Efficacy is not really a question at this point, it's really just safety. I wouldn't say it's a complete substitute for finasteride, however if you can do a low dose of finasteride avoiding side effects, in combination with RU, that's quite a combo.
Am I the only one that noticed he didn't get the memo. RU58841 is supposed to be applied topically not orally. The safety concerns that were mentioned in the video were pertaining to oral administration. From what I have read RU58841 has no side effects when applied topically and it outperforms finasteride.
Minoxidil + microneedling + RU have done wonders in just 90days for me, the most obvious improvment is in the lateral hair that also tends to recess and makes your forhead look huge Frontal hairs are also growing in numbers, they're just not much longer than 15~20mm for now
Anageninc, code 15off then bitcoin, comes out to 118.5$ for 10g, which lasts 8 months for me RU + Minoxidil comes out to 20.5€ per month for me You don't have to pay with bitcoin, but it gives an additionnal 10% off, whereas bank card makes it 5% more expensive, so I figured I'd pay with bitcoin@cz_ar
@@tonygabashvili8357 Yes, and I actually started minoxidil first, although adding microneedling on top is better for regrowth RU is to limit further loss
@@arunjames3208 How has that worked out for you thus far? I just started Fin a couple weeks ago and was gonna start Minoxidil soon, as well, with some microneedling.
You guys should do a video on Breezula, in particular on why it loses its effectiveness after 6 months - what could be causing that and how it might be avoided. Is it androgen receptor upregulation? Could cycling off the drug avoid the problem? It's such a promising treatment if not for this BIG problem.
@@TheMusciman Why wouldn't they? A lot of people are using it already. Solving the diminishing returns problem would help a lot of people. And none of the things they discussed in this video are approved yet.
@@dimitrikorsakov2570 Well in the video they basically advise to stay away because the drugs are unapproved, same goes for breezula, as licensed doctors they can't do that.
@@TheMusciman They advise to stay away because they're untested. Breezula has been tested in large trials and shown to be safe. I'm not asking them to tell ppl to use Breezula, I'm asking them to speculate based on their medical knowledge on what the reason might be fore the diminishing returns of B after 6 months.
The truth is very few men are hyper-responders to the treatments we have available today. Most men will regrow some minuscule blonde hairs you can't really count as "hair" and slow down their hair loss slightly if they're very lucky, or they get side effects. We need better treatments.
Thanks for doing these videos, it means sooooo much to us who are psychologically dealing with hair loss & really helps us deal with it. These videos are extremely helpful, I appreciate all you do 🙏
Please can you also talk about Azelaic Acid as a DHT blocker? It seems to be used by many hair clinics in combination with Minoxidil. Thank you for this wonderful channel!
@@jellypeanutbutter666 Its not ego driven, I just wanna keep what I've had on my head at least until age 30. I've had heavy hair loss for two years and I'm 20 now. If women can get tit jobs and heavy makeup to keep men wanting them into their 50s, why can't I just get to keep something I've always had?
I would like this question to be taken in consideration for the next Q+A podcast... Once shaft diameter is below 50% of its original diameter, what's the best expectative of recovering of this particular hair? let's say it has been miniaturized down to 25% of original diameter... Thanks.
@@James-cg4jo but people have regained a lot of hair with bicalutamide where there was nothing before. Like going from NW6 to NW2. I doubt that they had more than 50% diameter in all those hairs. If you inhibit all androgens you seem to recover quite a lot of hair that is even way beneath the 50% line.
Can you make a video on androgen receptor upregulation? Prostate cancer patients develop resistance to antiandrogents, but do alopecia patients develop this resistance?
Went straight into bashing RU58841 without explaining it's mechanism of action, how such modality can technically be advantageous, what we know from the admittedly limited trials etcetera. A bit patronizing.
Would really like if you guys can devote an episode to talking about the benefits of taking finasteride and minoxidil at the same time, which I'm currently doing.
Can you make a video on premature graying of hair.. i know the show is about hair loss . But people who search for that can have these problems as well.. how to undo hair graying out
14 minutes and you don't say anything, it's actually impressive. You talk about how ru is not approved, that you have to buy it online, how the body is dynamic, how "it can have side effects for a lot of people". It's like asking a banker how to invest and him telling you that there are a lot of ways to make money, nothing is proven and there is no guarantee you'll make a return on investment. Can you say how the product is made, what it contains, how it interacts with the hair follicle, reference some peer reviewed studies/papers? It's a 14 minute video and I've learned jack shit. That's why MPMD has a boom of subscribers, if you wanna learn about anything related to hair loss, he is the only youtuber I found that doesn't talk shit for >10 minutes, the only problem is that in order to get a better understanding of this topic, you can't rely on only 1 guy's expertise
@Munish Diffuse patterned or DUPA Diffuse unpatterned? More than all types of hairloss...this one is ignored a lot...this is what I've got....Can't believe I'm worried about hair at this age man.....
Someone claims that hair loss sufferers should take finasteride togheter with anti aromatasi... This way the T not converted in DHT is not converted in estrogens too and it is good for regrow hair... Is it a legitimate thought?
Can you please do a video on treatment options for hair loss due to scalp psoriasis? Can psoriasis accelerate MPB? Can the hairs lost due to psoriasis grow back even if the spot has been affected by psoriasis for a long period of time? Would treatments like dermarolling and PRP make things better or worse? Could minoxidil and finasteride be beneficial?
Hey! You might not see this since it's been a year.. but I had the exact same thing. Psoriasis started on my head. It started as a small red spot and grew. My naturopathic doctor put me on high doses of Vitamin D. It turns out I was SUPER vitamin D deficient and that was causing the issues. I'm now taking 20000 IUs a day and my scalp psoriasis is gone. I recommend seeing a naturopath and starting taking high-doses of Vitamin D. It is safe as long as you take it with Vitamin K2. The two go hand and hand. "Dr Berg" on TH-cam has a lot of videos on Psoriasis if you want to learn more. Take care
@plumpychunky Just saw your reply. I discovered the same thing. Taking high amounts of vitamin D controls my psoriasis to a huge extent. I was taking 60000 IU per day now I'm down to 20000. If I stop taking it for a few days, the psoriasis starts flaring up again. Still doesn't get rid of it completely though so I use a bit of topical steroids. I considered K2 but it's not easily available in my country. I appreciate your response :). I'm surprised that vitamin D supplementation isn't the first line of treatment. It seems to work for a lot of people. None of the doctors I went to, even the naturopaths had recommended vitamin D treatment. I started it for another reason and my psoriasis improved as a side effect.
So cool you do this guys! I know you are professionals and my dream of a video would be you talking with Derek from the youtube channel more plates more dates who is not a professional, but who do a lot of research with one of he's strongest field being hormones and hair. He seem to know he's stuff and youre knowlagde seem to not be in any conflict as I had seen all videos on hairloss from both channels. You guys made me dear to take finasteride and I am happy for that now.
@@arhamnabil9461 Hair feel stronger and of better quality, but I only been on a short period so too early to tell. I believe in blocking DHT to be the best answer, but sometimes it is not enough for everyone cause other androgens are likely to do the same. No side effect, but I have a lot of experience with hormones and notice changes quite easy. I felt a bit more horny the first weeks, after that i felt normal. I am on a low dose. 0.5mg every other day.
For about a month and a half, there was shedding in first month like 20 hairs in the morning shower which has now reduced and stabilised to 5 or 6 hairs
Why both at the same time? Why not the most important one (Finasteride) first for a year? Then you see results/side effects and can always decide to add Minoxidil. If you start both at the same time, you don't know which is causing which results and side effects.
Ive recently moved onto RU58841 as of late May 2020. Noticed hair thinning and a receding hairline in 2007/2008 aged 20/21. Male pattern baldness very common on my mothers side. Jumped onto finasteride in october 2008. Halted it with some slight thickening. In around 2011 added minoxidil which over the following years was inconsistent with application just due to it being more of a chore to apply than popping a pill. In around 2018 noticed I was losing ground again so decided to be more regimented with the minoxidil doing twice a day without fail and have recently swapped finasteride for dutasteride and added the RU58841. Early days but hair is feeling better and denser. Wanted to go for a more heavy duty bulletproof approach as I felt after the number of years I was using the same products my body was starting to almost override them and build a tolerance thus making them less effective. Hopefully by December time there will be some visible results.
I have been using it constantly for 2.5 years and have no problems at all. I dissolve approx. 0.1 to 0.2 g RU58841 in 60 mL of 5% minoxidil solution. I use it topical twice a day (about 1 mL per application). I have succesfully stopped my genetic hair loss with it.
Great video! I was waiting for this topic :) Could you guys make a video on Gyno and how to prevent and diagnose etc and also the idea of using finasteride 6 times a week and dutesteride once a week... Thanks :)
They have talked about this. They recommend 1mg Finasteride 3 times a week and if that's not enough 1mg Dutasteride 1 time a week as an additional. If you experience side effect use 0,5mg Dutasteride once a week
How do I know finasteride is working. I'm still shedding hair but I don't know if its normal shedding or if medication does not work. Shedding: how can one tell if fallen out hair is due to normal shedding VS follicle miniaturisation? Can it be determined based on the fallen hair length/thickness etc? Appreciate your work!
I’ve seen some videos explaining that finasteride does not block DHT created from TRT, only DHT from naturally occurring testosterone. BUT RU58841 does block all DHT at the hair follicle regardless.
Can you make a video whether there is any merit to the scalp tension theory in regards to MPB? Simplified theory is scalp tension in the MPB areas leads to low oxygen, where low oxygen condition lead to more T being converted to DHT.
RU seems to have very good anecdotal evidence going for it, there is also a fairly old human study (but too small with a sub-efficacious dosage) It's also not new at all, the formula has become public much like finasteride, it's been developped in the 80s by a french insitude (vive la france) Also RU is best used in conjunction to a 5ar inhibitor, so that it binds to the remaining androgens like the increased testoterone and remaining DHT The fact that is binds to testosterone as well is a good thing since it doesn't seem to be leaving the scalp and going systemic
They've said in the past that although the product states each use should be half a cap full... it just depends on you. If you only need your temples then use that much. If you only need a small circle on your crown then use that much. Use however much covers the areas you need covered.
thx for your videos can u pls ans. my question - i have had hair loss for for about 2 to 3 yrs now and im wondering if theres any connection to excesive sweating (hyperhidrosis) on the scalp that could be causing hair loss and i have always suspected it did and when i google it there is websites that say theres a connection from the sweat wich leaves a toxin that damages the hair but when i went to top doctor in the new york city wich was suggested by your office he claims that hair loss has no connection to hyperhidrosis and i am so convinced otherwise pls help me bc i have started prp treatment and i am wondering if its all a waste of money bc i am so convinced that until i take care of my hyperhidrosis that i wont be able to see any progress bc my sweat is prevnting it??????
When it comes to Exosomes your missing a key opinion that were watching you for. We thank you for asking us to be cautious but on the flip side with the data thats out and the thousands who have tried it what is your option?
Fluridil is commerical avalable in Czech republic in phramacies. It is antagonist and competes for receptor for both testosteron and DHT. Would that work to a certain degree? If I also lowers dht, since it has higgher binding affinity.
@@tagada7 So since it is commercial avalable without prescirption it is safe to use? My regime is: Finasterid, low dosage dutasterid, minoxidl, laser helmet, dermaroller, steoxidine, topical alfatradiol (avalable in Germany for men) But I still slowly losing hair, and I'm only 27. Since I blokced most of my DHT, I was thinking is is remaining tesosteron that causes my hairloss? That was why I hope antagonist will work like Eucapil, if there is other treatmens similar on the market? (I don't feel safe using Ru) Btw I have been doing these treatmens for years
@@tagada7 Yes, have been doing most of the treatmens and sadly still slowly progressiing. Have been on taking finasterid everyday and 2 pills avodart every week for years. pluss the other treatmens. Yes I can see like horse shoe shape expesially when hair is wet.
@@tagada7 Ok thanks. I use like alfatradiol, minox, stemoxidine, eucapil. Do you know if I can combine all those into one application? or will the solution dilute. Since It is beginning to be abit annying applying so many times a day. (Heard that Eucapil decompose in water, not sure if there is water in any of the other treatments)
@@tagada7 Hi Milano! Do you use Ru? Since I have thought about it a long time and want to try it. I'm just scared of long term side effects. Do you know if someone has ruined their body or died from it/cancer? Since there is so mixed opinions on the internett. If I decide to buy it, I was thinking of buying powder from anagenic and make my own solution between 20mg-50mg.
It's normal brother. You're just shedding. I'm on fin and the same thing happened to me. Wait at least 6 months before you see any real visible gains. It's a slow process mate, add min and dermarolling to help out.
I have a slowly receding hairline.A few months back i purchased laser comb for combatting my hairline.But i have noticed that after using the same my hair shedding has increased . My hair have also become thin as compared to earlier.Do you think its normal or is it something unusual.should i stop using laser comb
Well I don't know much about laser combs and am not an expert but there is an initial shedding phase if you start a stimulation therapy for your hair . The phase starts after a few days being on the therapy and the shedding phase can last upto a month or so depending on the condition of a person . The hairs which are shedding may have been in their telogen phase (around 10% of our hair remains in that phase ). In this phase the hairs are weak and are merely hanging by a thread . When we try to stimulate the hair growth the healthy hair from inside the scalp pushes the hair outside causing the hair to fall . Bottom line if you have been using it since months(4-5) and see no results and same response then you should go for another alternatives . But if it's been few days on the laser therapy then you should definitely give it some time ( a couple of Month at least).
I need help. One big question that I can't seem to find the answer for: Is dermarolling for the scalp counter intuitive? From my understanding, after dermarolling the scalp it provokes an inflammation response. So this is a good thing right? Sort of. Isn't DHT recruited to the area of inflammation? So wouldn't that mean there is more DHT going to your scalp? Isn't DHT itself inflaming the scalp? So why are we inflaming the scalp when we seek to reduce inflammation for a healthier hair growth environment? I don't understand.
Dermarolling efficacy is not related to the inflammation of the area -- the purpose is that dermarolling pins puncture the growth hormone gland (GHG) in the hair follicle. That's why they recommend a depth of 1.5mm depth needles. You need to puncture and stimulate the GHG -- that is the purpose of Dermarolling. The inflammation is a side effect of the skin being broken, and/or the glycol or alcohol of the minoxidil or other hair products rubbed into the open punctures
Hi Docs, I am from India, Really Thanks for the show. It was quite learning .I have 2 questions. Sorry if it was already anwered in previous videos. I would suggest to have a FAQ , so that people wont repeat the questions . 1) Does mastrubation cause hair loss 2) Can we use hair oil and Biotin capsules along with ( Minoxidil & Finasteride) ? If so, what time of the day ?
Masturbation gets rid of "relaxin" a natural hormone/drug in the body that prevents hair loss. So masturbation is probably not good. You CAN use biotin and castor oil along with minox and Fin. Time of day does not matter, up to you
Look into oxidative stress. Supplementing with ZMA helps me a lot, as does the implementation of a solid skin care routine. I use a salicylic acid cleanser, SPF moisturiser during the day and apply benzoyl peroxide on top of the moisturisers twice a day.
Is the ru58841 premixed kb solution just as effective as the premixed pg solution? For reference, my scalp gets oily and somewhat itchy after just 1 day without washing it. Would both the kb and pg solutions work equally?
in regards to finasride, How common is gyno with this drug in your research? if a person had alittle gyno when going on the drug what are the chances it would have an effect on it? I hear its low risk for gyno at 7mg aweek, as it only can raise estro levels by up to 15%. anyway would like your view on this topic since you have many that use it that sees you. thanks.
what would be the next step assuming taking finasteride titrating up to even 1.25mg daily and u still need more results, switch to duocastride or add minoxidil say 1x a week??
Don't think ill get a response in time, but I put minoxidil in my hair this morning and would like to do micro needling tonight around 7 -8 pm that is about 12-13 hours later. Would this be okay? I would not put MIN or FIN in my hair until tomorrow night.
I tried finasteride, didn't have any side effects on me but sadly no positive effects either. So, i think i might give RU a shot. Is there anyone who did the same?
I have the same doubt. A doctor told i can take only one tab of 1 mg every 2 days. But i read that the half life is only 5 to 7 hours. It would be good to know more about it.
It's actually half life in your body is 7/8 hours but it build up in the scalp and can stay there for considerable amount of time about 30 days this is why people can get side effects later as the drug increases over time .get blood work done before taking it you would be able to get some idear on your chances just by knowing your test and estrogen levels before using it
@@kalinkolev8712 you know I was thinking about microdosing finasteride we're going topical but I found some people who try that after recovering from finasteride and they said the second go-around sides were even worse so I decided against it
How low can the efficacy of the finasteride go after years of taking it? Can it go to a point where there is no reason in taking it anymore since it has no effect whatsoever anymore?
I am no expert but have digged deeper into this field . Once you stop taking finasteride completely you would be in a state where you would have been not taking finasteride at the first place itself . The chemistry of the drug lasts 20-25(approx) days after once taking it . You can always take a break from finasteride if you have been using it for a long period of time (say 6 months or an year ) . You can easily go on a break of 2-3 months and then continue using it afterwards . Bottom line is once you start using the drug u gotta keep taking it as long as you want your hairs on your head . And yes its effect does fades away after a specific time once you stop taking it.
What is your opinion on the Drake et al. (1999) study that says that 0.2 mg a day of finasteride has a similar effect on scalp DHT as 1 mg a day. If we want to use that steady state, could we take finasteride 0.5 mg 3 times a week? Thank you!
@@peterjohannesschmidt8373 Hey thanks, I know that! I found the Drake et al paper very interesting to read and just wanted their opinion on that instead. Thanks for responding though!
You really need to adress the factor of testosterone itself in killing hair follicles, DHT is not the only thing killing hair. It would be very useful for people battling hairloss if you could talk about some topical antiandrogens like fluridil, alfatradiol, fludamide, spironolactone...
Not really. T is no where near as potent as DHT is in negatively affecting the hair follicle and studies show that healthy baseline T levels in most men isn't enough to do this. T levels would have to be very high in individuals who are ALSO prone to hair loss via increased sensitivity to androgens. In such individuals, DHT is the main thing, not T, that is causing the hair loss. Most men will see good enough results just by getting DHT lower by 50-70%.
@@BlahBlahPoop617 I have no idea where this myth of "T isn't as bad for hair follicle as DHT". The condition is called androgenic alopecia, testosterone is an androgen. There was a good video by the channel MorePlatesMoreDates that shows even when your DHT is virtually undetectable (how low it is) when you crush it using dutasteride, how much hairloss still happens due to T. The guy had
Hi, Could you please talk about the use of Spirolactone in lotion and their side effects? The use of this lotion is exactly the same than Minoxidil? Also, It works like Spirolactone in tablets or could be less "invasive"? Thanks in advance
@@RoseRose-op2wi im using spiro cream mixed in pantostin so it becomes more liquidy then I apply it on scalp all over. also use 2% minoxidill but not sure if I will continue with it because then I wont know which of the products that is the most effective. currently feel that im shedding more hairs atm than normally but thats the part of the process with hairloss treatments I heard. only been on spiro for 5 days and minox 2 weeks. I did get slight breast pain yesterday that lasted a few hours then stopped. could have been the spiro going systemic. but im not worried. spiro cream applied topically attatches to dht/t receptors in the folicle preventing it from getting dht/t on it so the folicle stops shrinking. it works in similar ways as RU does.
@@classicfun3288 Thanks for your answer. Today I went with my dermatologist and he told me that I should use both; Spirolactone and Minoxidil because Spirolactone can help me stoping my hair loss and the process of miniaturisation and Minoxidil is going to help me to regrow new and healthy hair. Maybe you should ask to your Dr just to be sure.
@@RoseRose-op2wi are you a woman? im a male and im just gonna stick with the spirolactone minoxidill and pantostin and hope for the best. good luck to you.
There's new research from north Carolina state university which shows the prospect of a miRNA that could promote hair regeneration. Please do a video on that topic .
Hey guys hope everything is well. I have been using oral finasteride 1mg 3 times a week for about 3 months and recently been having some pretty severe pain in my left nipple. Yesterday, I noticed nipple discharge from both of my nipples when I squeeze and am pretty concerned. Booked in to see my dermatologist, but would like a second opinion. What would you all recommend?
Plz answer!!! What will happen to my toddler after shaking a bottle of ru58841 everywhere, including onto himself? He does not have access to any of my medications, but he got ahold of my bottle while in a hotel on vacation. I immediately, and I mean immediately, put him in the shower and scrubbed him down. The product had no chance to dry. Is this something to worry about? Are there any affects my baby boy may experience? Plz answer, I'm so worried!
Wouldn't a hematopoietic stem cell approach be ineffective due to the difference in germ lines? Or is it done to trigger epithelial stem cells via induction?
If ru58841 goes systemic, how long do the side effects last? I used one 50mg does on my scalp and I feel very dizzy, no energy, and no libido with Ed. Someone please let me know because I'm scared 😔
im using ru for 6 months now first 3 months on 50mg no sides so i increased the dose to about 65mg and felt dizzy and low energy so i stopped taking it for 1 week. now im feeling good again but going back on 50mg are u sure its just from Ru or did u use any other antiandrogens
Good day doctors,im desperate.i have a receding hairline,and im only 17. My dermatologist prescribed hair thickening shampoos,serum and a cream,i asked her how could we know exactly the cause of hairloss,i asked her about blood test,she refused,she said she was sure it was genetics since my dad is bald too.i dont want to spend money on something that doesnt work.what can i do?could there be another reason??pls help ms
Great video as always, Docs. I have a few questions if u not bothered. Im using fin for almost 5 months, going great, had first result after 2 months. Does that mean Im a good responder and 1y result will be even better ? At the start I had some diffu thining and about Norwood 1, now more than 50% of thinned hair is totally fine. Im 24 yo and faced first noticed problems about 3-4 years ago.
Potentially as implants cause auto immune disorders in some women, and one of the symptoms of autoimmune disorders is bald spots as the WBC attack your own cells inclusive of your hair cells. Hope this helped somewhat.
I think yes it can cause eyebrows and eyelashes to fall. Fun fact: Finasteride simulates testosterone and gets used by th e 5ar enzyme. I wish docs would explain this more because it is central to understanding the chemical engineering of many hair loss drugs. When 5ar enzymes consume finasteride instead of testosterone they don't make DHT and the testosterone that would have been consumed by the 5ar enzyme remains free thus "increasing" free testosterone.
Finasteride is just the best , almost 5 months on it with 1mg 3 times a week . No side effects with almost %100 stabilization and little bit improvement . The only side effects i feel is i am not waking up with hard on as frequent as i used to be and i don't think about sex as much as i used to be but not to the point where i can't maintain erection or can't get erection
Say you take something like finasteride and then you stop a few years later. Would you lose your hair no matter what? Even if you wouldn’t have lost that hair before hand if you didn’t take the tablet? I hope you understand what I mean aha. Keep it up!
A Donkey yeah that’s also what I thought but can’t seem to find anything proving either point. I want to start it early like most to get the best out of it but then if it causes me to lose hair no matter what then idk haha. Guess we will have to wait and see if someone knows.
so I understand what you are saying,, there is no clear evidence either way in human studies. That begs the question, Why cant /wont leading hair loss doctors do a Randomised control trial to investigate this for us so the literature is there to make an informed decision. (and other molecules e.g dut) I cannot understand why the research is not completed by those who have a interest in improving practice (and providing evidence based medicine), especially since the patent has expired. It is actually more harmful ethically to not do it the research given how many people online take it without the appropriate investigations (im sure socrates would agree) at little cost. In is concerning to be how this issue has so many people rubbing research grade products on their heads in the hope of the cure... and too an extent that is due to failure of pharmaceutical companies to expedite their research fully. Plus, considering how many people are already seem to be taking it, a trial isnt inconceivable.
If huge doses of ru goes systemic is a preety fucked up scenario since its a very potent anti androgen that blocks both DHT and testosterone and could mess even with your heart.
One of my biggest question regarding the hair loss : People who suffer from androgenetic alopecia are their hair prone to DHT because of their genes or is it there body is producing too much of DHT ?.... I mean people who don't go through androgenetic alopecia can we say that their bodies don't produce that much amount of DHT as compared to people going through androgenetic alopecia OR is it just every male's hair in this world is prone to too much of DHT ? In simple words does "genes" contribute to the factor of producing more DHT or does it contribute towards weakening of hair follicles due to presence of DHT in one's body ?
Yep, you can have the same dht as someone else but whilst he has all his hair, you could be bald. It is all down to genetics and sensitivity of scalp to dht
9:22 RU58841
Thank you!
Almost logged off. Thx for the heads up.
Thank you 🙏🏼
Thank you.
Everyone should crowdfund some company willing to conduct proper studies on RU58841 so we can put to rest safety and efficacy questions.
Efficacy is not really a question at this point, it's really just safety. I wouldn't say it's a complete substitute for finasteride, however if you can do a low dose of finasteride avoiding side effects, in combination with RU, that's quite a combo.
the average clinical trial costs $20 million, good luck with that
@@johnmoore1495 getting away with no sides from RU is a challenge too
@J K if you knew anything about RU you’d know lol
Am I the only one that noticed he didn't get the memo. RU58841 is supposed to be applied topically not orally. The safety concerns that were mentioned in the video were pertaining to oral administration. From what I have read RU58841 has no side effects when applied topically and it outperforms finasteride.
Props to these docs for answering these questions. This is truly the leading edge premiere hair loss show, anywhere
More Plates More Dates is a great channel as well regarding hair loss.
9:20 for ru58841
Thank you!
You the real mvp
Probably, we will find the cure before this universe die.
Minoxidil + microneedling + RU have done wonders in just 90days for me, the most obvious improvment is in the lateral hair that also tends to recess and makes your forhead look huge
Frontal hairs are also growing in numbers, they're just not much longer than 15~20mm for now
Anageninc, code 15off then bitcoin, comes out to 118.5$ for 10g, which lasts 8 months for me
RU + Minoxidil comes out to 20.5€ per month for me
You don't have to pay with bitcoin, but it gives an additionnal 10% off, whereas bank card makes it 5% more expensive, so I figured I'd pay with bitcoin@cz_ar
@cz_archemyo
I have tried Ru and I had elevated bp heart sound in my ears when trying to sleep at night. So I stopped.
It's probably just the minoxidil that gave you those results if you started them at the same time.
@@tonygabashvili8357 Yes, and I actually started minoxidil first, although adding microneedling on top is better for regrowth
RU is to limit further loss
As soon as I read RU58841, I clicked the video 😅, always wanted them to talk about it 😁
I am using finasteride on alternate days as suggested and also topical minoxidil, wish me luck
www.ebay.com/itm/123992109364
@@arunjames3208 How has that worked out for you thus far? I just started Fin a couple weeks ago and was gonna start Minoxidil soon, as well, with some microneedling.
You guys should do a video on Breezula, in particular on why it loses its effectiveness after 6 months - what could be causing that and how it might be avoided. Is it androgen receptor upregulation? Could cycling off the drug avoid the problem? It's such a promising treatment if not for this BIG problem.
Breezula isn't even approved yet why would they advise on how to use it
@@TheMusciman Why wouldn't they? A lot of people are using it already. Solving the diminishing returns problem would help a lot of people. And none of the things they discussed in this video are approved yet.
@@dimitrikorsakov2570 Well in the video they basically advise to stay away because the drugs are unapproved, same goes for breezula, as licensed doctors they can't do that.
@@TheMusciman They advise to stay away because they're untested. Breezula has been tested in large trials and shown to be safe. I'm not asking them to tell ppl to use Breezula, I'm asking them to speculate based on their medical knowledge on what the reason might be fore the diminishing returns of B after 6 months.
@@dimitrikorsakov2570 ru has been extensively tested as well, it got dropped before the stage three trials.
the show should be called hair growth, that way is optimistic
Well settle for realistic right now.
The truth is very few men are hyper-responders to the treatments we have available today. Most men will regrow some minuscule blonde hairs you can't really count as "hair" and slow down their hair loss slightly if they're very lucky, or they get side effects. We need better treatments.
Thanks for doing these videos, it means sooooo much to us who are psychologically dealing with hair loss & really helps us deal with it. These videos are extremely helpful, I appreciate all you do 🙏
Could you make a video on alfatradiol and flutamide as well?
www.ebay.com/itm/123992109364
Yes ola
Flutamide dont recommend it that shit it heavy .
Fluridil and alfa are better options
Raging N13 I’m in two minds if I should start using - it’s pricey, £50 for 30 bottles of 2ml I each
I’ve used Alfatradiol for the past month , gone through 200ml already - haven’t really notice any change but probably to early to tell
Please can you also talk about Azelaic Acid as a DHT blocker? It seems to be used by many hair clinics in combination with Minoxidil. Thank you for this wonderful channel!
How to get azelaic acid from?
Great duo. I would love to listen to a thorough discussion about the best over protocol with More Plates More Dates
Do you know how we treat MPB? We gene modify our children to not produce androgen receptors in the scalp
Then human males can shift our ego-driven anxiety to another area 🎉. 🐈 & 🐁
@@jellypeanutbutter666 Its not ego driven, I just wanna keep what I've had on my head at least until age 30. I've had heavy hair loss for two years and I'm 20 now. If women can get tit jobs and heavy makeup to keep men wanting them into their 50s, why can't I just get to keep something I've always had?
@@junkaccount2535 I feel that too, I’m 20 dealing w it too, might hop on RU
I would like this question to be taken in consideration for the next Q+A podcast... Once shaft diameter is below 50% of its original diameter, what's the best expectative of recovering of this particular hair? let's say it has been miniaturized down to 25% of original diameter... Thanks.
Such a good question
He said in other video the hair is gone
@@James-cg4jo but people have regained a lot of hair with bicalutamide where there was nothing before. Like going from NW6 to NW2. I doubt that they had more than 50% diameter in all those hairs.
If you inhibit all androgens you seem to recover quite a lot of hair that is even way beneath the 50% line.
Minox and derma rolling would get u back
Can you make a video on androgen receptor upregulation? Prostate cancer patients develop resistance to antiandrogents, but do alopecia patients develop this resistance?
Wow! One of the first viewers out of the Tons of people who are going to watch this! THANKS for speaking on the topic! Cheers!
Great video! Can you cover well known natural supplements like nutrafol in a future video?
What can nutrafol do?
Went straight into bashing RU58841 without explaining it's mechanism of action, how such modality can technically be advantageous, what we know from the admittedly limited trials etcetera.
A bit patronizing.
Would really like if you guys can devote an episode to talking about the benefits of taking finasteride and minoxidil at the same time, which I'm currently doing.
Thats the best mate. Nothing else works really.
www.ebay.com/itm/123992109364
I would be verry careful of taking finasteride
Can you make a video on premature graying of hair.. i know the show is about hair loss . But people who search for that can have these problems as well.. how to undo hair graying out
Dye it
Thank your lucky stars !....white hair is much less prone to falling out
@@agaragar21 are you sure about that? Because hair goes grey first and then falls out. So when you say white hair is less prone
14 minutes and you don't say anything, it's actually impressive. You talk about how ru is not approved, that you have to buy it online, how the body is dynamic, how "it can have side effects for a lot of people". It's like asking a banker how to invest and him telling you that there are a lot of ways to make money, nothing is proven and there is no guarantee you'll make a return on investment. Can you say how the product is made, what it contains, how it interacts with the hair follicle, reference some peer reviewed studies/papers? It's a 14 minute video and I've learned jack shit.
That's why MPMD has a boom of subscribers, if you wanna learn about anything related to hair loss, he is the only youtuber I found that doesn't talk shit for >10 minutes, the only problem is that in order to get a better understanding of this topic, you can't rely on only 1 guy's expertise
Incredible. I totally agree. At least Moreplatemoredates go deeply in this stuff. This video is probably the most useless in YT
Thank you for saving me 14 minutes. I was a few min in and literally falling asleep at their presentation method
thank you
Thanks for saving our time
Please make a video on diffuse hair loss, and how to treat it???
Propecia is the best way
@Munish Diffuse patterned or DUPA Diffuse unpatterned?
More than all types of hairloss...this one is ignored a lot...this is what I've got....Can't believe I'm worried about hair at this age man.....
Someone claims that hair loss sufferers should take finasteride togheter with anti aromatasi... This way the T not converted in DHT is not converted in estrogens too and it is good for regrow hair... Is it a legitimate thought?
I wouldn't mess with estrogen unless u need to. I would just reduce estrogen naturally by losing fat and gaining muscle.
No that's not a good idea
T is much worse for hair than estrogen. Its called androgenic alopecia for a reason.
@@kevinbunn7915 estrogen is an androgen....
Even more harm, Both 5-alpha reductase and aromatase are parts of many other reactions in the body, not just androgens.
Can you please do a video on treatment options for hair loss due to scalp psoriasis? Can psoriasis accelerate MPB? Can the hairs lost due to psoriasis grow back even if the spot has been affected by psoriasis for a long period of time? Would treatments like dermarolling and PRP make things better or worse? Could minoxidil and finasteride be beneficial?
Nizoral shampoo
Hey! You might not see this since it's been a year.. but I had the exact same thing. Psoriasis started on my head. It started as a small red spot and grew. My naturopathic doctor put me on high doses of Vitamin D. It turns out I was SUPER vitamin D deficient and that was causing the issues. I'm now taking 20000 IUs a day and my scalp psoriasis is gone. I recommend seeing a naturopath and starting taking high-doses of Vitamin D. It is safe as long as you take it with Vitamin K2. The two go hand and hand. "Dr Berg" on TH-cam has a lot of videos on Psoriasis if you want to learn more. Take care
@plumpychunky
Just saw your reply. I discovered the same thing. Taking high amounts of vitamin D controls my psoriasis to a huge extent. I was taking 60000 IU per day now I'm down to 20000. If I stop taking it for a few days, the psoriasis starts flaring up again. Still doesn't get rid of it completely though so I use a bit of topical steroids. I considered K2 but it's not easily available in my country.
I appreciate your response :). I'm surprised that vitamin D supplementation isn't the first line of treatment. It seems to work for a lot of people. None of the doctors I went to, even the naturopaths had recommended vitamin D treatment. I started it for another reason and my psoriasis improved as a side effect.
So cool you do this guys! I know you are professionals and my dream of a video would be you talking with Derek from the youtube channel more plates more dates who is not a professional, but who do a lot of research with one of he's strongest field being hormones and hair. He seem to know he's stuff and youre knowlagde seem to not be in any conflict as I had seen all videos on hairloss from both channels. You guys made me dear to take finasteride and I am happy for that now.
Dont forget Kevin Mann also
So the finasteride is doing its work?
Any side effects or something?
non non any thoughts on topical Finasteride?
@@arhamnabil9461 Hair feel stronger and of better quality, but I only been on a short period so too early to tell. I believe in blocking DHT to be the best answer, but sometimes it is not enough for everyone cause other androgens are likely to do the same. No side effect, but I have a lot of experience with hormones and notice changes quite easy. I felt a bit more horny the first weeks, after that i felt normal. I am on a low dose. 0.5mg every other day.
@@johndupont8596 Could be an alternative, but as for now I would stay with tablets as it's way easier to just take a pill.
glad to see thumbnails returned to the original format of
😬🗿
I am using finasteride on alternate days as suggested and also topical minoxidil, wish me luck🍀
how long have you been using minox for? any results? shed?
For about a month and a half, there was shedding in first month like 20 hairs in the morning shower which has now reduced and stabilised to 5 or 6 hairs
Good luck mate
Why both at the same time? Why not the most important one (Finasteride) first for a year? Then you see results/side effects and can always decide to add Minoxidil. If you start both at the same time, you don't know which is causing which results and side effects.
are you on 1mg?
I read somewhere that Taurine helps with perifollicular fibrosis. Can you confirm?
Hlo doctor.. what's your opinion about Redensyl..is it more effective than minoxidil.. please reply
Ive recently moved onto RU58841 as of late May 2020. Noticed hair thinning and a receding hairline in 2007/2008 aged 20/21. Male pattern baldness very common on my mothers side. Jumped onto finasteride in october 2008. Halted it with some slight thickening. In around 2011 added minoxidil which over the following years was inconsistent with application just due to it being more of a chore to apply than popping a pill. In around 2018 noticed I was losing ground again so decided to be more regimented with the minoxidil doing twice a day without fail and have recently swapped finasteride for dutasteride and added the RU58841. Early days but hair is feeling better and denser. Wanted to go for a more heavy duty bulletproof approach as I felt after the number of years I was using the same products my body was starting to almost override them and build a tolerance thus making them less effective. Hopefully by December time there will be some visible results.
Any results mate? Also are you using Minoxidil with Ru and Finasteride?
Results?
Any results on RU58841 Mike?
@@RishiintheAirdidn’t you know anyone that speak about these things dies a sudden death
Rest in peace Mike.
CAN YOU PLEASE TALK ABOUT THE EFFECT OF TESTESTERONE ON HAIR LOSS AND HOW TO COMBAT IT
topical anti androgen like RU
As far as i know, testosterone is not the problem, dht is what causes problem.
Angela Milton for most people finasteride alone is enough but you can also loose hair due to the increased scalp Testosterone
Castration.
@@kazm9669 😐
I have been using it constantly for 2.5 years and have no problems at all. I dissolve approx. 0.1 to 0.2 g RU58841 in 60 mL of 5% minoxidil solution. I use it topical twice a day (about 1 mL per application). I have succesfully stopped my genetic hair loss with it.
Where do you buy it ?
@@Charly_dvorak Actifolic
Great video! I was waiting for this topic :) Could you guys make a video on Gyno and how to prevent and diagnose etc and also the idea of using finasteride 6 times a week and dutesteride once a week... Thanks :)
They have talked about this. They recommend 1mg Finasteride 3 times a week and if that's not enough 1mg Dutasteride 1 time a week as an additional. If you experience side effect use 0,5mg Dutasteride once a week
@@Dreamzzgirl aha! Thanks I'll look through their other videos... I probably missed it....
@@Dreamzzgirl what about just finasteride?
How do I know finasteride is working. I'm still shedding hair but I don't know if its normal shedding or if medication does not work.
Shedding: how can one tell if fallen out hair is due to normal shedding VS follicle miniaturisation?
Can it be determined based on the fallen hair length/thickness etc?
Appreciate your work!
How is it 2 years later
How is it now?
Great vids docs, do you have experience with Finasteride and TRT? Does it decreases the likelihood of having sides? (or maybe increases it?). THanks.
I'm on TRT and fin, so keen to know too
I’ve seen some videos explaining that finasteride does not block DHT created from TRT, only DHT from naturally occurring testosterone.
BUT RU58841 does block all DHT at the hair follicle regardless.
@@lukerobeson9957 thats not right. fina is a 5 alpha reductase inhibitor , doesnt matter where the T comes from
@@lukerobeson9957 link?
I’ve been on finestride and Dutasteride and can say fin has no real noticeable sides on TRT...
Those doctors may consider a further research on Ru58841? I’m volunteering to be tested on.
research was stopped because of financial issues
Can you make a video whether there is any merit to the scalp tension theory in regards to MPB? Simplified theory is scalp tension in the MPB areas leads to low oxygen, where low oxygen condition lead to more T being converted to DHT.
Were did you get information from about scalp tension with hairloss ?
Thank you for the video! Great content as always.
Glad you enjoyed it!
Finally 'bout RU..
www.ebay.com/itm/123992109364
How is it going bro? Do u have success/sides with it?
RU seems to have very good anecdotal evidence going for it, there is also a fairly old human study (but too small with a sub-efficacious dosage)
It's also not new at all, the formula has become public much like finasteride, it's been developped in the 80s by a french insitude (vive la france)
Also RU is best used in conjunction to a 5ar inhibitor, so that it binds to the remaining androgens like the increased testoterone and remaining DHT
The fact that is binds to testosterone as well is a good thing since it doesn't seem to be leaving the scalp and going systemic
It def goes systematic bro
@@Man-u-flex Johnson has never worked this well though
How about today in 2024, would you recommend exosomes? I have been suggested that by my hair transplant doctor! Thank you
What is the minoxidil foam dose if you recommend using it once a day? 1 or 2mg?
Please answer me 🌹
They've said in the past that although the product states each use should be half a cap full... it just depends on you. If you only need your temples then use that much. If you only need a small circle on your crown then use that much. Use however much covers the areas you need covered.
thx for your videos can u pls ans. my question - i have had hair loss for for about 2 to 3 yrs now and im wondering if theres any connection to excesive sweating (hyperhidrosis) on the scalp that could be causing hair loss and i have always suspected it did and when i google it there is websites that say theres a connection from the sweat wich leaves a toxin that damages the hair but when i went to top doctor in the new york city wich was suggested by your office he claims that hair loss has no connection to hyperhidrosis and i am so convinced otherwise pls help me bc i have started prp treatment and i am wondering if its all a waste of money bc i am so convinced that until i take care of my hyperhidrosis that i wont be able to see any progress bc my sweat is prevnting it??????
When it comes to Exosomes your missing a key opinion that were watching you for. We thank you for asking us to be cautious but on the flip side with the data thats out and the thousands who have tried it what is your option?
What is your opinion at this point? I have not done research on exosomes yet
Hello Doctor, i an on Finasteride and PRP currently. If I start Minoxidil, will I loose my hair dur to post minoxidl hair loss
Fluridil is commerical avalable in Czech republic in phramacies. It is antagonist and competes for receptor for both testosteron and DHT. Would that work to a certain degree? If I also lowers dht, since it has higgher binding affinity.
@@tagada7 So since it is commercial avalable without prescirption it is safe to use?
My regime is: Finasterid, low dosage dutasterid, minoxidl, laser helmet, dermaroller, steoxidine, topical alfatradiol (avalable in Germany for men)
But I still slowly losing hair, and I'm only 27. Since I blokced most of my DHT, I was thinking is is remaining tesosteron that causes my hairloss? That was why I hope antagonist will work like Eucapil, if there is other treatmens similar on the market? (I don't feel safe using Ru)
Btw I have been doing these treatmens for years
@@tagada7 Yes, have been doing most of the treatmens and sadly still slowly progressiing. Have been on taking finasterid everyday and 2 pills avodart every week for years. pluss the other treatmens. Yes I can see like horse shoe shape expesially when hair is wet.
@@tagada7 Ok thanks. I use like alfatradiol, minox, stemoxidine, eucapil. Do you know if I can combine all those into one application? or will the solution dilute. Since It is beginning to be abit annying applying so many times a day. (Heard that Eucapil decompose in water, not sure if there is water in any of the other treatments)
@@tagada7 Hi Milano! Do you use Ru? Since I have thought about it a long time and want to try it. I'm just scared of long term side effects. Do you know if someone has ruined their body or died from it/cancer? Since there is so mixed opinions on the internett. If I decide to buy it, I was thinking of buying powder from anagenic and make my own solution between 20mg-50mg.
Thank you for another fun and informative video! Please could you do a video on mental health and finasteride and whether there is a correlation?
Did you started Finasterid?
Im taking finastride only for a moth now ,my hair is becoming more thin and falling out easily is it normal should i stop?
That is normal. they speak about it in other videos, just stick with it. the shedding phase is very normal.
@@trickerdgaming can you tell me which vidbcause there is so many finastride video of their
It's normal brother. You're just shedding. I'm on fin and the same thing happened to me. Wait at least 6 months before you see any real visible gains. It's a slow process mate, add min and dermarolling to help out.
@@mikeross111 thnxs mate, now i am in my 5th month i hope it works as am taking only fin nothing else.
@@I-A-67 are you already improving?
I have a slowly receding hairline.A few months back i purchased laser comb for combatting my hairline.But i have noticed that after using the same my hair shedding has increased . My hair have also become thin as compared to earlier.Do you think its normal or is it something unusual.should i stop using laser comb
Well I don't know much about laser combs and am not an expert but there is an initial shedding phase if you start a stimulation therapy for your hair . The phase starts after a few days being on the therapy and the shedding phase can last upto a month or so depending on the condition of a person . The hairs which are shedding may have been in their telogen phase (around 10% of our hair remains in that phase ). In this phase the hairs are weak and are merely hanging by a thread . When we try to stimulate the hair growth the healthy hair from inside the scalp pushes the hair outside causing the hair to fall .
Bottom line if you have been using it since months(4-5) and see no results and same response then you should go for another alternatives . But if it's been few days on the laser therapy then you should definitely give it some time ( a couple of Month at least).
That's because Laser comb doesn't do anything to address the main problem i.e DHT.. It can be used as an adjunct with finasteride and min
@@arhamnabil9461 sir ru 58841 help me to treat hairfall completly
@@jiimboombhaa4079how long did it take? u had shedding?
I need help. One big question that I can't seem to find the answer for: Is dermarolling for the scalp counter intuitive? From my understanding, after dermarolling the scalp it provokes an inflammation response. So this is a good thing right? Sort of. Isn't DHT recruited to the area of inflammation? So wouldn't that mean there is more DHT going to your scalp? Isn't DHT itself inflaming the scalp? So why are we inflaming the scalp when we seek to reduce inflammation for a healthier hair growth environment? I don't understand.
Dermarolling efficacy is not related to the inflammation of the area -- the purpose is that dermarolling pins puncture the growth hormone gland (GHG) in the hair follicle. That's why they recommend a depth of 1.5mm depth needles. You need to puncture and stimulate the GHG -- that is the purpose of Dermarolling. The inflammation is a side effect of the skin being broken, and/or the glycol or alcohol of the minoxidil or other hair products rubbed into the open punctures
Could you talk about Oral Castor oil? There are some anecdotes it can help with hair regrowth.
It doesn't.
They said in a video 99% of the time vitamins or oral stuff like that won’t help MPB
@@mark8200 Male pattern baldness... Nothing can stop it.. Fines and minox works and everything else is so so but not proven
Hi Docs, I am from India, Really Thanks for the show. It was quite learning .I have 2 questions. Sorry if it was already anwered in previous videos. I would suggest to have a FAQ , so that people wont repeat the questions . 1) Does mastrubation cause hair loss 2) Can we use hair oil and Biotin capsules along with ( Minoxidil & Finasteride) ? If so, what time of the day ?
Masturbation gets rid of "relaxin" a natural hormone/drug in the body that prevents hair loss. So masturbation is probably not good. You CAN use biotin and castor oil along with minox and Fin. Time of day does not matter, up to you
But masturbation has not clinically been shown to cause excessive hair loss either, its probably just not ideal
@@MrRobot01010 Dammit. I knew all those years of "Spanking the Monkey" would have there consequences.
My acne has gotten way worse since taking finasteride, is there a way to curb that?
Yeah me too...
Is it save to take Isotretinoin for the acne, together with finasteride?
Look into oxidative stress. Supplementing with ZMA helps me a lot, as does the implementation of a solid skin care routine. I use a salicylic acid cleanser, SPF moisturiser during the day and apply benzoyl peroxide on top of the moisturisers twice a day.
Queen helene mint mask cleared my acne completely. Cheap too
Just takes time, same thing happened when I stopped smoking weed.
Is the ru58841 premixed kb solution just as effective as the premixed pg solution? For reference, my scalp gets oily and somewhat itchy after just 1 day without washing it. Would both the kb and pg solutions work equally?
in regards to finasride, How common is gyno with this drug in your research? if a person had alittle gyno when going on the drug what are the chances it would have an effect on it? I hear its low risk for gyno at 7mg aweek, as it only can raise estro levels by up to 15%. anyway would like your view on this topic since you have many that use it that sees you. thanks.
7mg of finesteride? What the hell?
what would be the next step assuming taking finasteride titrating up to even 1.25mg daily and u still need more results, switch to duocastride or add minoxidil say 1x a week??
Don't think ill get a response in time, but I put minoxidil in my hair this morning and would like to do micro needling tonight around 7 -8 pm that is about 12-13 hours later. Would this be okay? I would not put MIN or FIN in my hair until tomorrow night.
I micro need right after my 4hrs is up.
I put minoxidil on right after needling never had an issue
I tried finasteride, didn't have any side effects on me but sadly no positive effects either. So, i think i might give RU a shot. Is there anyone who did the same?
What about now? It take 3-6 months
You’ve said Finasteride’s half life is 28 days, but the FDA says 5-6 hours? Can you please clear that up for me!
I have the same doubt. A doctor told i can take only one tab of 1 mg every 2 days. But i read that the half life is only 5 to 7 hours. It would be good to know more about it.
It's actually half life in your body is 7/8 hours but it build up in the scalp and can stay there for considerable amount of time about 30 days this is why people can get side effects later as the drug increases over time .get blood work done before taking it you would be able to get some idear on your chances just by knowing your test and estrogen levels before using it
i am 24 years old... losing hair quickly... i was on minoxidil for 3 month but it didn't work... should i now skip finasteride and go to dutastride ?
You should use finasteride. It should be the first line of attack when you start to notice hair loss.
I had absolutely horrible side effects with Fin. I stopped taking it after about 4 weeks. Looking for other alternatives.
same
Yep
Have you tried small dosage of topical fin? And have you tried RU?
@@kalinkolev8712 you know I was thinking about microdosing finasteride we're going topical but I found some people who try that after recovering from finasteride and they said the second go-around sides were even worse so I decided against it
Try lower doses after you fully recover. Topical fin goes systemic, it seems pointless if you're trying to avoid sides.
How low can the efficacy of the finasteride go after years of taking it? Can it go to a point where there is no reason in taking it anymore since it has no effect whatsoever anymore?
I am no expert but have digged deeper into this field .
Once you stop taking finasteride completely you would be in a state where you would have been not taking finasteride at the first place itself . The chemistry of the drug lasts 20-25(approx) days after once taking it . You can always take a break from finasteride if you have been using it for a long period of time (say 6 months or an year ) . You can easily go on a break of 2-3 months and then continue using it afterwards . Bottom line is once you start using the drug u gotta keep taking it as long as you want your hairs on your head . And yes its effect does fades away after a specific time once you stop taking it.
@@tagada7 do you take fin?
@@tagada7 haha how long have you been on it?
@@tagada7 1mg daily?
@@tagada7 wish I could handle that I got side effects from 1mg daily
What is your opinion on the Drake et al. (1999) study that says that 0.2 mg a day of finasteride has a similar effect on scalp DHT as 1 mg a day. If we want to use that steady state, could we take finasteride 0.5 mg 3 times a week? Thank you!
Many times before they've suggested 1mg 3x per week ...
@@peterjohannesschmidt8373 Hey thanks, I know that! I found the Drake et al paper very interesting to read and just wanted their opinion on that instead. Thanks for responding though!
Hi, can you please do a video on chronic telogen effuvium and treatments? Does topical minoxidil work? Can you ever stop it?
Mino works.. if u stop it the hair u gained will go with it
i got no side effects from 70mg ru daily. got reduced libido and reduced hardness from once-every-3-days dutasteride
same with me. awful side effects with 1mg oral finasteride and 0 side effects with RU.
When you used ru, did you notice any hair growth?
You really need to adress the factor of testosterone itself in killing hair follicles, DHT is not the only thing killing hair. It would be very useful for people battling hairloss if you could talk about some topical antiandrogens like fluridil, alfatradiol, fludamide, spironolactone...
Not really. T is no where near as potent as DHT is in negatively affecting the hair follicle and studies show that healthy baseline T levels in most men isn't enough to do this. T levels would have to be very high in individuals who are ALSO prone to hair loss via increased sensitivity to androgens. In such individuals, DHT is the main thing, not T, that is causing the hair loss. Most men will see good enough results just by getting DHT lower by 50-70%.
@@BlahBlahPoop617 I have no idea where this myth of "T isn't as bad for hair follicle as DHT". The condition is called androgenic alopecia, testosterone is an androgen. There was a good video by the channel MorePlatesMoreDates that shows even when your DHT is virtually undetectable (how low it is) when you crush it using dutasteride, how much hairloss still happens due to T.
The guy had
I really wish they would address this as well
Does testosterone cause hair loss as well doctor ?
Hi,
Could you please talk about the use of Spirolactone in lotion and their side effects? The use of this lotion is exactly the same than Minoxidil? Also, It works like Spirolactone in tablets or could be less "invasive"?
Thanks in advance
I currently use topical spirolactone no side effects at all.
@@classicfun3288 Thanks a lot. Are you using alone or with other medication? It is working?
@@RoseRose-op2wi im using spiro cream mixed in pantostin so it becomes more liquidy then I apply it on scalp all over. also use 2% minoxidill but not sure if I will continue with it because then I wont know which of the products that is the most effective. currently feel that im shedding more hairs atm than normally but thats the part of the process with hairloss treatments I heard. only been on spiro for 5 days and minox 2 weeks. I did get slight breast pain yesterday that lasted a few hours then stopped. could have been the spiro going systemic. but im not worried. spiro cream applied topically attatches to dht/t receptors in the folicle preventing it from getting dht/t on it so the folicle stops shrinking. it works in similar ways as RU does.
@@classicfun3288 Thanks for your answer. Today I went with my dermatologist and he told me that I should use both; Spirolactone and Minoxidil because Spirolactone can help me stoping my hair loss and the process of miniaturisation and Minoxidil is going to help me to regrow new and healthy hair. Maybe you should ask to your Dr just to be sure.
@@RoseRose-op2wi are you a woman? im a male and im just gonna stick with the spirolactone minoxidill and pantostin and hope for the best. good luck to you.
Can someone use (neo hair lotion) after hair transplantation if it's yes what time must he start using it thanks in advance to anyone 👀👂
There's new research from north Carolina state university which shows the prospect of a miRNA that could promote hair regeneration. Please do a video on that topic .
Hey guys hope everything is well. I have been using oral finasteride 1mg 3 times a week for about 3 months and recently been having some pretty severe pain in my left nipple. Yesterday, I noticed nipple discharge from both of my nipples when I squeeze and am pretty concerned. Booked in to see my dermatologist, but would like a second opinion. What would you all recommend?
Update?
@@hbf_chiller6790 they dead
probably rise in estrogen and prolactin but who cares he died now xD
That sounds like a prolactin issue bud. That’s lactation. You need to get your hormone levels checked.
I had same issue. I stopped fin and pain stopped. Doctor said it can happen to a small number of people who take it.
Plz answer!!!
What will happen to my toddler after shaking a bottle of ru58841 everywhere, including onto himself? He does not have access to any of my medications, but he got ahold of my bottle while in a hotel on vacation. I immediately, and I mean immediately, put him in the shower and scrubbed him down. The product had no chance to dry. Is this something to worry about? Are there any affects my baby boy may experience? Plz answer, I'm so worried!
Uum ...hope your kid is ok
Any plans for a video on how to become a hair transplant surgeon? I’m considering this career path in my next life.
Ru58841 is making my hairline shed like crazy, plus it is very itchy. I’ve been on minoxidil for years. I dint know what todo ?
did it stop? regrowth?
Wouldn't a hematopoietic stem cell approach be ineffective due to the difference in germ lines? Or is it done to trigger epithelial stem cells via induction?
can you make a video on the study going on japan for hair cloning or a company in europe that got success in growing hair in a lab.
Good video, thanks for talking about RU58841.
Thanks for watching!
You're welcome, thank you for the great information!
www.ebay.com/itm/123992109364
Great information👍
If ru58841 goes systemic, how long do the side effects last? I used one 50mg does on my scalp and I feel very dizzy, no energy, and no libido with Ed. Someone please let me know because I'm scared 😔
Jesus Christ man. Hope ur feeling better
@@vocalone1008 thanks mate but I still don't feel better and it's been a week now
im using ru for 6 months now first 3 months on 50mg no sides so i increased the dose to about 65mg and felt dizzy and low energy so i stopped taking it for 1 week.
now im feeling good again but going back on 50mg
are u sure its just from Ru or did u use any other antiandrogens
@@bebareo no it was just RU58841 my guy, glad your feeling better, i still got really bad insomnia aswell.
@@bebareo libido low aswell still
Good day doctors,im desperate.i have a receding hairline,and im only 17. My dermatologist prescribed hair thickening shampoos,serum and a cream,i asked her how could we know exactly the cause of hairloss,i asked her about blood test,she refused,she said she was sure it was genetics since my dad is bald too.i dont want to spend money on something that doesnt work.what can i do?could there be another reason??pls help ms
You should go to a dermatologist and ask for Propecia. It's supposed to be for males 18 and older, but they might give you a prescription anyway.
Great video as always, Docs. I have a few questions if u not bothered. Im using fin for almost 5 months, going great, had first result after 2 months. Does that mean Im a good responder and 1y result will be even better ? At the start I had some diffu thining and about Norwood 1, now more than 50% of thinned hair is totally fine. Im 24 yo and faced first noticed problems about 3-4 years ago.
Can you get ru from your dermatologist in Australia nsw
Ru or dutasteride.. Which one is better.. I am from India and sadly not able to find ru.
They both can destroy your dht and libido
is there any possibility that breast implants can cause male pattern hair loss in women? is it possible that they "activated" hair loss?
Potentially as implants cause auto immune disorders in some women, and one of the symptoms of autoimmune disorders is bald spots as the WBC attack your own cells inclusive of your hair cells. Hope this helped somewhat.
No, male pattern hair loss is created by the male hormone dht not implants or injuries
Can DHT cause eyebrow hair to fall out ?
No
I think yes it can cause eyebrows and eyelashes to fall.
Fun fact: Finasteride simulates testosterone and gets used by th e 5ar enzyme. I wish docs would explain this more because it is central to understanding the chemical engineering of many hair loss drugs. When 5ar enzymes consume finasteride instead of testosterone they don't make DHT and the testosterone that would have been consumed by the 5ar enzyme remains free thus "increasing" free testosterone.
Where can we buy RU58841? Im here in the Philippines...
I think you can buy it in Indonesia
Well if I don’t reverse my hair loss I’m planning to kill myself, so I guess r58841 is probably pretty safe in comparison
I feel the same my life has been a waste for 35 yrs over hair loss and people think its a fn joke 😢 hope they are happy when i am gone
@@kingssing that is a joke. hair loss is not that big of a deal 🤣
What about Fluridil? Is it effective or not?
Most of people that use it claim weak to no improvement and others claim that they got sides from it
But it worked for some ppl it just depends on how you respond most ppl are disappointed with results
I just started RU58841
Can you talk about breezula please?
Finasteride is just the best , almost 5 months on it with 1mg 3 times a week . No side effects with almost %100 stabilization and little bit improvement . The only side effects i feel is i am not waking up with hard on as frequent as i used to be and i don't think about sex as much as i used to be but not to the point where i can't maintain erection or can't get erection
www.ebay.com/itm/123992109364
And that's how it starts and that why I jumped of that shit
Procapil vs minoxidil ? 😊
Say you take something like finasteride and then you stop a few years later. Would you lose your hair no matter what? Even if you wouldn’t have lost that hair before hand if you didn’t take the tablet? I hope you understand what I mean aha. Keep it up!
Topilutamide
A Donkey yeah that’s also what I thought but can’t seem to find anything proving either point. I want to start it early like most to get the best out of it but then if it causes me to lose hair no matter what then idk haha. Guess we will have to wait and see if someone knows.
Docs, how do you still maintain your hair? Like hairloss with age increases thinning and shedding. How do you maintain your hair? thanks
Neither of them or on anything. They both said they tried finesteride for a while but it didn't do muvh
@@user-vq5fv9yi5s I used minoxidil for 1 day can I stop using it now? Im getting urinary problem with it idk why.
@@alidaud258 idk not a doctor
@@alidaud258 of course. I doubt it was the cause though.
Can you talk about redensyl please?
Thanks for a Valuable info Dr zahid
so I understand what you are saying,, there is no clear evidence either way in human studies. That begs the question, Why cant /wont leading hair loss doctors do a Randomised control trial to investigate this for us so the literature is there to make an informed decision. (and other molecules e.g dut) I cannot understand why the research is not completed by those who have a interest in improving practice (and providing evidence based medicine), especially since the patent has expired. It is actually more harmful ethically to not do it the research given how many people online take it without the appropriate investigations (im sure socrates would agree) at little cost. In is concerning to be how this issue has so many people rubbing research grade products on their heads in the hope of the cure... and too an extent that is due to failure of pharmaceutical companies to expedite their research fully. Plus, considering how many people are already seem to be taking it, a trial isnt inconceivable.
If RU58841 goes systemic, what hormones are affected? Could side effects be offset by manually raising Testosterone via HRT?
it if it blocks the AR
If huge doses of ru goes systemic is a preety fucked up scenario since its a very potent anti androgen that blocks both DHT and testosterone and could mess even with your heart.
One of my biggest question regarding the hair loss :
People who suffer from androgenetic alopecia are their hair prone to DHT because of their genes or is it there body is producing too much of DHT ?.... I mean people who don't go through androgenetic alopecia can we say that their bodies don't produce that much amount of DHT as compared to people going through androgenetic alopecia OR is it just every male's hair in this world is prone to too much of DHT ? In simple words does "genes" contribute to the factor of producing more DHT or does it contribute towards weakening of hair follicles due to presence of DHT in one's body ?
Yep, you can have the same dht as someone else but whilst he has all his hair, you could be bald. It is all down to genetics and sensitivity of scalp to dht