LONGEVITY: The Science of Aging and How to Turn On Your Longevity Genes to Live Longer
ฝัง
- เผยแพร่เมื่อ 29 พ.ค. 2024
- Dr. Rajsree Nambudripad, MD is board-certified in Internal Medicine and founder of OC Integrative Medicine in Fullerton, California. In this video, Dr. Rajsree explains the science of aging and all the factors that affect your longevity, from genetics, to diet, exercise, exposures, and lifestyle. What's the difference between Lifespan and Healthspan? Biological Age vs. Chronological Age? What are the hallmarks of aging? Learn about Sirtuins, AMKP, and mTOR, and Autophagy and how they impact your longevity. How does the gut microbiome impact your Longevity? How does chronic inflammation affect Longevity? She reviews the latest science on Diet, Lifestyle, and Supplements to promote health and longevity.
00:00 Introduction
00:42 Lifespan vs. Healthspan
01:31 Outward Signs of Aging
01:57 Proactive and Preventative Approach to Health and Longevity
02:20 Key Lab Biomarkers
03:45 Chronological Age vs. Biological Age
04:18 Supercentenarians
04:31 Factor Influencing Longevity
05:03 Hallmarks of Aging
08:23 Epigenetic Clock
08:59 Sirtuins, AMPK, and mTOR
13:30 Autophagy
14:58 Time Restricted Eating
16:00 Gut Microbiome and Longevity
17:19 Inflammation and Longevity
17:48 Inflammaging
18:43 Sugar and Advanced Glycation Endproducts
20:18 David Sinclair, PhD and Information Theory of Aging
20:48 Yamanaka Genes (Fountain of Youth Genes)
21:14 The Future: Gene Therapy and Senolytics
22:22 Blue Zones
23:47 Diet: Key Principles
25:35 Intermittent Fasting
26:31 Exercise
27:20 Hormesis
28:09 Supplements to Improve Your Healthspan
29:53 Berberine for Insulin Resistance
30:42 Sleep
31:02 Minimize Exposure to Toxins
31:44 Relationships with People
32:17 Case Example: Mike
32:40 Key Points
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This information, including but not limited to, text, graphics, images and other material contained on this video and website are for informational and educational purposes only. No material in this video is intended to be a substitute for professional medical advice, diagnosis, treatment, or medical supplement approved by the Food and Drug Administration. The information provided should not be used for diagnosing or treating a health problem or disease, and those seeking personal medical advice should consult with a licensed physician. Never disregard professional medical advice or delay in seeking it because of something you have seen in this video. No physician-patient relationship is created by this video or the information provided. Furthermore, neither Rajsree Nambudripad, MD or any contributor to this video, makes any representations, express or implied, with respect to the information provided herein or to its use. - ยานยนต์และพาหนะ
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Thank you everyone for watching! I look forward to reading all your questions and comments, so please post them below! To learn more about any of the supplements described in the video, see link below:
dr-rajsrees-public-supplement-store.myshopify.com/
I did doc thank ypu so much
Hi doctor Rajsree,
I'm glad I found your channel,
I'm a new subscriber here.
Thanks for using real voice, explaining it in an easy to understand method with pictures and text.
Please can you tell me if there is any kind of test that I can get done to find out if I have been affected by living in damp and black mould overgrowth, home for a dacade.
Is there any particular tests that will show how much our health has been affected by living in such environment. So we can find good cure once we know the root cause and diagnose what is causing the symptoms like headaches chronic fatigue and memory problems.
Let your food be your medicine.
@@pataguam3522 Yes indeed. Thanks for watching.
@@drrajsree 9.77h
I am 75, and feel better than in my 40s. No meds, no aches or pain. Never had any surgeries or hospitalizations. Eat wisely, and exercise regularly. Keep negative people at arms length, and live a life of gratitude.
That’s amazing! I like the part about keeping negative people at arms length 👍
Hello Elizabeth 👋 I'm Carmine I like your post and would like to ask to ask you some questions may I? One of my goals in life is to be medication free have you always exercise d ? What's your routine consist of ? How do i live a life of gratitude ? any other tips ?
You have been truly blessed!! Enjoy!!
Why do you keep negative people at arms length….so you can still slap them once in a while? 😂
0@@raewise6345
Probably one of the best videos on healthy life style
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
All family doctors should watch this video ❤
Thank you so much!
BEE our own HEALth Care Guru... Thanks for sharing what really works BEST
Just a general comment, I'm a health nut and it's my favorite subject, and since discovering your channel you are now my new health guru I follow. I have very high standards, so this is saying something!!! Thank you immeasurably!!!
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
You are brilliant. You remind me of the saying " There is always something that you can do before you see your Dr.".
Thank you so much!
I've watched hundreds of videos from all the doctors on youtube.
You've done an amazing job by condensing all the available science on this topic.
You are a gem, thank you so much for putting all this info together. ❤️
If all doctors were like you, we will be a much healthier society.
Wow! I really appreciate your feedback! Thank you so much for your encouragement and support. It means a lot to me. Best wishes in your health, RN.
Thank for all this valuable information Eva from Greece 77 years old
@@user-be4mj2sy5z Thanks so much for watching! I've always wanted to visit Greece!
I have followed many anti-aging materials but this is the most comprehensive one.Thank you I will watch repeatedly.
Thank you so much for such kind feedback! Great to hear from you! RN
I’m sure I am aging backwards. At 65 I was horrible and sleeping 4 hrs in the middle of the day. Fat and all metabolic markers were way out of range. But when my Pre Diabetes had advanced to #2 diabetes, that got my attention. Today at 75 I feel great and my metabolic health proves it. 80 lbs gone and I ride a electric Unicycle for transportation and I high intensity sprint. And listen to Doctors like you!
That's incredible! Thanks for sharing. Best wishes in your health, RN
That's great to hear. Did you go on diabetic tablets or other medication?
@@cesschartz7813 no medicine as a matter of fact my doctor didn’t suggest anything but another appointment in a few months. (I’ll tell the rest of the story if you want to hear it)let me know.
@@4406bbldb Stunning! Thank you for the quick response. Sure, I would love to know more🙏☺️.
@@cesschartz7813 thanks for watching.
Wish you Rajsree a very long longevity.
Thank you so much! This comment put a big smile on my face!
@Rajsree Nambudripad, MD things' that make our HEARTS SMILE 😍😍😍😍
All I can say is thank you for sharing your knowledge on healthy life style.
Thanks so much for watching! 😊
This sums up everything really nicely. I wish more content creators would do this. Instead, they insert memes, give shot-outs, engage in rants, insert sound effects, and just generally waste a lot of time. This video is just the opposite and worth listening to multiple times.
Thank you so much for such valuable and encouraging feedback! It really means a lot to me.
@@drrajsree You're very welcome!
0:12: ⏳ This video discusses longevity and how to live a healthy life.
5:01: 🧬 The video discusses the factors that contribute to aging on a DNA and cellular level.
9:43: 🧬 Sirtuins are enzymes that unravel histones and regulate gene expression, but their activity declines with age due to diminishing NAD levels.
14:30: 🍽 Fasting and calorie restriction promote longevity by activating autophagy and improving lifespan in various species.
19:07: 🍭 Minimizing sugar intake and foods that quickly turn into sugar can help in looking younger and living longer.
24:01: 🥦 To live longer, it is important to follow a customized diet that includes whole foods, limits refined sugar and processed foods, and focuses on plant-based sources of protein.
28:53: 🔑 Omega-3 fish oil, magnesium, antioxidants, and berberine are recommended for various health benefits.
Recap by Tammy AI
Thanks so much for watching! 😊 Great notes!
This is one of the best videos on longevity I head so far. I'm 75 now. Unknowingly following your advices so far like eating veg food, sleeping, interacting with a network of relatives and friends friends, moderate exercise on bed only for1 hr daily etc. I am glad as you confirmed my habits are good in your seminar.Thanks Dr.
That’s wonderful! Thanks so much for your kind feedback. Best wishes on your health, RN
I am from the Philippines. Do you have a published book that is for sale?
@@lorsicat6288 Not at this time. But my mother-in-law, Dr. Devi Nambudripad has many on Amazon. She is a pioneer in holistic medicine. Check them out!
I think this video was possibly the best I’ve ever seen on health and longevity! Thank you for covering all aspects for us🥳🎉
Thank you so much! I really appreciate your feedback!
@@drrajsree Bar None this is the most comprehensively accurate presentation on the subject that I have seen yet watching thousands of hours of medical education videos past ten years,, moreover best presentation Style. Familiar with all the work of the md-ph.d mentioned and numerous more. All that is proven important and significant to date, is in this presentation, I follow it all and I've been planning on adding berberine. So far I am 83, mentally Sharp, some sarcopenia, and Joint injuries from Sports. Have made major strides to return my lab chemistry dashboard such as you mentioned to Optimum and normalcy in some cases. This is truly a stunning work. Thank you Raj!
@@mat1500 Thank you so much for your very kind and encouraging feedback. It means a lot to me. Congrats on your health at 83 and best wishes for a long and healthy life! RN
This video was like gold.I think that this is the proper way to do.Thank you very much doctor.
Thank you so very much I really appreciate your feedback!☺️🙏🏼
I do intermittent fasting 16/8 since more than one year! Significative weight loss and great blood test. It's MAGICAL 🥰💪
That’s amazing! Thanks so much for watching in sharing your success.
I enjoyed listening to your brief description of reverse aging. I am 80 years old but I dress and _feel 40.
@@mariaadizaslastadizas5380 That's amazing! Thanks for watching and wishes in your health, RN
Fantastic video. Complete, detailed and simple. Thank you.
Thank you so much! Appreciate your watching and posting your feedback.
This is the best video I have seen on longevity!!! I just subscribed to your channel. There are several other videos that I want to watch. Thank you Rajsree.
Thanks so much for your support! 🙏🏼
Dr. R.N. This TubeTube is the best I have ever listened to. I want to download your TH-cam on my phone. Thanks indeed. JD.
Thank you so much! I really appreciate your kind feedback and encouragement. Best wishes, RN
This was a fantastic explanation of aging
Thank you so much!
Wonderful, Very insightful and knowledgeable!!
Thanks so much for watching! 😊
I think this video was possibly the best I’ve ever seen on health and longevity! Thank you for covering all aspects for us
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
This video simply summarized everything about the field in a simple way that anyone can understand. How's that possible?
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
I watched dozens of SIBO videos and I discover Dr. Nambudripad's videos which are the ones that makes more sense than any other. I watched her SIBO/IBS/SIFO video's and her giddiness is what has been working for me, unfortunately I am on antibiotics at the moment since I my issues got to a significant level. Now I am seeing the light at the end of the tunnel and hopping that there is no severe damage after antibiotics. Thank you for these amazing videos Dr Rajsree. Now, I need to start thinking on supplements and pre/probiotics, the question is, how am I going to know that these products are good quality? Please, no offense, but I bought so much product and nothing work that now, I am so skeptical of everything. Maybe nothing work because I was doing everything wrong until this channel .... Any comments about the her products will be appreciate it. Thank you again. 💚
Thanks so much for your kind feedback! I do carry my own line of supplements you're welcome to check out that has worked well for my patients. Best wishes in your health, RN
🥰
It's the worst when you appear older than your peers. 2 years ago, I attended my paternal cousin's marriage. My cousin and I share many physicial resemblances and, we can easily pass by as siblings. At the wedding ceremony, many of the groom's relatives and friends assumed that I am her older brother despite the fact that I am 6 years younger to her. I look much older than my real age. It wasn't a problem at school because I was the "big boy" but as I am getting older, it's becoming a major problem.
Sorry to hear this. Thanks for watching.
I know people who looked older at certain points in their life, but as they aged, they started to look their age or younger.
@@mrshonourable Great observation. Thanks for watching!
I tried ozone therapy and now my gut seems damaged. Any suggestions on how to repair?
@@helenehughes5465 Sorry to hear this. Please watch my video on Leaky Gut.
It is great that more people get to know through your videos that lifestyle is the key to longevity. Thanks for posting!Thanks Dr.
Thanks so much for watching!
Great advice !! Thank you Dr. for sharing a such great info with us.
Thanks so much for watching! 😊
Great video! It covers practically all the many angles. I pretty much do all the things in this video and feel like half my age (70). I would only add that I get out early in my day to get the morning sunlight which has been key to my circadian rhythm and great sleep.
Thanks for sharing!
Thank you, Dr. Nabudripad. You are a goddess. Those who have you as a doctor are very lucky. This video has made me more aware and understand our health better.
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
An excellent commentry by Dr Rajsree Nambudripad. It encompasses the total science of good health. Following Dr Rajsree's tips is sure to help. I'm following her advice !!
Thanks so much for watching! 😊
Thank you for posting the highest quality and most timely content, Dr Rajsree! Every one of your videos are packed with the most pertinent details for maintaining optimal health & wellness! I appreciate you!
Thanks so much for watching Tony! I truly appreciate your encouragement and support! It really means a lot to me. Cheers to great health! Best wishes, RN
Yah I'm thousand times agree
Thank you so much for the advise given which is the best gift one can give to any other human beings. Thanks to your parents, teachers and peers who gave us such an altruistic noble daughter. Good Luck!!! Dr. Jayantha Pathirana from Sri Lanka
Thanks so much for your kind support! 🙏 I really appreciate hearing from you in Sri Lanka! Best wishes, RN
Wow! Proud of such a great doctor with her unmistakable voice giving us advice online
Thank you kindly for your support and encouragement! It really means a lot to me! Best wishes in your health, RN
Thank you dr Rajsree great as always brilliantly explained and giving us knowledge about our health a big thank you doc you're blessing.
Thanks so much for watching Tess! :) Hope you're doing great. Your encouragement and support always mean a lot me!
I have the best relationship with my music instrument which responds to me I truly love making me feel great.
That’s wonderful! Thanks for watching
Ty Dr. for connecting all the info.
Thank you so much for watching and for your kind feedback!
Excellent health & wellbeing video ! Thank you so much doctor .More success to your personal & professional endeavors .
Thank you so much for watching! Really appreciate your kind words and support!
Concise, precise and clear.
Thanks so much for watching! 😊
Thank you Doctor Rajsree, this is fantastic ❤
Many thanks!
Excellent summary of the biology of aging! The most comprehensive I have seen. You are definitely not a typical medical doctor. Most M.D.s are not very knowledgeable about biological gerontology, or even more general biochemistry and physiology outside of their specialty. If all doctors were as informed as you people would be much healthier.
Thanks so much for watching!
Best video on "health span" I've seen. Very comprehensive. One question. Why are some Keto advocates pushing the notion that legumes (beans, peanuts, etc.) and whole grains (oats, wheat, etc.) cause leaky gut and the diseases associated with it? But we see that beans and whole grains are popular in the blue zones.
Thanks for watching and great question! It comes down to individual sensitivity. For some people, whole grains and legumes are harder to digest and cause bloating and gut irritation (due to lectins).
Wonderful! I would love to live a longevity life.
Thanks so much for watching! 😊
Many thanks Dr. Rajsree . A very highly useful information to keep a healthy body. I admire the time restricted eating topics .
Thanks for watching!
Great video ma'am, pranaam for your services. Thank 🙏🙏🙏🙏🙏 you so much.
Thanks so much for watching and for your kind feedback.
Great video Dr . Thank you.
Thanks so much for watching!
Thanks so much Dr for you effective & detail presentation 🙏
Thank you so much for watching and for your kind feedback
Thanks Rajsree for a great video that emphasizes the main steps to take in order to boost longevity and general health
Thanks so much for watching and commenting! :)
@@drrajsree5:39 😅
😊
Awesome explanation of healthy longevity life!! Love how you share all your knowledge. So easy to understand . You are a brilliant Dr.! Thank you for sharing ❤
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
Fabulous.....this informative video speaks volumes. We need to keep putting the information out there.....I love the new vocabulary, i.e. sirtuins; AMPK; MTOR; Hormesis.....Thank you for sharing....Sending God's blessings.prosperity, abundance and success.!!!!!!
Thank you so much!
Thanks for beautiful compact narrative with wholistic approach
Thank you so much for your kind feedback!
I am doing great with my life style. Great nutrition, spirituality and appreciating life. Mature life is great when healthy and seeing life being a gift. Longevity without a positive and joyful living is not good. Many are suffering even though they live long into their 90's... The important thing is to live a healthy and happy life. Hmm, do you have something to make me handsome? Let me know, lol. May be epigenetics can do that? Thank you.
Glad you're doing well with a well balanced lifestyle! Ha, ha, that's a good question! Thanks so much for watching! 😊
video is a masterpiece 🙏🏻
Oh my goodness, thank you for such kind praise! It means a lot to me! Best wishes, RN
Beautiful lecture thank you for sharing
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
Very educational....thanks!
Glad it was helpful!
Nice topic to understand and apply in daily life. Thank you very much. I learned much
Thank you so much! I appreciate your kind feedback.
Fantastic video. I love it!
Thank you very much!
Thank you!
Thanks so much for watching! 😊
Such an elaborate explanation hats off 👏
Thank you, kindly! I really appreciate your feedback!☺️
Very Comprehensive. Thank you.👋👍
Thanks so much for watching! 😊
Thank you so much for this amazing video with such useful insights and information. I will certainly incorporate these practices.
Thanks so much for watching! 😊
It's a very important video. You are covered in everything. Thanks for sharing this.
Thanks so much for watching! 😊
Please show this again . Hard to take all vitamins and things in first time. Really found it very interesting. Thank you so much .
Thanks so much for watching!
Thank you for this wonderful and powerful video.I learnt many things for the benefir of my health
Thank you so much!
Wonderful and most needed information for all the people.
Thanks so much for watching and commenting!
so grateful that your channel has reached me. wonderful research and very i totally agree with your advices
Thanks so much for watching! Best wishes, RN
Thanks a lot par Doctor for explaining and giving good messages to know to be healthy for us.
You're most welcome. Thanks for watching and commenting. Great to hear from you! RN
Hi Rajsree,you don't stop to amaze me. The video is excellent and I've learnt a lot. I have been following your advise and tips for some time now and not only myself but those around me have noticed the difference. Thanks a lot for all your hard work. Love ,Nora.
Wow, thank you so much for your very kind feedback and encouragement. It means a lot to me! I’m so glad you’ve noticed a difference with some of the tips. Best wishes in your health, RN.
We love you and appreciate you very much 🙏
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
Thanks Dr. This video is so great that health is a great value than other things.
Thanks so much for watching!
Fabulously informative video. Easily assimilable language, kudos to you!
Thank you kindly! Appreciate your support!
Great information doctor
Thanks so much for watching! 😊
This is an incredible presentation. Your explanations far outshine those of most MDs. A sincere thank you.
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
Excellent! Thank you.
Thanks so much for watching! 😊
Great video Rajsreen. I bet that at your young age and if you follow your recommended practice, you gonna live well over 100. All the best and Thank you for these awesome information.
Thanks so much for watching!
Amazing info., thanks…
Thanks so much for watching!
Thank you so much madam
Thanks so much for watching. Best wishes, RN
Awesome information all in one podcast!
Thanks so much for watching! 😊
I'm aiming to live to 125... I'm 47 now and have already started taking action a few years ago
That’s amazing! Thanks so much for watching.
EXCELLENT VIDEO ON LONGEVITY, BOTH IN CONTENT AND PRESENTATION. THANKS PLEASE KEEP TEACHING MORE AND MORE.
Thanks so much for watching! 😊
You are great and indeed a gift to humanity.
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
@@drrajsree please if you have any stuff to guide interested people especially into the longevity science (because of it’s holistic parameters) I will be keen. Even if you have online tutorials tailored in such a way that we can clear grey areas by questions, I will be keen.
Amazing video, thank you so much. Keep it up.
Thanks so much for watching!
the most interesting I've seen, thank you.
Glad you enjoyed it!
Thanks, I have really enjoyed all this great information on longevity. Great Job. 😊
Thanks so much for watching! 😊
God Bless you doctor !!!
Thanks so much for your kind support and blessings! 🙏 I really appreciate hearing from you! Best wishes, RN
Thanks for your blessings!
Thanks so much for your kind support and blessings ! 🙏 I really appreciate hearing from you! Best wishes, RN
Interesting Doctor Raj🛡️♀️🌐Biological & Chronological Age, Genetics, Diet, Exercise, Activity Level, Relationships
Thanks so much for watching!
Thank you for this excellent video.❤
Thanks so much for watching!
Excellent - At 84 No aches and pains - whole food plant based eating lifestyle
Thanks so much for watching! 😊
Thank you Doctor Rajsree for sharing your vast and extensive knowledge in maintaining a healthy lifestyle, it just priceless the best health and medical information any one has posted on public media..Your natural beautiful and soothing voice is very captivating..please do not stop educsting the world you can change the world by improving medical and science ..thank you again always Anandjee 🙏🙏🙏♥️🌹♥️🌹♥️🌹🙏🙏👍👍👍
Oh wow! This is one of the nicest, most encouraging comments I have ever seen! Your kind words mean a lot to me!☺️
Absolutely love this! Thank you so much for summarizing all this information on longevity, health and happiness. It also strengthens me with what I'm doing in my life for longevity and healthspan. We need more people like you! And more people who actually follow this, what I'm trying in my mimicked Blue-zone in Portugal! Thank you so much!💚🙏
Thanks so much for watching and commenting from Portugal! Best wishes in your health, RN
ola
I’m agree with your video Dr❤❤❤
Best video on this topic!!
Thanks so much for your kind support! 🙏 I really appreciate hearing from you! Best wishes, RN
Thank you Dr. Rajsree !! This video has unlocked the matrix for me!! 😆💕🙏
Wonderful! Thanks so much for watching.
I learned a lot from your topic, before I learn from the lectures about anti-oxidant, sirtuins, phyto-chemicals when I joined a distribution company of food supplements but with your discussions about longevity, greatly unlock on how our cells functions together our proper diet and fasting, proper sleep, exercise and community relationship of being complementary to achieve longer and joyful life. Its amazing topic! Thank you so much.
Thanks so much for watching and commenting!
Great and very helpful thank U
Thanks so much for watching!
I love your videos. Thank you.
Thank you so much!
Subscribed today... stay curioUS
Ty. Been wondering about what you just covered
Thanks so much for watching! 😊
Glad I found this video! Excellent ! Info
Thanks so much for watching! 😊
Very educative video. Love your animation!
Thank you so much! Appreciate your feedback! :)
Nice summary. Perfect for anyone who is new to the topic and who wants to invest less than an hour.
Thanks so much!