Thank you. I have high IBC and low ferritin levels on a consistent basis. Drs. cant help me. They put me on iron sups, with no change. Please help. Always tired
Thanks for your query, Dr Anshuman. It’s because in Anaemia of Inflammation/AI ( earlier called , Anaemia of chronic disease) : transferrin level is low. So, TIBC level becomes low. If you follow my hotel-room analogy , If your total room number in hotel decreases ; the maximum number of people who can stay in hotel also decreases. The concept that you need to understand in AI/ACD the main problem is that iron is “ locked up” in reticuloendothelial macrophages, making it unavailable to developing red blood cells. So, body don’t need to make more transferrin to “ hunt down “ iron. (Unlike Iron deficiency anaemia. Where body is searching badly to get more iron.) So, transferrin level decreases in Anaemia of inflammation/Anaemia of chronic disease >> concurrently, TIBC decreases in Anaemia of inflammation (earlier called, Anaemia of chronic disease). I have not got time to discuss Anaemia of inflammation here ; but, as you asked I explained here. Hope this clears your doubt.
Surely will do , Ayan. Please be assured 😃👍that I have kept your request in mind. I will do it when I do a series on shock. Thank you for your constant appreciation , feedback and support. Really, it means a lot.
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Thank you Dr Kishore. Truly appreciate all your videos.
You’re most welcome 🙏👍
Thank you sir..was confused with this tibc in iron profile ..a big thank you from a neetpg aspirant
This was so helpful
thank you so much ❤
Thanks dr❤
How is this possible.?? Please tell sir.. My iron is 123 but my tibc is 448..my age is 26..
❤
Thank you. I have high IBC and low ferritin levels on a consistent basis. Drs. cant help me. They put me on iron sups, with no change. Please help. Always tired
Why does it decrease in AOCD?
Thanks for your query, Dr Anshuman. It’s because in Anaemia of Inflammation/AI ( earlier called , Anaemia of chronic disease) : transferrin level is low. So, TIBC level becomes low.
If you follow my hotel-room analogy , If your total room number in hotel decreases ; the maximum number of people who can stay in hotel also decreases.
The concept that you need to understand in AI/ACD the main problem is that iron is “ locked up” in reticuloendothelial macrophages, making it unavailable to developing red blood cells. So, body don’t need to make more transferrin to “ hunt down “ iron. (Unlike Iron deficiency anaemia. Where body is searching badly to get more iron.)
So, transferrin level decreases in Anaemia of inflammation/Anaemia of chronic disease >> concurrently, TIBC decreases in Anaemia of inflammation (earlier called, Anaemia of chronic disease). I have not got time to discuss Anaemia of inflammation here ; but, as you asked I explained here. Hope this clears your doubt.
Yes sir . I don't know if he understood or not .. but to me it is as cleas as water ..
@@pathology360thank u sir ❤
Welcome 🙏 , Arijit.
Sir septic shock??
Surely will do , Ayan. Please be assured 😃👍that I have kept your request in mind. I will do it when I do a series on shock. Thank you for your constant appreciation , feedback and support. Really, it means a lot.