Mantle Cell Lymphoma - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma (NHL) - Hematology

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  • เผยแพร่เมื่อ 15 ต.ค. 2024
  • Mantle Cell Lymphoma - Aggressive B-Cell Neoplasm - Non-Hodgkin’s Lymphoma (NHL) - Hematology
    Hematological malignancies can be divided into leukemias, lymphomas, and multiple myeloma.
    Lymphomas can be divided into Hodgkin's lymphoma and non-Hodgkin's lymphoma.
    Non-Hodgkin's lymphoma can be subdivided into aggressive lymphoma and indolent lymphoma.
    Aggressive non-Hodgkin's lymphoma includes:
    *Diffuse large B-cell lymphoma​ (DLBCL)
    *Burkitt's lymphoma.
    *Mantle cell lymphoma.
    *Precursor T-cell lymphoblastic lymphoma.
    *B-lymphoblastic lymphoma.
    Indolent non-Hodgkin's lymphomas include:
    *Follicular lymphoma
    *Marginal zone B-cell lymphoma (MALToma)
    *Hairy cell leukemia/ lymphoma.
    *Waldenstrom macroglobulinemia.
    *Mycosis fungoides/ Sezary syndrome.
    Mantle cell lymphoma is a rare, aggressive B-cell non-Hodgkin's lymphoma that affects people around 63 years of age...More common in females than males...t(11;14) translocation is common. Overexpression of BCL-1 "cyclin D1" leads to increased proliferation of cancer cells.
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ความคิดเห็น • 120

  • @MedicosisPerfectionalis
    @MedicosisPerfectionalis  3 ปีที่แล้ว

    ♥️ Cardiac Pharmacology: www.medicosisperfectionalis.com/
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  • @stevehaynes2857
    @stevehaynes2857 8 หลายเดือนก่อน +2

    My father-in-law was diagnosed with this 9 days ago, on a Thursday. He died 2 days later. He was 90 years of age and did not want treatment. He went very peacefully, much respect to him and all the hospital staff.

  • @darrelleporteous2780
    @darrelleporteous2780 ปีที่แล้ว +6

    Thanks for this video. It has been 4 yrs since my diagnosis of mantle cell. I have watched and read a number of articles but yours is very simple and easy to understand. I had the treatment you described and a stem cell transplant. I was 60 & female. I’m now 66 and have never been healthier. I am proactive re diet and exercise. I took control of my own health.

  • @myenchantedlife5262
    @myenchantedlife5262 5 ปีที่แล้ว +16

    I was just diagnosed with this, it is my second cancer I also have Pancreatic Neuroendocrine Cancer. Needless to say not a good day but thank you for the information

    • @starrysky1588
      @starrysky1588 3 ปีที่แล้ว

      How are you doing now??

    • @myenchantedlife5262
      @myenchantedlife5262 3 ปีที่แล้ว +5

      @@starrysky1588 I work hard at being as healthy as I can. I focus on food as my main source of healthcare and keeping my organs working well. My liver and kidneys have improved greatly. My main struggle is digesting food and I struggle to be able to be active. I am just happy for each day I get with my family. Thank you for asking

    • @starrysky1588
      @starrysky1588 3 ปีที่แล้ว +1

      @@myenchantedlife5262 I am glad to hear that your kidney and liver are improving. You will heal more just be patient. Being active is after all, not the primary goal of life. You can rest and read books and do many other things. The main concern is health. I wish you a complete recovery! And indeed, every day we all get to spend with family is a blessing for all of us!

    • @jamesbon1
      @jamesbon1 3 ปีที่แล้ว

      Good to hear you're improving. I was diagnosed in 2017 with MCL at 51. I am in complete remission so far. Hoping for a cure.

    • @zeyneptosun6422
      @zeyneptosun6422 3 ปีที่แล้ว

      James Bon what kt protocols did you get? My father diagnosed with mcl last week

  • @kk70x7
    @kk70x7 3 ปีที่แล้ว +4

    Was just assigned clinical trials for Mantle Cell and even though I had been a Hematology specialist in a past life; had never even heard of this. THANKS, subscribed! :-)

  • @gabrielweissenbach4048
    @gabrielweissenbach4048 3 ปีที่แล้ว +2

    Very nice explanation. You really have a talent for bringing informationen to the man.
    Just one thing to correct: MCL is an indolent lymphoma which can change to aggressive.

  • @empathintuitive
    @empathintuitive 4 ปีที่แล้ว +9

    Ur videos are more than awesome,and what u r providing to us is priceless!!!
    Huge respect🙏🙏

  • @macmad6959
    @macmad6959 2 ปีที่แล้ว +10

    I have recently been diagnosed with Mantle B Cell Lymphoma, I start my chemo next week, but great to understand where the mantle sits within the lympthnode, i am 55 was fit and healthy, and literally started to lose weight in the last few months, and my spleen is massively enlarged, if all goes well in the next 6 months, i will be having a stem cell transplant, anyone out there who has this horrific disease, STAY POSITIVE x.

    • @darrelleporteous2780
      @darrelleporteous2780 ปีที่แล้ว +1

      Hi Macmad, I am 5 yrs from completion of a successful treatment for mantle cell. Stem cell transplant wasn't pleasant but it has certainly done the trick. The problem I had wasn't the treatment as it is a well documented process and procedure that many people have been through with great outcomes but the after care in my case was left wanting. More information needs to be given re recovery back to normal healthy life. It has taken me 5 yrs to work out the best ways to help my self return to normal health state. I now follow a diet that includes fermented foods which have helped return my microbiome to a good state. All the antibiotics and toxic drugs destroyed my gut. My advice to you is be proactive about your after treatment health. It is as important as you treatment. Do your research about gut health. It wouldn't have taken me 5 yrs to get to where I am if I had been told this straight after my treatment finished.
      I am now 66 I have taken control of my health, I eat lots of fermented foods, kefir, sauerkraut, youghurt made at home high in benificial microbes . I exercise multiple times a week and I have a supportive husband, family and friends by the way I'm in Australia ,,
      Good luck with your treatment I know you will be ok.

    • @macmad6959
      @macmad6959 ปีที่แล้ว +1

      @@darrelleporteous2780 Hi Darrelle, Thanks for taking the time to reach out and give me your own experiences, i am sorry to hear you found the after care treatment inadequate, in your case, as surely that's the most important part after SCT, we all need to be monitored, i know gut health is an exptremely important factor in keeping a suitable bio balance, i have a great team supprt team around me, said to be one of the best private facilities currently in London, I have heard the SCT is the toughest, and the biggest low you could even imagine, i will be in Hospital for 3 weeks in April, once my stem cell has been harvested and transplanted, i am under no illusion what's ahead of me, but know with the love of my wife,daughter, family & friends, i have the best support network available, outside of the most amazing staff who care for me currently every 3 weeks, my current treatment consisting of R-Chop and CYTARabine, which is administered and alternated every 3 weeks, ( 2 sessions) per day, with a 12 hour gap between another (2 sessions), i have been having my first sessions at 18:00 hrs, followed by next next session at 06:00 hrs, i am then left for another 12 hours, before my last 2 session will begin, again at 18:00hrs and again at 06:00hrs.
      This is done as a impatient over 3 day hospital stay.
      I don't appear to be suffering any noticable side effects, to either R-Chop or CYTARabine, i did have suffer a small infection, which was diagnosed as pleurisy and strong antibiotics, resovled the issue.
      I am a very positive guy, and this is just a mild set back, i am hopefull to pull through this and come out the other side,
      Wishing you all best for the future,
      Darren (Macmad)

    • @wasirajpoot6424
      @wasirajpoot6424 ปีที่แล้ว

      @macmad6959
      My father died of mantle cell lymphoma😭 the doctors here in Pakistan couldn't do much about it, he was 45 and got very week and within 9months after diagnosis he died and his spleen also got enlarged.
      I wish we could save him but all wishes to you get well soon

    • @macmad6959
      @macmad6959 ปีที่แล้ว

      @@wasirajpoot6424 I am sorry to hear about your father losing his life so young through MCL.
      And I thank you for your kind thoughts and well wishes.
      Darren (Macmad)

    • @hurairaali9038
      @hurairaali9038 5 หลายเดือนก่อน

      ​@@wasirajpoot6424 These success stories from london aurstalia etc are very positive ...I am a final year medical student in pakistan and very sorry about your father he is surely in a better place right now... All I can think of is becoming a good doctor and provide early diagnosis plus accurate treatment, I wish our medical system here in pakistan to be this much effecient like in other developed countries...

  • @rahmahl5762
    @rahmahl5762 4 ปีที่แล้ว +7

    Because you watch MEDICOSIS you're un the top, YES YES YES . thank youuu

  • @ezz3227
    @ezz3227 2 ปีที่แล้ว +2

    Amazing u summed up with simplicity,love it

  • @atropabelladonna997
    @atropabelladonna997 3 ปีที่แล้ว +5

    WALLAH medicine makes sense but only on medicosis perfectionalis... ❤️

  • @Shinnoshuke8894
    @Shinnoshuke8894 6 ปีที่แล้ว +3

    Thank you so much ☺️ I’m gonna write about this disorder for my 3000 words essay.

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  6 ปีที่แล้ว +2

      Cool...I am so delighted that I have helped

    • @Shinnoshuke8894
      @Shinnoshuke8894 5 ปีที่แล้ว +2

      Medicosis Perfectionalis I got 80% for the essay. 😁😆Thank you so much

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 ปีที่แล้ว +2

      Wonderful...That’s great, bro! Thanks for letting me know! Keep slaying it!

  • @yadinoori7372
    @yadinoori7372 2 ปีที่แล้ว

    I love how u know how good u r

  • @23dfmahghd
    @23dfmahghd 9 หลายเดือนก่อน

    I am confused about the cycles For example If patient will be treated with RCHOP RDHAP protocol 6 cycles every cycle is 21 days , is that mean that the total duration of treatment is 126 days? approximately 4 months? Am I right!

  • @quiquechavez2493
    @quiquechavez2493 4 ปีที่แล้ว

    Amazing explanation. I was diagnosed with MCL in 2016 at 46
    Went into remission in 2017 at 47 and relapsed in 2019 at 49
    Started my 2nd treatment today of lenalidomide pill and start rituximab in 2weeks for 5weeks

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 ปีที่แล้ว

      You mean CML?

    • @quiquechavez2493
      @quiquechavez2493 4 ปีที่แล้ว

      @@MedicosisPerfectionalis mantle cell lymphoma

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 ปีที่แล้ว +2

      Oh! Sorry! Thanks for clarifying.
      I wish you the best...Follow up with your doctor!
      And never give up!

    • @SweetyD2023
      @SweetyD2023 4 ปีที่แล้ว +7

      I have Mantle Cell Lymphoma non-hodgkin's & was diagnosed in Stage four in 2011. I was 50 years old & a woman. Did all the chemo & radiation but the cancer was too strong & within a couple weeks symptoms returned with swollen lymph nodes & tumors on my arms & legs. I was offered a stem cell transplant & so far I'm still here in Jan 2020, almost eight years later! They tried to gather my own healthy stem cells because there's no risk of them being rejected but I didn't have any. The next best thing is collecting them from your blood family. I have three sisters from the same mom & dad but they didn't match me. They found a German woman living in Germany that matched mine! I'll be 60 in April. I hope I've gave you some hope. Only God knows when it's your time to leave this world. Hang on. Don't give up! Sending prayers up!

    • @SweetyD2023
      @SweetyD2023 4 ปีที่แล้ว

      Have they offered you a stem cell transplant? I'm not surprised at all that your MCL came back so fast. Chemo & radiation won't cure it. It just keeps it at bay for a short time. They gave me every chemo meds available & even some experimental drugs. I went to the Mayo Clinic. They gave me all the chemo my body could handle! Try a stem cell transplant if you haven't already. Many blessings to you. ❤

  • @kandiceblu1
    @kandiceblu1 ปีที่แล้ว +1

    I’m only at the beginning of this video but I’m a 28 year survivor of mantle cell lymphoma I am a female and I was 38 years old at the time of onset but I’ve been re-diagnosed with a new cancer but I haven’t received the results yet but it’s in a different place so I don’t know what is going on as of this moment…..

  • @thisismyname007
    @thisismyname007 3 ปีที่แล้ว +3

    The Nordic protocol worked for me. Alternating rounds of high does R-CHOP and in hospital high dose of cytarabine. Now I’m on Rituximab maintenance which is chemo but my hair doesn’t fall out. The maintenance regime is like an insurance policy. I’m three and a half years on from diagnosis and I’m OK.

    • @starrysky1588
      @starrysky1588 3 ปีที่แล้ว

      That's great! Wish you a healthy life!

    • @zeyneptosun6422
      @zeyneptosun6422 3 ปีที่แล้ว

      So happy to hear good news. My father diagnosed with MCL last week. The chemo plan is 3 cycle R-CHOP and 3 cycle R-DHAP and the otolog ctem cell trans. Then rtx maintance therapy. Can you givi more detail about your journey? Will be very appreciated

    • @thisismyname007
      @thisismyname007 3 ปีที่แล้ว

      I've been in "complete remission" for four years now. I gather that the outcome depends on the nature of the mutations in the MCL cells. It looks like one group of patients will relapse within two years and the other group will go for up to ten years or more. The good news is that when I do relapse, there are drugs like Ibrutinab that "pushes the pause button" on the MCL cell division process. And now there is CAR-T therapy that might even be "curative." CAR-T has not been in use long enough to say just how long it is effective.

    • @zeyneptosun6422
      @zeyneptosun6422 3 ปีที่แล้ว

      Even Dwarfs Started Small than you. I hope you are completely cured already ;)

  • @farahasad2366
    @farahasad2366 2 ปีที่แล้ว

    🥰 saved my hematology exam

  • @Lastonbanda837
    @Lastonbanda837 3 ปีที่แล้ว

    Thank you , most appreciated for your work😀

  • @kemnana8740
    @kemnana8740 5 ปีที่แล้ว +2

    medicine make sense here only indeed!

  • @arianab8869
    @arianab8869 2 ปีที่แล้ว

    Why do you need to do a bone marrow biopsy if there is cytopenia again? (is it just to rule out leukemia?)

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  2 ปีที่แล้ว

      Because the cause of the cytopenia is usually bone marrow disease. The question is “which one”?! This help us make an accurate diagnosis on which treatment depends.

  • @worldaround6520
    @worldaround6520 ปีที่แล้ว +1

    Thank you sir.

  • @doctorofmedicine1113
    @doctorofmedicine1113 5 ปีที่แล้ว +2

    Once again thank you

  • @hamzaalreef1381
    @hamzaalreef1381 5 ปีที่แล้ว +1

    Thanks for information!! I diagnosed with non Hodgkin Lymphoma b cell consist with mental cell i start getting chemotherapy R maxi chop and Retuximab and next cycle cytarabine and retuximab after 4 cycle pet scan was negative but i complete 6 cycle now dr suggest me to do autologous bone marrow, i want your suggestions for bone marrow its must needed ?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  5 ปีที่แล้ว +1

      It’s not a must, but it can be of huge benefit depending on your situation...I can’t give you any info about that...I am not an expert on that issue...Talk to your doctor, try to get a piece of paper and write down your pros and cons of it, and hopefully you will see the big picture and can make a better decision...You can always get a second opinion.
      Wish you the best!

    • @kristinwiese8299
      @kristinwiese8299 5 ปีที่แล้ว +1

      My dad was diagnosed with diffuse large b cell lymphoma and mantle cell lymphoma about 2 months ago. He's been fortunate enough to be able to take his chemo at home although he still has to go to ohio state james cancer hospital to get chemo shots in his spine. I pray that they get yours into remission. It takes a very strong person to be able to go thru this.

    • @SweetyD2023
      @SweetyD2023 4 ปีที่แล้ว +3

      Yes do the bone marrow transplant. Chemo drugs & radiation only last between doses but won't cure it. I have MCL non-hodgkin's. When they found mine I was in stage four. After all the chemo & radiation my body could stand they gave me a stem cell transplant. That was almost eight years ago. Btw, I was 51 when diagnosed & a woman. Many blessings to you.

    • @thisismyname007
      @thisismyname007 3 ปีที่แล้ว

      The autologous stem cell transplant is like dropping an H-bomb on your immune system. The drugs they give you kill everything and the infusion of your own bone marrow cells rescues you. It’s the way to go if you don’t have co-morbidities like maybe diabetes or whatever.

    • @starrysky1588
      @starrysky1588 3 ปีที่แล้ว

      @@kristinwiese8299 How is your dad's health now?

  • @nvshereefmohamed7152
    @nvshereefmohamed7152 4 ปีที่แล้ว +2

    My father has been diagnosed MCL . the doctor says it is in stage 3 after PET scan and he started chemo therapy. My question is is it curable in its stage 3?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 ปีที่แล้ว +1

      Could be.
      I don’t know 🤷‍♂️
      Please follow up with your doctor.
      Never give up!

    • @SweetyD2023
      @SweetyD2023 4 ปีที่แล้ว +2

      I was in Stage four MCL non-hodgkin's & had a stem cell transplant. That was eight years ago. I'm a woman. That would depend on how old & how healthy he is too.

    • @nvshereefmohamed7152
      @nvshereefmohamed7152 4 ปีที่แล้ว

      @@SweetyD2023 sweety
      Have you cured completly

    • @thisismyname007
      @thisismyname007 3 ปีที่แล้ว

      Stage 1 or 4 doesn’t matter. MCL is not like a solid cell cancer that can be surgically removed if you identify it early.

    • @zeyneptosun6422
      @zeyneptosun6422 3 ปีที่แล้ว

      Sweety D soo happy for you...how are you doing right now? Which chemo protocols did you get?

  • @vivalavivarium
    @vivalavivarium 11 หลายเดือนก่อน

    you from saint louis?

  • @moristhetiger
    @moristhetiger ปีที่แล้ว +1

    THANKS..

  • @jyotindroadhikarimayum
    @jyotindroadhikarimayum 4 ปีที่แล้ว

    How is epithelioid histiocyte different from tingible body macrophage?

  • @aimanahabubakar8855
    @aimanahabubakar8855 3 ปีที่แล้ว

    Thank you very much 😊

  • @thepoppyvalentine
    @thepoppyvalentine 6 ปีที่แล้ว +2

    Thanks so much for this. :)

  • @worldaround6520
    @worldaround6520 ปีที่แล้ว

    The word indolent means not wanting dolor pain

  • @nvshereefmohamed7152
    @nvshereefmohamed7152 4 ปีที่แล้ว

    After having finished three chemotherapy, i didn't have any of the side effects supposed to be affected. What does it mean?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 ปีที่แล้ว +1

      Can you tell me more?

    • @nvshereefmohamed7152
      @nvshereefmohamed7152 4 ปีที่แล้ว +1

      @@MedicosisPerfectionalis
      Sir. It has been told by the doctors that i may be suffering with side effects such as vomiting, hair falling, fever, digestive problems etc...during chemotherapy for mamtle cell lymphoma. I finished 3 cycles. I didnt have any of the side effect. What does it mean? Is it positive or negative?

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 ปีที่แล้ว +1

      It’s good.
      Not having side effects is a good thing!
      Please continue to follow up with your doctor

    • @starrysky1588
      @starrysky1588 3 ปีที่แล้ว +1

      @@nvshereefmohamed7152 how are you doing now??

    • @zeyneptosun6422
      @zeyneptosun6422 3 ปีที่แล้ว

      nvshereef mohamed how are you doing now?

  • @sahilkurdiya8464
    @sahilkurdiya8464 4 ปีที่แล้ว

    Too good video

  • @realindian2306
    @realindian2306 4 ปีที่แล้ว

    Where is the best treatment in mental cell lymphoma

    • @MedicosisPerfectionalis
      @MedicosisPerfectionalis  4 ปีที่แล้ว +1

      It depends!
      Please talk to your doctor!

    • @realindian2306
      @realindian2306 4 ปีที่แล้ว

      @@MedicosisPerfectionalis is this cure 100

    • @jamesbon1
      @jamesbon1 3 ปีที่แล้ว

      @@realindian2306 There is no cure for MCL (yet!), only treatment.

  • @saharafsheen6964
    @saharafsheen6964 5 ปีที่แล้ว +1

    Awesome

  • @noorzozo2220
    @noorzozo2220 6 ปีที่แล้ว +1

    👏👏👏👏👏thanks

  • @SherienElBehery
    @SherienElBehery 4 หลายเดือนก่อน +1

    👏👍

  • @quiquechavez2493
    @quiquechavez2493 4 ปีที่แล้ว +2

    Sorry ibrutinub (pill)

  • @sarantis1995
    @sarantis1995 2 ปีที่แล้ว

    I appreciate your effort but your voice sounds extremely boring, I am sorry. It really didn't help stick to the narration, the opposite I'd say. It's not even loud enough. It's a good video from. An informative point of view though.