I have two additions: 1. Thyroid hormones can diffuse into cells passively, as well. However the rate of diffusion wont be enough to provide target functions. 2. If TH receptor did not bind the hormone, it would associate with co-repressors which inhibits the gen transcription further. So, the lack of the hormone will lead to profound effect on target tissue due to both lack of activation and exaggerated inhibition. To exert its effect, the receptor needs to be dissociated from co-repressors and binded to free T3, then the receptor will form heterodimers with RXR to accelarte transcription. Thyroid hormone resistance is due to many reasons, but one of them is loss-of-function mutation of the TH receptor beta gene. In this scenario, those mutant receptors have low affinity, and despite accumulation of the large amount of active hormones, TSH will remain elevated or inappropriately normal, since it does not sense or react the T3. This disorder should be in mind and needs to be distinguished from the patients with TSHoma and dysalbuminemic hyperthyroxinemia.
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Finaly i found a video witch explained how these thyroids hormones work in a way i can understand. Thanks!
This is amazing! It’s like you’re in my brain! Thank you! PLEASE make more videos! And never stop teaching ! You have a gift!
How can I keep calm after beating hypothyroidism with doctor iyaremoses on TH-cam herbs medication doctor link#driyaremoses.
I have two additions:
1. Thyroid hormones can diffuse into cells passively, as well. However the rate of diffusion wont be enough to provide target functions.
2. If TH receptor did not bind the hormone, it would associate with co-repressors which inhibits the gen transcription further. So, the lack of the hormone will lead to profound effect on target tissue due to both lack of activation and exaggerated inhibition. To exert its effect, the receptor needs to be dissociated from co-repressors and binded to free T3, then the receptor will form heterodimers with RXR to accelarte transcription. Thyroid hormone resistance is due to many reasons, but one of them is loss-of-function mutation of the TH receptor beta gene. In this scenario, those mutant receptors have low affinity, and despite accumulation of the large amount of active hormones, TSH will remain elevated or inappropriately normal, since it does not sense or react the T3. This disorder should be in mind and needs to be distinguished from the patients with TSHoma and dysalbuminemic hyperthyroxinemia.
Made an account just to say how great your channel is. Thank you for all the great work .
How can I keep calm after beating hypothyroidism with doctor iyaremoses on TH-cam herbs medication doctor link#driyaremoses.
Thanks for the clear explaination
You are a genius and your videos are amazing! Please make more videos, thank you
This is AWESOME!!!! Thanks for making this video. You save the world!
That’s very kind of you to say. Thanks.
Thank You so much dear ❤️💚♥️🌼
How can all of these complicated things resulted from evolution😭 Nature is amazing!
amazing thanx
Awesome video! Really helped :D
Thank u very much😍
How can I keep calm after beating hypothyroidism with doctor iyaremoses on TH-cam herbs medication doctor link#driyaremoses.
the T3 receptor is located in the nucleus or cytoplasm of Target Tissue Cells ?
thanks for the clear explanation, but you are need to complete the hypothyroidism pleas
What about T2, T1, T0 ?
Thanks alot
Hi dr how are you ,ok i have internal thyroid gland above 25 years. I am started medicine up to now no have change so dr what i do?
I recommend you consult your doctor. Best wishes.
is T3 an extracellular messenger?
thanks bro i appreciate the help.
you are very rapid
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No hypothyroidism?
How can I keep calm after beating hypothyroidism with doctor iyaremoses on TH-cam herbs medication doctor link#driyaremoses.
mababa ang tsh ko po
Oi