In anticipation of the comments: yes, that's my arm in the thumbnail, and no, it's not photoshopped 💊MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin 📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
Hi Doc, I’ve been on TMG for over 10 years. I read years ago that it was good for the body, especially the liver and cardiovascular system. I also read that it turns into SAM-e as it is metabolized in the body. So, it is a cheap way to get those benefits as well.
@DrBradStanfield awesome work again Brad. I started on Creatine (age 48) and it ‘seemed’ to really spike my blood pressure from (125/83) to (138/95) is that a know/common issue? I stopped and it ‘seemed’ to go back down. My GP was at a loss as to why.
I’ve been on TMG for over 10 years. I read years ago that it was good for the body, especially the liver and cardiovascular system. I also read that it turns into SAM-e as it is metabolized in the body. So, it is a cheap way to get those benefits as well.
Microvitamin is already on its 5th revised version. I absolutely respect that he updates the formula continuously in accordance with discoveries and conclusions from his research.
I would like to see studies for TMG on groups that take creatine versus groups that don't. It seems that TMG's effect may be a result of higher creatine levels and therefore it may be far less effective on those already supplementing with creatine. This is backed up by observations that TMG requires an exercise program to deliver any benefits. Sounds just like creatine supplementaiton to me.
The link number 4 in the video description is to a systematic review of the literature, where they included one study where this issue was addressed: "In the study by Favero et al., it was concluded that BET supplementation did not affect strength and power performance, whether it was alone or added to CR supplementation. The study was designed as a double-blind randomized PL-controlled trial, and subjects were randomly assigned to receive either BET, CR, BET and CR, or a PL for 10 days. Subjects were instructed to refrain from any exercise training program throughout the study, and muscle strength and power were assessed at baseline and after the 10 days of supplementation. Although CR was shown to improve strength and power outcome measures, BET had no additive effect" Although very limited, short period study
There is another good reason to take TMG: It can replace up to 40% of choline, which most humans appear to be insufficient in, and TMG is way cheaper than the equivaltent dose of choline.
TMG cut my deep sleep to 50% or even less when I take it before going to sleep. No issues in taking it in the morning, though, around 1 gram, and sometimes as a post workout (if I workout before lunch time)
For betainHCL, they increase gastric acid secretion for adequate digestion of nutrients. I do recommend beatineHCl for elder patient and Helicobacter pylori infeced patient. Interestingly, quite many patients with SIBO (in a way, it is quite sure low gastric acid induces low digestive ability and absorption) has high homocyseine. One another feature is many of sudden hearing disturbance patients comes with high homocysteine.
@@camwells9726 Yes. TMG (Trimethyglicine), Betaine, is not the same as Betaine HCL (Betaine Hydrochloride), which should be taken in instances where you may have acid reflux symptoms as Betaine HCL raises the level of your stomach acidity to a natural level, which in turn should then trigger the flap at the top of your stomach to close properly. Low stomach acid can have the effect of the top flap staying open, causing the acid reflux issues. Further, low stomach acidy reduces digestion of foods which can cause bloating and also impinges the body's absorption of key nutrients. I have taken Betaine HCL and it worked well for me for the above issues, and I have started taking TMG to hopefully gain the benefits associated with exercise as discussed by the Doc in this video.
Very glad to see that you have increased the levels of B12 in the latest version of MicroVitamin! This was the single ingredient micro dosage that seemed "out of wack" to me due to the its very low rate of absorption in the body. Definitely an improvement Dr. Brad!
The optimal doze of TMG, based on the studies is around 3 grams per day. Including 500 mg is neither here nor there, just like some of the other negligible dosages of the included ingredients, such as taurine, glycine and a few others. Dr Brad is very intelligent so would know this, but it's good marketing. I do enjoy his content though.
@@SoulKing.... There's not enough research done to determine the "optimal" dose. But the best info we have is from the rodent taurine longevity study and is extrapolated to 6 grams per day for a 75 kg human. No need to take it prior to the half lifespan point though, i.e. 40-45 years old. Doing this added 10%-12% of lifespan compared to the rodents in the control group. While I'd love to see human studies on this, they'd take 40-50 years to complete.
Dr Brad, great video! As always, you are on the cutting edge of non-biased research. You are doing many MANY people a big service! May you do a video on Longvida Curcumin? TYIA! I look forward to the video!
If having more muscle is so protective, why is it never discussed or taken into consideration during a check-up? I have a lot of muscle -- been lifting since I was a teen and am in my 50s.... but my PCP looks at my BMI and says "obese" without noting a large amount of my weight is muscle(though, admittedly, I'm not lean). Maybe this is more an American thing where our insurance based healthcare system relies on generalized checklists, instead of individual factors?
My gut response is that there's no money in it for the doctor to recognize a good diet and lifestyle including your high muscle mass. Regular doctors are trained to find symptoms to treat with pharmaceutical drugs.
just my .02. Why explain something that no one is going to listen to? Worked in health/fitness industry going on 30 years now. Most people do not listen to basic nutrition advice, let alone exercise. And the stats prove it. Now should a doctor take into consideration muscle mass, absolutely. But in order to do that properly they have to invest in the tools to track and assess them. When research tells us that 90% of the US population doesn't even eat the recommended servings of vegetables, and half meet the recommendation for exercise.. it's a hard sell to add that to a clinic. There have been studies where people were literally paid to exercise, and they still weren't consistent Again, this does not excuse a doctor from updating their knowledge. But if majority of people your doctor sees don't fall into your category of muscle mass, it's easy for them to go with a default mindset.
Second CoachW above. I was a military medic and counseled people during their annual physical exams that more muscle helps protect against injury, increases resting calorie burn making staying lean easier, and will make them healthier as they age. Rarely did they listen. They had to fail fitness tests, have someone point out they were unhealthy/fat, or some other uncomfortable reality. When you are seeing up to 40 patients a day... Doctors have no time to reiterate counseling that you may not listen to. This is just muscle and weight tho... Imagine losing a patient due to diabetes complications cause they ate themselves into amputation, sepsis, kidney failure, and cardiac arrest. The two things most everyone will not do without extreme motivation is change the way they eat and work out intensely. Doctors telling people rarely makes a difference until something actually goes wrong.
Ok, so assuming you have a high amount of muscle tissue, there is still a lot of nuances. What is your body fat %? This % is important. Yes, you are going to the wrong doctor. Diet, sleep quality, activity levels, hydration, nutrition, lifestyle are all critical to health. Muscle tissue and strength are only helpful if all factors are also correct. Find a doctor in your area that lifts and has a low to correct body fat %. BMI should never be used for persons that lift. Body fat % (dexa scan, visual, MRI for visceral fat) is the critical component.
After starting to take TMG, I cannot sleep well, it increased my energy production too much. Before going to sleep I need to work hard and deplete my energy.
@HealthTips-fh8si Same thing happened to me. I read about it and some suggestions were to take it in the morning, or just as the doc in the video said together with NMN, which is what I switched to. I take it in the morning when I work out and it's been a great change so far. Maybe this will help you too.
Couch Greg Doucette would disagree and provides proven facts that it is the NMN! His facts? He yells at you at a high pitched whiny voice, that trumps any scientific study!
There is a really good human RCT on NMN with 3 groups, one on low dose NMN one on high dose NMN and one control group. Both NMN groups experienced a significant increase in exercise endurance. So I’m not sure why Dr Brad Stanford seems to think it probably doesn’t work. The evidence I have seen suggests that it does work.
TMG is an anti inflammatory, and you have said that anti inflammatories can lessen the effectiveness of exercise, So should TMG be taken before or after exercise for best results?
I have post concussion syndrome and I started to take NMNH 10 days ago. On day 3 I got the sense of the right side of my body back and that was amazing. Even though it was aching, I could at least feel it. For 1,5 years I have not felt the right side of my body (the muscles). I will try vitamin B3 after this though. Much cheaper. Will try TMG as well. Thank you. Update: I will not try B3 because I saw now that I have already taken it since the concussion in a high dosage (303% RDI). It is the NMNH then that has made all the difference for me.
Another great video. I just started taking your MicroVitamin this morning :) Do you have any plans on making videos on hair growth? That would be much appreciated please. Thanks
What would be reassuring and useful information for me? Re TMG, Betaine, Creatine. The kidney test is a test of how much creatinine (the waste product of creatine) is or is not filtered out by the kidneys. Where would TMG/creatine supplementation factor into the process? More simply, will increasing one's intake of creatine impact kidney health? I'd appreciate it if you could address this in a future video.
I’ve started questioning everything, especially government health advice! After reading "Health and Beauty Mastery", I completely changed my approach. This book reveals so many shocking truths about the health industry!
You should consider doing a video on methylation as it affects an estimated 60% of the population. Not everyone metabolizes vitamins the supplements the same and some people can be doing chronic harm to themselves from simply taking things based on social media guidance.
Dr. Brad, I started taking nmn about 2 years ago with no other changes to my diet. 3 months after starting nmn my eyesight significantly improved. I no longer need glasses for driving. My ophthalmologist said that my retina may have regenerated. I also feel younger and others say I look younger. I am 66 years old and compete with my two teenage Sons well, so in my case nmn definitely does work. I have been taking TMG now for about a year and have not noticed any additional benefits but continue taking it because it is recommended with nmn.
It’d be fantastic to hear why you recommend a different supplement stack to Bryan Johnson (Project Blueprint). Some great crossover but also differences between your multivitamins.
If you are physically active and your nutrition is sub-optimal (most regular viewers here) then TMG at 1-3 grams per day should be useful. Some people don't need the methyl groups in TMG, just like many don't need the methylation in methyl folate or methyl B-12. There are tests for methylation for folate and B-12, so there may also be a similar test to determine whether TMG will be useful, but I haven't seen it yet.
so what's your thoughts on supplements such as TMG on the developing body? all these studies are done with adults, but wondering about the teen athlete trying to gain an edge and safety of these supplements.
Maybe you should do a video on TMG vs. Glycine. Is one better than the other. Do they both accomplish the same thing in the bigger picture? I take 1.5 grams of glycine per day. And, Sometimes I take a pre-workout that has TMG before hard cycling workouts. I've often wondered should I switch to TMG, or is what I am doing just as effective?
well, TMG (as the name says) is basically Glycine with 3 methyl groups. Glycine has its own benefits, such as lowering inflammation and helping the body produce more gluthatione (the main antioxidant produced by the body, which declines with age), while the benefits that were discussed in the video here were relative to lower homocysteine levels, which is actually done by the methyl groups instead, not by glycine. If I understand it well, at least. So, the two substances achieve completely different results (bear in mind that the amount of glycine in TMG is quite minimal). Personally, at the age of 47, I take TMG and "glycine with NAC", which boosts glutathione production even more. I keep active as much as possible during the day, I exercise everyday (but without getting too crazy about it, very rarely more than 30 minutes). I eat well (tons of vegetables, olive oil, fermented food, only wholegrains and berries as carbs, quite a lot of good quality proteins, at least 120 grams, plus the additional green banana in the evening (after dinner I like to make my "dessert" with 2 slices of rye bread, a squeezed green banana, lemon juice, cinnamon and black currants, if I have eaten a lot of carbs I also add a coffee spoon of allulose to lower sugar absorption. It has become a habit). While 10 years ago I was in terrible shape and in bad health, now I have a body fat percentage of 8-9% and a Vo2Max nearing 49, and I feel pretty amazing.
I thought there was an indication in the intro to this video, that suggested TMG dosing would be covered. Did I miss something, though? That is...I did not hear anything about optimal dosing of TMG.
I am interested in trying out this formulation but would like to know what the absorption rate is for this supplement. Some supplements have a very low absorption as they transit the digestive tract and from experience I know that the digestive tract will absorb liquids more easily and completely than solids which sometimes can pass through with little absorption.
HCl makes the substance more acidic. It can raise stomach pH, which can be beneficial for absorption of minerals (e.g. calcium supplements) and nutrition. However you get less (weight percentage-wise) Betaine. Unlike its HCl counterpart, pure Betaine is very hygroscopic, which may affect the shelf-life negatively.
@@thomasmuller1850 but any positive effects dr Brad is talking about can still, theoretically, be achieved with the HCl version? Some sources say they’re completely different, some say they’re pretty much the same thing
@@peterRobinson10101 the doctor says that Betaine and TMG are the same thing. But more specifically, I know that TMG is betaine anhydrous. Betaine HCl is different. But I’m bot sure if the positive effects can be the same or not
My question is: if TMG increases methionine levels, how can it be beneficial if high methionine consumption has been associated with accelerated aging?
it increases methionine by decreasing homocysteine (homocysteine is the waste product from your body using methinione). Your body can convert homocysteine back to methionine with help of B12 & Methyl folate as the electron donors or TMG as the electron donor. Excess Homocysteine is what causes accelerated aging, not excess methionine (a deficiency of B12, Folate, B6 and/or TMG is what allows the homocysteine to build up without being converted back to methionine). With B6 the body can convert homocysteine to glutathione also. Vitamin C will recycle used Glutathione back to its active useful form.
@@jhfgjtjutyiuod Technically homocystein does not increase aging, it's just a symptom of poor recycling of folate and methionine; where folate serve as a cofactor for nucleiotide synthesis in DNA formation, and methionine as the precursor for Sam-e used in DNA methylation. Folate, cobalamine and TMG are methyl group donors, not electron donors. Vitamin C does not recycle glutathione, but glutathione (reductase) can reduce oxidated vitamin C. Glutathione can do this with any antioxidant, as it's our primary redox agent. Any nutrient involved in the one carbon cycle can be overconsumed, leading to depletion or disturbance of the others. Balance is key. Also, TMG dependent methionine synthase is a reserve route used when the primary MTHFR route is insufficient. This means that rather than TMG supplementation, it's better to improve your overall diet. If the recycling rate of methionine were to exceed the recycling rate of folate (both usually goes through MTHFR) this disrupts growth regulation. Lastly, there's no one "active"/"useful" form of any nutrient or metabolite in the body, this is dependent on where they are in their respective metabolic processes.
I’ve been taking betaine hcl with my food since 2012. Was I inadvertently supplementing with TMG in this case or is there a difference between the two?
Hi, thanks for the update. I wanted to buy your supplement but when I saw serving size 4 capsules a day I decided not to. Is there a reason why you can't make it a 1 capsule serving size?
I love the idea of microvitamin but 50mg of Niacin is not microdosing and is not in proportion to the other B's. I see less than 50mg of Niacin in the megadosing multis on the market. Im after a multi with 1 to 2mg equivalent of each B and true microdoses of nutrients to support diet and minimise overusing transport proteins and enzymes with synthetic vits. Hard to find.
Make sure to let your doctor know before any blood work is done. I was taking 3 grams ofTMG and from what I can tell it threw off my Creatinine levels, eGRF, bUN and my Creatinine ratio. after not taking it for 2 days and retesting they all came back in normal ranges. Retesting was done 7 days after the first test.
Bro thats normal when you increase creatine levels the residue creatinine is increased as well but it does not mean is a bad thing, creatinine is bad when is high naturaly.
Does that mean your creatinine was shown as high and your eGFR was low after TMG, or was it the other way around? (ie. Was your kidney function shown worse than it actually was or better than it really was?)
@@georgen5250 I agree with you. I mentioned it because if you don't let the doctor know they might think there is something wrong with you when there is not and may be looking to try to fix something that is not broken.
Brad! I would love if you could answer this for me Everytime I take betain consistently I end up getting very ill, feeling tons of fatigue and vomiting. It took me 4 x before I completely zeroed in that betain was the culprit. What could cause this? Even if I take with b vitamins. Is there a deficiency somewhere in my bodies ability to process methyl groups or to detox what those methyl groups help to detox?
Thank you so much doc, I have been asking and hoping you and some other content creators with the knowledge would cover TMG! started using it this month and I am very adamant to keep using it! For the benefit related to strength training, would you suggest a higher dose (2g) on the day of exercise and then 1gr or 500mg on the other days?
I am overwhelmed by so many studies and so much information about supplements. We should be taking pills all day long if we followed the advice of all the gurus.
If you dig into research papers, you'd come to the same conclusion and practicality indeed quickely becomes an issue. Thus we should choose wisely choices. However taking multiple supplements doesn't imply you take tons of pills. I've combined 12 supplments in two capsules a day using a company offering custom capsules. What takes up more space and tastes alright I purchased in cheaper powder form and combined the powders to create beverages, which I drink not only for their pleasant effects, but also because I enjoy their taste. Of course it was a lot of work initially, but it made it very easy to stick to that routine for the rest of my life.
@@jorgecastillo6128 incorrect, supplements have benefits going beyond those foods. I also don't see how of all things fatty meat would have a benefit in a good diet. It's adding unhealthy fats and heme iron and causes a range of negative health consequences like high Apo B, TMAO, homocysteine, CRP, while adding no significant amounts of nutrients that could not be derived from other sources, except for vitamine B12, which is like the cheapest and lowest dose supplement in the world. The other nutrients are contained in insufficient quantities anyways - you will not nearly get a good amount of creatine, carnitine, carnosine, taurine or coenzyme Q10 by eating meat.
@DrBradStanfield I ordered and received your multi-vitamin, but I live in SW Florida and the humidity caused them to swell and almost ‘burst’. They are kept in a dark cabinet in an air conditioned house. Are there plans for a coated version/some other solution? Thanks.
Brad I drink 250ml of organic beetroot juice every day for high blood pressure. Will I also be getting TMG, and the advantages it brings, from that or should I also supplement?
id love to know your researched opinion on the peptides BPC157 and TB500, allegedly theyre amazing for recovering from broken bones and improving overall recovery function
@@MixtrisUFOimagesNot yawn. How long have you been in the game? For me, I cannot tell you how many “just inject it bro” turned out to be harmful once the data came in 5-10 years later. The human body is complex interactions, and when you artificially throw it out of sync it can have unforeseen harmful consequences. He knows this and bases his decisions on “ok this has been proven to both work and safe via quality clinical trials”.
@@MixtrisUFOimages When you're talking about injecting something yourself which you bought from unregulated compounding pharmacies, that alone is enough to be discouraged by an actual responsible practicing doctor. Furthermore, with something specifically purported to boost angiogenisis and vasculogenisis it would be wise to extensively research potential cancer causing or tumor accelerating side effects. That being said I think you should personally take it and tell us all how it goes!
Is there enough betaine in beets, spinach, or wheat germ to have a an significant impact or are the concentrations too low and therefore supplements are required?
I looked at testosterone studies and it seems the slow decline will start by 40 for majority of men and for some men (minority) there is no decline at all. However there is significant variation in T levels and the gradual decrease.
I happened to recently buy some pure carrot juice and drinking that stuff almost makes me puke because of the betaine content that is present in carrots, like beets.
I appreciate your integrity and honesty Dr. Brad. Don't ever change! As an aside, after watching your video on Fatty15, next, you should do a video on Timeline's Mitopure. I sense it's a get-rich-quick scheme promoted by well-known health advocates that should know better.
@@katisugarbaker7349 I subscribed to it early on in my supplement discovery, and was roped in by the slick marketing and glowing endorsements. I had no results after sticking with it for 4 months. IMO, for what they charge it should be a miracle pill! It's also disturbing when very smart health professionals invest in too many of these new supplement companies. I begin to question what's more important to them: actual human-tested science and beneficial results for a broad cohort, or making a buck? Siim Land called BS on Mitopure and did a damning review. I wonder what Dr. Brad would have to say :)
In anticipation of the comments: yes, that's my arm in the thumbnail, and no, it's not photoshopped
💊MicroVitamin (multivitamin & mineral that I take): drstanfield.com/products/microvitamin
📜Roadmap - how to look young & feel strong: drstanfield.com/pages/roadmap
Haha nice :)
Will TMG help if you are on TRT and your levels are within the normal range while on TRT, or will it only help if your testosterone levels are low?
Sadly your Multivitamin dont ship to Israel. Will that change at some point? Thanks
Hi Doc, I’ve been on TMG for over 10 years. I read years ago that it was good for the body, especially the liver and cardiovascular system. I also read that it turns into SAM-e as it is metabolized in the body. So, it is a cheap way to get those benefits as well.
@DrBradStanfield awesome work again Brad. I started on Creatine (age 48) and it ‘seemed’ to really spike my blood pressure from (125/83) to (138/95) is that a know/common issue? I stopped and it ‘seemed’ to go back down. My GP was at a loss as to why.
I’ve been on TMG for over 10 years. I read years ago that it was good for the body, especially the liver and cardiovascular system. I also read that it turns into SAM-e as it is metabolized in the body. So, it is a cheap way to get those benefits as well.
Do you combine it with creatine and do you lift weight? If so do you notice the boosts?
How much do you take? 🙏🏻
Microvitamin is already on its 5th revised version. I absolutely respect that he updates the formula continuously in accordance with discoveries and conclusions from his research.
D3 and k2 should be 10hrs apart. His multi is wrong.
@@user-pf5xq3lq8i source on that ? I think it's better taken together to prevent artery calcification
@@user-pf5xq3lq8iSorry but why’s wrong in your opinion?
@@user-pf5xq3lq8i Why? I thought they work synergistically
@@user-pf5xq3lq8iwhat happens if you don’t do it that way?
I would like to see studies for TMG on groups that take creatine versus groups that don't. It seems that TMG's effect may be a result of higher creatine levels and therefore it may be far less effective on those already supplementing with creatine. This is backed up by observations that TMG requires an exercise program to deliver any benefits. Sounds just like creatine supplementaiton to me.
Creatine is cheap too!
TMG made me feel very sick and breathing issues at night, when I took it, with and without creatine.
Yup, that was my first thought as well. More research is needed.
Agreed. That would be an important study to do
The link number 4 in the video description is to a systematic review of the literature, where they included one study where this issue was addressed:
"In the study by Favero et al., it was concluded that BET supplementation did not affect strength and power performance, whether it was alone or added to CR supplementation. The study was designed as a double-blind randomized PL-controlled trial, and subjects were randomly assigned to receive either BET, CR, BET and CR, or a PL for 10 days. Subjects were instructed to refrain from any exercise training program throughout the study, and muscle strength and power were assessed at baseline and after the 10 days of supplementation. Although CR was shown to improve strength and power outcome measures, BET had no additive effect"
Although very limited, short period study
How about beet root powder which contains other good compounds besides TMG
how about beet root
@@marc09969 Spot on. The whole food is generaly better than the extract/supplement.
There is another good reason to take TMG: It can replace up to 40% of choline, which most humans appear to be insufficient in, and TMG is way cheaper than the equivaltent dose of choline.
TMG cut my deep sleep to 50% or even less when I take it before going to sleep. No issues in taking it in the morning, though, around 1 gram, and sometimes as a post workout (if I workout before lunch time)
I try to take most supplements in the first half of the day for this reason except ZMA and melatonin
Same, had super disruptive sleep patterns. Glad I switched to taking it in the morning along with NMN.
For betainHCL, they increase gastric acid secretion for adequate digestion of nutrients. I do recommend beatineHCl for elder patient and Helicobacter pylori infeced patient. Interestingly, quite many patients with SIBO (in a way, it is quite sure low gastric acid induces low digestive ability and absorption) has high homocyseine. One another feature is many of sudden hearing disturbance patients comes with high homocysteine.
Is betaine hcl different to regular betaine?
@@camwells9726 Yes. TMG (Trimethyglicine), Betaine, is not the same as Betaine HCL (Betaine Hydrochloride), which should be taken in instances where you may have acid reflux symptoms as Betaine HCL raises the level of your stomach acidity to a natural level, which in turn should then trigger the flap at the top of your stomach to close properly. Low stomach acid can have the effect of the top flap staying open, causing the acid reflux issues. Further, low stomach acidy reduces digestion of foods which can cause bloating and also impinges the body's absorption of key nutrients. I have taken Betaine HCL and it worked well for me for the above issues, and I have started taking TMG to hopefully gain the benefits associated with exercise as discussed by the Doc in this video.
Very glad to see that you have increased the levels of B12 in the latest version of MicroVitamin! This was the single ingredient micro dosage that seemed "out of wack" to me due to the its very low rate of absorption in the body. Definitely an improvement Dr. Brad!
The optimal doze of TMG, based on the studies is around 3 grams per day. Including 500 mg is neither here nor there, just like some of the other negligible dosages of the included ingredients, such as taurine, glycine and a few others. Dr Brad is very intelligent so would know this, but it's good marketing.
I do enjoy his content though.
He is wrong many times..he is a fraud.
What is the optimal dose for taurine?
@@SoulKing.... There's not enough research done to determine the "optimal" dose. But the best info we have is from the rodent taurine longevity study and is extrapolated to 6 grams per day for a 75 kg human.
No need to take it prior to the half lifespan point though, i.e. 40-45 years old. Doing this added 10%-12% of lifespan compared to the rodents in the control group.
While I'd love to see human studies on this, they'd take 40-50 years to complete.
That's a huge dose. It could lead to fluid retention on the brain.
@@TheAETHER22 Any actual evidence of this? I've been taking 6 grams daily for over a year and my tests have never been better.
i kind of figured this out 2 months ago. i stopped NMN and just kept taking TMG and some other things. same effect.
What kind of magnesium is in your multivitamin? And what time of day should it be taken?
It says Magnesium Taurinate 126mg on the pack.
Dr Brad, great video! As always, you are on the cutting edge of non-biased research. You are doing many MANY people a big service!
May you do a video on Longvida Curcumin?
TYIA! I look forward to the video!
If having more muscle is so protective, why is it never discussed or taken into consideration during a check-up? I have a lot of muscle -- been lifting since I was a teen and am in my 50s.... but my PCP looks at my BMI and says "obese" without noting a large amount of my weight is muscle(though, admittedly, I'm not lean). Maybe this is more an American thing where our insurance based healthcare system relies on generalized checklists, instead of individual factors?
My gut response is that there's no money in it for the doctor to recognize a good diet and lifestyle including your high muscle mass. Regular doctors are trained to find symptoms to treat with pharmaceutical drugs.
just my .02. Why explain something that no one is going to listen to?
Worked in health/fitness industry going on 30 years now. Most people do not listen to basic nutrition advice, let alone exercise. And the stats prove it. Now should a doctor take into consideration muscle mass, absolutely. But in order to do that properly they have to invest in the tools to track and assess them. When research tells us that 90% of the US population doesn't even eat the recommended servings of vegetables, and half meet the recommendation for exercise.. it's a hard sell to add that to a clinic.
There have been studies where people were literally paid to exercise, and they still weren't consistent
Again, this does not excuse a doctor from updating their knowledge. But if majority of people your doctor sees don't fall into your category of muscle mass, it's easy for them to go with a default mindset.
Second CoachW above. I was a military medic and counseled people during their annual physical exams that more muscle helps protect against injury, increases resting calorie burn making staying lean easier, and will make them healthier as they age.
Rarely did they listen. They had to fail fitness tests, have someone point out they were unhealthy/fat, or some other uncomfortable reality.
When you are seeing up to 40 patients a day... Doctors have no time to reiterate counseling that you may not listen to. This is just muscle and weight tho... Imagine losing a patient due to diabetes complications cause they ate themselves into amputation, sepsis, kidney failure, and cardiac arrest.
The two things most everyone will not do without extreme motivation is change the way they eat and work out intensely. Doctors telling people rarely makes a difference until something actually goes wrong.
It should be. This is a problem
Ok, so assuming you have a high amount of muscle tissue, there is still a lot of nuances. What is your body fat %? This % is important. Yes, you are going to the wrong doctor. Diet, sleep quality, activity levels, hydration, nutrition, lifestyle are all critical to health. Muscle tissue and strength are only helpful if all factors are also correct. Find a doctor in your area that lifts and has a low to correct body fat %. BMI should never be used for persons that lift. Body fat % (dexa scan, visual, MRI for visceral fat) is the critical component.
After starting to take TMG, I cannot sleep well, it increased my energy production too much. Before going to sleep I need to work hard and deplete my energy.
@HealthTips-fh8si Same thing happened to me. I read about it and some suggestions were to take it in the morning, or just as the doc in the video said together with NMN, which is what I switched to. I take it in the morning when I work out and it's been a great change so far. Maybe this will help you too.
I take it first thing in the morning.
Do glycine and TMG counteract each other?
One is a methyl donor and other prevents excess methylation?
Not at all. I know this since I take both at the same time. I usually just sweeten my green tea with glycine throughout the day 😊
Couch Greg Doucette would disagree and provides proven facts that it is the NMN! His facts? He yells at you at a high pitched whiny voice, that trumps any scientific study!
That *what* is the NMN? What are you talking about, disagree with what???
harder than last time!
There is a really good human RCT on NMN with 3 groups, one on low dose NMN one on high dose NMN and one control group. Both NMN groups experienced a significant increase in exercise endurance. So I’m not sure why Dr Brad Stanford seems to think it probably doesn’t work. The evidence I have seen suggests that it does work.
@vincentpolaczuk4240 check out my NMN video. I go through that study you are referring to
Some say to combine NMN with TMG for better performance. DYOR
TMG is an anti inflammatory, and you have said that anti inflammatories can lessen the effectiveness of exercise, So should TMG be taken before or after exercise for best results?
I think you’re thinking of anti oxidants not anti inflammatories
@@tmaori yes, I think you're right! I'd still like to know about when to take anti inflammatories AND anti oxidants in relation to exercise.
Opinion on the other trendy herb: Moringa??
I've taken TMG for well over 30 years for better digestion. Works very well.
You sure that's anhydrous or actual TMG or rather betaine HCL? Both are named "betaine" but have totally different actions in the body....
@@EGGHEADIUS You're quite right. My mistake. Thank you.
I have post concussion syndrome and I started to take NMNH 10 days ago. On day 3 I got the sense of the right side of my body back and that was amazing. Even though it was aching, I could at least feel it. For 1,5 years I have not felt the right side of my body (the muscles). I will try vitamin B3 after this though. Much cheaper. Will try TMG as well. Thank you. Update: I will not try B3 because I saw now that I have already taken it since the concussion in a high dosage (303% RDI). It is the NMNH then that has made all the difference for me.
Fantastic!
Another great video. I just started taking your MicroVitamin this morning :)
Do you have any plans on making videos on hair growth? That would be much appreciated please. Thanks
What would be reassuring and useful information for me? Re TMG, Betaine, Creatine. The kidney test is a test of how much creatinine (the waste product of creatine) is or is not filtered out by the kidneys. Where would TMG/creatine supplementation factor into the process? More simply, will increasing one's intake of creatine impact kidney health? I'd appreciate it if you could address this in a future video.
I’ve started questioning everything, especially government health advice! After reading "Health and Beauty Mastery", I completely changed my approach. This book reveals so many shocking truths about the health industry!
I heard about that
This is a spam comment with artificially boosted likes. I've seen it pasted in several recent videos. Ignore it.
Can you benefit from TMG only when you exercise? for example if you do strenuous exercise more occasionally? Or should it be taken daily?
I started buying wheatgerm for the tmg. But I also like it to top my salads or add crunch to some other stuff.
You should consider doing a video on methylation as it affects an estimated 60% of the population. Not everyone metabolizes vitamins the supplements the same and some people can be doing chronic harm to themselves from simply taking things based on social media guidance.
Dr. Brad, I started taking nmn about 2 years ago with no other changes to my diet. 3 months after starting nmn my eyesight significantly improved. I no longer need glasses for driving. My ophthalmologist said that my retina may have regenerated. I also feel younger and others say I look younger. I am 66 years old and compete with my two teenage Sons well, so in my case nmn definitely does work. I have been taking TMG now for about a year and have not noticed any additional benefits but continue taking it because it is recommended with nmn.
I have also heard that it restores menstruation in the women who are at the early stages of ovarian decline (perimenopause or menopause)
It’d be fantastic to hear why you recommend a different supplement stack to Bryan Johnson (Project Blueprint). Some great crossover but also differences between your multivitamins.
I already take glycine, do I need to take trimethylglicine too?
I take both: I take the glycine for sleep and I also use TMG (3 grams) to lower my homocysteine.
If you are physically active and your nutrition is sub-optimal (most regular viewers here) then TMG at 1-3 grams per day should be useful. Some people don't need the methyl groups in TMG, just like many don't need the methylation in methyl folate or methyl B-12. There are tests for methylation for folate and B-12, so there may also be a similar test to determine whether TMG will be useful, but I haven't seen it yet.
Can carp feed grade betaine powder be suitable for human consumption? Price difference is big and FeedStimulants 1kg costs just 15Eu, made in Holland.
As always, good video
so what's your thoughts on supplements such as TMG on the developing body? all these studies are done with adults, but wondering about the teen athlete trying to gain an edge and safety of these supplements.
Maybe you should do a video on TMG vs. Glycine. Is one better than the other. Do they both accomplish the same thing in the bigger picture? I take 1.5 grams of glycine per day. And, Sometimes I take a pre-workout that has TMG before hard cycling workouts. I've often wondered should I switch to TMG, or is what I am doing just as effective?
well, TMG (as the name says) is basically Glycine with 3 methyl groups. Glycine has its own benefits, such as lowering inflammation and helping the body produce more gluthatione (the main antioxidant produced by the body, which declines with age), while the benefits that were discussed in the video here were relative to lower homocysteine levels, which is actually done by the methyl groups instead, not by glycine. If I understand it well, at least. So, the two substances achieve completely different results (bear in mind that the amount of glycine in TMG is quite minimal). Personally, at the age of 47, I take TMG and "glycine with NAC", which boosts glutathione production even more. I keep active as much as possible during the day, I exercise everyday (but without getting too crazy about it, very rarely more than 30 minutes). I eat well (tons of vegetables, olive oil, fermented food, only wholegrains and berries as carbs, quite a lot of good quality proteins, at least 120 grams, plus the additional green banana in the evening (after dinner I like to make my "dessert" with 2 slices of rye bread, a squeezed green banana, lemon juice, cinnamon and black currants, if I have eaten a lot of carbs I also add a coffee spoon of allulose to lower sugar absorption. It has become a habit). While 10 years ago I was in terrible shape and in bad health, now I have a body fat percentage of 8-9% and a Vo2Max nearing 49, and I feel pretty amazing.
Does this help inhibit myostatin?
So when is the best time during the day to take TMG? Before working out or exercise?
I thought there was an indication in the intro to this video, that suggested TMG dosing would be covered.
Did I miss something, though?
That is...I did not hear anything about optimal dosing of TMG.
I am interested in trying out this formulation but would like to know what the absorption rate is for this supplement. Some supplements have a very low absorption as they transit the digestive tract and from experience I know that the digestive tract will absorb liquids more easily and completely than solids which sometimes can pass through with little absorption.
What's the difference between TMG and Betaine HCl? My local supplement store has the HCl version, but I'm not sure that's the same thing
HCl is for dígestion, TMG is fo sport, muscle. But search for yourself too, i dont want to say wrong things.
HCl makes the substance more acidic. It can raise stomach pH, which can be beneficial for absorption of minerals (e.g. calcium supplements) and nutrition. However you get less (weight percentage-wise) Betaine. Unlike its HCl counterpart, pure Betaine is very hygroscopic, which may affect the shelf-life negatively.
The Dr says in the video that they are rhe same thing.
@@thomasmuller1850 but any positive effects dr Brad is talking about can still, theoretically, be achieved with the HCl version? Some sources say they’re completely different, some say they’re pretty much the same thing
@@peterRobinson10101 the doctor says that Betaine and TMG are the same thing. But more specifically, I know that TMG is betaine anhydrous. Betaine HCl is different. But I’m bot sure if the positive effects can be the same or not
Whenever i get 500mg TMG i get crazy headaches throughout the day and suffer extreme dizziness. I don't know whats wrong.
My research led me to testing thar shows a decrease /inhibiting affect on myostatin, very impressive
My question is: if TMG increases methionine levels, how can it be beneficial if high methionine consumption has been associated with accelerated aging?
it increases methionine by decreasing homocysteine (homocysteine is the waste product from your body using methinione). Your body can convert homocysteine back to methionine with help of B12 & Methyl folate as the electron donors or TMG as the electron donor. Excess Homocysteine is what causes accelerated aging, not excess methionine (a deficiency of B12, Folate, B6 and/or TMG is what allows the homocysteine to build up without being converted back to methionine). With B6 the body can convert homocysteine to glutathione also. Vitamin C will recycle used Glutathione back to its active useful form.
@@jhfgjtjutyiuod Technically homocystein does not increase aging, it's just a symptom of poor recycling of folate and methionine; where folate serve as a cofactor for nucleiotide synthesis in DNA formation, and methionine as the precursor for Sam-e used in DNA methylation. Folate, cobalamine and TMG are methyl group donors, not electron donors. Vitamin C does not recycle glutathione, but glutathione (reductase) can reduce oxidated vitamin C. Glutathione can do this with any antioxidant, as it's our primary redox agent.
Any nutrient involved in the one carbon cycle can be overconsumed, leading to depletion or disturbance of the others. Balance is key. Also, TMG dependent methionine synthase is a reserve route used when the primary MTHFR route is insufficient. This means that rather than TMG supplementation, it's better to improve your overall diet. If the recycling rate of methionine were to exceed the recycling rate of folate (both usually goes through MTHFR) this disrupts growth regulation. Lastly, there's no one "active"/"useful" form of any nutrient or metabolite in the body, this is dependent on where they are in their respective metabolic processes.
@@jhfgjtjutyiuod wow.. thanks for the details.. so ppl can easily supplement the B vitamins instead of TMG .. so there is no need to buy tmg right?
Mr Stanfield, is that actually your arm on the thumbnail? If yes HOLY COW U FIT AS HELL
May we take Magnesium Glycinate to hit 2 birds with one stone?; magnesium + glycine?
I heard that combining TMG with NAC is a good idea. Can you confirm?
I’ve been taking betaine hcl with my food since 2012. Was I inadvertently supplementing with TMG in this case or is there a difference between the two?
Do you think supplementing with TMG and creatine both would be harmful or helpful.
Makes me feel great during the day, wrecks my sleep at night.
Thanks for all this doc
Can we take TMG AND DMG?
What's the difference between TMG and plain old glycine?
Do you need to supplement with TMG if you drink beetroot powder pre-workout? Or does the beetroot powder have enough TMG to facilitate strength?
Ive been adding TMG to my post workout shake but now wonder if it's best pre workout.
Hi, thanks for the update. I wanted to buy your supplement but when I saw serving size 4 capsules a day I decided not to. Is there a reason why you can't make it a 1 capsule serving size?
He reuses to discuss liposomal transport bevause his pill company cant make em. Lol. What a shill.
It would be a very large capsule...
I love the idea of microvitamin but 50mg of Niacin is not microdosing and is not in proportion to the other B's. I see less than 50mg of Niacin in the megadosing multis on the market. Im after a multi with 1 to 2mg equivalent of each B and true microdoses of nutrients to support diet and minimise overusing transport proteins and enzymes with synthetic vits. Hard to find.
Well, I am taking 2000 mg B3 daily, that's 2 grams : ) 50mg really is a micro dose.
@@xakep4182 That doesn't mean 50mg is a microdose just because you take 2 grams.
Make sure to let your doctor know before any blood work is done. I was taking 3 grams ofTMG and from what I can tell it threw off my Creatinine levels, eGRF, bUN and my Creatinine ratio. after not taking it for 2 days and retesting they all came back in normal ranges. Retesting was done 7 days after the first test.
Bro thats normal when you increase creatine levels the residue creatinine is increased as well but it does not mean is a bad thing, creatinine is bad when is high naturaly.
Does that mean your creatinine was shown as high and your eGFR was low after TMG, or was it the other way around? (ie. Was your kidney function shown worse than it actually was or better than it really was?)
3g is a lot of TMG. According to the Micro vitamin pack, it has a daily dose of 500mg.
@@georgen5250 I agree with you. I mentioned it because if you don't let the doctor know they might think there is something wrong with you when there is not and may be looking to try to fix something that is not broken.
@@jamebrow check out some of his other vids about TMG. It would seem that around 3 grams is the amount used in most of the studies he talks about.
Brad! I would love if you could answer this for me
Everytime I take betain consistently I end up getting very ill, feeling tons of fatigue and vomiting.
It took me 4 x before I completely zeroed in that betain was the culprit.
What could cause this? Even if I take with b vitamins.
Is there a deficiency somewhere in my bodies ability to process methyl groups or to detox what those methyl groups help to detox?
are we suppsoed to be taking it every day?
I would love to have that product. Will there be shipping to Argentina in the futute?
are there additive benefits on top of supplementing creatine? some study shows none
(in resistance training performance)
~cursor hovering over betaine one click purchase button in amazon while listening to the whole video on 2x~
Is betaine (TMG not HCL) acidic in taste? I have TMG+b6 powder and its ultra acidic intaste. Did they sell hcl to me?
Why biotin?
i take 4 grams of TMG 5 days a week. I feel like a champion!
Can you add Serbia for the delivery of your products. I would be able to spread it's usage since my family has medical practice.
Thank you so much doc, I have been asking and hoping you and some other content creators with the knowledge would cover TMG! started using it this month and I am very adamant to keep using it! For the benefit related to strength training, would you suggest a higher dose (2g) on the day of exercise and then 1gr or 500mg on the other days?
So the betain HCL pills and TMG is the same thing?
I am overwhelmed by so many studies and so much information about supplements. We should be taking pills all day long if we followed the advice of all the gurus.
If you dig into research papers, you'd come to the same conclusion and practicality indeed quickely becomes an issue. Thus we should choose wisely choices.
However taking multiple supplements doesn't imply you take tons of pills. I've combined 12 supplments in two capsules a day using a company offering custom capsules. What takes up more space and tastes alright I purchased in cheaper powder form and combined the powders to create beverages, which I drink not only for their pleasant effects, but also because I enjoy their taste. Of course it was a lot of work initially, but it made it very easy to stick to that routine for the rest of my life.
Supplements are not needed if you just eat eggs, fatty meat and seafood.
@@jorgecastillo6128 incorrect, supplements have benefits going beyond those foods.
I also don't see how of all things fatty meat would have a benefit in a good diet. It's adding unhealthy fats and heme iron and causes a range of negative health consequences like high Apo B, TMAO, homocysteine, CRP, while adding no significant amounts of nutrients that could not be derived from other sources, except for vitamine B12, which is like the cheapest and lowest dose supplement in the world. The other nutrients are contained in insufficient quantities anyways - you will not nearly get a good amount of creatine, carnitine, carnosine, taurine or coenzyme Q10 by eating meat.
@DrBradStanfield I ordered and received your multi-vitamin, but I live in SW Florida and the humidity caused them to swell and almost ‘burst’. They are kept in a dark cabinet in an air conditioned house. Are there plans for a coated version/some other solution? Thanks.
Please email me and I’ll get this sorted out for you
Waiting for your supplement to ship globally or on common global platforms (e.g. iherb)
So if you are on TRT, is it pointless taking TMG?
Soooo Mix your Omega 3 WITH TMG?
May you make a video covering oral dutasteride? Would this drug be more effective than finasteride? (You made a previous video covering finasteride)
Does DMG have the same benefits?
Brad I drink 250ml of organic beetroot juice every day for high blood pressure. Will I also be getting TMG, and the advantages it brings, from that or should I also supplement?
Is your microvitamin supplement available in Australia?
yes it is :-)
So popeye the sailor man was right?
If you want to be filled with tons of oxalates, eat spinich hahah
Nmn sucks - either use NAD+ IV or lathmized NAD+ (shrunk to permeate blood brain barrier)
id love to know your researched opinion on the peptides BPC157 and TB500, allegedly theyre amazing for recovering from broken bones and improving overall recovery function
I heard it gives you tendons of steel.
@@5kribbles 'wolverine combo' I heard, sucks you gotta inject it tho 😅
@MixtrisUFOimages o ya? Doctors not on board with it really?
@@MixtrisUFOimagesNot yawn. How long have you been in the game? For me, I cannot tell you how many “just inject it bro” turned out to be harmful once the data came in 5-10 years later.
The human body is complex interactions, and when you artificially throw it out of sync it can have unforeseen harmful consequences.
He knows this and bases his decisions on “ok this has been proven to both work and safe via quality clinical trials”.
@@MixtrisUFOimages When you're talking about injecting something yourself which you bought from unregulated compounding pharmacies, that alone is enough to be discouraged by an actual responsible practicing doctor.
Furthermore, with something specifically purported to boost angiogenisis and vasculogenisis it would be wise to extensively research potential cancer causing or tumor accelerating side effects.
That being said I think you should personally take it and tell us all how it goes!
My Go-to suppliment guy
It made me irritable. Over methylation? (500 mg)
Probably your diet of bad foods
What is the recommended dose? I already eat several cups of spinach daily
I dont understand the downside of having suplements at like 1000% level? Do we not just peeout extra? 75% seems too low...
There's a need of more stats on implications on different age groups.
It's not data it's data! (nice video BTW)
Is there enough betaine in beets, spinach, or wheat germ to have a an significant impact or are the concentrations too low and therefore supplements are required?
no
Where does glycine supplementation factor in?
TMG increases LDL cholesterol though which is a known heart risk factor. Wonder why you didn't mention this?
Why can't i get the multivitamin in NZ. Won't even let me choose NZ as a country! I am more or less down the road from your Practice.
Good Video! But what are the Difference between betain tmg and betain hcl? Is this also the same?
totally different, the other one is for stomach acid
@@WaterspoutsOfTheDeep Thanks for this info! I have been wondering…
So many people take this stuff and don't work out. Then they wonder why nothing is happening.
I looked at testosterone studies and it seems the slow decline will start by 40 for majority of men and for some men (minority) there is no decline at all. However there is significant variation in T levels and the gradual decrease.
Is beta alanine and TMG the same thing?
I think I am getting gassy from your Microvitamin. Any suggestion how not to?
I happened to recently buy some pure carrot juice and drinking that stuff almost makes me puke because of the betaine content that is present in carrots, like beets.
I appreciate your integrity and honesty Dr. Brad. Don't ever change! As an aside, after watching your video on Fatty15, next, you should do a video on Timeline's Mitopure. I sense it's a get-rich-quick scheme promoted by well-known health advocates that should know better.
I had no results but why do you “sense” it’s useless?
@@katisugarbaker7349 I subscribed to it early on in my supplement discovery, and was roped in by the slick marketing and glowing endorsements. I had no results after sticking with it for 4 months. IMO, for what they charge it should be a miracle pill! It's also disturbing when very smart health professionals invest in too many of these new supplement companies. I begin to question what's more important to them: actual human-tested science and beneficial results for a broad cohort, or making a buck? Siim Land called BS on Mitopure and did a damning review. I wonder what Dr. Brad would have to say :)
Physionic covered Mitopure and observed a bit of "chart crime" in conclusions 😁
One of the adverse effects of TMG is teeth grinding.
What about DMG?
What about increasing brain fluid
TMG makes me feel sick and gives me breathing issues at night.
weird have you ever taken gaba? i thought i was gonna die'
Start low and slow with every single supplement.