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*_OK. So if a man that does not work out, but goes on long walks several times a week and follows 100% a 365 days a year Health Keto diet with IF and OMAD, takes TMG (Betaine) and/or Creatine supplements; what happens?_* *_Are there any benefits or would said man have to actually lift weights to see benefits?_* *_You see, I now think "just taking Creatine without workout" is beneficial; because it's a Nootropic?_* *_Please correct me if I have misunderstood._*
*_Yes, yes, I know you answered this in the video, but I think taking Creatine in the morning can give a little extra energy in the evening._* *_Not all health science has to be about lifting weights._*
I have early dementia symptoms and I’ve taken tmg today, made me feel a bit shaky, wired and nauseous, especially when I have my coffee, but I’m feeling a bit clearer and more energetic. I’ll report back. It’s not as good as bena gene, I wish you’d do a video on that, that’s by far the most effective supplement I take.
Just started taking this. 1 week later i feel great. Better focas, solid lifting, and oddly my stools are back to normal. Also my blood pressure is now better. I have no idea why TMG helps my IBS but it does! I can't find any info on this online.
Another thing you can do for your stool is put psyllium husk in a protein shake or just take it on its own. It’s a dietary fiber that helps tremendously if I don’t eat enough fiber for the day.
I have early dementia symptoms and I’ve taken tmg today, made me feel a bit shaky, wired and nauseous, especially when I have my coffee, but I’m feeling a bit clearer and more energetic. I’ll report back. It’s not as good as bena gene, I wish you’d do a video on that, that’s by far the most effective supplement I take. Edit : tmg is much better than bena gene, I feel happy, calmer, more energetic my dementia symptoms have reduced significantly. But I am taking tumeric, collagen, vitamin k 2 . Hylaronic acid (sometimes) magnesium threonate,, l theanine and rhodiola. I feel Amazing
Thank you for sharing good to hear your doing well! Do you take a b complex with tmg? *On b complex I find that taking an UnDeffated dessicated liver 3-4grams is actually just as if not more effective because how bio available it is with blood.
Consider glycine for your situation. You're already getting some from your collagen I imagine but Magnesium Bisglycinate ( also known as Magnesium Glycinate, the same substance named two different ways) might be something to look into. I'm aware you're already taking magnesium threonate of course but I'll throw out this info to see if you might want to explore.
@@runzization no I haven’t been and over the last week the tmg hasn’t been as effective, it’s actually made me kinda spaced out and tired, I wonder if it’s cuz I’m not taking a b complex?
Just a tip for those who don't know, lifting heavy 1-3 reps over 90% of your Maximum does give maximum strength gains with minimal muscle growth, if you don't care about optimizing for strength, but instead want big muscles then you can choae any rep range from 6, all the way up to 35 reps to get very similar muscle growth as long as it is done close to failure. So if you start with a weight you can do 6 reps with then you don't have to increase the weight until you can do over 30 reps until failure, if you prefer that. This is great for those who likes to lift light weights (must be at least 40% of max) instead of heavy. Just don't lift too light weights,.if you can make above 40 reps in a set then it becomes more of endurance training instead.
*But at even higher reps below 25% iirc it does strengthen connective tissues just as much without as much risk of injury from higher weights so if rehabbing or if older it may pay to mix it up.
@@johnassal5838 Yeah, but why waste time doing hundred of reps when 25-35 reps is already very safe and you also gain muscle and strength? One can even just do one set per day since it's the total sets per week that counts more than per day and the recovery is faster. Those who needs to be extra careful should use resistance bands as they are safer than weights and therefore great for rehab and still build muscle and strength just fine. So adding bands to body weight movements to reduce the reps to 25-35 reps is preferable. 1 very light (over 40 reps) set can be a good warm up though before adding the bands though.
@@SkepticalCaveman Oh it's not the best option for everyone at all unless you're trying to increase the strength of those supporting tissues without the high load usually required. It's really best if you're basically injury prone but want to keep pushing. Personally I'm a bit paranoid about injury and would be happy to mix in a minority of days with 70+ reps at >25% 1rm if it helps prevent injury under load. Of course I'm pushing 50 too. But yeah it has significant downsides like taking so damn long to do the reps and is painful AF for the last few dozen, no denying it.
@@johnassal5838 25% is very low. You wont be able to combat muscle decline for lomg at that rate. It's really important build muscle when one is still young enough to do so because it's hard to mentain muscle mass, not to mention build muscle, when one gets older so already having large muscles before the decline is important. 25-35 reps (around 40%) should not be any problem for a man your age, try adding rubber bands, the risk of injury is very low since the maximum load is only at the end of the movement using them unlike weights.
@@SkepticalCaveman That's great advice on the bands but just to be clear nobody is building muscle at ≥25% 1RM. What it does actively build (at ultra high reps) is the tendons, ligaments and fascia just as well as high % 1RM without any significant weight making it possible to build that cushion with essentially no risk, even while rehabbing. Ordinarily it's a horse race between the effect on connective tissue and muscle of high loading, which is fine right up until you can lift more than those tissues have adapted to. It's often bad form or technique preceding injury but after/if you've been sidelined for extended periods by injury a few 70 rep ultra low weight sets could be worth the PITA. Especially if they'd count as endurance exercise as well. Overall it's definitely pretty niche and will never replace what you're advocating.
Brad got Jacked! But.. I have to ask the question again... why TMG as opposed to just taking Choline??? TMG is a metabolite of Choline, so why wouldn't you start with choline to get the cognitive benefits from the boost to acetylcholine levels as well...... I used to think it was to avoid boosting TMAO levels, but that also occurs with Betaine, albeit to a somewhat lesser degree. I've never found an answer to this....
The choice between supplementing with trimethylglycine (TMG) or choline depends on several factors, including individual differences, desired effects, and potential side effects. Choline is an essential nutrient that serves as a precursor for the synthesis of acetylcholine, a neurotransmitter involved in cognitive functions, memory, and muscle control. Supplementing with choline can potentially increase acetylcholine levels and provide cognitive benefits. However, some individuals may experience side effects such as fishy body odor, gastrointestinal discomfort, or potential interactions with certain medications. On the other hand, TMG (also known as betaine anhydrous) is a metabolite of choline and can also serve as a methyl donor in various metabolic processes. It has been suggested that TMG may have cognitive-enhancing effects similar to choline, but without directly increasing acetylcholine levels. The potential advantages of using TMG over choline include: 1. Lower risk of fishy odor: TMG is less likely to cause the unpleasant fishy body odor that can occur with high doses of choline. 2. Better tolerance: Some individuals may tolerate TMG better than choline, as it is less prone to causing gastrointestinal discomfort or other side effects associated with high choline intake. 3. Methylation support: TMG serves as a methyl donor, which can support various metabolic processes, including the methylation of homocysteine, an essential step in maintaining healthy cardiovascular and neurological function. However, it's important to note that while TMG may provide cognitive benefits through its role in methylation and potentially other mechanisms, it does not directly increase acetylcholine levels like choline does. Regarding the concern about trimethylamine N-oxide (TMAO) levels, both choline and TMG have been linked to increased TMAO production, although the extent of the increase may vary. TMAO has been associated with an increased risk of cardiovascular disease, but the evidence is still inconclusive, and the impact may depend on individual factors and overall dietary patterns. In summary, the choice between TMG and choline may depend on individual preferences, tolerance, and the desired effects. TMG may be preferred by those who wish to avoid the potential side effects of high choline intake or those seeking methylation support, while choline may be more suitable for individuals specifically aiming to increase acetylcholine levels for cognitive enhancement. It's always advisable to consult with a healthcare professional before starting any new supplement regimen.
Nice gains. I take collagen + AKG + creatine + TMG, those are the main supplements that have been known to aid muscle growth. After a year and a half I can overhead press 80kg for 5 reps, people think I'm on steroids, only lift 3 days a week, it's great. Not sure if due to the supplements, but I have a pretty positive impression of them so far
@@Dr.WhetFarts How long did it take? My dad reached a 360lb bench natty, and Marvin Eder did incredible things natty, some of the best genetics ever, so I know it's possible, but I know I have a long ways to go
I don't take AKG, but do take the above along with hylauronic acid, cod liver oil + fish oil and psyllium husk pill with every meal, to slow carb absorption. Not really sure if the fiber in the husk pill helps, but perhaps I can experiment by checking my blood sugar after meals.
TMG converts homocysteine to methionine which reverts back to homocysteine, which makes it an inefficient mechanism. Plus even when TMG decreases homocysteine, it increases methionine which is not good for longevity. So to decrease homocysteine it is better to take Serine+B6 which not only does not produce methionine but it also contributes to glutathione production, which is a powerful antioxidant.
TMG co factors include the b complex for the methyl donor group. So that's why the study of including diet, multi, and exercise are necessary. You take a single mineral and it reduces all the other minerals. All about balance so on the other stack taken at night is glycine &NAC
Dr. Michael Lustgarten is currently experimenting your suggested approach for the reason you mentioned ( a concern about homocysteine supplements increasing methionine). I wonder whether the serine plus B6 approach has been studied, and if so, what the results were.
It is true that TMG has a role in homocysteine metabolism, and TMG converts homocysteine to methionine. Methionine can then be converted back to homocysteine, but the efficiency of this conversion can vary depending on a person's diet and metabolic status. While the effectiveness of TMG can vary from person to person, some studies have shown that it is effective in reducing homocysteine levels. However, it is also true that TMG can increase methionine levels while lowering homocysteine levels. High levels of methionine may be associated with some health problems related to longevity. Therefore, long-term use of TMG may not be recommended for some individuals. Serine and B6 vitamin are another compound that can affect homocysteine metabolism. Serine can help convert homocysteine to another amino acid, cysteine. Additionally, B6 vitamin also plays an important role in homocysteine metabolism. However, there is no definitive evidence that Serine+B6 is more effective than TMG. While some studies have shown that Serine+B6 may be effective in reducing homocysteine levels, other research suggests that TMG may be more effective. Furthermore, both Serine+B6 and TMG may be effective in the production of other compounds, such as methionine, which plays a role in the production of glutathione, an important antioxidant. In conclusion, while there is some evidence regarding the effects of Serine+B6 on homocysteine metabolism, it has been shown that TMG is effective in reducing homocysteine levels and may be more effective in some individuals. Since both compounds have potential benefits and side effects, it is best to consult a doctor to determine which one to use.
Inefficient mechanism... that's like saying the methylation cycle is inefficient because it recycles homocysteine to methionine. Methionine is not bad for longevity... lack of glycine is the problem. B6 becomes toxic in higher doses according to some.
I'd like to see a comprehensive video on which supplements to take to boost exercise performance (NR, NMN, any adaptogens, etc) and which ones to avoid that might prevent/blunt hormesis (antioxidants, metformin, berberine, etc). I'm really more interested in the latter.
Thnx for his info. Started TMG for high blood pressure ( read that homocysteine could be a cause), but encountered diarrhea. Hope it will go away after getting used to TMG.
Doctor what are your thoughts on emerging popular adaptogens such as Fadogia Agrestis and Tongkat Ali?Are you optimistic about their potential possible benefits?
Thank you Dr Stanfield for your value added assessments and backing up your assessments with studies. I appreciate your efforts to help me make best decisions to improve and maintain my health at age 71…life is wonderful and precious…
2000 mg of betaine (2g) looks like a good idea. Creatine(5 g) is also helpful with a pre workout(6 g citrulline malate,3.2 g beta alanine,2g taurine) needing 1 g of l tyrosine to delay muscle soreness. I'll have to buy betaine & 1 g l tyrosine.(garter snake veins are on the way. Farmer carries also build grip strength...)
Not that interested in the exercise effect as I’m no longer an athlete. But the homocysteine thing scares the crap out of me. Also a link to cardiovascular diseases. Another channel recently mentioned homocysteine and he started taking B6 and L-Serine to bring his levels down. I believe he mentioned a study that, or at least his theory was, B12 had no effect on homocysteine levels. Unfortunately B12 is usually prescribed.
I take a product with Betaine HCl. It’s called Doctor’s Best Betaine HCl with Pepsin and Gentian Bitters. It is formulated as a digestive aid to help with acid indigestion by making the stomach more acidic. It does work well for that. It contains 650 mg of Betaine per capsule.
Hey Brad, I am not sure why don’t promote folic acid for homocysteine lowering. I don’t know a study that shows a significant effect with only 1g of TMG. +higher doses can possibly increase LDL/ApoB. So the meta analysis you stated concludes: „Folic acid has no adverse effects on blood lipids; and therefore, folic acid supplementation should remain the preferred homocysteine-lowering treatment in healthy humans.“
@@auslanderbuchsbaum5623 I think Betain methylates / converts any B vit into a usable form. I read it also reduces inflammation which lowers anxiety and depression.
I under methylate and also have histamine intolerance, so I take it with NAC as an alternative to SAME. Been using it for years. If not for this is be on antihistamines daily.
I read this somewhere: "The breakdown of TMG in the body can make trimethylamine. TMG supplementation can cause a person’s urine and sweat to smell fishy" Any comments on this from people already taking TMG? Thank you.
How can you know that the benefits of TMG aren't from the increased creatine concentration? A lot of people supplement creatine so I think this is an important question to answer
Speaking of methylation, please do a video on MTHFR mutation and how, or if, to treat it. There is tremendous disagreement between the functional and the 'conventional' medical professionals. Everything from "change you diet completely and carefully titrate these specific supplements" (methyl-folate, methyl-B12, etc), to "it's no big deal at all, requiring no intervention". Which is it?
I take TMG for homocysteine and because its a good methl doner which I think is beneficial for certain longevity supplements. For muscles I take creatine and HMB. Mostly because I'm afraid my work, which is basically 12 hours of cardio, is burning muscle instead of building it.
I take 500 mg TMG every other day and eat beets several times per week...limit red meat to keep TMAO lower...likewise limiting animal protein lowers the amount of methionine (feed back) might inhibit homocysteine to methionine conversion...(your thoughts?)
Love your videos. But there is another video from “conquer aging or die trying” that claims B6 and Serine may be a better choice than TMG for longevity.
I was taking TMG, 500 mg, 2X/d, but stopped, forget why. Next week running up a hill pulled a calf muscle. Major ouch for over a week. Back on TMG then and forever since.
I take 1.5 grams 3 times a day. But I live an active lifestyle and lift weights 6 days a week. But I also take all the regular life extension supplements. Glynac etc.
However there are studies showing that TMG supplementation is increasing LDL cholesterol levels, so it's a no for me.
ปีที่แล้ว +1
We can see that no one have the imagination to give basic info like the best time of day to have it, and with what is better the assimilation, maybe plain water, and also if there are synergetic supplements to take with TMG? So important.
Dr. Stanfield is THE most honest adviser and expert when it comes to supplements on youtube. His talking about the lies of the propoenents of Resveritral for example shows how many shady characters there are here.
Dr.Brad what is Your opinion about TMAO which is genereted from TMG,choline and l-carnitine? New reaserch is showing that TMAO is bad for cardiovascular system. I am confused couse in one hand lowering homocysteine is good and other hand we make more TMAO which is bad...
Do you know if betaine hydrochloride will be as effective as straight betaine? Have been taking betaine HCL for a long time to control gastric reflux with excellent results, if there are other benefits then that’s a fortuitous bonus.
@@constanceelaine3909 Well I know that they are used for different purposes however the molecular structure is very similar which is why I submitted my original question. For instance, magnesium threonate and magnesium glycinate behave differently in the body but they both are a source of magnesium.
There’s a human study showing that’s not a concern if you are using NR (and likely NMN). Since I take niacin though, which raises homocysteine levels, TMG is a good option to counteract that increase
Really? There's some controversies, but it seems that both NR and NMN produces NAM. And we need Methyl groups to get rid of that. So, even NR and NMN might be a load on Methyl groups. But it probably is a bit slower than taking NAM durectly. Brenner and Sinclair might say otherwise. But other researchers who traced these things seems to say most goes via NAM. I wouldn't take 300 mg or more of any kind of vitamin B3 without TMG. This research obvoiusly must be made in the body, and furthermore, not just be measured in the blood.
@@DrBradStanfield I also heard Niacin raises NAD+ but also inhibits SIRT1 because it builds up on the end of the pathway, since it’s mechanism in elevating NAD+ levels is different from NR and NMN. I’ve heard NR+NMN do the opposite (activate SIRT), is the Niacin inhibition a cause for concern?
What is the difference between Glycine and TMG? If I am taking NAC should I be taking glycine or TMG with the NAC? I bought just regular glycine and have been using that with NAC. Is this right or should it be TMG? I am not doing a workout if this helps. I am confused. I noticed NMN is available on Amazon again.
@Jacques Treehorn You can continue to take Glycine with NAC. That gives you two of the three amino acids which are needed to build Glutathion. Yiu get enoyugh of the third from your protein. But these two are limiting. TMG hasn't anything to do with this, except that it too gives you some Glycine. TMG supplies methyl groups. This is important for building Creatine. But especially if you take large doses of some form of vitamin B3. The body spends Methyl groups when it sheds any excess of it. If you supplement with Creatine, you might not need TMG.
Glycine isn't TMG, TMG has a recommended upper limit to avoid raising cholesterol levels, glycine is basically safe in relatively large amounts, so pretty different
Another good, smart, brief, no-nonsense video on longevity science! But I still think our current best radical treatment to enhance human longevity is thymus organelles (improving immunity function). I wish like hell someone would do a quick study on this to see if rat longevity expands by 30-50%, as I speculate it probably will.
There's a study that suggests Betaine at doses over 4g a day can increase LDL cholesterol, so your dosage of 1g a day seems to be a good recommendation! Is there any evidence, that supplementing MTG alongside Creatine gives additive effects? I'm afraid that the mechanism for muscle performance behind MTG is too similar to that of Creatine's. Nevertheless, all the other benefits of Betaine look promising!
Two different brands of TMG, supposedly high quality, gave me headaches, I would rather to get betaine from Spinach , beets and wheat germ and stay away from supplements that I am not sure about purity and identity.
Good morning Dr Stanfield. Is TMG the same as Glycine? I am having 600 mg of NAC and 1000 of Glycine daily and planning to start NMN + Resveratrol. Do I need to take TMG along with NMN or the Glycine I am having along with NAC is suffice? This is such a new field. Would appreciate your suggestion and guidance. Thanks.
Thanks Dr Brad, this was a great video. i wonder if you could make a video about supplements that can enhance or create a healty hormonal environment for males. Thanks
I'm 76, 70% disabled Vet and had open heart/triple bypass surgery last October. I was very careful with doing anything that would tear the sutures out of my sternum. But, I gradually started weight training again and some cardio. I don't take any HGH, Roids, or unnatural supplements and have gained back my biceps, etc. I take Creatine Monohydrate, GLYNAC and Nattakinase daily. I've got good strength for my age (Deadlifts of 165x8x3, etc.) for functional lifting, etc. outside work. I wonder at what point do I stop adding on supplements? 45 a day, 75/day, 100/day? LOL Cheers, Bob
so im not a big supplements fan, but I have been more intentional with consuming wheat bran products. In my own experience, it makes recomping so much easier.
Thank you Dr Stanfield. Is there any truth to some claims I've read that taking TMG at the therapeutic dose mentioned in the trials has been known to increase LDL cholesterol?
There's one side of TMG that people often don't consider though. It's immunomodulatory, and while that may suit people with chronic inflammation perhaps, doesn't suit everyone. It can really change your immune cells population proportions. I always had my neutrophils on the lower side, but within the healthy range still, taking TMG pushes me into mild neutropenia, and even moderate neutropenia at some point, so that was worrying, I had to stop taking it. Like I said for many people this could be good, reduced inflammation, but like most supplements it's not a one size fits all. I'm finding that more and more. Check papers about betaine and the immune system there are many interesting things going on.
Thanks for this! I always noted I bulked up more and performed better speed wise on my cycle while eating wheat. But have a slight allergy and found I felt better overall off it. I have ordered some TMG powder. Does not seem expensive at your recommend dose. If I remember will report back how it works as a reply to this comment.
Does timing matter at all? Do you get any benefit on your work out days to take it before the workout vs after or is it like creatine which sort of accumulates over days in the body?
Cheers much and didn't know you had muscles lol looks are deceiving and I've been taking probably 500g of betaine hcl every night after dinner, is that good or bad?
In Dr. Stanfield's bicep shot profile pic for this video, he looked like an 18 year old Freshmen at University. Whatever he's taking.....it's working!!
How to figure out which supplements to take? NMN, NR, NAD+, NAC, Reversatrol, TMG, etc... I'm 48 female 135lb 5' tall wanting to get fit. I'm on hormone replacement therapy estradiol patch, progesterone, testosterone gel. Plus I take levothyroxine a low dose for hypothyroidism. I want to turn back time as much as poosible but I honestly don't know where to start with all these supplements. Out of those supplements which one has the lowest amount of niacin?
Low vitamin B6 is strongly associated with Alzheimer. Those who have a high level of B6 have 4 times less chances of getting it. So I wonder if using B6 to protect the brain from degeneration and as a methyl donor to lower homocysteine wouldn't be even better, all the more than for TMG to work it would take a really high dosage.
Please tell me. For muscle growth, to increase protein synthesis. How should I take betaine? Every day or only on training days? Take before and after workout or throughout the day?
Fish apparently have far more Tmao , than the level TMG would raise.From what I understand no studies have shown any mechanism of damage, simply that there is and increase associated with.
@@trentbusta1 for whatever reason food sources of choline like eggs and fish don’t raise TMAO but choline containing supplements do. I agree that no mechanism of action has been shown though.
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Does TMG raise stomach acid? I have a stomach ulcer so I don't want that.
Does high stomach acid mean I have high TMG?
Thanks
*_OK. So if a man that does not work out, but goes on long walks several times a week and follows 100% a 365 days a year Health Keto diet with IF and OMAD, takes TMG (Betaine) and/or Creatine supplements; what happens?_*
*_Are there any benefits or would said man have to actually lift weights to see benefits?_*
*_You see, I now think "just taking Creatine without workout" is beneficial; because it's a Nootropic?_*
*_Please correct me if I have misunderstood._*
*_Yes, yes, I know you answered this in the video, but I think taking Creatine in the morning can give a little extra energy in the evening._*
*_Not all health science has to be about lifting weights._*
Doesn't TMG increase LDL levels?
when you didnt know dr brad was a BEAST 💪
He seems to actually practice what he preaches, that’s how you know he’s a good guy
Yup! Dr. Brad has some guns.👍
"Why's there a dumbbell in your office?"
"Gotta get a pump for my next video brah"
I have early dementia symptoms and I’ve taken tmg today, made me feel a bit shaky, wired and nauseous, especially when I have my coffee, but I’m feeling a bit clearer and more energetic. I’ll report back.
It’s not as good as bena gene, I wish you’d do a video on that, that’s by far the most effective supplement I take.
The PlantChomper guy was surprisingly buff too lol. No kidding. I know it's April 1st but he looked good.
Just started taking this. 1 week later i feel great. Better focas, solid lifting, and oddly my stools are back to normal. Also my blood pressure is now better. I have no idea why TMG helps my IBS but it does! I can't find any info on this online.
Possibly by reducing inflammation in the colon. It has an anti-inflammatory effect.
Another thing you can do for your stool is put psyllium husk in a protein shake or just take it on its own. It’s a dietary fiber that helps tremendously if I don’t eat enough fiber for the day.
I have early dementia symptoms and I’ve taken tmg today, made me feel a bit shaky, wired and nauseous, especially when I have my coffee, but I’m feeling a bit clearer and more energetic. I’ll report back.
It’s not as good as bena gene, I wish you’d do a video on that, that’s by far the most effective supplement I take.
Edit : tmg is much better than bena gene, I feel happy, calmer, more energetic my dementia symptoms have reduced significantly.
But I am taking tumeric, collagen, vitamin k 2 . Hylaronic acid (sometimes) magnesium threonate,, l theanine and rhodiola. I feel Amazing
Thank you for sharing good to hear your doing well! Do you take a b complex with tmg?
*On b complex I find that taking an UnDeffated dessicated liver 3-4grams is actually just as if not more effective because how bio available it is with blood.
It does the same thing for me. Moral of the story is we are all wired a bit different. Find supps that work for you
Consider glycine for your situation. You're already getting some from your collagen I imagine but Magnesium Bisglycinate ( also known as Magnesium Glycinate, the same substance named two different ways) might be something to look into. I'm aware you're already taking magnesium threonate of course but I'll throw out this info to see if you might want to explore.
@@Iron-Bridge I think I am in my vitamin d tablets, but why do you suggest this? What’s the specific benefits of having the 2 types?
@@runzization no I haven’t been and over the last week the tmg hasn’t been as effective, it’s actually made me kinda spaced out and tired, I wonder if it’s cuz I’m not taking a b complex?
Just a tip for those who don't know, lifting heavy 1-3 reps over 90% of your Maximum does give maximum strength gains with minimal muscle growth, if you don't care about optimizing for strength, but instead want big muscles then you can choae any rep range from 6, all the way up to 35 reps to get very similar muscle growth as long as it is done close to failure. So if you start with a weight you can do 6 reps with then you don't have to increase the weight until you can do over 30 reps until failure, if you prefer that.
This is great for those who likes to lift light weights (must be at least 40% of max) instead of heavy. Just don't lift too light weights,.if you can make above 40 reps in a set then it becomes more of endurance training instead.
*But at even higher reps below 25% iirc it does strengthen connective tissues just as much without as much risk of injury from higher weights so if rehabbing or if older it may pay to mix it up.
@@johnassal5838 Yeah, but why waste time doing hundred of reps when 25-35 reps is already very safe and you also gain muscle and strength? One can even just do one set per day since it's the total sets per week that counts more than per day and the recovery is faster.
Those who needs to be extra careful should use resistance bands as they are safer than weights and therefore great for rehab and still build muscle and strength just fine. So adding bands to body weight movements to reduce the reps to 25-35 reps is preferable. 1 very light (over 40 reps) set can be a good warm up though before adding the bands though.
@@SkepticalCaveman Oh it's not the best option for everyone at all unless you're trying to increase the strength of those supporting tissues without the high load usually required. It's really best if you're basically injury prone but want to keep pushing. Personally I'm a bit paranoid about injury and would be happy to mix in a minority of days with 70+ reps at >25% 1rm if it helps prevent injury under load. Of course I'm pushing 50 too. But yeah it has significant downsides like taking so damn long to do the reps and is painful AF for the last few dozen, no denying it.
@@johnassal5838 25% is very low. You wont be able to combat muscle decline for lomg at that rate. It's really important build muscle when one is still young enough to do so because it's hard to mentain muscle mass, not to mention build muscle, when one gets older so already having large muscles before the decline is important. 25-35 reps (around 40%) should not be any problem for a man your age, try adding rubber bands, the risk of injury is very low since the maximum load is only at the end of the movement using them unlike weights.
@@SkepticalCaveman That's great advice on the bands but just to be clear nobody is building muscle at ≥25% 1RM. What it does actively build (at ultra high reps) is the tendons, ligaments and fascia just as well as high % 1RM without any significant weight making it possible to build that cushion with essentially no risk, even while rehabbing. Ordinarily it's a horse race between the effect on connective tissue and muscle of high loading, which is fine right up until you can lift more than those tissues have adapted to. It's often bad form or technique preceding injury but after/if you've been sidelined for extended periods by injury a few 70 rep ultra low weight sets could be worth the PITA. Especially if they'd count as endurance exercise as well. Overall it's definitely pretty niche and will never replace what you're advocating.
Excellent presentation Dr. Brad. I regularly take TMG along with NR and this video has cleared up some questions I had.
Glad you found the video useful, thanks for your support
What is NR
@@Bambotb nicotinamide riboside
@@DrBradStanfield i took tmg but i stop NR .. i took niacin in stade of nr ??? Its ok .. thanks dr
@@Jazmine914 Niacinamide can increase blood sugar level, so be careful.
Brad got Jacked! But.. I have to ask the question again... why TMG as opposed to just taking Choline???
TMG is a metabolite of Choline, so why wouldn't you start with choline to get the cognitive benefits from the boost to acetylcholine levels as well......
I used to think it was to avoid boosting TMAO levels, but that also occurs with Betaine, albeit to a somewhat lesser degree.
I've never found an answer to this....
The choice between supplementing with trimethylglycine (TMG) or choline depends on several factors, including individual differences, desired effects, and potential side effects.
Choline is an essential nutrient that serves as a precursor for the synthesis of acetylcholine, a neurotransmitter involved in cognitive functions, memory, and muscle control. Supplementing with choline can potentially increase acetylcholine levels and provide cognitive benefits. However, some individuals may experience side effects such as fishy body odor, gastrointestinal discomfort, or potential interactions with certain medications.
On the other hand, TMG (also known as betaine anhydrous) is a metabolite of choline and can also serve as a methyl donor in various metabolic processes. It has been suggested that TMG may have cognitive-enhancing effects similar to choline, but without directly increasing acetylcholine levels.
The potential advantages of using TMG over choline include:
1. Lower risk of fishy odor: TMG is less likely to cause the unpleasant fishy body odor that can occur with high doses of choline.
2. Better tolerance: Some individuals may tolerate TMG better than choline, as it is less prone to causing gastrointestinal discomfort or other side effects associated with high choline intake.
3. Methylation support: TMG serves as a methyl donor, which can support various metabolic processes, including the methylation of homocysteine, an essential step in maintaining healthy cardiovascular and neurological function.
However, it's important to note that while TMG may provide cognitive benefits through its role in methylation and potentially other mechanisms, it does not directly increase acetylcholine levels like choline does.
Regarding the concern about trimethylamine N-oxide (TMAO) levels, both choline and TMG have been linked to increased TMAO production, although the extent of the increase may vary. TMAO has been associated with an increased risk of cardiovascular disease, but the evidence is still inconclusive, and the impact may depend on individual factors and overall dietary patterns.
In summary, the choice between TMG and choline may depend on individual preferences, tolerance, and the desired effects. TMG may be preferred by those who wish to avoid the potential side effects of high choline intake or those seeking methylation support, while choline may be more suitable for individuals specifically aiming to increase acetylcholine levels for cognitive enhancement. It's always advisable to consult with a healthcare professional before starting any new supplement regimen.
I just took TMG, now I'm sitting on the couch.
how wonderful
Nice gains. I take collagen + AKG + creatine + TMG, those are the main supplements that have been known to aid muscle growth. After a year and a half I can overhead press 80kg for 5 reps, people think I'm on steroids, only lift 3 days a week, it's great. Not sure if due to the supplements, but I have a pretty positive impression of them so far
Lol great story, but you would be completely delusional if you thought your gains were due to those supplements.
@@KingRockets Well you have to lift weights too
Never took anything but whey and i overhead press 100kg for 8
@@Dr.WhetFarts How long did it take? My dad reached a 360lb bench natty, and Marvin Eder did incredible things natty, some of the best genetics ever, so I know it's possible, but I know I have a long ways to go
I don't take AKG, but do take the above along with hylauronic acid, cod liver oil + fish oil and psyllium husk pill with every meal, to slow carb absorption. Not really sure if the fiber in the husk pill helps, but perhaps I can experiment by checking my blood sugar after meals.
I really like you being critical in your general approach. Great job!
TMG converts homocysteine to methionine which reverts back to homocysteine, which makes it an inefficient mechanism. Plus even when TMG decreases homocysteine, it increases methionine which is not good for longevity. So to decrease homocysteine it is better to take Serine+B6 which not only does not produce methionine but it also contributes to glutathione production, which is a powerful antioxidant.
TMG co factors include the b complex for the methyl donor group. So that's why the study of including diet, multi, and exercise are necessary. You take a single mineral and it reduces all the other minerals.
All about balance so on the other stack taken at night is glycine &NAC
Dr. Michael Lustgarten is currently experimenting your suggested approach for the reason you mentioned ( a concern about homocysteine supplements increasing methionine). I wonder whether the serine plus B6 approach has been studied, and if so, what the results were.
It is true that TMG has a role in homocysteine metabolism, and TMG converts homocysteine to methionine. Methionine can then be converted back to homocysteine, but the efficiency of this conversion can vary depending on a person's diet and metabolic status. While the effectiveness of TMG can vary from person to person, some studies have shown that it is effective in reducing homocysteine levels.
However, it is also true that TMG can increase methionine levels while lowering homocysteine levels. High levels of methionine may be associated with some health problems related to longevity. Therefore, long-term use of TMG may not be recommended for some individuals.
Serine and B6 vitamin are another compound that can affect homocysteine metabolism. Serine can help convert homocysteine to another amino acid, cysteine. Additionally, B6 vitamin also plays an important role in homocysteine metabolism.
However, there is no definitive evidence that Serine+B6 is more effective than TMG. While some studies have shown that Serine+B6 may be effective in reducing homocysteine levels, other research suggests that TMG may be more effective.
Furthermore, both Serine+B6 and TMG may be effective in the production of other compounds, such as methionine, which plays a role in the production of glutathione, an important antioxidant.
In conclusion, while there is some evidence regarding the effects of Serine+B6 on homocysteine metabolism, it has been shown that TMG is effective in reducing homocysteine levels and may be more effective in some individuals. Since both compounds have potential benefits and side effects, it is best to consult a doctor to determine which one to use.
@@emre-ss8fnDid you find a TH-camr who taught you all that? Nice info
Inefficient mechanism... that's like saying the methylation cycle is inefficient because it recycles homocysteine to methionine. Methionine is not bad for longevity... lack of glycine is the problem. B6 becomes toxic in higher doses according to some.
I'd like to see a comprehensive video on which supplements to take to boost exercise performance (NR, NMN, any adaptogens, etc) and which ones to avoid that might prevent/blunt hormesis (antioxidants, metformin, berberine, etc). I'm really more interested in the latter.
Thnx for his info. Started TMG for high blood pressure ( read that homocysteine could be a cause), but encountered diarrhea. Hope it will go away after getting used to TMG.
ga' damn Doctor Brad is jacked
4 mins video, you don't see that very often. I like it a lot!!
Doctor what are your thoughts on emerging popular adaptogens such as Fadogia Agrestis and Tongkat Ali?Are you optimistic about their potential possible benefits?
Another terrific video Dr. Brad! I was taking TMG with NMN from DNA but ran out. Time to repurchase! 😊
Thank you Dr Stanfield for your value added assessments and backing up your assessments with studies. I appreciate your efforts to help me make best decisions to improve and maintain my health at age 71…life is wonderful and precious…
2000 mg of betaine (2g) looks like a good idea. Creatine(5 g) is also helpful with a pre workout(6 g citrulline malate,3.2 g beta alanine,2g taurine) needing 1 g of l tyrosine to delay muscle soreness. I'll have to buy betaine & 1 g l tyrosine.(garter snake veins are on the way. Farmer carries also build grip strength...)
Is Betaine or TMG give the same benefits as Betaine HCL? Thank you.
What are the differences between TMG and glycine supplementation?
The methyl groups. Half of people don't methylate properly
Can you give us an update on TMG/trimethylglycine please?
Should we take it with food, on an empty stomach, or doesn't it matter?
Not that interested in the exercise effect as I’m no longer an athlete. But the homocysteine thing scares the crap out of me. Also a link to cardiovascular diseases. Another channel recently mentioned homocysteine and he started taking B6 and L-Serine to bring his levels down. I believe he mentioned a study that, or at least his theory was, B12 had no effect on homocysteine levels. Unfortunately B12 is usually prescribed.
I take a product with Betaine HCl. It’s called Doctor’s Best Betaine HCl with Pepsin and Gentian Bitters. It is formulated as a digestive aid to help with acid indigestion by making the stomach more acidic.
It does work well for that.
It contains 650 mg of Betaine per capsule.
Hey Brad, I am not sure why don’t promote folic acid for homocysteine lowering. I don’t know a study that shows a significant effect with only 1g of TMG. +higher doses can possibly increase LDL/ApoB.
So the meta analysis you stated concludes:
„Folic acid has no adverse effects on blood lipids; and therefore, folic acid supplementation should remain the preferred homocysteine-lowering treatment in healthy humans.“
Thanks for pointing this out, I think I'll ditch Betaine and replace it with a B-complex (I read that B6 and B12 also lower homocysteine).
@@auslanderbuchsbaum5623 I think Betain methylates / converts any B vit into a usable form. I read it also reduces inflammation which lowers anxiety and depression.
Feeding the TH-cam algorithm. Informative video. Thanks.
It is in our top 3 best sellers Brad!
I under methylate and also have histamine intolerance, so I take it with NAC as an alternative to SAME. Been using it for years. If not for this is be on antihistamines daily.
I read this somewhere: "The breakdown of TMG in the body can make trimethylamine. TMG supplementation can cause a person’s urine and sweat to smell fishy"
Any comments on this from people already taking TMG? Thank you.
How can you know that the benefits of TMG aren't from the increased creatine concentration? A lot of people supplement creatine so I think this is an important question to answer
One of the references covers exactly this
@@billsemenoff which one?
@@samvandervelden8243 the fourth one
@@billsemenoff thanks
I read the article 4 abstract and conclusion does NOT agree with results above conclusion? wtf? Also it was a 10 DAY STUDY again wtf?
Docta gettin stacked!
Speaking of methylation, please do a video on MTHFR mutation and how, or if, to treat it. There is tremendous disagreement between the functional and the 'conventional' medical professionals. Everything from "change you diet completely and carefully titrate these specific supplements" (methyl-folate, methyl-B12, etc), to "it's no big deal at all, requiring no intervention". Which is it?
I take TMG for homocysteine and because its a good methl doner which I think is beneficial for certain longevity supplements. For muscles I take creatine and HMB. Mostly because I'm afraid my work, which is basically 12 hours of cardio, is burning muscle instead of building it.
Your Job?
Yeah, what job involves 12 hours of cardio? Sounds intense.
I hear you as I also work 12 hrs a day of cardio
I take 500 mg TMG every other day and eat beets several times per week...limit red meat to keep TMAO lower...likewise limiting animal protein lowers the amount of methionine (feed back) might inhibit homocysteine to methionine conversion...(your thoughts?)
Thanks again Doctor Brad for the important info.
Love the channel. What do you think about probiotics? Having trouble finding reliable information.
What about the concerns about increased LDL with betaine supplementation ?
Love your videos. But there is another video from “conquer aging or die trying” that claims B6 and Serine may be a better choice than TMG for longevity.
Great video a as always Brad, will love to hear your opinion on MOTS-c !
I was taking TMG, 500 mg, 2X/d, but stopped, forget why. Next week running up a hill pulled a calf muscle. Major ouch for over a week. Back on TMG then and forever since.
Thanks for the great information !! Can you take TMG powder in coffie?
I take 1.5 grams 3 times a day. But I live an active lifestyle and lift weights 6 days a week. But I also take all the regular life extension supplements. Glynac etc.
However there are studies showing that TMG supplementation is increasing LDL cholesterol levels, so it's a no for me.
We can see that no one have the imagination to give basic info like the best time of day to have it, and with what is better the assimilation, maybe plain water, and also if there are synergetic supplements to take with TMG? So important.
Dr. Stanfield is THE most honest adviser and expert when it comes to supplements on youtube. His talking about the lies of the propoenents of Resveritral for example shows how many shady characters there are here.
I chug a shot of Whiskey whenever he says "increased by a whopping"
Your going to kill yourself bro. 😁
Could TMG serve the same benefits as GlyNAC, if TMG is combined with NAC?
Does TMG confer the same benefit as glycine itself WRT combining with NAC to give the body precursors to glutathione?
wow your arms! didnt expect that. what is your workout plan?
Dr.Brad what is Your opinion about TMAO which is genereted from TMG,choline and l-carnitine? New reaserch is showing that TMAO is bad for cardiovascular system. I am confused couse in one hand lowering homocysteine is good and other hand we make more TMAO which is bad...
Dr. Brad kindly make a video on Science based Ways for fat loss.
He already made
Do you know if betaine hydrochloride will be as effective as straight betaine? Have been taking betaine HCL for a long time to control gastric reflux with excellent results, if there are other benefits then that’s a fortuitous bonus.
I was wondering the same thing; I take betaine HCL as well.
No. It is different. Betaine hcl is for acidity. Tmg is for methylation.
Totally different and definitely not to be confused.
@@constanceelaine3909
Well I know that they are used for different purposes however the molecular structure is very similar which is why I submitted my original question.
For instance, magnesium threonate and magnesium glycinate behave differently in the body but they both are a source of magnesium.
So I had to answer my own question. Apparently betaine hydrochloride is just as effective as a methyl donor as straight betaine.
I would mainly take TMG to prevent a methyl deficiency when taking an NAD+ precursor.
There’s a human study showing that’s not a concern if you are using NR (and likely NMN). Since I take niacin though, which raises homocysteine levels, TMG is a good option to counteract that increase
Really?
There's some controversies, but it seems that both NR and NMN produces NAM.
And we need Methyl groups to get rid of that.
So, even NR and NMN might be a load on Methyl groups.
But it probably is a bit slower than taking NAM durectly.
Brenner and Sinclair might say otherwise. But other researchers who traced these things seems to say most goes via NAM.
I wouldn't take 300 mg or more of any kind of vitamin B3 without TMG.
This research obvoiusly must be made in the body, and furthermore, not just be measured in the blood.
@@DrBradStanfield I also heard Niacin raises NAD+ but also inhibits SIRT1 because it builds up on the end of the pathway, since it’s mechanism in elevating NAD+ levels is different from NR and NMN. I’ve heard NR+NMN do the opposite (activate SIRT), is the Niacin inhibition a cause for concern?
What is the difference between Glycine and TMG? If I am taking NAC should I be taking glycine or TMG with the NAC? I bought just regular glycine and have been using that with NAC. Is this right or should it be TMG? I am not doing a workout if this helps. I am confused.
I noticed NMN is available on Amazon again.
@Jacques Treehorn
You can continue to take Glycine with NAC.
That gives you two of the three amino acids which are needed to build Glutathion. Yiu get enoyugh of the third from your protein. But these two are limiting.
TMG hasn't anything to do with this, except that it too gives you some Glycine.
TMG supplies methyl groups. This is important for building Creatine. But especially if you take large doses of some form of vitamin B3.
The body spends Methyl groups when it sheds any excess of it.
If you supplement with Creatine, you might not need TMG.
@@larsnystrom6698 I started taking NAC but no additional glycine since I am taking TMG. Does this make sense?
Glycine isn't TMG, TMG has a recommended upper limit to avoid raising cholesterol levels, glycine is basically safe in relatively large amounts, so pretty different
Another good, smart, brief, no-nonsense video on longevity science! But I still think our current best radical treatment to enhance human longevity is thymus organelles (improving immunity function). I wish like hell someone would do a quick study on this to see if rat longevity expands by 30-50%, as I speculate it probably will.
do you mean ovine/bovine thymus glandular extracts?
Love TMG but it causes me severe insomnia. Had to discontinue.
Do these positive effects also include betaine HCl?
There's a study that suggests Betaine at doses over 4g a day can increase LDL cholesterol, so your dosage of 1g a day seems to be a good recommendation!
Is there any evidence, that supplementing MTG alongside Creatine gives additive effects? I'm afraid that the mechanism for muscle performance behind MTG is too similar to that of Creatine's.
Nevertheless, all the other benefits of Betaine look promising!
I wouldn’t be worried about an increase in LDL.
Please do a video about how to put Ulcerative colitis into remission!
Two different brands of TMG, supposedly high quality, gave me headaches, I would rather to get betaine from Spinach , beets and wheat germ and stay away from supplements that I am not sure about purity and identity.
Good morning Dr Stanfield. Is TMG the same as Glycine? I am having 600 mg of NAC and 1000 of Glycine daily and planning to start NMN + Resveratrol. Do I need to take TMG along with NMN or the Glycine I am having along with NAC is suffice?
This is such a new field. Would appreciate your suggestion and guidance. Thanks.
Resveratrol has been debunked. See Dr. Brad's video on the $720M scam.
Thanks Dr Brad, this was a great video. i wonder if you could make a video about supplements that can enhance or create a healty hormonal environment for males. Thanks
TMG also enhances the antidepressant effects of ketamine, while mitigating the psychotomimetic effects.
Great content. Will Betaine HCL offer similar homocysteine lowering effects as TMG?
i was wondering that too as I take it for reflux
No. HCL is much different chemistry than anhydrous. Google it.
You are simply amazing.😊
Hi love you chanel just a quick question can TMG increase cholesterol levels???
I'm 76, 70% disabled Vet and had open heart/triple bypass surgery last October. I was very careful with doing anything that would tear the sutures out of my sternum. But, I gradually started weight training again and some cardio. I don't take any HGH, Roids, or unnatural supplements and have gained back my biceps, etc. I take Creatine Monohydrate, GLYNAC and Nattakinase daily. I've got good strength for my age (Deadlifts of 165x8x3, etc.) for functional lifting, etc. outside work. I wonder at what point do I stop adding on supplements? 45 a day, 75/day, 100/day? LOL Cheers, Bob
TMG's in spinach? Maybe Popeye was right!!!💪🥗😄
He was always a bit spastic though because the oxalates block the magnesium upload. 😂
It also contains Ecdysterone, a plant steroid similar to testosterone.
Thanks doc, keep up the good work, straight to the point. 👍 💙
I always like your videos they are very easy to digest .
so im not a big supplements fan, but I have been more intentional with consuming wheat bran products. In my own experience, it makes recomping so much easier.
Thank you Dr Stanfield. Is there any truth to some claims I've read that taking TMG at the therapeutic dose mentioned in the trials has been known to increase LDL cholesterol?
There's one side of TMG that people often don't consider though. It's immunomodulatory, and while that may suit people with chronic inflammation perhaps, doesn't suit everyone. It can really change your immune cells population proportions. I always had my neutrophils on the lower side, but within the healthy range still, taking TMG pushes me into mild neutropenia, and even moderate neutropenia at some point, so that was worrying, I had to stop taking it. Like I said for many people this could be good, reduced inflammation, but like most supplements it's not a one size fits all. I'm finding that more and more. Check papers about betaine and the immune system there are many interesting things going on.
Thanks for this! I always noted I bulked up more and performed better speed wise on my cycle while eating wheat. But have a slight allergy and found I felt better overall off it. I have ordered some TMG powder. Does not seem expensive at your recommend dose. If I remember will report back how it works as a reply to this comment.
Hi what is the recommended dose?
Does timing matter at all? Do you get any benefit on your work out days to take it before the workout vs after or is it like creatine which sort of accumulates over days in the body?
Nice video 👍🏻
Cheers much and didn't know you had muscles lol looks are deceiving and I've been taking probably 500g of betaine hcl every night after dinner, is that good or bad?
Dr Brad. Please share your bodybuilding routine.
In Dr. Stanfield's bicep shot profile pic for this video, he looked like an 18 year old Freshmen at University. Whatever he's taking.....it's working!!
Do you have to take it right before your workout or does the timing not matter?
I always like your videos.Thanks you.
Lower homocysteine can be achieved by just eating a plant based diet in general. That is not where the TMG is required.
How to figure out which supplements to take? NMN, NR, NAD+, NAC, Reversatrol, TMG, etc... I'm 48 female 135lb 5' tall wanting to get fit. I'm on hormone replacement therapy estradiol patch, progesterone, testosterone gel. Plus I take levothyroxine a low dose for hypothyroidism. I want to turn back time as much as poosible but I honestly don't know where to start with all these supplements.
Out of those supplements which one has the lowest amount of niacin?
Very good work you are doing!!!
TMG is a must
Choline is merabolized in betaine. Is there any advantage of taking TMG vs choline?
Dr. Brad, is it OK to take a glutathione supplement and a NAC supplement at the same time?
Low vitamin B6 is strongly associated with Alzheimer. Those who have a high level of B6 have 4 times less chances of getting it. So I wonder if using B6 to protect the brain from degeneration and as a methyl donor to lower homocysteine wouldn't be even better, all the more than for TMG to work it would take a really high dosage.
Thank you Doc!
Very interesting! Betaine recycles ATP so that energy gets utilized. Thank you.
FLEXING again...! :D
Please tell me. For muscle growth, to increase protein synthesis. How should I take betaine? Every day or only on training days? Take before and after workout or throughout the day?
It raises methionine though and that's usually implicated with reduction in lifespan.
Great info as usual Dr Brad! Are you concerned about the potential to raise TMAO, which is associated with coronary artery disease?
Fish apparently have far more Tmao , than the level TMG would raise.From what I understand no studies have shown any mechanism of damage, simply that there is and increase associated with.
@@trentbusta1 for whatever reason food sources of choline like eggs and fish don’t raise TMAO but choline containing supplements do. I agree that no mechanism of action has been shown though.
@@TheBiffsterLife interesting, are you aware fish already contains a relatively large quantity of tmao?
@@trentbusta1 yes, i rate TMAO as relatively low probability of being harmful, but with high enough impact that I’d still prefer to keep it low.
I believe Molybdenum and Soluble Fibre lowers TMAO. I'm not aware of the dosage needed though, maybe something nominal.
Thanks Brad :)
Thank you, you are great!
Wow! STUNNING biceps muscles!
And I have seen materials that say that betaine serves as a precursor to TMAO in the intestine and is associated with atherosclerosis.
Honestly, I had to go look for an interview before I believed he wasn't an AI (but in the zoom interview it was the same clothes and background :)