody brought it up again so promptly forgot as effectively there was no cure at that price point.
If your in a blue state the ACA covers it and the price went way down once there were more treatment options. If your in a red state well thats death cults for ya. Sorry. Really.
I lost my mom 4 years ago to hep-C related cancer. She got it from a blood transfusion right after I was born, before they developed the detection methods you talked about. I really hope this cure becomes widespread and cheap enough that hep-C can go the way of smallpox.
My condolences to you and your family poseidon, it makes me wonder what other things in blood transfusions could cause other problems, since 1976s we've discovered more and more which allows us to purge things like this.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I recently Was treated for Hep C... after 6 weeks of treatment no more virus was detected in my blood, treatment continued for another 6 weeks... I am so grateful that there are really smart people in this world that figure these things out!❤️
Me too! I had it for 12 years or so and then Finnish government decided to eradicate it from our country and offered the treatment for free to everyone affected. I had the Glecaprevir/pibrentasvir one
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
The (IMO misguided) uproar about the cost of the drug really shouldn't overshadow the fact that curing HCV is one of the biggest medical successes of our lifetime.
@@WellBattle6nsulin is extremely difficult to make and only a few companies have the ability to make it. It has never been made by an amateur contrary to what people assume. It's cheaper in Europe as the governments cover most of the cost
@@williamthebonquerer9181 Mass production of insulin has been around since the early 1930s, & even today production is a matter of keeping the bacteria that actually makes it happy & productive. It's so easy to mass produce that it was cheap for much of the history of the drug & why it's still cheap outside America. The issue isn't one of technology or logistics, it's an issue of market manipulation & lack of regulation.
@@williamthebonquerer9181 The issue isn't patents, which have expired long ago, but regulation on insulin. Only one type of insulin is approved because of all the clinical trials and safety requirements, and the company that makes it has a monopoly. There is little regulation on making your own insulin. The open insulin project is a group of biohackers in oakland who engineered bacteria and yeast to make insulin and are trying to make the tech to produce it cheap and widely available, so that everyone can home brew their own in the future.
Thank you so much for this video, my parent contracted HepC a year before I was born. All my childhood I was worried about it. Once the cure came out I was super excited, but later got very depressed once I learned about that it's only available for late stage HepC in most of Europe. I almost encouraged my parent to seek for the cure nevertheless. A few years passed and suddenly health insurance would finally cover it, my parent was yet very skeptical about the actual benefit, couldn't believe what the doctors said. Now my parent is cured, first few months after healing they got a lot of energy, but eventually the energy levels dropped again - apparently a common thing for those who received the cure.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
India, I believe, challenged Gilead on its pricing and threatened to make the drug themselves despite the obvious patent infringements. Does anyone know how that situation panned out?
They denied Gilead's patent request, & began indigenous production. It's created an ongoing medical tourism to India, where traveling halfway across the planet is more affordable than buying a pill at home.
@@TrollOfReason Thank you. That certainly is a great work around to help their own people. I guess Gilead et al are still making bank in the west, especially in the U.S. despite the decline of the disease.
@@conor7154you do realise that a lot of drug patents are completely stupid and are completely awarded by manipulating the patent laws for variations? India has a patent system but you can't patent innovative processes for the same drug as in the US (which means the patent never actually expires as the company keeps filing new processes when the patent is about to expire), it has to be a new molecule entirely to award patent
In Mongolia Because of India and egypt creating indigenous production they started selling discount to us as altriustic live saving for developing country scheme which made drug became very affordable.
I find the Asianometry topics of choice for video exposition are uncannily aligned with my own interests. I followed the trials and lead up to approval of this compound very closely when it happened a decade ago. Also, I recall Kalydeco (ivacaftor), the cure for a very specific type of cystic fibrosis, was also of particularly intense fascination and wonder what the long term status of the treatment's efficacy is today.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
My mother contracted Hepatitis C from a blood transfusion in the 1980s. She became acutely ill in 1990, to the degree that the doctors told my dad he needed to start thinking about what to do as a single father. My mom survived the acute phase but dealt with other health issues, including a brain hemorrhage in 1995. She died in the summer of 2013 after being diagnosed with liver failure and being hospitalized for a severe GI bleed, and I read an article in the NYT that fall about Harvoni. I wish she'd taken better care of herself - she finished a bottle of chardonnay every day, which couldn't have done anything good for her liver. I will always wonder whether, if she had stopped drinking, she would have had the chance to take Harvoni and would still be alive today.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
P.S. Protease is "pro-tee-ace", not "pro-teez". Most enzyme names end in the suffix "-ase", which is pronounced as its own syllable with a hard S: basically like "ace". E.g. alanine aminotransfer-ase mentioned earlier in the video or RNA polymer-ase. Protease is built of "prote" for protein and "-ase" for enzyme. Sometimes an enzyme name is constructed by [name of substrate]-ase, like protease (protein substrate), lipase (lipid substrate), nuclease (noo-klee-ace, nucleic acid substrate), telomerase (telomere substrate); and sometimes it's just [function]-ase like aminotransferase (transfers amino acids, lol), DNA polymerase (polymerizes/lengthens strands of cDNA from a DNA template), or reverse transcriptase (produces cDNA from an RNA template). After further investigation I found out that the etymology of this "-ase" ending is basically "someone used this once and we stuck with it" lol. A libfix from the name of the first discovered enzyme, diastase. Sorry, having a biochemistry background, hearing "pro-teez" with the subtitle protease just made me giggle really hard lol.
Thank you for saving me the effort to write a post like yours. 😅 That "pro-tease" pronunciation initially made me laugh... but then made my ears "bleed" 🤣
Really great video as always! I love that you are dipping your toes into more biology and biotech focused topics and I look forward to more. There are certainly many interesting stories to cover. I could suggest the discovery of CRISPR Cas9 and the later patent war between The Doudna and the Zhang lab/Broad institute along with the many improvements and innovations being built on it since then. Also the Merck/Vioxx story, or the technology behind flowcytometry and cell sorting machines. Also the stories behind the development of Cryo-EM or Lightsheet Flourescent Microscopy two very cool and cutting edge technologies.
@@rdallas81 rofecoxib (Vioxx) is available again in Canada and you can get Celebrex in the US which is basically the same thing. I think the whole story was a bit overblown. Subsequent studies have shown that most NSAIDs come with an elevated risk of heart attack if taken high dose over long periods (except aspirin which has a protective effect). So Vioxx is probably no worse then ibuprofen in that respect. It was just the first large clinical study that was able to statistically show the effect.
The problem is TH-cam doesn't recommend related content anymore. The sidebar is full of random crap I might generally enjoy watching regardless of the current topic.
My mother had Hepatitis C, she had it for a long time without knowing about it, At the point of detecting her liver was 75% affected We were very concerned and prepared for the worst. We went to various doctors but we fortunately found a specialist. Now normally we'd have to leave our country for India for treatment and it would cost upwards of 4 crore taka (400,000$) But by the Grace of God, our country just the previous year started preparing the Hepatitis C drug in our country that costs 45lac taka (45,000$) for the full dosage. It's been 6 years now and she is now healthy, by the Grace of God. We were very fortunate and I pray others in a worse situation gets better
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
It's incredible how excellent scientists and physicians were at determining clinical patterns from observation and then discovering the causative agents.
Nice vid! Didn't know there was a cure. Hey man, I hope you can talk about Chimei group one day. About how they became a powerhouse in the plastic industry and the Museum they have in Tainan.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I love the wide, diverse range of topics covered in your videos. Hopefully you'll touch on batteries or more precisely the ones used in BEVs (Battery Electric Vehicles) such as lithium ion batteries or the ones talked about recently by Toyota, the solid state battery.
Good one! I have friends that went through both interferon and sofosbuvir, and there's no comparison - the side effects of the former were stunning in scope. Also the treatment lasted 12 months or more compared to four for Sovaldi, which as far as I could tell was free of any side effects at all. The use of AI in developing leads in medicinal chemistry will probably speed up the development of new antivirals and other meds significantly - a subject we're hearing a lot about in the pharmacology world. Thank you kindly for covering this - it's quite a success story...
My mom was diagnosed with hepatitis C in mid 00s. She was treated with Russian made Interferon alpha type drugs. It has good results, she recoverd, but in mid 10s she developed cirrhosis and died last year in age of 58.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Right up my alley! You did a great job covering this. I’d advise anyone interested in science and viruses to check out “This week in virology” podcast (not my podcast, just a listener of it).
There are still many viruses that have been with us for many years but we still don't have a cure. Herpes is one that comes to mind. And then there's newer viruses like the sars cov 2. We'll always need research it seems, and then there's the new resistant bacteria and viruses.
Such a good video! Sound like virology is not what you’ve an expert in but you did a great job explaining everything simply and correctly. Only shame is that you didn’t ask anyone how to pronounce ‘protease’, which in your video sounds like it’s a tease delivered by a pro 😉 but honestly, great video and here’s to some day you making another one about the success of the hepC vaccine!
This would have been nice to have back when I went through chemo for Hep C. My regimen consisted of a twice weekly shot of Interferon, in tandem w/ Ribavirin, and it was brutal! I lost 50 lbs over a six month period and was experiencing severe bouts of tachacardia, which would make me pass out and I'd wake up to find myself on the floor w/ a bloody nose or big bruise somewhere. smh
I did this treatment or a chemical very similar about 7 years ago. It was $180,000 for 6 months. I think the name of it sounded very similar but it was different than what you mentioned. I was told it was 95% effective when I did the treatment. And I am cured of hepatitis C.
Very interesting video! My mom went through Interferon + Ribavarin treatment in early 2010s. The side-effects made it very difficult to be a functional adult with a job, considering the full treatment lasted for about a year. And it was a lot more expensive than 1000 dollars. I'm glad she went though it (still virus-free to this day) but it's good to know that there's a much better alternative these days.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I used meds Harvoni for Hepatitis C for 12 weeks - first meds Canada / USA in 2013 . I was in experimental group for Layla University , Chicago . Thank you !!!! Hepatitis never come back . Today is August 2023
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Considering your usual subject matter revolves around silicon related technologies, this foray into virology / molecular biology / immunology must have stretched your comfort zone a bit. I applaud your bravery as this story is multifaceted and difficult to explain to laypeople. As a medical professional, I will say that your presentation was accurate and covered the principal issues quite well. Overall you have provided an excellent primer on the subject. That said, I will offer two tiny nitpicks. ALT (alanine aminotransferase) is generally pronounced as the individual letters by the medical community and “protease” is pronounced as three syllables (pro-tee-ace). Again, outstanding work on your part to put this summary together. Continued good luck to you and your channel from a longtime subscriber.
Just for my own purposes, would you be willing to include a pastebin link in your description to a list of sources? I love your content, but I always like to do more reading, especially with something as exciting as this.
Fascinating! Thank you. My Mum had jaundice and nearly died in hospital in Tehran during the 70s! I'm not sure which Hep she had but I wouldn't be here had she not survived.
I am a recovering addict and this stuff cured me, 3 months of anti virals, cost the state funded insurance like $30k! The meds are so overpriced and they make you feel so bad. I felt like a grandpa after a month, your bones hurt, your super tired and no amount of caffeine helps, it was worth it tho been cured since! Finished my mechanical engineer bachelors and sober!
What drug did you take? I had Maviret, it's Glecaprevir/pibrentasvir and experienced literally no side effects. Not even the mildest. Nothing. Was completely cured ❤
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I've had hep C twice. Once while getting a random STD screening they told me I had hep C my thankfully my body was fighting the virus off naturally. I got tested a few more times and they took my blood and other samples for research made me awnser some questions and oddly gave me 50$ for each of these 4 testings. Three years later while in the hospital they told me I had very early hep C and was confused. I did the treatment in 2021 thank god its covered in Canada. I wanted to die I felt like shit for months. I know someone who did the old treatment in the 90's, they have so many allergies now and other heath problems. While doing treatment they were constantly in pain, it was like chemo. Hep c is rather scary it can live on surfaces for a long time, the virus has mutated like crazy. And now we're seeing Hep D and other forms pop up. Even A&B infects a bunch of people every year its important to get the vax for hep BOTH OF THEM the second booster is super important without it the vax is worthless. a Its gross how companies are able to charge 50k for treatment, considering much like TB how dangerous hepatitis is. You do not want people having a, b or c and spreading that shit around. "I've heard" people buying it off the darkweb due to India being able to make any medicine with no fucks given about laws(Along with other medications). Its real and much much cheaper, customs can still take it away if they find it tho and even threaten charges on you. Would suck having the government stealing your treatment because you cant afford "their" treatment. I hate American pharma companies, only support euro/japanese ones.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I'm assuming he also got contaminated by Factor VIII from bayer? My uncle also got it, in addition to HIV from it. Unfortunately, after he was cured from his hep, he heard he already had gotten cancer from the hep and died shortly after.
@@DrAugurk something like that. He's very competent (his brother, also but less gravely haemophilic, is a doctor) and can speak at length of drugs and treatments for his condition.
My friend’s mother had a blood transfusion in the early ‘80s, before blood was heavily tested. She got hepatitis C, and she thought it was fatal. She’s still around thanks to this.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I had it during the '70s and never received any treatment as there was none. Full forward 20 years and I was required to vaccinate against Hep B but never sero-converted, which needed to be investigated with routine testing over several years. All the while, I was asymptomatic. Around 10 years further on, I was declared cured by not showing any select antibody activity over a couple of years. One of the lucky ones who required no treatment.
I work for gilead. I have some gripes with some of their pricing, but 1000 for a CURE is a great deal. With a single-use treatment cost being that low, the failure in this case is government healthcare support for low income patients.
I sold an inferior biotech drug from Amgen in the late 90’s. The name was Infergen. Ribaviron was used as a combination agent along with Interferon to increase its efficacy. These drugs were major failures with many side effects. The main issue was the disease’s ability to mutate. I was absolutely blown away when a cure was discovered. This is why the pharmaceutical/biopharma industry is so important in the discovery of these groundbreaking discoveries.
This kind of reminds me of HIV in a way. RNA viruses (I believe all viruses are RNA based as it has to match with another strand to duplicate, just like DNA does when a cell undergoes mitosis) don’t have great transcription checking (basically spellcheck for RNA). In the case of HIV, there is no transcription check which leads to significant changes during each replication. This single failure to spellcheck is why HIV hasn’t been able have a vaccine created. The only thing we can do is interfere with its duplication processes. That’s why HIV requires several drugs in combination as attacking the virus with a single vector leads to resistance. Gilead essentially only produces antiviral medication; predominantly HIV treatment.
The latest Hep C cures are Proteas inhibitors and your right that they are similar to HIV drugs. They are much less toxic then the earlier Interferon Ribaviren combos.
Like Sulfamides in some bacteria...makes a malthusian method do not kill bacteria...or FUNGUS... on the other hand ...protease inhibitors has a very bad history ...im talking about AZT (zidovudine) and a lot of drugs..m
There is a cure for HIV and it was found for a guy that was HIV positive and had developed cancer? They put him through immunotherapy and by chance it cured his cancer and also his HIV?
@@jameshatton4405A person being cured doesn't mean we have a cure. There are people who are naturally immune to HIV, and the case you refer to was an instance where the patient got a bone marrow transfusion from such a person. It's not something we can replicate and there are a LOT of reasons you don't want to do it unless it's absolutely necessary. Current HIV treatments are far safer, cheaper and easier.
Great history but incomplete. What is the current cost of the drug in various countries? It is my understanding that Gilead soon began selling Sofosbuvir, then Harvoni, at sharply reduced prices to national health systems. I recall hearing that a full course of one of the cures was made available in Egypt (which has a high incidence of hep C) a year or two after the drug was introduced. To cite the intro price of $1000 per pill without noting the dramatic price cuts is unfair to Gilead.
Having my three middle fingers severed off in 2009 and a heart attack in 2015 and a rigorous heart check in 2017 my Hep C was obviously never detected in all the blond test. In 2021 I moved to a small town I like to call Mexico, Texas. I wonder if there is a connection. I’m glad I haven’t drank booze in 37 years.
All i know is, one day i went to the doctor, she asked me why i hadent cured my hep C, i told her i knew many ppl who went through interferon and i was scared...not of the treatment..rather tha it wouldnt work. She looked at me weird and said.."oh no we have a cure now, you take a pill for month andnits gone" It was unreal. Im cured.
When you said: "...regularly injects drugs.", my mind's eye showed me a hospital, with little, sharp, sparks for every needle. When darkness blinds you, try flipping it, for size.
My uncle was diagnosed literally months before the cure was made available in a study his doctor managed to get him into. Saved his life.
Incredible luck!
That doctor is a hero.
In 1996, My dad was treated with Interferon-beta for a grawitz tumor in his kidney. 8 inches in diameter, had been labelled terminal. Yet the I-b reduced the tumor to size of a penny. Gave him a couple extra years, after which the cancer returned in the bones. Unfortunately I-b was ineffective in hard tissues. He passed in 2004.
Hep C takes years to kill.
@@paulmichaelfreedman8334 there are other tumors/cancers like this - you can knock them back only so often, then they come back and get you. 😠
I got diagnosed with hep c a couple years after this drug was approved by the FDA. I remember the big sigh of relief I experienced when my doctor told me that it seems like it cleared on its own and no further treatment is needed after further and subsequent retestings. Apparently about 20% to 35% of those infected with hep c can spontaneously recover. I consider myself very lucky.
I had this happen too. With simultaneous B and C. I was told I was very lucky and I apologized to my body.
@@sn1000kthat makes *me* want to apologize to your. ody
@@LibraryofCelsuswow
The human immune system is marvelous and varies a lot along persons.
Best wishes.
Same here. My Hep C cleared itself and was told the same thing from my doctor that I should count myself incredibly lucky. Thank the universe that I didn't get HIV or AIDS or something like that.
I didn't know we cured hepatitis c. Thanks for the info.
I kinda forgot, mostly because headlines were like "cure found, it costs $100k, not a joke or typo", nobody brought it up again so promptly forgot as effectively there was no cure at that price point.
cure ... for the rich.
Keep in mind "We" means the actual first-world. Not the USA.
If your in a blue state the ACA covers it and the price went way down once there were more treatment options. If your in a red state well thats death cults for ya. Sorry. Really.
@@Mordecrox costs $100k, but making the pill probably costs just $15 to make
I lost my mom 4 years ago to hep-C related cancer. She got it from a blood transfusion right after I was born, before they developed the detection methods you talked about. I really hope this cure becomes widespread and cheap enough that hep-C can go the way of smallpox.
Sorry to hear about what happened. Alot of diseases should go the way of smallpox! These microbes/parasites have absolutely no value to this planet.
My condolences to you and your family poseidon, it makes me wonder what other things in blood transfusions could cause other problems, since 1976s we've discovered more and more which allows us to purge things like this.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I recently Was treated for Hep C... after 6 weeks of treatment no more virus was detected in my blood, treatment continued for another 6 weeks... I am so grateful that there are really smart people in this world that figure these things out!❤️
Me too! I had it for 12 years or so and then Finnish government decided to eradicate it from our country and offered the treatment for free to everyone affected. I had the Glecaprevir/pibrentasvir one
@@SetiSupremenow u are free from hep c
@@brother9440 Yes, I am. It's nice to not have worry about my blood.
I got diagnosed with hep c recently, hope mine is curable I’m nervous 🙏🏼
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
The (IMO misguided) uproar about the cost of the drug really shouldn't overshadow the fact that curing HCV is one of the biggest medical successes of our lifetime.
it is cheap compared to the cost of liver transplant
And it’s a cure, not like insulin being a treatment and getting jacked up in price by manufacturers
@@WellBattle6nsulin is extremely difficult to make and only a few companies have the ability to make it. It has never been made by an amateur contrary to what people assume.
It's cheaper in Europe as the governments cover most of the cost
@@williamthebonquerer9181
Mass production of insulin has been around since the early 1930s, & even today production is a matter of keeping the bacteria that actually makes it happy & productive. It's so easy to mass produce that it was cheap for much of the history of the drug & why it's still cheap outside America.
The issue isn't one of technology or logistics, it's an issue of market manipulation & lack of regulation.
@@williamthebonquerer9181 The issue isn't patents, which have expired long ago, but regulation on insulin. Only one type of insulin is approved because of all the clinical trials and safety requirements, and the company that makes it has a monopoly. There is little regulation on making your own insulin. The open insulin project is a group of biohackers in oakland who engineered bacteria and yeast to make insulin and are trying to make the tech to produce it cheap and widely available, so that everyone can home brew their own in the future.
Thank you so much for this video, my parent contracted HepC a year before I was born. All my childhood I was worried about it. Once the cure came out I was super excited, but later got very depressed once I learned about that it's only available for late stage HepC in most of Europe. I almost encouraged my parent to seek for the cure nevertheless. A few years passed and suddenly health insurance would finally cover it, my parent was yet very skeptical about the actual benefit, couldn't believe what the doctors said. Now my parent is cured, first few months after healing they got a lot of energy, but eventually the energy levels dropped again - apparently a common thing for those who received the cure.
So are they cured?
your parent ,they, ok.i guess but why ?
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
India, I believe, challenged Gilead on its pricing and threatened to make the drug themselves despite the obvious patent infringements. Does anyone know how that situation panned out?
They denied Gilead's patent request, & began indigenous production. It's created an ongoing medical tourism to India, where traveling halfway across the planet is more affordable than buying a pill at home.
@@TrollOfReason Thank you. That certainly is a great work around to help their own people. I guess Gilead et al are still making bank in the west, especially in the U.S. despite the decline of the disease.
@@conor7154you do realise that a lot of drug patents are completely stupid and are completely awarded by manipulating the patent laws for variations?
India has a patent system but you can't patent innovative processes for the same drug as in the US (which means the patent never actually expires as the company keeps filing new processes when the patent is about to expire), it has to be a new molecule entirely to award patent
@@conor7154 does Gilead stop school shootings in the US with their drug patent or something?
In Mongolia Because of India and egypt creating indigenous production they started selling discount to us as altriustic live saving for developing country scheme which made drug became very affordable.
Biology undergrad here u did an awesome job with this video
I’m impressed with how many subjects u do these in depth videos on
I was totally oblivious to the progress they made. Thanks you for your ever-excellent video essays!
I find the Asianometry topics of choice for video exposition are uncannily aligned with my own interests. I followed the trials and lead up to approval of this compound very closely when it happened a decade ago. Also, I recall Kalydeco (ivacaftor), the cure for a very specific type of cystic fibrosis, was also of particularly intense fascination and wonder what the long term status of the treatment's efficacy is today.
As a doctor who studied about Hep c, thanks for the background history about this, didn't learn this in med school
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Good video. One small gripe: protease is pronounced “pro-te-ase”. It’s not teasing at all. 😉
pro tee ay-zz(aze as in haze)
great vid!
Hey man, love your videos. Protease is pronounced prow-tee-ayz
The -ase suffix denotes an enzyme that breaks down something - in this case protein. Hence the pronunciation.
Such an antitease comment.
Another fantastic mini doc. I am working my way through your library and I feel as though I've finally found a school that I can enjoy.
Thank you for doing such great research and videos. Knocked it out of the park!
My mother contracted Hepatitis C from a blood transfusion in the 1980s. She became acutely ill in 1990, to the degree that the doctors told my dad he needed to start thinking about what to do as a single father. My mom survived the acute phase but dealt with other health issues, including a brain hemorrhage in 1995. She died in the summer of 2013 after being diagnosed with liver failure and being hospitalized for a severe GI bleed, and I read an article in the NYT that fall about Harvoni. I wish she'd taken better care of herself - she finished a bottle of chardonnay every day, which couldn't have done anything good for her liver. I will always wonder whether, if she had stopped drinking, she would have had the chance to take Harvoni and would still be alive today.
I'm once again amazed at the amount of topics you are able to research, understand, and make understandable.
I sold a very ineffective treatment in the late 90’s. Was so glad they finally came out with a cure. There is hope for all diseases.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Another excellent report. Keep up the great work.
P.S. Protease is "pro-tee-ace", not "pro-teez". Most enzyme names end in the suffix "-ase", which is pronounced as its own syllable with a hard S: basically like "ace". E.g. alanine aminotransfer-ase mentioned earlier in the video or RNA polymer-ase.
Protease is built of "prote" for protein and "-ase" for enzyme. Sometimes an enzyme name is constructed by [name of substrate]-ase, like protease (protein substrate), lipase (lipid substrate), nuclease (noo-klee-ace, nucleic acid substrate), telomerase (telomere substrate); and sometimes it's just [function]-ase like aminotransferase (transfers amino acids, lol), DNA polymerase (polymerizes/lengthens strands of cDNA from a DNA template), or reverse transcriptase (produces cDNA from an RNA template).
After further investigation I found out that the etymology of this "-ase" ending is basically "someone used this once and we stuck with it" lol. A libfix from the name of the first discovered enzyme, diastase.
Sorry, having a biochemistry background, hearing "pro-teez" with the subtitle protease just made me giggle really hard lol.
Thank you for saving me the effort to write a post like yours. 😅 That "pro-tease" pronunciation initially made me laugh... but then made my ears "bleed" 🤣
@@Julian-tf8njStop Bitching.
Great video, so thorough. Asianometry is my favorite science channel, for this kind of historical reaching seminar.
Really great video as always! I love that you are dipping your toes into more biology and biotech focused topics and I look forward to more. There are certainly many interesting stories to cover.
I could suggest the discovery of CRISPR Cas9 and the later patent war between The Doudna and the Zhang lab/Broad institute along with the many improvements and innovations being built on it since then. Also the Merck/Vioxx story, or the technology behind flowcytometry and cell sorting machines. Also the stories behind the development of Cryo-EM or Lightsheet Flourescent Microscopy two very cool and cutting edge technologies.
I was prescribed Vioxx for years.
Then one day my pharmacist said they took it off the market.
I also had liver problems too.
@@rdallas81 rofecoxib (Vioxx) is available again in Canada and you can get Celebrex in the US which is basically the same thing. I think the whole story was a bit overblown. Subsequent studies have shown that most NSAIDs come with an elevated risk of heart attack if taken high dose over long periods (except aspirin which has a protective effect). So Vioxx is probably no worse then ibuprofen in that respect. It was just the first large clinical study that was able to statistically show the effect.
Forgot how much I love this channel! Keep up the awesome work Asianometry!
The problem is TH-cam doesn't recommend related content anymore. The sidebar is full of random crap I might generally enjoy watching regardless of the current topic.
Your videos are so consistently high quality. Thanks for sharing
My mother had Hepatitis C, she had it for a long time without knowing about it,
At the point of detecting her liver was 75% affected
We were very concerned and prepared for the worst.
We went to various doctors but we fortunately found a specialist.
Now normally we'd have to leave our country for India for treatment and it would cost upwards of 4 crore taka (400,000$)
But by the Grace of God, our country just the previous year started preparing the Hepatitis C drug in our country that costs 45lac taka (45,000$) for the full dosage.
It's been 6 years now and she is now healthy, by the Grace of God. We were very fortunate and I pray others in a worse situation gets better
Did the state pay for the treatment?
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I would love a longer deep dive video from you! I would suggest a topic, but you are better at picking them than I could hope to be XD
It's incredible how excellent scientists and physicians were at determining clinical patterns from observation and then discovering the causative agents.
Nice vid! Didn't know there was a cure.
Hey man, I hope you can talk about Chimei group one day.
About how they became a powerhouse in the plastic industry and the Museum they have in Tainan.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I love the wide, diverse range of topics covered in your videos. Hopefully you'll touch on batteries or more precisely the ones used in BEVs (Battery Electric Vehicles) such as lithium ion batteries or the ones talked about recently by Toyota, the solid state battery.
Videos like this are what make TH-cam great. Keep going and thank you!!
Good one! I have friends that went through both interferon and sofosbuvir, and there's no comparison - the side effects of the former were stunning in scope. Also the treatment lasted 12 months or more compared to four for Sovaldi, which as far as I could tell was free of any side effects at all.
The use of AI in developing leads in medicinal chemistry will probably speed up the development of new antivirals and other meds
significantly - a subject we're hearing a lot about in the pharmacology world.
Thank you kindly for covering this - it's quite a success story...
More medical/pharmacology stuff! Love this
My mom was diagnosed with hepatitis C in mid 00s. She was treated with Russian made Interferon alpha type drugs. It has good results, she recoverd, but in mid 10s she developed cirrhosis and died last year in age of 58.
I’m sorry friend.
@@microdesigns2000 thanks.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Spellbinding story! Bravo, sir! 🎉😊
amazing episode, you should do more drug/sickness related ones
I learned a lot. You're brave for trying to pronounce those medical / chemical names. scientists like to give names that are impossible to say.
Right up my alley! You did a great job covering this.
I’d advise anyone interested in science and viruses to check out “This week in virology” podcast (not my podcast, just a listener of it).
A great disease/epidemiology/public health podcast is "This Podcast Will Kill You".
and don't listen to Huberman podcast, guy is a complete cherrypicking quack
There are still many viruses that have been with us for many years but we still don't have a cure. Herpes is one that comes to mind. And then there's newer viruses like the sars cov 2. We'll always need research it seems, and then there's the new resistant bacteria and viruses.
superb content!!! absolutely impressed!! great video!!
Such a good video! Sound like virology is not what you’ve an expert in but you did a great job explaining everything simply and correctly. Only shame is that you didn’t ask anyone how to pronounce ‘protease’, which in your video sounds like it’s a tease delivered by a pro 😉 but honestly, great video and here’s to some day you making another one about the success of the hepC vaccine!
This would have been nice to have back when I went through chemo for Hep C. My regimen consisted of a twice weekly shot of Interferon, in tandem w/ Ribavirin, and it was brutal! I lost 50 lbs over a six month period and was experiencing severe bouts of tachacardia, which would make me pass out and I'd wake up to find myself on the floor w/ a bloody nose or big bruise somewhere. smh
Hope you're doing well now.
That's a shame. I'm so sorry you went through that.
I did this treatment or a chemical very similar about 7 years ago. It was $180,000 for 6 months.
I think the name of it sounded very similar but it was different than what you mentioned. I was told it was 95% effective when I did the treatment.
And I am cured of hepatitis C.
Very interesting video!
My mom went through Interferon + Ribavarin treatment in early 2010s. The side-effects made it very difficult to be a functional adult with a job, considering the full treatment lasted for about a year. And it was a lot more expensive than 1000 dollars.
I'm glad she went though it (still virus-free to this day) but it's good to know that there's a much better alternative these days.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
I used meds Harvoni for Hepatitis C for 12 weeks - first meds Canada / USA in 2013 . I was in experimental group for Layla University , Chicago . Thank you !!!! Hepatitis never come back . Today is August 2023
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Just a quick note: protease is pronounced "pro-tee-ase". Very interesting video and a great job explaining some very complex topics!
more like "pro-tee-ace". as in Ace in ace of hearts.
the moment i heard the word "nanometers" i thought "ah yes.... an Asianometry video, feels like home"
Considering your usual subject matter revolves around silicon related technologies, this foray into virology / molecular biology / immunology must have stretched your comfort zone a bit. I applaud your bravery as this story is multifaceted and difficult to explain to laypeople. As a medical professional, I will say that your presentation was accurate and covered the principal issues quite well. Overall you have provided an excellent primer on the subject. That said, I will offer two tiny nitpicks. ALT (alanine aminotransferase) is generally pronounced as the individual letters by the medical community and “protease” is pronounced as three syllables (pro-tee-ace). Again, outstanding work on your part to put this summary together. Continued good luck to you and your channel from a longtime subscriber.
to defeat the bug, we must understand the bug 🐛🚀
Starship Troopers reference! :)
Just for my own purposes, would you be willing to include a pastebin link in your description to a list of sources?
I love your content, but I always like to do more reading, especially with something as exciting as this.
Fascinating! Thank you. My Mum had jaundice and nearly died in hospital in Tehran during the 70s! I'm not sure which Hep she had but I wouldn't be here had she not survived.
I am a recovering addict and this stuff cured me, 3 months of anti virals, cost the state funded insurance like $30k! The meds are so overpriced and they make you feel so bad. I felt like a grandpa after a month, your bones hurt, your super tired and no amount of caffeine helps, it was worth it tho been cured since! Finished my mechanical engineer bachelors and sober!
What drug did you take? I had Maviret, it's Glecaprevir/pibrentasvir and experienced literally no side effects. Not even the mildest. Nothing. Was completely cured ❤
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
protease is not pronounced as pro-tease, but pro-ti-ase. proteases are enzymes. most enzyme names end in -ase.
As a labtech (only worked in the medical routine) I am shocked how many methods didn't work in search for Hepatitis C.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Yhe visual of the girl with a gun shot wound to the chest getting a blood transfusion is by far my fav.
Fantastic episode!
It's been well over a decade since I lost my dad to liver failure from hep c, but I'm glad to know fewer will have to go through that going forward.
Thanks! Awesome. Good to know! Love the show 😀😀
This channel is consistently awesome.
شكرا لك سيدي الكريم. حلقة ممتعة ومفيدة.
I've had hep C twice. Once while getting a random STD screening they told me I had hep C my thankfully my body was fighting the virus off naturally. I got tested a few more times and they took my blood and other samples for research made me awnser some questions and oddly gave me 50$ for each of these 4 testings. Three years later while in the hospital they told me I had very early hep C and was confused. I did the treatment in 2021 thank god its covered in Canada. I wanted to die I felt like shit for months. I know someone who did the old treatment in the 90's, they have so many allergies now and other heath problems. While doing treatment they were constantly in pain, it was like chemo. Hep c is rather scary it can live on surfaces for a long time, the virus has mutated like crazy. And now we're seeing Hep D and other forms pop up. Even A&B infects a bunch of people every year its important to get the vax for hep BOTH OF THEM the second booster is super important without it the vax is worthless.
a
Its gross how companies are able to charge 50k for treatment, considering much like TB how dangerous hepatitis is. You do not want people having a, b or c and spreading that shit around. "I've heard" people buying it off the darkweb due to India being able to make any medicine with no fucks given about laws(Along with other medications). Its real and much much cheaper, customs can still take it away if they find it tho and even threaten charges on you. Would suck having the government stealing your treatment because you cant afford "their" treatment. I hate American pharma companies, only support euro/japanese ones.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
A haemophilic older friend of mine had the virus with no symptoms, he was completely cured some years ago.
Good news.
I'm assuming he also got contaminated by Factor VIII from bayer? My uncle also got it, in addition to HIV from it. Unfortunately, after he was cured from his hep, he heard he already had gotten cancer from the hep and died shortly after.
@@DrAugurk something like that. He's very competent (his brother, also but less gravely haemophilic, is a doctor) and can speak at length of drugs and treatments for his condition.
Have I mentioned how much I love this channel? No?? Well, I do.. Thank you for all your hard work. 😊
My friend’s mother had a blood transfusion in the early ‘80s, before blood was heavily tested. She got hepatitis C, and she thought it was fatal. She’s still around thanks to this.
Being recommended to Dr Abiola on TH-cam was a blessing after years of suffering . I have finally been cured from HEPATITIS virus thanks Dr Abiola you are indeed a Blessing to this generation #DRABIOLA ❤☮️🎉
Im impressed by level of knowledge you have on this topic! I now wonder if you studied any medical or biology related major.
Love the starship trooper reference 😂
Should also mention Dr. George Kuo, who worked together with Dr.Houghton and Dr.Qui-Lim Choo on the initial discovery but didn’t get the Nobel prize.
I had it during the '70s and never received any treatment as there was none. Full forward 20 years and I was required to vaccinate against Hep B but never sero-converted, which needed to be investigated with routine testing over several years. All the while, I was asymptomatic. Around 10 years further on, I was declared cured by not showing any select antibody activity over a couple of years. One of the lucky ones who required no treatment.
How are you able to research, understand, and present things in this easy-to-absorb manner
I could not understand
Loved the Starship Troopers reference :)
Well done on simplifying the absurd complexity of biotechnology to something palatable
Great topic
And kudos to Dr Choo
Protease, pronounced with 3 syllables prow·tee·ayz. Pretty much any biological term that ends in "ase" will pronounce the ending as ayz.
Any plans for a video about Lithuania's laser industry?
Fascinating, thank you
I work for gilead. I have some gripes with some of their pricing, but 1000 for a CURE is a great deal. With a single-use treatment cost being that low, the failure in this case is government healthcare support for low income patients.
Except it's not 1000 for a cure, it's 1000 for a single dose, and a cure requires 50 doses...
What is the Podcast called you mentioned at the beginning?
Can you make a video about Zongma Fortress and Unit 731?
Starship Trooper reference! Awesome
Unbelievably complicated work!
Thanks. I wish some that I knew had full access to this. And, hopefully one day, a thing so it can't carry. ❤
Nice Starship Troopers reference :D
I'd be interested in a video of Li Ka-shing. He seems to have dipped his fingers into quite a few pots.
In 2017 I was prescribed Zepatier for Hep c. It worked well for me. Viral load tested zero virus 3 times after meds were finished.
I sold an inferior biotech drug from Amgen in the late 90’s. The name was Infergen. Ribaviron was used as a combination agent along with Interferon to increase its efficacy. These drugs were major failures with many side effects. The main issue was the disease’s ability to mutate. I was absolutely blown away when a cure was discovered. This is why the pharmaceutical/biopharma industry is so important in the discovery of these groundbreaking discoveries.
Ribavirin. He meant.
This kind of reminds me of HIV in a way. RNA viruses (I believe all viruses are RNA based as it has to match with another strand to duplicate, just like DNA does when a cell undergoes mitosis) don’t have great transcription checking (basically spellcheck for RNA). In the case of HIV, there is no transcription check which leads to significant changes during each replication. This single failure to spellcheck is why HIV hasn’t been able have a vaccine created. The only thing we can do is interfere with its duplication processes. That’s why HIV requires several drugs in combination as attacking the virus with a single vector leads to resistance. Gilead essentially only produces antiviral medication; predominantly HIV treatment.
The latest Hep C cures are Proteas inhibitors and your right that they are similar to HIV drugs. They are much less toxic then the earlier Interferon Ribaviren combos.
Like Sulfamides in some bacteria...makes a malthusian method do not kill bacteria...or FUNGUS...
on the other hand ...protease inhibitors has a very bad history ...im talking about AZT (zidovudine) and a lot of drugs..m
There is a cure for HIV and it was found for a guy that was HIV positive and had developed cancer? They put him through immunotherapy and by chance it cured his cancer and also his HIV?
@@jameshatton4405A person being cured doesn't mean we have a cure. There are people who are naturally immune to HIV, and the case you refer to was an instance where the patient got a bone marrow transfusion from such a person. It's not something we can replicate and there are a LOT of reasons you don't want to do it unless it's absolutely necessary. Current HIV treatments are far safer, cheaper and easier.
I just started the sofosbuvir today. Kinda worried about side effects. Anyone have experience with this?
please I was wondering how are you able to probuce hight quality videos without it being to heavy
Bread analogy is useful but debatable: it’s still bread. When has bread ever infected my liver??
I had friends who died because the side effects of the first treatment were unbearable. Nice video! Thanks!
Great history but incomplete. What is the current cost of the drug in various countries? It is my understanding that Gilead soon began selling Sofosbuvir, then Harvoni, at sharply reduced prices to national health systems. I recall hearing that a full course of one of the cures was made available in Egypt (which has a high incidence of hep C) a year or two after the drug was introduced. To cite the intro price of $1000 per pill without noting the dramatic price cuts is unfair to Gilead.
13:29 Did you mean cameroon or gabon or was that map just out of date?
Having my three middle fingers severed off in 2009 and a heart attack in 2015 and a rigorous heart check in 2017 my Hep C was obviously never detected in all the blond test.
In 2021 I moved to a small town I like to call Mexico, Texas. I wonder if there is a connection. I’m glad I haven’t drank booze in 37 years.
11:18 Sliding in a meme I see.
Does something similar exist for chrons disease?
I am now ready for medical school. Thanks!
All i know is, one day i went to the doctor, she asked me why i hadent cured my hep C, i told her i knew many ppl who went through interferon and i was scared...not of the treatment..rather tha it wouldnt work. She looked at me weird and said.."oh no we have a cure now, you take a pill for month andnits gone"
It was unreal. Im cured.
How much is it in California..ineed to know..i have no insurance nothing..what can i do?
I recently got diagnosed with hep c, got an appointment with my doc in a couple weeks, hope mine can for cured 🙏🏼
Be*
When you said: "...regularly injects drugs.", my mind's eye showed me a hospital, with little, sharp, sparks for every needle.
When darkness blinds you, try flipping it, for size.
I have both hepatitis B and C and two decades and two years on dialysis. I never lose hope but I am wanting to get some help.